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1. 发明申请

WO2023072671A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS IX 审中-公开
公开(公告)号：WO2023072671A1
公开(公告)日：2023-05-04
申请号：PCT/EP2022/078908
申请日：2022-10-18
申请人： BASF SE
发明人： KOCH, Andreas , FEHR, Marcus , TEGGE, Vanessa , DEY, Chandan , LE VEZOUET, Ronan , RATH, Rakesh , POONOTH, Manojkumar , WINTER, Christian Harald , KHANNA, Smriti , CRAIG, Ian Robert , GRAMMENOS, Wassilios , STAMMLER, Gerd , MENTZEL, Tobias , DAS, Saikat , LUDWIG, Lydia , RUDOLF, Georg Christoph
IPC分类号： A01N37/36 , A01N37/50 , A01N43/20 , A01N43/44 , A01N43/80 , A01N43/82 , A01P3/00 , C07D205/04 , C07D261/08 , C07D271/06 , C07D305/06 , C07C15/12 , C07C57/42
摘要： The present invention relates to the use of strobilurin type compounds of formula I and the N- oxides and the salts thereof for combating phytopathogenic fungi containing an amino acid substitution F129L in the mitochondrial cytochrome b protein (also referred to as F129L mutation in the mitochondrial cytochrome b gene) conferring resistance to Qo inhibitors, and to methods for combating such fungi. The invention also relates to novel compounds, processes for preparing these compounds, to compositions comprising at least one such compound, and to seeds coated with at least one such compound.

2. 发明申请

WO2021219388A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS III 审中-公开
公开(公告)号：WO2021219388A1
公开(公告)日：2021-11-04
申请号：PCT/EP2021/059732
申请日：2021-04-15
申请人： BASF SE
发明人： KOCH, Andreas , FEHR, Marcus , TEGGE, Vanessa , DEY, Chandan , POONOTH, Manojkumar , KULKARNI, Sarang , LE VEZOUT, Ronan , WINTER, Christian Harald , RUDOLF, Georg Christoph , RATH, Rakesh , KHANNA, Smriti , CRAIG, Ian Robert , GRAMMENOS, Wassilios , GROTE, Thomas , STAMMLER, Gerd , MENTZEL, Tobias , HADEN, Egon , RHEINHEIMER, Joachim
IPC分类号： A01N37/36 , A01N37/50 , A01P3/00 , C07C15/12 , C07C15/44 , C07C57/42
摘要： The present invention relates to the use of strobilurin type compounds of formula I and the N-oxides and the salts thereof for combating phytopathogenic fungi containing an amino acid substitution F129L in the mitochondrial cytochrome b protein (also referred to as F129L mutation in the mitochondrial cytochrome b gene) conferring resistance to Qo inhibitors, and to methods for combating such fungi. The invention also relates to novel compounds, processes for preparing these compounds, to compositions comprising at least one such compound, and to seeds coated with at least one such compound.

3. 发明申请

WO2021219387A1 USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS II 审中-公开
公开(公告)号：WO2021219387A1
公开(公告)日：2021-11-04
申请号：PCT/EP2021/059730
申请日：2021-04-15
申请人： BASF SE
发明人： KOCH, Andreas , FEHR, Marcus , TEGGE, Vanessa , DEY, Chandan , POONOTH, Manojkumar , KULKARNI, Sarang , LE VEZOUET, Ronan , WINTER, Christian Harald , RUDOLF, Georg Christoph , RATH, Rakesh , KHANNA, Smriti , CRAIG, Ian Robert , GRAMMENOS, Wassilios , GROTE, Thomas , STAMMLER, Gerd , MENTZEL, Tobias , HADEN, Egon , RHEINHEIMER, Joachim
IPC分类号： A01N37/36 , A01N37/50 , A01P3/00 , C07C15/12 , C07C15/44 , C07C57/42
摘要： The present invention relates to the use of strobilurin type compounds of formula I and the N-oxides and the salts thereof for combating phytopathogenic fungi containing an amino acid substitution F129L in the mitochondrial cytochrome b protein (also referred to as F129L mutation in the mitochondrial cytochrome b gene) conferring resistance to Qo inhibitors, and to methods for combating such fungi. The invention also relates to novel compounds, processes for preparing these compounds, to compositions comprising at least one such compound, and to seeds coated with at least one such compound.

