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1. 发明申请

WO2015168465A1 INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF 审中-公开
标题翻译：运输运输的抑制剂及其用途
公开(公告)号：WO2015168465A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028633
申请日：2015-04-30
申请人： RGENIX, INC.
发明人： MARTINEZ, Eduardo, J. , TAVAZOIE, Sohail, F.
IPC分类号： C07C261/00 , C07C269/00 , C07C277/00 , C07C279/00
CPC分类号： C07C279/14 , A61K31/00 , A61K31/155 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/4168 , A61K31/4402 , A61K31/4427 , A61K31/505 , A61K31/53 , A61K31/704 , A61K31/7068 , A61K31/7105 , A61K45/06 , C07B2200/05 , C07C257/14 , C07C259/14 , C07C275/70 , C07C279/16 , C07C279/26 , C07C279/36 , C07C281/16 , C07C281/18 , C07C309/15 , C07C313/34 , C07C2601/02 , C07C2601/04 , C07D205/04 , C07D205/08 , C07D207/16 , C07D207/22 , C07D213/74 , C07D213/76 , C07D231/12 , C07D233/26 , C07D233/46 , C07D233/52 , C07D233/64 , C07D233/88 , C07D239/06 , C07D239/14 , C07D249/08 , C07D249/14 , C07D253/06 , C07D257/08 , C07D295/32 , C07D401/04 , C07D405/04 , C07D487/04 , C07F9/097 , C07F9/2458 , C07F9/3808 , C07F9/4006 , C07F9/48 , C07F9/5683 , C07F9/5721 , C07F9/65061 , C07H19/06 , A61K2300/00
摘要： This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
摘要翻译：本发明涉及抑制肌酸转运和/或肌酸激酶的化合物，包括这些化合物的药物组合物，以及利用这些化合物和组合物治疗癌症的方法。

2. 发明申请

WO03000652A8 PROCESS FOR PREPARATION OF CYCLOHEXANOL DERIVATIVES 审中-公开
标题翻译：环己烷衍生物的制备方法
公开(公告)号：WO03000652A8
公开(公告)日：2004-05-21
申请号：PCT/US0219753
申请日：2002-06-21
申请人： WYETH CORP , KIM KEUN-SIK , KIM KWANG-IL , LEE SUNG-WOO , PARK JIN-SOO , CHAI KI-BYUNG
发明人： KIM KEUN-SIK , KIM KWANG-IL , LEE SUNG-WOO , PARK JIN-SOO , CHAI KI-BYUNG
IPC分类号： C07C261/00 , C07B61/00 , C07C253/30 , C07C255/37
CPC分类号： C07C253/30 , C07C2601/14 , C07C255/37
摘要： A process for the preparation of cyclohexanol derivatives of formula (I) by reacting a compound of formula (II) with a compound of formula (III) in the presence of a base catalyst of formula (IV) or (V). In the above formula, R1-R9, A, B, X and p have tghe meanings given in the specification.
摘要翻译：在式（Ⅳ）或（Ⅴ）的碱催化剂存在下，使式（Ⅳ）化合物与式（Ⅳ）化合物反应制备式（Ⅰ）的环己醇衍生物的方法。在上式中，R1-R9，A，B，X和p具有本说明书中给出的含义。

3. 发明申请

WO03011223A3 IMMUNOMODULATORY COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫组化方法及其使用方法
公开(公告)号：WO03011223A3
公开(公告)日：2003-05-01
申请号：PCT/US0224258
申请日：2002-07-31
申请人： EISAI CO LTD , HAWKINS LYNN D , ISHIZAKA SALLY T , LEWIS MICHAEL , MCGUINNESS PAMELA , ROSE JEFFREY
发明人： HAWKINS LYNN D , ISHIZAKA SALLY T , LEWIS MICHAEL , MCGUINNESS PAMELA , ROSE JEFFREY
IPC分类号： A61K39/39 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P37/04 , C07C275/14 , C07F9/09 , C07F9/10 , C07F9/655 , A61K45/00 , A61K39/00 , A61K39/295 , C07C261/00
CPC分类号： C07F9/10 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/65515
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
摘要翻译：本发明涉及当与诸如用于细菌和病毒疾病的疫苗的抗原共同给予包括至少一种本发明的佐剂化合物的新型佐剂制剂与新的免疫刺激组合物共同施用时用作免疫佐剂的新化合物，包括抗原和至少一种本发明的佐剂化合物，以及通过将本发明化合物与待免疫动物的抗原共同给药的动物免疫方法。

4. 发明申请

WO2002100344A3 AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATIONS OF GABA ANALOGUES 审中-公开
公开(公告)号：WO2002100344A3
公开(公告)日：2002-12-19
申请号：PCT/US2002/018493
申请日：2002-06-11
申请人： XENOPORT, INC. , GALLOP, Mark, A. , CUNDY, Kenneth, C. , SCHEUERMAN, Randall, A. , BARRETT, Ronald, W. , ZERANGUE, Noa
发明人： GALLOP, Mark, A. , CUNDY, Kenneth, C. , SCHEUERMAN, Randall, A. , BARRETT, Ronald, W. , ZERANGUE, Noa
IPC分类号： C07C261/00
摘要： This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.

