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1. 发明申请

WO2016097914A1 A PROCESS FOR PREPARATION OF BIOAVAILABLE WHITE CURCUMIN - A UNIQUE BLEND OF HYDROGENATED CURCUMINOIDS 审中-公开
标题翻译：一种制备可生物降解的白矾石的方法 - 加氢的UR O A A UE IDS IDS
公开(公告)号：WO2016097914A1
公开(公告)日：2016-06-23
申请号：PCT/IB2015/059348
申请日：2015-12-04
申请人： AUREA BIOLABS PRIVATE LIMITED
发明人： GOPI, Sreeraj , JACOB, Joby , GEORGE, Robin
IPC分类号： A61K31/045 , A61K31/05 , C07C57/42 , C07C57/72 , C07C209/26
CPC分类号： A61K31/121 , A23L33/105 , A23V2002/00 , A61K47/6951 , C07C41/20 , C07C45/62 , C08B37/0015 , C07C43/23 , C07C49/225
摘要： The present invention discloses a process for preparation of white curcumin from purified curcuminoids. The curcuminoids are obtained by solvent extraction and crystallization of dried turmeric powder. The autoclave is charged with ethyl acetate and the 95% purity curcuminoids mixture is added to and stirred for uniformity at room temperature. 5% (w/w) of 10% palladium carbon is added to the reaction mixture and allowed for hydrogenation in the presence of hydrogen gas at 2 lbps pressure and stirred continuously for 15 hours. Once the reaction is completed, the reaction mixture is filtered and washed with ethyl acetate. The ethyl acetate is distilled off and crude mass is stirred with water to obtain a solid precipitate. Finally, the solid obtained is filtered and dried to pale brown crystals of white curcumin. White curcumin is encapsulated with beta- cyclodextrin, which exhibited increased bioavailability. White curcumin also exhibited anti-oxidant and chemopreventive activities.
摘要翻译：本发明公开了一种从纯化姜黄素制备白姜黄素的方法。姜黄素通过溶剂萃取和结晶的姜黄粉得到。向高压釜中加入乙酸乙酯，并将95％纯度的姜黄色调混合物加入并在室温下搅拌均匀。将5％（w / w）的10％钯碳加入到反应混合物中，并在氢气存在下以2l / s压力进行氢化并连续搅拌15小时。一旦反应完成，将反应混合物过滤并用乙酸乙酯洗涤。蒸馏除去乙酸乙酯，将粗物质与水一起搅拌，得到固体沉淀物。最后，将得到的固体过滤并干燥成白色姜黄素的淡棕色晶体。白色姜黄素用β-环糊精包封，其呈现出增加的生物利用度。白姜黄素还具有抗氧化和化学预防作用。

2. 发明申请

WO2012052550A1 CROSS-LINKER 审中-公开
标题翻译：交联剂
公开(公告)号：WO2012052550A1
公开(公告)日：2012-04-26
申请号：PCT/EP2011/068451
申请日：2011-10-21
申请人： NEXAM CHEMICAL AB , RÖME, Daniel , PERSSON, David , LAGER, Erik , MOMCILOVIC, Dane , KNUTSSON, Malin , ROSENBERG, Jan-Erik
发明人： RÖME, Daniel , PERSSON, David , LAGER, Erik , MOMCILOVIC, Dane , KNUTSSON, Malin , ROSENBERG, Jan-Erik
IPC分类号： C07C57/34 , C07C57/72 , C07C233/65 , C07D209/48 , C07D307/89 , C08G69/48 , C08L77/06
CPC分类号： C07D307/89 , C07C233/65 , C07D209/48 , C07D209/50 , C08G69/48 , C08L77/06
摘要： Disclosed are novel cross-linkable end-cappers for oligo-and polyamides. End-capped oligo-and polyamides comprising such an end-capper may be cured at a lower temperature compared to oligo-and polyamides end-capped with PEPA.
摘要翻译：公开了用于寡聚和聚酰胺的新型可交联封端剂。与使用PEPA封端的低聚物和聚酰胺相比，包含这种封端剂的封端的低聚物和聚酰胺可以在较低的温度下固化。

