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1. 发明申请

WO99014386A1 METHOD FOR SEPARATING TRIVALENT ACTINIDES FROM AT LEAST ONE TRIVALENT LANTHANIDE BY MEANS OF (BIS)ARYLDITHIOPHOSPHONIC ACID AS ORGANOPHOSPHATE AS SYNERGIST 审中-公开
标题翻译： PROCESS了分离的至少三价的锕系元素镧系三价（BIS）ARYLDITHIOPHOSPHINIGER ACID AS萃取剂和有机磷酸盐增效剂
公开(公告)号：WO99014386A1
公开(公告)日：1999-03-25
申请号：PCT/DE1998/002815
申请日：1998-09-15
IPC分类号： G21F9/06 , C07F9/16 , C07F9/30 , C22B3/26 , C22B3/34 , C22B3/38 , C22B59/00 , C22B60/02 , G21F9/12
CPC分类号： G21F9/125 , C07F9/16 , C22B3/007 , C22B59/00 , C22B60/026 , C22B60/0295 , Y02P10/234
摘要： The invention relates to a method for separating trivalent actinides from at least trivalent lanthanides, whereby said trivalent actinides are extracted from an aqueous solution containing a H concentration of 0.01 to 2 mol/1 by using an (aryl)dithiophosphonic acid of the general formula (4) = R1R2PS(SH), in which R1 = phenyl or naphthyl, R2 = phenyl or naphthyl, as well as rests of R1 and R2 substituted by methyl, ethyl, propyl, isopropyl, cyano, nitro or halogenyl, with addition of trioctylphosphate, tris-(2-propypentyl)-phosphate or tris-(2-ethylhexyl)-phosphate as synergist. The use of synergists according to the invention allows for a more selective extraction. In a more advantageous formulation, the aromatic solvent used is at least one component from the toluol, xylol, tert.-(butyl)-benzol, bis-(tert.-butyl)-benzol, bis-(tert.-butyl)-benzol, tris-(tert.-butyl)-benzol, bis-isopropylbenzol and tri-isopropylbenzol, resulting in increased selectivity An(III) and distribution coefficient DAn(III).
摘要翻译：本发明涉及一种用于从三价镧系元素三价锕系元素的分离的方法，其中从水溶液中的三价锕系元素具有0.01的H +浓度为2摩尔/ 1由通式的二（芳基）dithiophosphiniger酸装置（4）= R1R2PS（SH）与R1 =苯基或萘基，R 2 =苯基或萘基，以及甲基，乙基，丙基，isoprophyl-，氰基，硝基，卤代基取代的R1和R2的，根据本发明中的自由基此外磷酸三辛酯，三磷酸盐（2-propylpentil）或三（2-乙基己基）磷酸酯被提取为增效剂。在提取更大的选择性使用本发明的协同的结果。在本发明的一个有利的实施例中，作为芳族溶剂为选自甲苯，二甲苯，叔.-（丁基）苯，双 - （叔丁基）苯，三 - （叔丁基）的至少一个部件 - 苯，对异丙基苯和三异丙基苯使用，由此在除了（III）的选择性和分配系数DAN（III）可以增加。

2. 发明申请

WO2008005555A1 MODULATORS OF TOLL-LIKE RECEPTOR 7 审中-公开
标题翻译：类似受体的调节剂7
公开(公告)号：WO2008005555A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/015615
申请日：2007-07-06
申请人： GILEAD SCIENCES, INC. , CHONG, Lee, S. , DESAI, Manoj, C. , GALLAGHER, Brian , GRAUPE, Michael , HALCOMB, Randall, L. , YANG, Hong , ZHANG, Jennifer, R.
发明人： CHONG, Lee, S. , DESAI, Manoj, C. , GALLAGHER, Brian , GRAUPE, Michael , HALCOMB, Randall, L. , YANG, Hong , ZHANG, Jennifer, R.
IPC分类号： C07F9/141 , C07F9/16 , C07F9/22 , C07F9/28 , A61K31/66 , A61P31/00
CPC分类号： C07F9/65616
摘要： The present application provides for a compound of Formula (I) or (II): or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.
摘要翻译：本申请提供式（I）或（II）的化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物与至少一种另外的活性剂。