4. 发明申请

WO2017129991A3 PROCESSES FOR PREPARING STERICALLY CONGESTED DICARBOXYLIC ACID LIGANDS AND PRODUCTS THEREOF 审中-公开
公开(公告)号：WO2017129991A3
公开(公告)日：2017-08-03
申请号：PCT/GB2017/050214
申请日：2017-01-27
申请人： STOCKHOLM UNIVERSITY HOLDING AB
发明人： MENDOZA, Abraham , SUÁREZ PANTIGA, Samuel
IPC分类号： C07C51/285 , C07C57/34 , C07C57/46 , B01J23/46 , C07C49/213 , C07C49/215 , C07C49/217 , C07C49/225 , C07C49/233 , C07C49/657 , C07C57/38 , C07C57/42 , C07C57/58 , C07C61/39
摘要： There is provided herein a process for the preparation of a compound of formula I (I) or a salt thereof, wherein X 1 to X 4 , Y 1 to Y 4 , Z and n each have meanings provided in the description. There is also provided certain compounds of formula I.

5. 发明申请

WO2016097914A1 A PROCESS FOR PREPARATION OF BIOAVAILABLE WHITE CURCUMIN - A UNIQUE BLEND OF HYDROGENATED CURCUMINOIDS 审中-公开
标题翻译：一种制备可生物降解的白矾石的方法 - 加氢的UR O A A UE IDS IDS
公开(公告)号：WO2016097914A1
公开(公告)日：2016-06-23
申请号：PCT/IB2015/059348
申请日：2015-12-04
申请人： AUREA BIOLABS PRIVATE LIMITED
发明人： GOPI, Sreeraj , JACOB, Joby , GEORGE, Robin
IPC分类号： A61K31/045 , A61K31/05 , C07C57/42 , C07C57/72 , C07C209/26
CPC分类号： A61K31/121 , A23L33/105 , A23V2002/00 , A61K47/6951 , C07C41/20 , C07C45/62 , C08B37/0015 , C07C43/23 , C07C49/225
摘要： The present invention discloses a process for preparation of white curcumin from purified curcuminoids. The curcuminoids are obtained by solvent extraction and crystallization of dried turmeric powder. The autoclave is charged with ethyl acetate and the 95% purity curcuminoids mixture is added to and stirred for uniformity at room temperature. 5% (w/w) of 10% palladium carbon is added to the reaction mixture and allowed for hydrogenation in the presence of hydrogen gas at 2 lbps pressure and stirred continuously for 15 hours. Once the reaction is completed, the reaction mixture is filtered and washed with ethyl acetate. The ethyl acetate is distilled off and crude mass is stirred with water to obtain a solid precipitate. Finally, the solid obtained is filtered and dried to pale brown crystals of white curcumin. White curcumin is encapsulated with beta- cyclodextrin, which exhibited increased bioavailability. White curcumin also exhibited anti-oxidant and chemopreventive activities.
摘要翻译：本发明公开了一种从纯化姜黄素制备白姜黄素的方法。姜黄素通过溶剂萃取和结晶的姜黄粉得到。向高压釜中加入乙酸乙酯，并将95％纯度的姜黄色调混合物加入并在室温下搅拌均匀。将5％（w / w）的10％钯碳加入到反应混合物中，并在氢气存在下以2l / s压力进行氢化并连续搅拌15小时。一旦反应完成，将反应混合物过滤并用乙酸乙酯洗涤。蒸馏除去乙酸乙酯，将粗物质与水一起搅拌，得到固体沉淀物。最后，将得到的固体过滤并干燥成白色姜黄素的淡棕色晶体。白色姜黄素用β-环糊精包封，其呈现出增加的生物利用度。白姜黄素还具有抗氧化和化学预防作用。

