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1. 发明申请

WO2022055604A2 METHODS TO CONSTRUCT SHARP AND STABLE TIP CONTACTS WITH NANOMETER PRECISION IN A CONFINED NANOSCALE SPACE BETWEEN TWO MICROFLUIDIC CHAMBERS 审中-公开
公开(公告)号：WO2022055604A2
公开(公告)日：2022-03-17
申请号：PCT/US2021/040562
申请日：2021-07-06
申请人： QING, Quan
发明人： QING, Quan
IPC分类号： G01N27/32 , G01N33/487 , C12Q1/6869 , G01N21/65
摘要： Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties.

2. 发明申请

WO2015169097A1 一种用于分析铁铬液流电池中铁离子价态的双盐桥参比电极审中-公开
公开(公告)号：WO2015169097A1
公开(公告)日：2015-11-12
申请号：PCT/CN2014/095736
申请日：2014-12-31
申请人：苏州久润能源科技有限公司
发明人：马志啟 , 贺高红 , 张祖玲
IPC分类号： G01N27/32
CPC分类号： G01N27/32
摘要：一种用于分析铁铬液流电池中铁离子价态的双盐桥参比电极，包括普通饱和甘汞电极（12），在普通甘汞电极（12）的外部增加一个带螺纹的套管（11），套管（11）一端螺纹连接第一压紧螺帽（14），第一压紧螺帽（14）内设密封圈（13），并由第一压紧螺帽（14）固定在普通饱和甘汞电极（12）上，普通饱和甘汞电极（12）的陶瓷砂芯盐桥（1）位于套管（11）内；套管（11）另一端螺纹连接第二压紧螺帽（8），第二压紧螺帽（8）内设置两个密封圈（9），密封圈之间设有离子膜（10）；套管内填充第二节盐桥填充液，离子膜（10）作为第二盐桥的液接部位。该参比电极采用双盐桥结构，且第二盐桥液接部位使用选择性氯离子交换膜，避免了参比电极被污染的问题，具有抗酸、抗干扰能力强、性能稳定、可长期使用等优点，适合用于分析铁铬电解液中铁离子价态。

3. 发明申请

WO2019186354A1 AN IMPROVED ELECTRODE FOR ELECTROCHEMICAL DEVICE 审中-公开
公开(公告)号：WO2019186354A1
公开(公告)日：2019-10-03
申请号：PCT/IB2019/052388
申请日：2019-03-25
申请人： JAYPEE INSTITUTE OF INFORMATION TECHNOLOGY
发明人： SRIVASTAVA, Sudha , SAXENA, Rahul
IPC分类号： G01N33/50 , G01N27/32
摘要： The present disclosure is on a premise that the inventors of the present disclosure surprisingly observed that an electrode attached with graphene-polypyrrole based nano-composites can significantly improve the conductivity of the electrode, which in turn can significantly improve limit of detection (LOD) of the electrochemical device enabling quantitative detection of biological target in a sample to the tune of 0.5 fg/mL. Accordingly, an aspect of the present disclosure relates to an improved electrode for an electrochemical device, the electrochemical device capable of detecting a biological target in a sample, wherein at least part of a surface of the electrode is attached with a graphene-polypyrrole based composite, and wherein the graphene-polypyrrole based composite is attached with at least one biological targeting moiety. Aspects of the present disclosure also provide a method of the fabrication of the advantageous electrode of the present invention, an electrochemical device including the advantageous electrode and method of detection of a biological target.

4. 发明申请

WO2017204411A1 PH 감응 금속 산화물 복합재료 전극을 포함하는 복합 PH 센서 审中-公开
标题翻译：含PH感应金属氧化物复合电极的复合PH传感器
公开(公告)号：WO2017204411A1
公开(公告)日：2017-11-30
申请号：PCT/KR2016/008675
申请日：2016-08-08
申请人： 주식회사 이지센싱
发明人： 김신선
IPC分类号： G01N27/32 , G01N27/406 , G01N27/30
CPC分类号： G01N27/30 , G01N27/32 , G01N27/406
摘要： 본 발명에 따른 복합 pH 센서는 시료접촉부를 포함하고, 금속산화물이 매트릭스 재료에 분산된 복합재료 pH 감응전극; 기준전극; 일측이 상기 pH 감응전극의 시료접촉부와 동일면 상에 위치하고, 타측이 상기 기준전극의 적어도 일부분과 전해질 용액을 통하여 전기화학적으로 연결되며, 전해질 용액이 상기 일측으로부터 상기 타측으로 이동할 수 있는 심지; 및 상기 시료접촉부 및 상기 시료접촉부와 동일면 상에 위치하는 심지의 시료접촉부로 이루어진 센서 감응부;를 포함하는 것을 특징으로 한다.
摘要翻译：
根据本发明与样品接触部分的复合pH传感器中，金属氧化物分散在基质材料中的复合pH敏感电极; 参比电极; 一侧位于一个样品接触部分和pH敏感电极的同一侧，另一端通过至少一部分是电化学与参考电极的电解质溶液相连接，所述芯可以是从朝向另一一侧的电解质溶液移动; 以及传感器接触部分，其包括与样本接触部分位于同一平面上的样本接触部分和样本接触部分。

