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1. 发明申请

WO2021058961A1 NEEDLE AND USES THEREOF 审中-公开
公开(公告)号：WO2021058961A1
公开(公告)日：2021-04-01
申请号：PCT/GB2020/052316
申请日：2020-09-24
申请人： OXFORD UNIVERSITY INNOVATION LIMITED
发明人： VATISH, Manu , CIMPEANU, Radu , GEORGIOU, Ektoras , CASTREJON-PITA, Alfonso, Arturo
IPC分类号： A61B10/02 , A61B17/435
摘要： A needle for extraction of biological material from a fluid filled intracorporeal sac, the needle comprising: a shaft comprising a first flow channel comprising an inlet for aspirating biological material from the intracorporeal sac and a second flow channel comprising an outlet for supplying a flushing fluid to the intracorporeal sac; and wherein the outlet is configured to direct the flushing fluid in a direction substantially transverse to the first flow channel; and methods using the needle.

2. 发明申请

WO2021014462A1 SYSTEMS FOR ASPIRATION OF FLUIDS 审中-公开
公开(公告)号：WO2021014462A1
公开(公告)日：2021-01-28
申请号：PCT/IN2020/050612
申请日：2020-07-17
申请人： PAYELI, Sravan Kumar
发明人： PAYELI, Sravan Kumar , MOCHARLA, Pavani Srividya
IPC分类号： A61M1/00 , A61B17/435 , A61M5/315 , A61M39/22
摘要： An aspiration system (100) is provided with a piston unit (102) having a base member (104) and a plurality of arms (106) extending outwards from the base member. The plurality of arms is in a same plane and includes a first arm (106a), a second arm (106b), and a third arm (106c). A cap (108) affixed to a free end of the third arm of the piston unit. A hollow tube (110) having an open end is disposed over the third arm to form a hermetic seal with the cap. A nozzle (114) is positioned opposite to the open end and connectable to a fluid collection tube (116). The piston unit is acted upon by gravity to create a negative pressure inside the hollow tube to cause the aspiration of the biological fluids.

3. 发明申请

WO2020260174A1 DISPOSITIF DE PROTECTION POUR DISPOSITIF MÉDICAL 审中-公开
公开(公告)号：WO2020260174A1
公开(公告)日：2020-12-30
申请号：PCT/EP2020/067269
申请日：2020-06-22
申请人： ANECOVA S.A.
发明人： ASTRANSKAS, Mathieu , SVALANDER, Peter Christian , VELASCO, Alison , VELASCO, Martin
IPC分类号： A61B50/30 , A61B17/435 , A61B90/00
摘要： Dispositif de protection pour dispositif médical (1) comprenant un corps (3) sensiblement cylindrique et un tube (4), lesdits corps (3) et tube (4) étant creux et ouverts à leurs extrémités, le corps (3) comportant une partie distale (32) thermiquement isolante et des moyens d'assemblage, le tube (4) comportant des moyens d'assemblage complémentaires, le corps (3) étant adapté à coulisser sur le tube (4) selon une direction longitudinale depuis une première position correspondant à une configuration de prélèvement du dispositif de protection (2) vers une deuxième position correspondant à une configuration de protection du dispositif de protection, les moyens d'assemblage du corps (3) et les moyens d'assemblage complémentaires étant adaptés à bloquer le corps (3) en translation longitudinale dans la première position et la deuxième position.

4. 发明申请

WO2019243884A1 COMPOSITION AND KIT FOR USE IN A METHOD OF EMBRYO TRANSFER 审中-公开
公开(公告)号：WO2019243884A1
公开(公告)日：2019-12-26
申请号：PCT/IB2019/000601
申请日：2019-06-18
申请人： INCINTAS THERAPEUTICS, INC.
发明人： PIZOLATO, Jesse
IPC分类号： A61K9/00 , A61K31/57 , A61B17/435 , A61M31/00
摘要： An agent and apparatur for use in a method of embryo transfer ("ET") that improves fertility rates by hormonally enhancing the uterine wall of a patient either prior to or during the time of ET. Quantitative administration of transfer solutions is accomplished with a modified apparatus that provides for implantation of an embryo into the uterus of a patient.