3. 发明申请

WO2005082914A3 MODULATORS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 审中-公开
标题翻译： LOSOPHOSPHATIDIC ACID（LPA）信号调节剂
公开(公告)号：WO2005082914A3
公开(公告)日：2005-10-20
申请号：PCT/US2004042395
申请日：2004-12-15
申请人： UNIV TEXAS , HASEGAWA YUTAKA , MILLS GORDON B
发明人： HASEGAWA YUTAKA , MILLS GORDON B
IPC分类号： C07F9/09 , C07F9/117 , C07F9/14 , C07F9/141 , C07F9/16 , C07F9/165 , C07F9/20 , C07F9/38 , C07F9/547 , C07F9/6571 , C07F9/6574
CPC分类号： C07F9/1651 , C07F9/091 , C07F9/117 , C07F9/1403 , C07F9/2003 , C07F9/657118 , C07F9/657127 , C07F9/65742
摘要： The present invention provides phosphoric acid and phosphoric acid compounds as well as thioderivatives thereof of formulat (I, II, III, IV and V).
摘要翻译：本发明提供了磷酸和磷酸化合物以及其制剂（I，II，III，IV和V）的硫代衍生物。

4. 发明申请

WO2023049420A1 DRY POWDER FOAMABLE FORMULATIONS FOR DELIVERY OF MEDICAMENTS THROUGH THE MUCOSA 审中-公开
公开(公告)号：WO2023049420A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/044640
申请日：2022-09-24
申请人： DONALDSON, Chadwick , HAEBERLE, Adam , FUISZ, Joseph
发明人： DONALDSON, Chadwick , HAEBERLE, Adam , FUISZ, Joseph
IPC分类号： A61K31/66 , C07F9/02 , C07F9/06 , C07F9/165 , C07F9/16
摘要： Embodiments include formulations and methods for oromucosal administration of a dry powder to create a topical foam composition to deliver medicaments to an interior mucosal space, such as the oral cavity, nasal cavity, rectal cavity, vaginal cavity or esophagus. The active agent can be amifostine, an antibiotic, an anti-fungal, a non-steroidal anti-inflammatory drug or a steroidal anti-inflammatory drug. Oromucosal delivery allows one to target oral epithelial cells. Embodiments also include methods of treating mucositis. Conventional formulations and methods are generally ineffective because drugs cannot be directed toward epithelial cells of the GI that are most susceptible to mucositis. The formulations described herein increase concentration, permeability and residence time at a target site. The formulations also allow stable forms of amifostine, which obviates difficulties associated with storing, dosing and administering the drug.

5. 发明申请

WO2017027434A1 ANTIVIRAL BETA-AMINO ACID ESTER PHOSPHODIAMIDE COMPOUNDS 审中-公开
标题翻译：抗菌氨基酸酯磷酸二氢盐化合物
公开(公告)号：WO2017027434A1
公开(公告)日：2017-02-16
申请号：PCT/US2016/045946
申请日：2016-08-08
申请人： MERCK SHARP & DOHME CORP. , VACHAL, Petr , RAHEEM, Izzat , GUO, Zhiqiang , HARTINGH, Timothy John
发明人： VACHAL, Petr , RAHEEM, Izzat , GUO, Zhiqiang , HARTINGH, Timothy John
IPC分类号： C07F9/16 , A61K31/664 , A61P31/18
CPC分类号： C07F9/65616 , A61K31/675 , A61K45/06 , C07F9/16
摘要： Compounds of Formula (I) and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
摘要翻译：式（I）化合物及其药学上可接受的盐可用于抑制HIV逆转录酶。该化合物还可用于预防或治疗HIV的感染以及预防，延缓发作或进展以及AIDS的治疗。化合物及其盐可以用作药物组合物中的成分，任选地与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