6. 发明申请

WO2013110998A8 A PROCESS FOR PREPARATION OF ALKYNYL CARBOXYLIC ACIDS 审中-公开
标题翻译：一种制备烷基羧酸的方法
公开(公告)号：WO2013110998A8
公开(公告)日：2014-06-12
申请号：PCT/IB2013000083
申请日：2013-01-25
申请人： COUNCIL SCIENT IND RES , AHER RAVINDRA DATTATRAY , GADE MADHURI HANUMANT , REKULA REDDY SANTHOSH , KARABAL PRATIBHA UTTAM , SURYAVANSHI GURUNATH MALLAPPA , SUDALAI ARUMUGAM
发明人： AHER RAVINDRA DATTATRAY , GADE MADHURI HANUMANT , REKULA REDDY SANTHOSH , KARABAL PRATIBHA UTTAM , SURYAVANSHI GURUNATH MALLAPPA , SUDALAI ARUMUGAM
IPC分类号： C07C51/15 , C07C57/18 , C07C57/42 , C07C59/64
CPC分类号： C07C51/15 , C07C57/18 , C07C57/42 , C07C59/64
摘要： The invention provides a simple, efficient, environmental friendly catalytic system for the direct carboxylation reaction using C02 under mild condition. A single step heterogeneous catalytic process for preparation of alkynyl carboxylic acids of formula I is disclosed.
摘要翻译：本发明提供了在温和条件下使用CO 2的直接羧化反应的简单，有效的环境友好的催化体系。公开了用于制备式I的炔基羧酸的单步非均相催化方法。

7. 发明申请

WO2007045369A1 DIFLUORPHENOL-DERIVATE UND IHRE VERWENDUNG 审中-公开
标题翻译：氟苯酚衍生物及其
公开(公告)号：WO2007045369A1
公开(公告)日：2007-04-26
申请号：PCT/EP2006/009726
申请日：2006-10-09
申请人： BAYER HEALTHCARE AG , BARTEL, Stephan , HAHN, Michael , MORADI, Wahed, Ahmed , BECKER, Eva-Maria , RÖLLE, Thomas , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , KNORR, Andreas
发明人： BARTEL, Stephan , HAHN, Michael , MORADI, Wahed, Ahmed , BECKER, Eva-Maria , RÖLLE, Thomas , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , KNORR, Andreas
IPC分类号： C07D257/04 , C07C229/14 , C07C57/42 , A61K31/41 , A61K31/195 , A61P9/00
CPC分类号： C07C59/68 , C07C229/14 , C07D249/12 , C07D257/04 , C07D271/07 , C07D271/113
摘要： Die vorliegende Anmeldung betrifft neue Difluorphenol-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Behandlung und/oder Prävention kardiovaskulärer Erkrankungen.
摘要翻译：本申请涉及新的二氟苯酚衍生物，它们的制备方法，其用于疾病的治疗和/或预防和它们用于制备药物用于疾病的治疗和/或预防中的用途，特别是用于治疗心血管疾病的治疗和/或预防的用途。

8. 发明申请

WO2004046104A3 TREATMENT OF LUNG CELLS WITH HISTONE DEACETYLASE INHIBITORS 审中-公开
标题翻译：用HISTONE脱乙酰壳多糖酶抑制剂处理肺细胞
公开(公告)号：WO2004046104A3
公开(公告)日：2004-08-05
申请号：PCT/US0336981
申请日：2003-11-19
申请人： BEACON LAB , WIECH NORBERT L , LAN-HARGEST HSUAN-YIN
发明人： WIECH NORBERT L , LAN-HARGEST HSUAN-YIN
IPC分类号： A61K31/16 , A61K31/19 , C07C57/42 , C07C57/60 , C07C259/06 , C07D307/54 , C07C259/04
CPC分类号： A61K31/16 , A61K31/19 , C07C57/42 , C07C57/60 , C07C259/06 , C07D307/54
摘要： Lung disease, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma or acute and chronic bronchitis, can be treated with an oxyamide-containing compound.
摘要翻译：肺部疾病如囊性纤维化（CF），慢性阻塞性肺疾病（COPD），哮喘或急性和慢性支气管炎可用含有氧酰胺的化合物治疗。