5. 发明申请

WO02085843A2 PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES AND ARYL-FUSED AZAPOLYCYCLIC COMPOUNDS 审中-公开
标题翻译：制备1,3-取代的亚硝酸钠和亚磺酸的十一烷基化合物的方法
公开(公告)号：WO02085843A2
公开(公告)日：2002-10-31
申请号：PCT/IB0200660
申请日：2002-03-04
申请人： PFIZER PROD INC , SINGER ROBERT ALAN , MCKINLEY JASON DANIEL
发明人： SINGER ROBERT ALAN , MCKINLEY JASON DANIEL
IPC分类号： C07D317/30 , A61K31/439 , A61K31/4985 , A61K38/00 , A61P1/00 , A61P1/04 , A61P3/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P35/00 , C07B61/00 , C07C253/30 , C07C255/41 , C07C255/47 , C07C261/00 , C07C315/04 , C07C317/44 , C07D221/16 , C07D221/22 , C07D401/04 , C07D471/04 , C07D471/08 , C07D498/08 , C07D513/08
CPC分类号： C07C317/44 , C07C253/30 , C07C255/47 , C07C2602/08
摘要： The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of formulae (Ia, Ib and Ic) or a mixture thereof, wherein R , R , R , R , and R are defined herein. Compounds of formulae (Ia, Ib and Ic) or mixtures thereof are useful in the preparation of compounds of formula (II), wherein R , R and R are also defined herein.
摘要翻译：本发明涉及制备式（Ia，Ib和Ic）的任何中间体1,3-取代的茚或其混合物的方法，其中R 1，R 2，R 3， R 4和R 5如本文所定义。式（Ia，Ib和Ic）化合物或其混合物可用于制备式（II）化合物，其中R 2，R 3和R 6也在本文中定义。

6. 发明申请

WO00009477A1 UNSATURATED OLIGOPHENOL CYANATES 审中-公开
标题翻译：不饱和oligophenol氰酸
公开(公告)号：WO00009477A1
公开(公告)日：2000-02-24
申请号：PCT/EP1999/005757
申请日：1999-08-09
IPC分类号： G03F7/027 , C07C261/00 , C07C261/02 , C07D251/32 , C08F8/00 , C08F290/14 , C08G73/00 , C08G73/06 , C08J5/04 , C09D179/00
CPC分类号： C07C261/02 , C07C2603/68
摘要： The invention relates to unsaturated oligophenol cyanates of the general formula (I) [A-]n[B-A-]xB[-A]m, in which A is a group of formula (II) and B is a group of formula (III), where R , R and R are each hydrogen or a bond with a group B, there being either one or two bonds with B; and both R and R as well as R and R separately or jointly represent a direct bond or hydrogen and a bond with a group A, there being either one or two bonds with A. The indices m and n are 0 or 1 but not both 1 at the same time and x is a whole number between 0 and 10, where at least one of the numbers m, n and x is not 0. The above unsaturated oligophenol cyanates can be prepared by reacting the corresponding oligophenols with chlorine cyanide. They have a low viscosity and owing to their double bonds are able to undergo free-radical polymerization. They are especially suitable for use as matrix materials for fibre-reinforced composites and for radiation-curable varnishes and coatings.
摘要翻译：中描述的通式（I）[A-] n的[B-A-]×B [-A]米的不饱和oligophenol氰酸酯。其中，每个A是一个基团式（II）的且B为式的基团（III），其中R <1>，R <2>和R <3>各自为氢或一个键合到基团B，以及一个或两个键与B都存在，且R <4>和R <4“>和R <5>和R <5”>各自enweder一起代表一个直接键或氢，和一个Sindung到的基团的，其中一个或两个键合到一个存在。指数m和n是0或1，但不同时为1，并且x为0至10的整数，的数m，其中至少一个，n和x是大于零的其它所述不饱和oligophenol氰酸酯可以由相应的Oligophenole与氯化氰反应来制备。它们具有低粘度，是自由基固化由于存在双键。它们特别适合作为用于纤维增强复合材料和可辐射固化油漆和涂料的基体材料。