6. 发明申请

WO2009060174A1 HALOALKYLSUBSTITUTED ARYLOXYALKYLIMIDAZOLINES FOR USE AS PESTICIDES 审中-公开
标题翻译：用作杀虫剂的盐酸亚油酰基咪唑啉酮
公开(公告)号：WO2009060174A1
公开(公告)日：2009-05-14
申请号：PCT/GB2008/003604
申请日：2008-10-24
申请人： SYNGENTA PARTICIPATIONS AG , LUETHY, Christoph , O'SULLIVAN, Anthony, Cornelius , PITTERNA, Thomas , SCHAETZER, Jürgen, Harry
发明人： LUETHY, Christoph , O'SULLIVAN, Anthony, Cornelius , PITTERNA, Thomas , SCHAETZER, Jürgen, Harry
IPC分类号： A01N43/40 , A01N43/50 , C07D233/22 , C07D401/12 , C07F9/22 , C07F9/16 , C07C255/15
CPC分类号： C07D233/22 , A01N43/50 , C07D401/12
摘要： The present invention relates to novel imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, acarine, mollusc and nematode pests. A compound of formula (I) : and the salts and N-oxides thereof.
摘要翻译：本发明涉及新的咪唑啉衍生物及其作为杀虫，杀螨，杀软体动物和杀线虫剂的用途。本发明还延伸到包含这种咪唑啉衍生物的杀虫，杀螨，杀软体动物和杀线虫组合物，以及使用这些衍生物和/或组合物来对抗和控制昆虫，螨虫，软体动物和线虫的害虫的方法。式（I）的化合物及其盐和N-氧化物。

7. 发明申请

WO2009036909A1 HALOSUBSTITUTED ARYLOXYALKYLIMIDAZOLINES FOR USE AS PESTICIDES 审中-公开
标题翻译：作为杀虫剂使用的羟基苯甲酰胺基咪唑烷
公开(公告)号：WO2009036909A1
公开(公告)日：2009-03-26
申请号：PCT/EP2008/007363
申请日：2008-09-09
申请人： SYNGENTA PARTICIPATIONS AG , LUETHY, Christoph , O'SULLIVAN, Anthony, Cornelius , PITTERNA, Thomas , SCHAETZER, Jürgen, Harry
发明人： LUETHY, Christoph , O'SULLIVAN, Anthony, Cornelius , PITTERNA, Thomas , SCHAETZER, Jürgen, Harry
IPC分类号： C07D233/22 , C07D401/12 , C07F9/22 , C07F9/16 , C07C255/15 , A01N43/40 , A01N43/50
CPC分类号： C07D233/16 , A01N43/50
摘要： The present invention relates to novel imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, acarine, mollusc and nematode pests. A compound of formula (I) and salts and N-oxides thereof, wherein: R 1 is C 1-10 alkyl; R 2 is chloro, bromo or iodo; R 3 is C 2-5 alkyl, C 1-5 haloalkyl, C 1-6 hydroxyalkyl, C 1-5 alkoxy-(C 1-3 )-alkyl, di-(C 1-5 alkoxy)-(C 1-3 )-alkyl, C 1-5 alkylthio-(C 1-3 )-alkyl; C 1-5 alkylsulfinyl-(C 1-3 )alkyl; C 2-5 alkenyl, C 1-5 haloalkenyl, C 2-5 alkinyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, hydroxy, C 1-5 alkoxy, C 1-5 haloalkoxy, C 1-5 alkylthio, C 1-5 haloalkylthio, formyl, cyano, bromo, or iodo; Z is hydrogen, hydroxy, nitro, cyano, rhodano, formyl, G-, G-S-, G-S-S-, G-A-, R 7 R 8 N-, R 7 R 8 N-S-, R 7 R 8 N-A-, G-O-A-, G-S-A-, (R 10 O)(R 11 O)P(X)-, (R 10 O)(R 11 S)P(X)-, (R 10 O)(R 11 )P(X)-, (R 10 S)(R 11 S)P(X)-, (R 10 O)(R 14 R 15 N)P(X)-, (R 11 )(R 14 R 15 N)P(X)-, (R 14 R 15 N)(R 16 R 17 N)P(X)-, G-N=CH-, G-O-N=CH-, N≡C- N=CH-, or Z is a group of formula (II), wherein B is S-, S-S-, S(O)-, C(O)-, or (CH 2 ) n -; n is an integer from 1 to 6; and R 1 , R 2 , and R 3 are as defined above; and G is optionally substituted C 1-10 alkyl, optionally substituted C 2-10 alkenyl, optionally substituted C 2-10 alkynyl, optionally substituted C 3-7 cycloalkyl, optionally substituted C 3-7 cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; A is S(O), SO 2 , C(O) or C(S).
摘要翻译：本发明涉及新的咪唑啉衍生物及其作为杀虫，杀螨，杀软体动物和杀线虫剂的用途。本发明还延伸到包含这种咪唑啉衍生物的杀虫，杀螨，杀软体动物和杀线虫组合物，以及使用这些衍生物和/或组合物来对抗和控制昆虫，螨虫，软体动物和线虫的害虫的方法。式（I）化合物及其盐和N-氧化物，其中：R1为C1-10烷基; R2是氯，溴或碘; R3是C2-5烷基，C1-5卤代烷基，C1-6羟基烷基，C1-5烷氧基 - （C1-3） - 烷基，二 - （C1-5烷氧基） - （C1-3） - 烷基，C1-5烷硫基 - （C 1-3） - 烷基; C 1-5烷基亚磺酰基 - （C 1-3）烷基; C2-5烯基，C1-5卤代烯基，C2-5炔基，C3-6环烷基，C3-6环烯基，羟基，C1-5烷氧基，C1-5卤代烷氧基，C1-5烷硫基，C1-5卤代烷硫基，甲酰基，氰基，溴，或碘; Z是氢，羟基，硝基，氰基，罗丹明，甲酰基，G-，GS-，GSS-，GA-，R7R8N-，R7R8N-S-，R7R8N-A-，GOA-，GSA-，（R10O））（R10S）（R10R）（R10R）（R10S）P（X10）（R10O）（R11S）P（X） - ，（R10O）（X） - ，（R11）（R14R15N）P（X） - ，（R14R15N）（R16R17N）P（X） - ，GN = CH-，GON = CH-，N = 是式（II）的基团，其中B是S-，SS-，S（O） - ，C（O） - 或（CH 2）n - ; n是1至6的整数; 并且R 1，R 2和R 3如上所定义; 任选取代的C 2-10炔基，任选取代的C 3-7环烷基，任选取代的C 3-7环烯基，任选取代的芳基，任选取代的杂芳基或任选取代的杂环基; A是S（O），SO 2，C（O）或C（S）。