3. 发明申请

WO01074770A1 C2 PHENYL-SUBSTITUTED CYCLIC KETO-ENOLS USED AS PESTICIDES AND HERBICIDES 审中-公开
标题翻译： C2取代的环状酮烯醇AS杀虫剂和除草剂
公开(公告)号：WO01074770A1
公开(公告)日：2001-10-11
申请号：PCT/EP2001/003215
申请日：2001-03-21
IPC分类号： A01N35/06 , A01N37/02 , A01N43/06 , A01N43/08 , A01N43/12 , A01N43/16 , A01N43/36 , A01N43/38 , A01N43/90 , A01N47/06 , C07C45/46 , C07C45/67 , C07C49/513 , C07C49/657 , C07C49/747 , C07C57/32 , C07C57/72 , C07C62/22 , C07C69/013 , C07C69/24 , C07C69/612 , C07C69/738 , C07C69/757 , C07C233/51 , C07C323/22 , C07D207/38 , C07D209/54 , C07D307/94 , C07D309/14 , C07D309/38 , C07D491/10 , C07D491/107 , C07F7/08 , C07C49/733 , C07C233/52
CPC分类号： C07D491/10 , A01N43/06 , A01N43/12 , A01N43/16 , A01N43/36 , A01N43/38 , A01N43/90 , A01N47/06 , C07C45/46 , C07C49/657 , C07C49/747 , C07C69/013 , C07C69/612 , C07C69/738 , C07C69/757 , C07C233/51 , C07D207/38 , C07D209/54 , C07D307/94 , C07D309/14 , C07D309/38 , C07F7/0818
摘要： The invention relates to novel C2 phenyl-substituted cyclic keto-enols of formula (I), in which W, X, Y, Z and CKE have the meanings as cited in the description. The invention also relates to methods for producing said C2 phenyl-substituted cyclic keto-enols and to their use as pesticides and herbicides.
摘要翻译：本发明涉及式（I），其中W，X，Y，Z和CKE具有说明书中给出的含义的新C2取代的环酮 - 烯醇，它们的制备方法和它们作为杀虫剂和除草剂的用途。

4. 发明申请

WO99008989A1 PROCESSES FOR PREPARING HYDROCINNAMIC ACID 审中-公开
标题翻译：制备水合酸的方法
公开(公告)号：WO99008989A1
公开(公告)日：1999-02-25
申请号：PCT/US1998/014940
申请日：1998-07-17
IPC分类号： C07C29/17 , C07C45/62 , C07C51/27 , C07C51/60 , C07C51/255 , C07C57/30 , C07C57/72
CPC分类号： C07C51/27 , C07C29/175 , C07C45/62 , C07C51/60 , C07C47/228 , C07C57/30 , C07C57/72 , C07C33/20
摘要： Processes for preparing aromatic carboxylic acids. Cinnamaldehyde is hydrogenated to produce a mixture of hydrogenation products, namely hydrocinnamaldehyde and hydrocinnamic alcohol. The mixture is then oxidized using a suitable oxidizing agent to substantially completely convert both hydrocinnamaldehyde and hydrocinnamic alcohol to hydrocinnamic acid.
摘要翻译：制备芳香族羧酸的方法。氢化肉桂醛以产生加氢产物，即氢化肉桂醛和氢化肉桂醇的混合物。然后使用合适的氧化剂将混合物氧化，以将氢化肉桂醛和氢化肉桂醇两者基本上完全转化成氢化肉桂酸。

5. 发明申请

WO2017171544A1 PREPARATION OF HALIDE PRODUCTS 审中-公开
标题翻译：卤化物产品的制备
公开(公告)号：WO2017171544A1
公开(公告)日：2017-10-05
申请号：PCT/NL2017/050193
申请日：2017-03-29
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
发明人： CROCKATT, Marc , GEERS, Leonard Ferdinand Gerard , VAN SOMEREN, Rudolf Gijsbertus , WILES, Charlotte
IPC分类号： C07C17/16 , C07C51/60 , C07C57/72
CPC分类号： C07C51/60 , C07C65/21
摘要： The invention is directed to a method for the preparation of an acyl or alkyl halide, comprising, respectively, reacting a carboxylic acid or an alcohol with a halogenation agent in the presence of a base, wherein the reaction is at least partially carried out in a continuous-flow reactor.
摘要翻译：本发明涉及一种制备酰基或烷基卤的方法，其分别包括使羧酸或醇与卤化剂在碱存在下反应，其中反应至少部分在连续流动反应器中进行。