5. 发明申请

WO2020243413A1 METHODS AND APPARATUS FOR MAKING A DETERMINATION ABOUT A PRESENCE OR AN ABSENCE OF A PARASITE IN A BLOOD SAMPLE 审中-公开
公开(公告)号：WO2020243413A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035095
申请日：2020-05-29
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： SUBRAMANIAM, Vishwanath , DREW, Mark , KADOWAKI, Jonathan , JONES, Travis , WEST, Joseph , YOTEBIENG, Marcel , PRAKASH, Shaurya , SCARMUZZI, Alexander , LLAPI, Redi , CROWLEY, Jack , METZLER, Sandra
IPC分类号： A61B5/145 , G01N27/32 , G01N27/327
摘要： Disclosed herein are methods and apparatus for making a determination whether a blood sample is, or is not, infected with a malaria parasite. The determination is made using a trained machine-learning (ML) algorithm. In some aspects, a microfluidic chip is used for the concentration of red blood cells infected with these parasites from uninfected red blood cells, the staining of the blood sample which differentially stains infected and uninfected red blood cells, and holds the sample of interest for imaging. The microfluidic chip is inserted into an optical subsystem that magnifies the image created from transmitted light microscopy. The magnified image is captured with a camera, and a trained ML algorithm assesses if the sample does or does not contain the parasite. Generally, the ML algorithm is executed on a portable computing device such as a smartphone.

6. 发明申请

WO2015061598A1 SYSTEMS AND METHODS FOR WHOLE BLOOD ASSAYS 审中-公开
标题翻译：用于全血测定的系统和方法
公开(公告)号：WO2015061598A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/062018
申请日：2014-10-23
申请人： QUIDEL CORPORATION
发明人： EGAN, Richard, L. , MIMMS, Larry, Thomas , YANTIRI-WERNIMONT, Ferda
IPC分类号： G01N33/82 , G01N27/32 , A61B5/145 , G01N27/327
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14556 , A61B5/7203 , A61B5/7278 , G01N33/56966 , G01N33/82 , G01N2333/805
摘要： A system comprised of a device for measuring hemoglobin content and/or determining a hematocrit value and/or measuring a hematocrit value, and a device for measuring or detecting an analyte, and a method for measuring or determining the presence of at least one analyte are described.
摘要翻译：包括用于测量血红蛋白含量和/或确定血细胞比容值和/或测量血细胞比容值的装置的系统，以及用于测量或检测分析物的装置，以及用于测量或确定至少一种分析物的存在的方法描述。

7. 发明申请

WO2013128182A1 POLYMERIC POLY (VINYL - DIAMINO - TRIAZINE) NANOPARTICLES FOR USE IN BIOSENSORS 审中-公开
标题翻译：聚合物（VINYL - DIAMINO - TRIAZINE）纳米粒子用于生物传感器
公开(公告)号：WO2013128182A1
公开(公告)日：2013-09-06
申请号：PCT/GB2013/050484
申请日：2013-02-27
申请人： LIFESCAN SCOTLAND LIMITED
发明人： LIU, Zuifang , SIMPSON, Louise , CARDOSI, Marco
IPC分类号： C12Q1/00 , G01N27/32
CPC分类号： C12Q1/001
摘要： A biosensor (such as an electrochemical-based analytical test strip configured for the determination of glucose in a whole blood sample) includes a substrate, an electrode disposed on the substrate and a uric acid scavenger layer containing polymeric vinyl-4,6-diamino-1,3,5-triazine (polyVDAT) nanoparticles. Aqueous compositions useful in, for example, the manufacturing of such biosensors include polyVDAT nanoparticles and water with the polyVDAT nanoparticles being present as a dispersion in the water. A method for determining an analyte in a bodily fluid sample containing uric acid includes applying a bodily fluid sample containing uric acid to a biosensor such that the bodily fluid sample comes into contact with a uric acid scavenger layer containing polymeric vinyl-4,6-diamino-1,3,5-triazine (polyVDAT) nanoparticles and determining the analyte based on an electronic signal produced by the biosensor.
摘要翻译：生物传感器（例如，配置用于测定全血样品中的葡萄糖的基于电化学的分析测试条）包括基底，设置在基底上的电极和含有聚合的乙烯基-4,6-二氨基 - 1,3,5-三嗪（polyVDAT）纳米粒子。可用于例如制造这种生物传感器的水性组合物包括polyVDAT纳米颗粒和水，其中polyVDAT纳米颗粒作为分散体存在于水中。一种用于测定含有尿酸的体液样品中的分析物的方法包括将含有尿酸的体液样品施加到生物传感器，使得体液样品与含有聚合的乙烯基-4,6-二氨基的尿酸清除剂层接触 -1,3,5-三嗪（polyVDAT）纳米颗粒，并基于由生物传感器产生的电子信号确定分析物。

