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    • 7. 发明申请
    • PROCESS FOR THE PREPARATION OF TRIAZINYLAMINOSTILBENE-DISULPHONIC ACID COMPOUNDS
    • 制备三亚氨基二苯醚类化合物的方法
    • WO02055509A1
    • 2002-07-18
    • PCT/EP2002/000070
    • 2002-01-07
    • C07D251/70C07D251/68
    • C07D251/68
    • A process for the preparation of a 4,4'-bistriazinylamino-stilbene-2,2'-disulphonic acid compound of formula (I) in which, independently, each R1 represents -NH2, -NH(C1-c10alkyl), -N(C1-C10alkyl)2, -NH(C2-C4hydroxyalkyl), -NH(C2-C4hydroxyalkyl)2, -N(C1-C10alkyl)(C2-C4hydroxyalalkyl), -NH(C1-C4alkoxy-C2-C4hydroxyalkyl), -N(C1-C4alkoxy-C2-C4hydroxyalkyl)2, -N(C1-C4alkoxy-C2-C4hydroxyalkyl)(C1-C10alkyl), -N(C1-C4alkoxy-C2-C4hydroxyalkyl)(C2-C4hydroxyalkyl), -NH(C1-C4alkoxy-C1-C4alkoxy-C1-C4-alkyl), -N(C1-C4alkoxy-C1-C4alkoxy-C1-C4-alkyl)2, -N(C1-C4alkoxy-C1-C4alkoxy-C1-C4-alkyl)(C1-C4alkyl), -N(C1-C4alkoxy-C1-C4alkoxy-C2-C4-alkyl)(C2-C4hydroxyalkyl)-NH(C5-C7cycloalkyl), -N(C5-C7cycloalkyl)2, -NH(C6-C10aryl), NH(C7-C13aralkyl) or a morpholino, piperidino or pyrrolidino residue; M represents H, Na, Li, K, Ca, Mg, ammonium, or ammonium that is mono-, di-, tri- or tetrasubstituted by C1-C4alkyl, C2-C4hydroxyalkyl or a mixture thereof, characterized by reacting a compound of the formula (II) in which R2 represents -C1-C10alkyl, which is substituted or unsubstituted, and X represents halogen, with at least 4 moles of an amine of formula R1H(3) or mixtures thereof.
    • 制备式(I)的4,4'-双三嗪基氨基 - 二苯乙烯-2,2'-二磺酸化合物的方法,其中R 1独立地表示-NH 2,-NH(C 1 -C 10烷基), - N (C 1 -C 10烷基)2,-NH(C 2 -C 4羟烷基),-NH(C 2 -C 4羟烷基)2,-N(C 1 -C 10烷基)(C 2 -C 4羟基烷基), - (C 1 -C 4烷氧基-C 2 -C 4羟烷基) N(C 1 -C 4烷氧基-C 2 -C 4羟烷基)2,-N(C 1 -C 4烷氧基-C 2羟基烷基)(C 1 -C 10烷基), - N(C 1 -C 4烷氧基-C 2 - C 1 -C 4烷氧基-C 1 -C 4烷氧基-C 1 -C 4烷基),-N(C 1 -C 4烷氧基-C 1 -C 4烷氧基-C 1 -C 4 - 烷基)2,-N(C 1 -C 4烷氧基-C 1 -C 4烷氧基-C 1 -C 4烷基) (C 1 -C 4烷基),-N(C 1 -C 4烷氧基-C 1 -C 4烷氧基-C 2 -C 4烷基)(C 2 -C 4羟烷基)-NH(C 5 -C 7环烷基) C10芳基),NH(C7-C13芳烷基)或吗啉代,哌啶子基或吡咯烷子基残基; M表示被C 1 -C 4烷基,C 2 -C 4羟烷基或其混合物单,二,三或四取代的H,Na,Li,K,Ca,Mg,铵或铵,其特征在于使 式(II)其中R2表示取代或未取代的-C1-C10烷基,X表示卤素,与至少4摩尔式R1H(3)的胺或其混合物。