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1. 发明申请

WO2005118527A2 FLUOROUS CAPPING REAGENTS, AND METHODS FOR PEPTIDE PURIFICATION 审中-公开
标题翻译：荧光吸附试剂，以及用于肽纯化的方法
公开(公告)号：WO2005118527A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/017507
申请日：2005-05-18
申请人： TRUSTEES OF TUFTS COLLEGE , KUMAR, Krishna , MONTANARI, Vittorio
发明人： KUMAR, Krishna , MONTANARI, Vittorio
IPC分类号： C07C309/03
CPC分类号： C07K7/06 , C07C229/36 , C07C311/48 , C07K1/04 , C07K1/10 , C07K5/06113 , C07K5/1016 , C07K7/08
摘要： Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbon. The trivalent iodonium fluorocarbon compound of the invention is useful for attaching a fluorocarbon group to a compound that has a nucleophilic functional group. Another aspect of the present invention relates to a method of preparing a trivalent iodonium fluorocarbon. Another aspect of the present invention relates to a method of preparing a fluorocarbon by treating a compound bearing a nucleophilic functional group with a trivalent iodonium fluorocarbon compound. Another aspect of the present invention relates to a method of purifying a mixture comprising a first and a second compound by treating the mixture with a trivalent iodonium fluorocarbon to attach a fluorocarbon group to the second compound leaving the first compound unchanged, and purifying the mixture by fluorous-phase purification.
摘要翻译：本发明的方面涉及制备碳氟化合物的化合物，制备碳氟化合物的方法，以及化合物的混合物的纯化方法。本发明的一个方面涉及三价碘代氟碳化合物。本发明的三价碘氟碳化合物可用于将氟碳基团连接到具有亲核官能团的化合物上。本发明的另一方面涉及制备三价碘代氟碳化合物的方法。本发明的另一方面涉及通过用三价碘氟碳化合物处理带有亲核官能团的化合物来制备碳氟化合物的方法。本发明的另一方面涉及一种通过用三价碘代氟碳处理混合物来纯化含有第一和第二化合物的混合物的方法，以将碳氟化合物基团连接到第二化合物上，使第一化合物保持不变，并通过氟相纯化。

2. 发明申请

WO2022046543A1 ALKANE MULTI-SULFONIC ACIDS, COMPOSITIONS THEREOF, AND RELATED METHODS 审中-公开
公开(公告)号：WO2022046543A1
公开(公告)日：2022-03-03
申请号：PCT/US2021/046857
申请日：2021-08-20
申请人： UNIVERSITY OF KANSAS
发明人： SHIFLETT, Mark Brandon , KORE, Rajkumar , SCURTO, Aaron M.
IPC分类号： C07C309/03 , C07C309/05 , C07C2/62
摘要： Alkane multi-sulfonic acids and salts thereof are provided. In embodiments, an alkane multi-sulfonic acid or salt thereof comprises an alkyl group and at least two sulfonic acid groups, the alkane multi-sulfonic acid having a total number of carbon atoms of from 2 to 9, wherein the alkane multi-sulfonic acid does not comprise a halogen.