6. 发明申请

WO9805638A3 2- AND 2,5-SUBSTITUTED PHENYLKETOENOLS 审中-公开
标题翻译： 2和2,5-取代PHENYLKETOENOLE
公开(公告)号：WO9805638A3
公开(公告)日：1998-03-19
申请号：PCT/EP9703973
申请日：1997-07-23
申请人： BAYER AG , LIEB FOLKER , FISCHER REINER , BRETSCHNEIDER THOMAS , RUTHER MICHAEL , GRAFF ALAN , SCHNEIDER UDO , ERDELEN CHRISTOPH , WACHENDORFF-NEUMANN ULRIKE , ANDERSCH WOLFRAM , TURBERG ANDREAS
发明人： LIEB FOLKER , FISCHER REINER , BRETSCHNEIDER THOMAS , RUTHER MICHAEL , GRAFF ALAN , SCHNEIDER UDO , ERDELEN CHRISTOPH , WACHENDORFF-NEUMANN ULRIKE , ANDERSCH WOLFRAM , TURBERG ANDREAS
IPC分类号： A01N43/08 , A01N43/10 , A01N43/16 , A01N43/36 , C07C57/34 , C07C57/46 , C07C57/58 , C07C57/72 , C07C59/64 , C07C59/88 , C07C69/612 , C07C69/65 , C07C69/734 , C07C69/757 , C07C233/51 , C07C233/52 , C07C235/36 , C07C255/29 , C07D207/38 , C07D209/54 , C07D209/96 , C07D231/56 , C07D307/20 , C07D307/60 , C07D307/94 , C07D309/14 , C07D309/38 , C07D311/02 , C07D311/74 , C07D313/04 , C07D333/32 , C07D333/50 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/14 , C07D491/10 , C07D491/107 , C07D493/04 , C07D493/10 , C07D495/10
CPC分类号： C07D405/14 , C07C57/34 , C07C57/58 , C07C59/64 , C07C59/88 , C07C69/65 , C07C69/734 , C07C69/757 , C07C233/51 , C07C233/52 , C07C235/36 , C07C255/29 , C07C2601/14 , C07D207/38 , C07D209/96 , C07D231/56 , C07D307/94 , C07D309/14 , C07D313/04 , C07D333/50 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/14 , C07D491/10 , C07D493/10
摘要： New phenyl-substituted cyclic ketoenols are disclosed having the formula (I), in which Het stands for one of the groups (1), (2), (3) and (4), in which A, B, D, G, X and Z have the meanings given in the description. Also disclosed are several processes and intermediate products for preparing the same and their use as pesticides. 00000
摘要翻译： 00000

7. 发明申请

WO2013090547A1 MALONIC ACID DI-SALTS AND A METHOD FOR PREPARING MALONYL DIHALIDES 审中-公开
标题翻译：马来酸钠盐和一种制备马来酸酐的方法
公开(公告)号：WO2013090547A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069468
申请日：2012-12-13
申请人： E. I. DU PONT DE NEMOURS AND COMPANY
发明人： ZHANG, Wenming , ANNIS, Gary David
IPC分类号： C07C257/06 , C07D487/04 , C07C57/34 , C07C51/60 , C07C57/72
CPC分类号： C07D471/04 , C07C51/60 , C07C55/36 , C07C57/34 , C07C57/36 , C07D213/55 , C07C57/72
摘要： A compound of Formula (2) is disclosed: wherein R 1 , M A and M B are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula (1): wherein R 1 and X are as defined in the disclosure comprising contacting a compound of Formula (2) with a halogenating agent. Also disclosed is a method for preparing a compound of Formula (4): wherein R 1 , R 3 and R 4 are as defined in the disclosure, comprising reacting a compound of Formula (5): wherein R 3 and R 4 are as defined in the disclosure with a compound of Formula (1), with a compound of Formula (1), the process of preparing the compound of Formula (4) includes the step of preparing the compound of Formula (1) from the compound of Formula (2) by the method disclosed above. Also disclosed is compound that is methyl 3,5-dichlorobenzeneethanimidate methyl 3,5 dichlorobenzeneethanimidate or ethyl 3,5 dichlorobenzeneethanimidate or salts thereof.
摘要翻译：公开了式（2）的化合物：其中R1，MA和MB如本公开所定义。还公开了制备式（1）化合物的方法：其中R 1和X如本公开所定义，包括使式（2）的化合物与卤化剂接触。还公开了制备式（4）化合物的方法：其中R 1，R 3和R 4如本公开内容所定义，包括使式（5）化合物：其中R 3和R 4如本公开所定义的化合物与式（1）的化合物与式（1）的化合物的制备方法包括由式（2）的化合物通过方法制备式（1）的化合物的步骤如上所述。还公开了3,5-二氯苯甲酰亚胺酸甲酯，3,5-二氯苯甲酰亚胺酸甲酯或3,5-二氯苯甲酰亚氨酸乙酯或其盐的化合物。