5. 发明申请

WO2019209775A3 DEVICE AND METHOD FOR IMPROVING IMPLANTATION OF FERTILIZED EGG DURING PREGNANCY 审中-公开
公开(公告)号：WO2019209775A3
公开(公告)日：2019-10-31
申请号：PCT/US2019/028630
申请日：2019-04-23
申请人： INGEN2, LLC
发明人： FALKNER, Peter T. , PLESSALA, Kirby J. , HADDAD, Michael
IPC分类号： A61B17/435 , A61B17/42 , A61B17/32 , A61B17/00
摘要： The disclosed invention comprises a device that utilizes a manually controlled articulating arm to make a precise, small abrasion on the intrauterine wall prior to ovulation. The preferred embodiment of the invention comprises a handle, an arm having a rigid portion and an articulating tip both of which are covered by a casing having non-irritant properties, wherein the handle is connected to the arm by a connection member that contains a trigger mechanism operable to move the articulating tip by pulling a trigger.

6. 发明申请

WO2017180021A1 СПОСОБ ОПРЕДЕЛЕНИЯ IN VITRO ПЕРСПЕКТИВНЫХ ЭМБРИОНОВ ДЛЯ ПОСЛЕДУЮЩЕЙ ИМПЛАНТАЦИИ В МАТКУ ПРИ ПРОВЕДЕНИИ ПРОЦЕДУРЫ ЭКСТРАКОРПОРАЛЬНОГО ОПЛОДОТВОРЕНИЯ (ЭКО)ИЗОБРЕТЕНИЕ ОТНОСИТСЯ К ОБЛАСТИ МЕДИЦИНЫ, А ИМЕННО К ГИНЕКОЛОГИИ И РЕПРОДУКТОЛОГИ, ЭМБРИОЛОГИИ, И МОЖЕТ БЫТЬ ИСПОЛЬЗОВАНО В ПРОГРАММАХ ЭКСТРАКОРПОРАЛЬНОГО ОПЛОДОТВОРЕНИЯ (ЭКО) И ПЕРЕНОС ЭМБРИОНОВ (ПЭ) С ЦЕЛЬЮ ПРОГНОЗИРОВАНИЯ ИХ ИСХОДОВ 审中-公开
标题翻译：一种用于在体外受精（IVF）本发明涉及医药，即妇科和生殖，胚胎学，并且可以在体外受精（IVF）中使用和胚胎移植过程中体外确定ADVANCED胚胎在子宫后续植入（ET ）与预测他们的产出的目的
公开(公告)号：WO2017180021A1
公开(公告)日：2017-10-19
申请号：PCT/RU2017/000015
申请日：2017-01-13
申请人： СЕНЕЧКИН, Илья Викторович
发明人： СЕНЕЧКИН, Илья Викторович
IPC分类号： A61B17/435 , G01N33/483
CPC分类号： A61B17/435 , G01N33/483
摘要： Изобретение относится к области медицины, а именно к гинекологии и репродуктологии, эмбриологии, и может быть использовано в программах экстракорпорального оплодотворения (ЭКО) и переноса эмбрионов (ПЭ) с целью прогнозирования их исходов. Для этого посредством цейтраферной видеозаписи у эмбрионов на стадии дробления 2-х клеток определяют плоскость дробления: горизонтальная (экваториальная - Е) или вертикальная (меридиональная - М). Определяют последовательность вторых делений дробления в этих плоскостях, которые могут быть: последовательные экваториальные (ЕЕ), последовательные меридиональные (ММ), меридиональное затем экваториальное (ME), экваториальное затем меридиональное (ЕМ). В случае, если последовательность вторых делений дробления в этих плоскостях соответствует (ЕМ) или (ММ), то такие эмбрионы считают перспективными для последующей имплантации в матку при проведении процедуры ЭКО. Изобретение обеспечивает наиболее раннее и точное определение самых качественных, а, соответственно, наиболее перспективных для формирования имплантационно-компетентных бластоцист для последующей имплантации в матку в рамках протокола ЭКО за счет того, что эмбрионы с последовательностью вторых делений дробления в плоскостях: экваториальное затем меридиональное (ЕМ) или последовательное меридиональное (ММ) менее всего склонны к органическим нарушениям, а следовательно, позволят получить желаемую беременность и в последующем приведет к рождению здорового ребенка.
摘要翻译：
本发明涉及医药，即妇科和生殖，胚胎学，并且可以在体外受精程序（IVF）和胚胎移植（ET），以便用来预测其结果。为了这个目的，通过时间推移录像卵裂期胚胎2细胞是确定的解理面：水平（赤道 - E）或垂直（子午 - M）。确定在这些平面上的第二切割分裂，其可以是的序列：一致赤道（EE），逐次子午（MM），然后赤道子午线（ME），然后赤道子午线（EM）。如果对应于这些平面（EM）或（MM）的第二序列切割分裂，这些胚胎被认为是有前途的用于IVF过程期间在子宫之后注入。本发明提供的最早和准确的确定最高的质量，并且相应地，最有前途的用于形成用于随后的植入植入能力的囊胚到协议IVF下子宫由于以下事实：胚胎的第二切割分割的平面中的序列：赤道然后子午（EM ）一致或子午（MM）是不易于器质性障碍，因此，将提供所需的妊娠和在下面的示一个健康的婴儿出生。