8. 发明申请

WO2009036908A1 HALOSUBSTITUTED ARYLOXYALKYLIMIDAZOLINES FOR USE AS PESTICIDES 审中-公开
标题翻译：作为杀虫剂使用的羟基苯甲酰胺基咪唑烷
公开(公告)号：WO2009036908A1
公开(公告)日：2009-03-26
申请号：PCT/EP2008/007356
申请日：2008-09-09
申请人： SYNGENTA PARTICIPATIONS AG , LUETHY, Christoph , O'SULLIVAN, Anthony, Cornelius , PITTERNA, Thomas , SCHAETZER, Jürgen, Harry
发明人： LUETHY, Christoph , O'SULLIVAN, Anthony, Cornelius , PITTERNA, Thomas , SCHAETZER, Jürgen, Harry
IPC分类号： A01N43/40 , A01N43/50 , C07D233/22 , C07D401/12 , C07F9/22 , C07F9/16 , C07C255/15
CPC分类号： C07D233/22 , A01N43/50 , C07D401/12
摘要： The present invention relates to novel imidazoline derivatives and their use as insecticidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, mollusc and nematode pests. A method of combating and/or controlling a pest selected from the group consisting of insects, nematodes and molluscs, which comprises applying to said pest, or to the locus of said pest, or to a plant susceptible to attack by said pest, a pesticidally effective amount of a compound of the formula (I) and the salts and N-oxides thereof, wherein: R 1 is C 1-10 alkyl; R 2 is chloro, bromo, iodo or methyl; R 3 is chloro or methyl; or R 3 together with R 2 is -(CH 2 ) 3 - or -(CH 2 ) 4 -; Z is hydrogen, hydroxy, nitro, cyano, rhodano, formyl, G-, G-S-, G-S-S-, G-A-, R 7 R 8 N-, R 7 R 8 N-S-. R 7 R 8 N-A-, G-O-A-, G-S-A-, (R 10 O)(R 11 O)P(X)-, (R 10 O)(R 11 S)P(X)-, (R 10 O)(R 11 )P(X)-, (R 10 S)(R 11 S)P(X)-, (R 10 O)(R 14 R 15 N)P(X)-, (R 11 XR 14 R 15 N)P(X)-, (R 14 R 15 N)(R 16 R 17 N)P(X)-, G-N=CH-, G-O-N=CH-, N≡C- N=CH-, or Z is a group of formula (II), wherein B is S-. S-S-, S(O)-, C(O)-, or (CH 2 ) n -; n is an integer from 1 to 6; R 1 , R 2 , and R 3 are as defined above; and G is optionally substituted C 1-10 alkyl, optionally substituted C 2-10 alkenyl, optionally substituted C 2-10 alkynyl, optionally substituted C 3-7 cycloalkyl, optionally substituted C 3-7 cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; A is S(O), SO 2 , C(O) or C(S).
摘要翻译：本发明涉及新的咪唑啉衍生物及其作为杀虫，杀软体动物和杀线虫剂的用途。本发明还延伸到包含这种咪唑啉衍生物的杀虫，杀软体动物和杀线虫组合物，以及使用这些衍生物和/或组合物来对抗和控制昆虫，软体动物和线虫的害虫的方法。一种对抗和/或控制选自昆虫，线虫和软体动物的害虫的方法，其包括向所述有害生物或所述害虫的所在地施用易受所述有害生物攻击的植物，农药有效量的式（I）化合物及其盐和N-氧化物，其中：R1是C1-10烷基; R2是氯，溴，碘或甲基; R3是氯或甲基; 或R 3与R 2一起为 - （CH 2）3 - 或 - （CH 2）4 - ; Z是氢，羟基，硝基，氰基，罗丹明，甲酰基，G-，G-S-，G-S-S-，G-A-，R7R8N-，R7R8N-S-。（R10O）（R11S）P（X） - ，（R10O）（R11）P（X） - ，（R10S），（R10O）（R11S）P（X） - ，（R10O）（R14R15N）P（X） - ，（R11XR14R15N）P（X） - ，（R14R15N）（R16R17N）P（X） - ，GN = CH-，GON = - ，N = C-N = CH-，或Z是式（II）的基团，其中B是S-。 S-S，S（O） - ，C（O） - 或（CH 2）n - n是1至6的整数; R1，R2和R3如上定义; 任选取代的C 2-10炔基，任选取代的C 3-7环烷基，任选取代的C 3-7环烯基，任选取代的芳基，任选取代的杂芳基或任选取代的杂环基; A是S（O），SO 2，C（O）或C（S）。