9. 发明申请

WO0141543A8 PESTICIDAL ACTIVITY OF FUNCTIONALIZED ALKENES 审中-公开
标题翻译：功能性碱的杀虫活性
公开(公告)号：WO0141543A8
公开(公告)日：2002-12-27
申请号：PCT/US0031558
申请日：2000-11-16
申请人： UNIV NORTH CAROLINA STATE , LINDERMAN RUSSELL J
发明人： LINDERMAN RUSSELL J
IPC分类号： A01N37/10 , A01N37/18 , A01N37/38 , C07C57/26 , C07C57/42 , C07C57/60 , C07C59/64 , C07C69/608 , C07C69/618 , G01N33/50
CPC分类号： G01N33/5082 , A01N37/10 , A01N37/18 , A01N37/38 , C07C57/26 , C07C57/42 , C07C57/60 , C07C59/64 , C07C69/608 , C07C69/618 , C07C2601/14 , Y10S514/875 , Y10S514/951
摘要： The present invention provides non-peptide organic compounds that have a structure analogous to or reminiscent of the TMOF structure and have pesticidal activity. Particular pesticidal compounds/non-peptide TMOF analogs of the present invention have formula (I) wherein: X is selected from the group consisting of -CHCH-, -CH2CH2-, and -CC-; Z is selected from the group consisting of -OH, -NH2 and -OR6 wherein R6 is loweralkyl; n and m are each at last (I) and together total an integer from 2, 3 or 4 to 6, 8, 10 or 12; and R1, R2, R3, R4 and R5 are each independently selected from the group consisting of -H, -OH, halo, loweralkyl, and loweralkoxy; subject to the proviso that: a pair of R1 and R2, R2 and R3, or R3 and R4 on the phenyl ring may together represent -CR7=CR8-CR9=CR10-, to form with the phenyl ring illustrated above a naphthyl ring system, wherein R7, R8, R9 and R10 are each independently selected from the group consisting of -H, -OH, halo, loweralkyl, and loweralkoxy. Thus the present invention concerns pesticidal compounds that inhibit digestion in pests by terminating or otherwise blocking synthesis of digestive enzymes by activating a TMOF receptor (collectively referred to herein as "pesticidal compounds"). The pesticidal compounds and other compounds of the present invention are usefully employed in the control of pests, particularly insect pests such as mosquitoes, which ingest blood.
摘要翻译：本发明提供了具有与TMOF结构类似或令人想起的具有杀虫活性的结构的非肽有机化合物。本发明的特定杀虫化合物/非肽TMOF类似物具有式（I），其中：X选自-CHCH - ， - CH 2 CH 2 - 和-CC-; Z选自-OH，-NH 2和-OR 6，其中R 6是低级烷基; n和m各自为最后（I），并且总共为2,3或4至6,8,10或12的整数; 并且R 1，R 2，R 3，R 4和R 5各自独立地选自-H，-OH，卤素，低级烷基和低级烷氧基; 条件是：苯环上的一对R 1和R 2，R 2和R 3或R 3和R 4可以一起表示-CR 7 = CR 8 -CR 9 = CR 10 - ，与上述苯环形成萘基环系其中R 7，R 8，R 9和R 10各自独立地选自-H，-OH，卤素，低级烷基和低级烷氧基。因此，本发明涉及通过终止或以其它方式阻断消化酶的合成来抑制害虫消化的农药化合物，其通过激活TMOF受体（本文统称为“杀虫化合物”）。本发明的杀虫化合物和其他化合物有效地用于控制害虫，特别是摄入血液的昆虫害虫如蚊子。

10. 发明申请

WO0177057A3 HALOGENATED TRIPHENYLETHYLENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS 审中-公开
标题翻译：作为选择性雌激素受体调节剂的氢化三苯乙烯衍生物
公开(公告)号：WO0177057A3
公开(公告)日：2002-06-13
申请号：PCT/US0111080
申请日：2001-04-05
申请人： DU PONT PHARM CO
发明人： KALTENBACH ROBERT F III , TRAINOR GEORGE L
IPC分类号： A61P9/10 , A61K31/201 , A61P9/00 , A61P13/08 , A61P13/10 , A61P19/10 , A61P35/00 , A61P43/00 , C07C47/24 , C07C57/42 , C07C57/60 , C07C69/65 , A61K31/192
CPC分类号： C07C57/60
摘要： The present invention describes novel halogenated triphenylethylene derivatives, or pharmaceutically acceptable prodrug or salt forms thereof, as selective estrogen receptor modulators for the treatment of and/or prevention of breast, uterine, ovarian, prostrate and colon cancer, osteoporosis, cardiovascular disease, and benign proliferative disorders, as well as methods for making the compounds and pharmaceutical compositions of this invention.
摘要翻译：本发明描述了新颖的卤代三苯基乙烯衍生物或其药学上可接受的前药或盐形式作为用于治疗和/或预防乳腺，子宫，卵巢，前列腺和结肠癌，骨质疏松症，心血管疾病和良性的选择性雌激素受体调节剂增殖性疾病，以及制备本发明化合物和药物组合物的方法。

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