7. 发明申请

WO1996033971A1 PHOTOACTIVATABLE POLYMERS FOR PRODUCING PATTERNED BIOMOLECULAR ASSEMBLIES 审中-公开
标题翻译：用于生产图案生物分子装置的可光聚合聚合物
公开(公告)号：WO1996033971A1
公开(公告)日：1996-10-31
申请号：PCT/US1996001496
申请日：1996-02-01
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE NAVY
发明人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE NAVY , CONRAD, David, W. , CHARLES, Paul, T., Jr.
IPC分类号： C07C261/00
CPC分类号： B82Y30/00 , B01J2219/00529 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , C07C247/18 , C07C271/12 , C40B40/06 , G01N33/54373 , G01N33/5438 , Y10T428/31725
摘要： The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.
摘要翻译：本发明涉及用于形成所述生物芯片和新型可光活化化合物2,6-DOCA，2-NOCA和LC-ASA胺的新型生物芯片和方法。

8. 发明申请

WO2011085280A1 COMPOSITIONS COMPRISING A REACTIVE MONOMER WITH A UREA OR URETHANE FUNCTIONAL GROUP 审中-公开
标题翻译：包含与UREA或URETHANE功能组的反应性单体的组合物
公开(公告)号：WO2011085280A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020620
申请日：2011-01-10
申请人： ISP INVESTMENTS INC. , HOOD, David, K. , MUSA, Osama, M.
发明人： HOOD, David, K. , MUSA, Osama, M.
IPC分类号： C08G12/34 , C07C261/00
CPC分类号： C08G18/8108 , C08F12/22 , C08F12/26 , C08F212/14 , C08F226/10 , C08F290/062 , C08G18/2855 , C09D4/00 , C09D11/101 , C08F222/1006 , C08F2222/1013 , C08F2222/1026
摘要： Disclosed herein are compositions comprising a reactive monomer, and, in particular, coating and/or reactive coating compositions. More particularly, compositions containing monomers comprising a lactam moiety, a urethane or urea functional group, and a polymerizable moiety are disclosed.
摘要翻译：本文公开了包含反应性单体，特别是涂层和/或反应性涂料组合物的组合物。更具体地，公开了含有内酰胺部分，氨基甲酸酯或脲官能团和可聚合部分的单体的组合物。

9. 发明申请

WO2004089890A3 PROCESS AND INTERMEDIATES FOR PREPARING BENZAZEPINES 审中-公开
标题翻译：制备苯甲酸酯的方法和中间体
公开(公告)号：WO2004089890A3
公开(公告)日：2005-06-30
申请号：PCT/US2004009909
申请日：2004-03-29
申请人： SMITHKLINE BEECHAM CORP , CONDE JOSE J , GOLDFINGER LEWILYNN L , MCGUIRE MICHAEL A , SHILCRAT SUSAN C , WALLACE MICHAEL D , YU MARVIN SUNGWHAN
发明人： CONDE JOSE J , GOLDFINGER LEWILYNN L , MCGUIRE MICHAEL A , SHILCRAT SUSAN C , WALLACE MICHAEL D , YU MARVIN SUNGWHAN
IPC分类号： C07C59/48 , C07C69/76 , C07C261/00 , C07D20060101 , C07D223/16 , C07D401/12
CPC分类号： C07D401/12 , C07D223/16
摘要： Disclosed is a new process and intermediates for preparing benzazepines of Formula wherein R and R are as defined herein.
摘要翻译：公开了用于制备式的苯并吖庚因的新方法和中间体，其中R 1和R 2如本文所定义。

10. 发明申请

WO01072699A1 INHIBITION OF ANGIOGENESIS AND TUMOR GROWTH 审中-公开
标题翻译：抑制血管生成和肿瘤生长
公开(公告)号：WO01072699A1
公开(公告)日：2001-10-04
申请号：PCT/US2001/009756
申请日：2001-03-27
IPC分类号： A61K38/55 , A61K31/165 , A61K31/166 , A61K31/192 , A61K31/216 , A61P29/00 , A61P35/00 , A61P43/00 , C07C237/22 , C07C271/22 , C07C261/00 , A61K38/00
CPC分类号： A61K31/216 , A61K31/165 , A61K31/192
摘要： Compounds which inhibit tumor growth and angiogenesis, of general formula (II) are provided. These compounds include glycyl lysine derivatives bound to a central aromatic linking core.
摘要翻译：提供通式（II）抑制肿瘤生长和血管生成的化合物。这些化合物包括与中心芳族连接核心结合的甘氨酰赖氨酸衍生物。

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