3. 发明申请

WO2018160618A1 HIGH-AND LOW-POTENTIAL, WATER-SOLUBLE, ROBUST QUINONES 审中-公开
公开(公告)号：WO2018160618A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020086
申请日：2018-02-28
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： STAHL, Shannon, S. , GERKEN, James, B. , ANSON, Colin, W. , SUH, Sung-Eun , STAMOULIS, Alexiouis, G.
IPC分类号： C07F9/572 , C07F9/6503 , C07D231/12 , C07F9/6561 , C07C309/03 , C07C309/04 , C07C309/09 , C07C309/13 , C07C309/29 , C07C309/42 , C07D403/10 , C07D403/14 , C07D487/04 , C07D487/22 , C07D495/04 , C07D209/48 , C07D285/01 , C07D513/22 , C07F9/38 , H01B1/12 , H01M8/1032 , H01M8/1034 , H01M8/1039 , H01M8/18 , H01M10/00
CPC分类号： C07F9/5728 , C07C309/03 , C07C309/04 , C07C309/09 , C07C309/11 , C07C309/13 , C07C309/19 , C07C309/29 , C07C309/42 , C07C317/22 , C07C323/66 , C07D209/48 , C07D231/12 , C07D285/01 , C07D403/10 , C07D403/14 , C07D487/04 , C07D487/22 , C07D495/04 , C07D513/22 , C07F9/3808 , C07F9/3834 , C07F9/572 , C07F9/65031 , C07F9/6561 , H01M8/188 , Y02E60/528
摘要： Substituted hydroquinones, 1,4-quinones, catechols, 1,2-quinones, anthraquinones, and anthrahydroquinones are disclosed herein. The substituted hydroquinones and catechols have the formula: while the substituted 1,4-quinones or 1,2-have the corresponding oxidized structure (1,4- benzoquinones and 1,2-benzoquinones). One or more of R 1 , R 2 , R 3 and R 4 include a sulfonate moiety, a sulfonimide moiety, or a phosphonate moiety, and any of R 1 , R 2 , R 3 and R4 that do not include one of these moieties include an alkyl, a cycloalkyl, a thioether, a sulfoxide, a sulfone, a haloalkyl, a halogen, a nitrile, an imide, a pyrazole, or combinations thereof. The substituted anthraquinones have the formula: while the substituted anthrahydroquinones have the corresponding reduced structure. One or more of R 1 -R 8 have a sulfonate or phosphate tethered to the ring by a thi other, amine, or ether including one or more alkyl groups. Any of R1-R8 that do not contain one of these moieties include an alkyl, a cycloalkyl, a thiother, a sulfoxide, a sulfone, a haloalkyl, a halogen, a hydroxyl, an alkoxyl, an ether, an amine, or hydrogen The substituted hydroquinones, 1,4-quinones, catechols, 1,2-quinones, anthraquinones, or anthrahydroquinones are soluble in water, stable in aqueous acid solutions, and have useful reduction potentials in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.

4. 发明申请

WO2010033976A2 SPECIFIC BRANCHED ALDEHYDES, ALCOHOLS, SURFACTANTS AND CONSUMER PRODUCTS BASED THEREON 审中-公开
标题翻译：特殊分支醛，醇，表面活性剂和消费品
公开(公告)号：WO2010033976A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057811
申请日：2009-09-22
申请人： THE PROCTER & GAMBLE COMPANY , SCHEIBEL, Jeffrey, John , SHUMATE, Robert, Edward
发明人： SCHEIBEL, Jeffrey, John , SHUMATE, Robert, Edward
IPC分类号： C07C45/50 , C07C29/141 , C07C29/16 , C07C29/17 , C07C31/125 , C07C41/03 , C07C43/11 , C07C47/02 , C07C47/21 , C07C305/04 , C11D1/72 , C11D1/831 , C07C309/03 , C11D1/14
CPC分类号： C11D1/16 , C07C29/141 , C07C29/16 , C07C29/175 , C07C31/125 , C07C43/11 , C07C45/50 , C07C45/62 , C07C47/21 , C07C305/06 , C07C309/04 , C11D1/143 , C11D1/146 , C11D1/72 , C11D1/831 , C11D3/2048 , C11D3/2065 , C11D3/2072 , C07C47/02
摘要： A process for preparing a detergent alcohol mixture comprising the steps of providing one or more poly-branched poly-olefins, wherein the poly-branched poly-olefins must contain one non-branched terminal olefin and one or more additional branched olefins in the molecule; hydroformylating said poly-branched poly-olefins to produce a poly-branched olefin containing aldehyde product with one or more olefins or mixture thereof; reducing the aldehyde product of step (b) in the presence of hydrogen and a hydrogenation catalyst to form a poly-branched detergent alcohol mixture; and removing said poly-branched alcohol mixture from said catalyst and branched aldehydes, alcohols and surfactants produced from the products of this process.
摘要翻译：一种制备洗涤剂醇混合物的方法，包括提供一种或多种多支链聚烯烃的步骤，其中多支链聚烯烃在分子中必须含有一个非支化末端烯烃和一种或多种另外的支链烯烃; 加氢甲酰化所述多支链聚烯烃以制备含有一种或多种烯烃或其混合物的含多元支链烯烃的醛产物; 在氢气和氢化催化剂的存在下还原步骤（b）的醛产物以形成多支链洗涤剂醇混合物; 并从所述催化剂中除去所述多支化醇混合物，并从该方法的产物中制备支链醛，醇和表面活性剂。

5. 发明申请

WO2021101508A1 SALTS OF TRANEXAMIC ACID ESTERS 审中-公开
公开(公告)号：WO2021101508A1
公开(公告)日：2021-05-27
申请号：PCT/US2019/062022
申请日：2019-11-18
申请人： ACTERA INGREDIENTS, INC.
发明人： WINN, Daniel , DA SILVA SOUZA, Ivan, Domicio
IPC分类号： C07C219/24 , C07C309/03 , C07C309/24 , A61K31/195 , A61K9/00 , A61P17/00
摘要： Various salts of tranexamic acid esters compounds are described, along with compositions including such compounds. Methods of use for treatment of external surfaces (e.g. skin) and processes of producing the compounds and compositions are also described.