7. 发明申请

WO2017173232A1 UTERINE CONTRACTION DEVICE 审中-公开
标题翻译：子宫收缩装置
公开(公告)号：WO2017173232A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025313
申请日：2017-03-31
申请人： LANGELL, John Thomas , HOLMAN, Paul Sanford , EYRE, Zachary Warren , GOATES, Thomas Jon , BRODERICK, Sarah Owens , PIEPER, Jared Reese
发明人： LANGELL, John Thomas , HOLMAN, Paul Sanford , EYRE, Zachary Warren , GOATES, Thomas Jon , BRODERICK, Sarah Owens , PIEPER, Jared Reese
IPC分类号： A61B17/12 , A61B17/42 , A61B17/425 , A61B17/43 , A61B17/435 , A61D19/00
CPC分类号： A61B17/4241 , A61B2017/00477 , A61B2017/00561 , A61B2017/306 , A61B2017/3419 , A61B2090/036
摘要： The present disclosure describes a uterine contraction device which may be utilized to treat and/or prevent postpartum hemorrhaging. The uterine contraction device includes a catheter and a pressure seal adjustably coupled to the catheter. A distal section of the catheter is configured for insertion into the uterus, and a proximal end of the catheter is configured for attachment to a vacuum device. Negative pressure generated by the vacuum device is transmitted to the distal section, while the pressure seal forms a seal at the vaginal introitus to maintain the negative pressure within the uterus to assist in contracting the uterus.
摘要翻译：本公开描述了可用于治疗和/或预防产后出血的子宫收缩装置。子宫收缩装置包括导管和可调节地联接到导管的压力密封件。导管的远侧部分构造成用于插入子宫中，并且导管的近侧端部构造成用于附接至真空装置。由真空装置产生的负压被传递到远端部分，而压力密封在阴道入口处形成密封以维持子宫内的负压以帮助收缩子宫。

8. 发明申请

WO2017087455A1 RECOVERY AND PROCESSING OF HUMAN EMBRYOS FORMED IN VIVO 审中-公开
标题翻译：人胚胎体内形成的回收和处理
公开(公告)号：WO2017087455A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062171
申请日：2016-11-16
申请人： PREVIVO GENETICS, INC. , WOODARD, Steven Paul
发明人： WOODARD, Steven Paul , CARSON, Sandra Ann , BUSTER, John E. , CESARIO, Moses
IPC分类号： A61B17/42 , A61B17/435 , A61K31/57 , A61K31/575 , A61M3/02
CPC分类号： A61K31/57 , A61B17/435 , A61B18/00 , A61B2017/4216 , A61B2217/005 , A61B2217/007 , A61K31/565 , A61K31/568 , A61K31/573
摘要： A process for recovering one or more blastocysts from a uterus of a human includes placing a device transvaginally into a cervical canal of the patient; delivering fluid through the device to the uterus and applying a vacuum to the uterus to aspirate fluid and entrained one or more blastocysts from the uterus; and causing a disruption to the uterus and/or to one or more embryos remaining in the uterus following removal of one or more blastocysts from the uterus to reduce the chance that any such retained embryos remaining in the uterus will form a viable pregnancy. Causing a disruption includes one or more of the following: inducing a mechanical disruption of the uterus, delivering a hormonal agent to the uterus, delivering a chemical agent to the uterus, inducing a thermal disruption of the uterus, and using ultrasound or radiofrequency energy to induce the disruption.
摘要翻译：从人的子宫回收一个或多个囊胚的方法包括将装置经阴道放入患者的子宫颈管内; 通过该装置将流体输送到子宫并向子宫施加真空以抽吸流体并从子宫夹带一个或多个囊胚; 并且在从子宫中移出一个或多个胚泡后，对子宫和/或留在子宫中的一个或多个胚胎造成破坏，以减少保留在子宫中的任何这种保留的胚胎将形成活的妊娠的机会。导致中断包括以下一种或多种：引起子宫的机械破坏，向子宫递送激素药剂，向子宫递送化学药剂，诱导子宫的热中断，以及使用超声波或射频能量诱发中断。