8. 发明申请

WO2022067051A1 APTAMER SENSORS WITH REFERENCE AND COUNTER VOLTAGE CONTROL 审中-公开
公开(公告)号：WO2022067051A1
公开(公告)日：2022-03-31
申请号：PCT/US2021/051972
申请日：2021-09-24
申请人： UNIVERSITY OF CINCINNATI
发明人： HEIKENFELD, Jason
IPC分类号： A61B5/157 , G01N27/27 , G01N27/32 , G01N33/483 , G01N33/487 , G01N33/50
摘要： Devices and methods for measuring an analyte. A sensing device (10) includes a sensor (12) and a detection circuit (14) operatively coupled to the sensor. The sensor includes a working electrode (16) having an aptamer and an attached redox couple to electrochemically measure the analyte. The detection circuit is configured to apply a first scan having a first scan range to the sensor, and determine a position of a redox peak in the first scan. In response to the first scan range not matching the position of the redox peak, the detector circuit defines a second scan range that matches the position of the redox peak, and applies a second scan having the second scan range to the sensor.

9. 发明申请

WO2021056188A1 ELECTRICAL CONDUCTORS AND METHODS OF CONDUCTING IONS USING CALSEQUESTRIN PROTEINS 审中-公开
公开(公告)号：WO2021056188A1
公开(公告)日：2021-04-01
申请号：PCT/CN2019/107535
申请日：2019-09-24
申请人： PEKING UNIVERSITY
发明人： WANG, Shiqiang , FAN, Xuexin
IPC分类号： C07K14/47 , B82Y30/00 , G01N27/32
摘要： An in vitro electrical conductor is provided. The in vitro electrical conductor may include a plurality of Calsequestrin (CSQ) protein molecules. The CSQ protein molecules may be connected to form a tendril, a network structure, or a biological tunnel structure. An electrical device including the in vitro electrical conductor is provided. An ionic transistor including the in vitro electrical conductor is provided. An in vitro method of conducting ions from an ion source to an ion sink is further provided. The method may include providing an electrical conductor including a plurality of CSQ protein molecules and conducting ions through the electrical conductor to the ion sink. The CSQ protein molecules may be connected to form a tendril, a network structure, or a biological tunnel structure.

10. 发明申请

WO2009093840A2 METHOD AND APPARATUS FOR ESTIMATING FEATURES OF TARGET MATERIALS BY USING KINETIC CHANGE INFORMATION 审中-公开
标题翻译：用动态变化信息估算目标材料特征的方法和装置
公开(公告)号：WO2009093840A2
公开(公告)日：2009-07-30
申请号：PCT/KR2009000308
申请日：2009-01-21
IPC分类号： G01N33/48 , G01N27/26 , G01N27/27 , G01N27/32 , G01N33/66
CPC分类号： G01N33/86 , G01N27/3274 , G01N33/5302 , G01N33/66
摘要： Disclosed are a method and an apparatus for estimating the features (concentration, weight, volume, etc.) of target materials, by using kinetic change information depending on time, when measuring the results of a chemical reaction between two materials, target materials and reactant, with an optical or electrochemical method. More particularly, the disclosed method and apparatus: draws a correlation in advance between the kinetic change information for the features of the target materials and the features of the target materials from several statically acceptable samples; and estimates the features of the target materials in new samples by using the correlation, wherein the kinetic change information for the features of the target materials reveals the optical or electrochemical change, depending on time, of the results of the chemical reaction. In addition, the invention relates to a method and an apparatus for correcting errors by using kinetic change information of target materials, more particularly to a method and an apparatus for correcting the features of the first material by using the kinetic change information for the features (concentration, content, etc.) of the first material, a correlation between the kinetic change information and the features of the second material, and a correlation between measurement errors of the features of the second material and the features of the first material.
摘要翻译：公开了一种用于在测量两种材料，靶材料和反应物之间的化学反应的结果时，通过使用随时间的动力学变化信息来估计目标材料的特征（浓度，重量，体积等）的方法和装置，用光学或电化学方法。更具体地，所公开的方法和装置：在来自几个静态可接受的样本的目标材料的特征的动力学变化信息和目标材料的特征之间预先绘制相关性; 并通过使用相关性估计新样本中的目标材料的特征，其中针对目标材料的特征的动力学变化信息显示取决于化学反应结果的时间的光学或电化学变化。另外，本发明涉及一种通过使用目标材料的动力学变化信息来校正误差的方法和装置，更具体地说，涉及通过使用特征的动力学变化信息来校正第一材料的特征的方法和装置（浓度，含量等），动力学变化信息与第二材料的特征之间的相关性，以及第二材料的特征的测量误差与第一材料的特征之间的相关性。

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