8. 发明申请

WO2012069004A1 他喷他多的中间体的合成与应用审中-公开
公开(公告)号：WO2012069004A1
公开(公告)日：2012-05-31
申请号：PCT/CN2011/082915
申请日：2011-11-25
申请人：中国医学科学院药物研究所 , 冯文化 , 马慧
发明人：冯文化 , 马慧
IPC分类号： C07D263/22 , C07C59/64 , C07C51/09 , C07C57/72 , C07C51/60 , C07C235/34 , C07C231/02 , C07C33/22 , C07C29/147 , C07C309/68 , C07C303/28 , C07C211/27 , C07C209/50 , C07C39/02 , C07C37/055 , C07C209/68
CPC分类号： C07C213/00 , C07B2200/07 , C07C51/60 , C07C213/02 , C07C231/02 , C07D263/22 , C07C215/54 , C07C217/62 , C07C235/34 , C07C57/72
摘要：本发明公开了一种他喷他多的关键中间体：（1R,2R）-1-乙基-2-甲基苯乙烷类化合物的制备方法，以及应用这个关键中间体制备他喷他多及衍生物的方法。

9. 发明申请

WO2014138989A1 METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF HYDROXAMIC ACID COMPOUNDS 审中-公开
标题翻译：用于合成羟基酸化合物的方法和中间体
公开(公告)号：WO2014138989A1
公开(公告)日：2014-09-18
申请号：PCT/CA2014/050235
申请日：2014-03-13
申请人： METHYLGENE INC.
发明人： VAISBURG, Arkadii , RAEPPEL, Franck , ROY, Simon , ZHOU, Nancy Z.
IPC分类号： C07C57/42 , C07C259/06 , C07C57/38 , C07C57/72
CPC分类号： C07C51/353 , C07C51/36 , C07C51/60 , C07C259/06 , C07C57/42 , C07C57/38 , C07C57/72
摘要： Methods are disclosed for making a compound of formula and intermediates therefor, where R is aryl or heteroaryl, and L is C3_8alkylene, wherein each of R, L, and the illustrated phenyl group are independently optionally substituted with one or more substituents selected from the group consisting of C].6alkyl, Ci.6alkoxy, CF3, CHF2, CH2F, fluoro, and cyano, which methods can avoid the use of iodo-phenyl esters, or aryl alkynes, or both, or, in which synthetic methods at least one of the intermediates is a solid at room temperature that does not require purification by chromatography.
摘要翻译：公开了制备式的化合物及其中间体的方法，其中R是芳基或杂芳基，L是C 3-8亚烷基，其中R，L和所示苯基中的每一个独立地任选被一个或多个选自由C 1-6烷基，C 1-6烷氧基，CF 3，CHF 2，CH 2 F，氟和氰基组成，该方法可以避免使用碘 - 苯基酯或芳基炔烃或两者，或者其中合成方法至少一种的中间体在室温下是固体，其不需要通过色谱法纯化。

10. 发明申请

WO02072524A3 METHOD FOR PRODUCING VINYL, ARYL AND HETEROARYL ACETIC ACIDS AND DERIVATIVES THEREOF 审中-公开
标题翻译：制备乙烯基，芳基和乙酰乙酸及其衍生物的方法
公开(公告)号：WO02072524A3
公开(公告)日：2002-11-14
申请号：PCT/EP0202423
申请日：2002-03-06
申请人： STUDIENGESELLSCHAFT KOHLE MBH , GOOSSEN LUKAS
发明人： GOOSSEN LUKAS
IPC分类号： C07C51/353 , C07B61/00 , C07C51/09 , C07C51/347 , C07C57/72 , C07C67/343 , C07C69/614 , C07C231/12 , C07C233/11 , C07D295/185 , C07D333/24 , C07C69/612 , C07C69/616 , C07C69/65 , C07C69/738 , C07C233/54
CPC分类号： C07D295/185 , C07C51/09 , C07C51/347 , C07C67/343 , C07D333/24 , C07C57/30 , C07C69/612 , C07C69/73 , C07C69/614 , C07C69/65 , C07C69/738 , C07C69/734
摘要： The invention relates to a method for producing vinyl, aryl and heteroaryl acetic acids and derivatives thereof by reacting vinyl, aryl or heteroaryl boron acids and the derivatives thereof with alpha -halo- or alpha -pseudohalo acetic acids and derivatives thereof, which include a substituent from the group of hydrogen, alkyl or vinyl, aryl and heteroaryl in the 2nd position, in the presence of a palladium catalyst, a base and water. Said method enables the preparation of a plurality of functionalised vinyl, aryl and heteroaryl acetic acids and the derivatives thereof.
摘要翻译：一种用于生产乙烯，芳基和杂芳基，和由乙烯基，芳基或杂芳基硼酸和具有α或α+ -Halo--Pseudohaloessigsäuren及其衍生物，其在2-位从所选择的一个取代基及其衍生物反应而得到的其衍生物的过程系列氢，烷基或乙烯基，芳基和杂芳基在钯催化剂，碱和水存在下进行。该方法允许制备各种官能化乙烯基，芳基和杂芳基乙酸及其衍生物。

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