9. 发明申请

WO2014205440A3 UTERINE LAVAGE FOR EMBRYO RETRIEVAL 审中-公开
标题翻译：子宫颈切除术
公开(公告)号：WO2014205440A3
公开(公告)日：2015-05-07
申请号：PCT/US2014043664
申请日：2014-06-23
申请人： PREVIVO GENETICS LLC
发明人： BUSTER JOHN E , CESARIO MOSES , WOODARD STEVEN PAUL
IPC分类号： A61B17/435 , A61B17/42 , A61M3/02
CPC分类号： A61B17/435 , A61B17/42 , A61B50/13 , A61B2017/4216 , A61B2050/185 , A61B2050/311 , A61B2217/005 , A61B2217/007
摘要： A device for recovering one or more blastocysts from the uterus of a human includes an outer guide member for insertion into a cervical canal. The outer guide member includes a distal portion with an activatable seal for isolating the uterus from the external environment and defines a lumen having a longitudinal axis. The device includes an inner catheter located within the lumen and slidable along the longitudinal axis. The inner catheter has a distal tip positionable distally of the seal to extend into the uterus and includes a fluid delivery lumen terminating at a distal fluid delivery port for delivering fluid into the uterus. The device defines a distal suction port for aspirating fluid and entrained blastocysts from the uterus. Distal fluid delivery and suction ports are arranged such that, in use, fluid delivered from the distal fluid delivery port travels through the distal suction port to the uterus.
摘要翻译：用于从人的子宫恢复一个或多个胚泡的装置包括用于插入到宫颈管中的外部引导构件。外引导构件包括具有可激活密封件的远侧部分，用于将子宫与外部环境隔离并且限定具有纵向轴线的管腔。该装置包括位于内腔内且可沿着纵向轴线滑动的内导管。内导管具有可远离密封件定位以延伸到子宫中的远侧末端，并且包括终止于远端流体输送端口处的流体输送腔，用于将流体输送到子宫中。该装置定义了用于从子宫抽吸流体和夹带的囊胚的远端吸入口。远端流体输送和吸入口被布置成使得在使用中，从远侧流体输送口递送的流体穿过远端吸入口移动到子宫。

10. 发明申请

WO2014205440A2 UTERINE LAVAGE FOR EMBRYO RETRIEVAL 审中-公开
标题翻译：子宫颈切除术
公开(公告)号：WO2014205440A2
公开(公告)日：2014-12-24
申请号：PCT/US2014/043664
申请日：2014-06-23
申请人： PREVIVO GENETICS, LLC
发明人： BUSTER, John E. , CESARIO, Moses , WOODARD, Steven Paul
IPC分类号： A61B17/435
CPC分类号： A61B17/435 , A61B17/42 , A61B50/13 , A61B2017/4216 , A61B2050/185 , A61B2050/311 , A61B2217/005 , A61B2217/007
摘要： A device for recovering one or more blastocysts from the uterus of a human includes an outer guide member for insertion into a cervical canal. The outer guide member includes a distal portion with an activatable seal for isolating the uterus from the external environment and defines a lumen having a longitudinal axis. The device includes an inner catheter located within the lumen and slidable along the longitudinal axis. The inner catheter has a distal tip positionable distally of the seal to extend into the uterus and includes a fluid delivery lumen terminating at a distal fluid delivery port for delivering fluid into the uterus. The device defines a distal suction port for aspirating fluid and entrained blastocysts from the uterus. Distal fluid delivery and suction ports are arranged such that, in use, fluid delivered from the distal fluid delivery port travels through the distal suction port to the uterus.
摘要翻译：用于从人的子宫恢复一个或多个胚泡的装置包括用于插入到宫颈管中的外部引导构件。外引导构件包括具有可激活密封件的远侧部分，用于将子宫与外部环境隔离并且限定具有纵向轴线的管腔。该装置包括位于内腔内且可沿着纵向轴线滑动的内导管。内导管具有可远离密封件定位以延伸到子宫中的远侧末端，并且包括终止于远端流体输送端口处的流体输送腔，用于将流体输送到子宫中。该装置定义了用于从子宫抽吸流体和夹带的囊胚的远端吸入口。远端流体输送和吸入口被布置成使得在使用中，从远侧流体输送口递送的流体穿过远端吸入口移动到子宫。

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