6. 发明申请

WO2014056939A1 LIPIDIC BIOMATERIALS FOR ENCAPSULATION AND TRIGGERED RELEASE 审中-公开
标题翻译：用于包扎和触发释放的脂质生物材料
公开(公告)号：WO2014056939A1
公开(公告)日：2014-04-17
申请号：PCT/EP2013/070976
申请日：2013-10-08
申请人： UNIVERSITÄT ZÜRICH
发明人： LANDAU, Ehud Moshe , SIEGEL, Jay Steven
IPC分类号： C07D233/64 , A61K9/00 , A61K9/127 , C07C69/24 , C07C69/608 , C07C309/03 , C07C211/21 , C07C323/59 , C07C233/03 , C07C233/20 , C07C233/49 , C07C245/08 , C07C255/24
CPC分类号： A61K9/0002 , A61K9/1274 , C07C69/608 , C07C211/21 , C07C233/03 , C07C233/20 , C07C233/49 , C07C245/08 , C07C255/24 , C07C323/59 , C07C2601/02 , C07D233/64
摘要： The present invention relates to novel compounds, particularly for use as additives in a lipidic cubic phase material, and to novel lipidic cubic phase materials. These materials are biocompatible, stable and transparent and can encapsulate active compounds such as drugs and release them at will by chemical and/or photochemical triggering. A method of controlled release of a predetermined active compound, comprises the steps of: forming a lipidic cubic phase material by mixing a lipophilic component and a hydrophilic component comprising an aqueous solution containing the active compound; placing the lipidic cubic phase material in a region of interest; releasing the active compound by subjecting the lipidic cubic phase material to a chemical or photochemical stimulus.
摘要翻译：本发明涉及新型化合物，特别是用作脂质立方相材料中的添加剂，以及新颖的脂质立体相材料。这些材料是生物相容的，稳定的和透明的，并且可以包封活性化合物如药物，并通过化学和/或光化学触发随意释放它们。一种控制释放预定活性化合物的方法包括以下步骤：通过将亲脂组分和包含含有活性化合物的水溶液的亲水组分混合形成脂质立方相材料; 将脂质立方相材料放置在感兴趣的区域中; 通过使脂质立方相材料经受化学或光化学刺激来释放活性化合物。

7. 发明申请

WO2011066706A1 一种助焊剂用非卤素活性剂审中-公开
公开(公告)号：WO2011066706A1
公开(公告)日：2011-06-09
申请号：PCT/CN2010/000285
申请日：2010-03-08
申请人：湖南阿斯达生化科技有限公司 , 易宗明 , 刘艺
发明人：易宗明 , 刘艺
IPC分类号： C07C309/00 , C07C309/02 , C07C309/03 , C07C309/04 , C07C309/05 , C07C309/06 , C07C309/08 , C07C309/29 , C07C309/30 , C07C309/39 , C07C309/42 , B23K35/22 , B23K35/24 , B23K35/36 , B23K35/362 , H05K3/34
CPC分类号： C07C309/04 , B23K35/22 , B23K35/24 , B23K35/36 , B23K35/362 , C07C309/05 , C07C309/06 , C07C309/08