9. 发明申请

WO00066598A1 IMPROVED PREPARATIONS OF THIOPHOSPHITES AND THIOPHOSPHONATES 审中-公开
标题翻译：改善硫代磷酸酯和硫代磷酸酯的制备
公开(公告)号：WO00066598A1
公开(公告)日：2000-11-09
申请号：PCT/US2000/011940
申请日：2000-05-03
IPC分类号： C07F9/201 , C07F9/40 , C07F9/16
CPC分类号： C07F9/4065 , C07F9/201
摘要： Improved methods for converting phosphite or phosphonate esters into corresponding thiophosphites or thiophosphonates and for synthesizing specific thiophosphite and thiophosphonate compounds so produced are disclosed and claimed. The methods start from phosphite diesters using P4S10 as the thionation reagent. The reaction mixture is refluxed until the reaction is complete and may be followed by separation and chloroformate ester phosphonation steps to produce pure thiophosphonocarboxylate triesters. Alternatively, these esters may be prepared directly by action of P4S10 on the corresponding phosphonocarboxylate esters. The former method was used to prepare dimethyl thiophosphite and thence trimethyl thiophosphonoformate, a key intermediate in synthesis of salts of thiophosphonoformic acid, which have anti-viral properties.
摘要翻译：公开和要求保护的方法将亚磷酸酯或膦酸酯转化成相应的硫代亚磷酸酯或硫代膦酸酯并合成特定的硫代亚磷酸酯和硫代膦酸酯化合物。该方法从使用P4S10作为硫化试剂的亚磷酸二酯开始。将反应混合物回流直到反应完成，然后分离和氯甲酸酯膦酸化步骤以产生纯的硫代膦酰基羧酸酯三酯。或者，这些酯可以通过P4S10在相应的膦酰基羧酸酯上的作用直接制备。使用前一种方法制备二硫代亚磷酸二甲酯，然后制备硫代膦酰甲酸三甲酯，这是合成硫代膦酰甲酸盐的关键中间体，具有抗病毒性质。

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