8. 发明申请

WO2013134869A1 NOVEL SULFONATE-BASED TRIMEBUTINE SALTS 审中-公开
标题翻译：新型的基于硫磺的TRIMEBUTINE SALTS
公开(公告)号：WO2013134869A1
公开(公告)日：2013-09-19
申请号：PCT/CA2013/050178
申请日：2013-03-11
申请人： GICARE PHARMA INC.
发明人： MEUNIER, Jean-François , LAU, Cheuk Kun , GUAY, Daniel , BYDLINSKI, Gregory , SPASSOVA, Nadejda , CANTIN, Louis-David , RANGER, Maxime
IPC分类号： C07C219/22 , A61K31/185 , A61K31/277 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61P29/00 , C07C309/03 , C07C309/28 , C07C327/48 , C07D213/71 , C07D277/36
CPC分类号： C07C229/38 , A61K9/1652 , A61K9/2054 , C07C219/22 , C07C309/04 , C07C309/08 , C07C309/30 , C07C309/39 , C07C309/42 , C07C309/46 , C07C309/58 , C07C309/59 , C07C327/48 , C07D213/71 , C07D277/36
摘要： The present description relates to compounds of Formula I (A + X - ), a diastereoisomer, an enantiomer, or a mixture thereof, pharmaceutical composition comprising same and uses thereof for gastrointestinal endoscopic and medical imaging applications, and for the treatment of visceral pain: Where R 1 and R 2 are as defined herein
摘要翻译：本发明涉及式I（A + X-），非对映异构体，对映异构体或其混合物的化合物，包含其的药物组合物及其用于胃肠内窥镜和医学成像应用以及用于治疗内脏痛的方面：其中 R1和R2如本文所定义

9. 发明申请

WO2006042652A1 VERFAHREN ZUR HERSTELLUNG VON LEDER UND DAFÜR GEEIGNETE VERBINDUNGEN 审中-公开
标题翻译：用于生产皮革和合适的化合物
公开(公告)号：WO2006042652A1
公开(公告)日：2006-04-27
申请号：PCT/EP2005/010855
申请日：2005-10-08
申请人： BASF Aktiengesellschaft , RÜBA, Eva , ERHARDT, Rainer , REESE, Oliver , SOMOGYI, Laszlo , ZAMPONI, Andrea , KIESOW, Harald , PABST, Gunther , HÜFFER, Stephan , DANISCH, Peter , SCHROEDER, Stefan
发明人： RÜBA, Eva , ERHARDT, Rainer , REESE, Oliver , SOMOGYI, Laszlo , ZAMPONI, Andrea , KIESOW, Harald , PABST, Gunther , HÜFFER, Stephan , DANISCH, Peter , SCHROEDER, Stefan
IPC分类号： C14C3/20 , C07C309/03 , C07C147/00
CPC分类号： C07C305/04 , C14C9/02
摘要： Verfahren zur Herstellung von Leder durch Kontaktieren von vorbehandelten Tierhäuten mit wenigstens einer Verbindung, die wenigstens eine Gruppe der Formel (I) aufweist (I), wobei die Variablen wie folgt definiert sind: Ar 1 ein aromatisches oder heteroaromatisches System, X ein elektronenziehender Rest oder Wasserstoff, Y eine bivalente funktionelle Gruppe oder eine Einfachbindung oder eine C 2 -C 20 -Alkylengruppe, bei der bis zu 3 nicht-benachbarte CH 2 -Gruppen durch Sauerstoff oder -NR 3 - ersetzt sein können, W ein Rest, der von einer Verbindung abgeleitet ist, die auf Leder hydrophobierend, fettend oder gerbend wirkt, B gewählt aus -C(R 1 )=CH 2 und CHR 1 -CH 2 -Q, wobei R 1 gewählt wird aus Wasserstoff, C 1 -C 10 -Alkyl und Phenyl und R 3 gleich oder verschieden, aus Wasserstoff, Phenyl und C 1 -C 10 -Alkyl, Q aus unter wässrig-alkalischen Bedingungen abspaltbaren Gruppen.
摘要翻译：通过预处理动物接触用于生产皮革的方法，与具有至少一个基团，其中各变量的定义的式（I）（I）的至少一种化合物隐藏如下：氩

10. 发明申请

WO00012469A1 NOVEL MERCAPTANS AND DISULFIDES 审中-公开
标题翻译：新的合并和破坏
公开(公告)号：WO00012469A1
公开(公告)日：2000-03-09
申请号：PCT/US1999/019876
申请日：1999-08-30
IPC分类号： C07C323/66 , C07F9/38 , C07C309/01 , C07C309/03 , C07F11/00
CPC分类号： C07C323/66 , C07F9/3808
摘要： This invention relates to novel compositions of matter which either terminate in a sulfhydryl moiety or are disulfides. The compounds also include a terminal sulfonate or phosphonate moiety, and have many uses, such as toxicity reducing agents when administered with many antineoplastic agents.
摘要翻译：本发明涉及终止于巯基部分或二硫化物的物质的新组合物。化合物还包括末端磺酸盐或膦酸盐部分，并且当与许多抗肿瘤剂一起施用时具有许多用途，例如毒性降低剂。

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