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1. 发明申请

WO1997014698A1 SYNTHESIS OF PERFLUOROARYL-SUBSTITUTED COMPOUNDS 审中-公开
标题翻译：全氟代替代化合物的合成
公开(公告)号：WO1997014698A1
公开(公告)日：1997-04-24
申请号：PCT/US1996015794
申请日：1996-10-02
申请人： THE DOW CHEMICAL COMPANY
发明人： THE DOW CHEMICAL COMPANY , FRAZIER, Kevin, A.
IPC分类号： C07F05/02
CPC分类号： C07F5/027
摘要： Perfluoroaryl-substituted compounds are prepared from perfluoroaryl compounds, particularly tris pentafluorophenyl borane is prepared from hexafluorobenzene. The method comprises contacting a perfluoroaryl compound with an organomagnesium reagent in the presence of a catalyst to form a perfluoroaryl magnesium compound, and contacting the perfluoroaryl magnesium compound with a trihalide element to form a tris perfluoroaryl-substituted compound.
摘要翻译：全氟芳基取代的化合物由全氟芳基化合物制备，特别是三氟五苯基硼烷由六氟苯制备。该方法包括在催化剂存在下使全氟芳基化合物与有机镁试剂接触以形成全氟芳基镁化合物，并使全氟芳基镁化合物与三卤化物元素接触以形成三全氟芳基取代的化合物。

2. 发明申请

WO1997011951A1 FUNGICIDES 审中-公开
标题翻译：杀菌剂
公开(公告)号：WO1997011951A1
公开(公告)日：1997-04-03
申请号：PCT/GB1996002228
申请日：1996-09-10
申请人： ZENECA LIMITED , LAWSON, Kevin, Robert , MOUND, William, Roderick , WHITTINGHAM, William, Guy
发明人： ZENECA LIMITED
IPC分类号： C07F05/02
CPC分类号： C07F5/027 , A01N55/08
摘要： A compound of formula (I), wherein A and A are, independently, phenyl, furyl or thienyl each optionally substituted by halogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4haloalkyl, C1-4haloalkoxy or C1-4haloalkylthio; R is C1-4alkyl, C1-4haloalkyl, C2-4alkenyl, C2-4haloalkenyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4)alkyl, benzyl or phenyl, wherein benzyl and phenyl are optionally substituted by halogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy or C1-4haloalkoxy; and R and R are, independently, hydrogen, C1-8alkyl, C1-8haloalkyl, C1-8alkoxy, C1-8haloalkoxy, halogen, nitro, COR , NR R or phenyl (optionally substituted by halogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy or NR R ); or R and R join together to form a ring, the ring being optionally substituted by halogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy or nitro; and R , R and R are independently hydrogen or C1-4alkyl.
摘要翻译：式（I）的化合物，其中A 1和A 2独立地是苯基，呋喃基或噻吩基，其各自任选被卤素，C 1-4烷基，C 1-4烷氧基，C 1-4烷硫基，C 1-4卤代烷基，C 1 -4卤代烷氧基或C1-4卤代烷硫基; R为C 1-4烷基，C 1-4卤代烷基，C 2-4烯基，C 2-4卤代烯基，C 3-7环烷基，C 3-7环烷基（C 1-4）烷基，苄基或苯基，其中苄基和苯基任选被卤素，C 1-4烷基， C 1-4卤代烷基，C 1-4烷氧基或C 1-4卤代烷氧基; R 1和R 2独立地是氢，C 1-8烷基，C 1-8卤代烷基，C 1-8烷氧基，C 1-8卤代烷氧基，卤素，硝基，COR 7，NR 5 R 6或苯基（任选被卤素，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基，C 1-4卤代烷氧基或NR 5 R 6取代）; 或R 1和R 2连接在一起形成环，该环任选被卤素，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基，C 1-4卤代烷氧基或硝基取代; 和R 5，R 6和R 7独立地是氢或C 1-4烷基。

3. 发明申请

WO1996000227A1 PREPARATION OF TRIARYLBORANE 审中-公开
标题翻译：三叉戟碱的制备
公开(公告)号：WO1996000227A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007127
申请日：1995-06-19
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： E.I. DU PONT DE NEMOURS AND COMPANY , CASALNUOVO, Albert, Loren , FOO, Thomas
IPC分类号： C07F05/02
CPC分类号： C07F5/027
摘要： Preparation of triarylborane from catalyst residues containing nickel complexes with triarylborane by heating the complexes at reduced pressure, and recovering the triarylborane by condensation.
摘要翻译：通过在减压下加热复合物，通过三芳基硼烷与镍络合物的催化剂残留物制备三芳基硼烷，并通过缩合回收三芳基硼烷。

4. 发明申请

WO1994017079A1 OPTICALLY ACTIVE beta-AMINOALKOXYBORANE COMPLEX 审中-公开
标题翻译：光活性β-亚氨基羟基硼烷复合物
公开(公告)号：WO1994017079A1
公开(公告)日：1994-08-04
申请号：PCT/JP1994000056
申请日：1994-01-17
申请人： NISSAN CHEMICAL INDUSTRIES LTD. , KASHIHARA, Hiroshi , SUZUKI, Mikio , OHARA, Yoshio
发明人： NISSAN CHEMICAL INDUSTRIES LTD.
IPC分类号： C07F05/02
CPC分类号： C07D207/08 , C07B53/00 , C07B2200/07 , C07C29/143 , C07C67/31 , C07C215/28 , C07C2601/14 , C07C2602/10 , C07C2603/24 , C07C2603/26 , C07D215/14 , C07F5/022 , C07C35/36 , C07C33/22 , C07C31/125 , C07C69/732
摘要： An optically active beta -aminoalkoxyborane complex of formula (I), wherein R is C1-C8 alkyl, C3-C7 cycloalkyl, C7-C11 aralkyl or C6-C10 aryl, R is hydrogen, C1-C8 alkyl, C3-C7 cycloalkyl or C7-C11 aralkyl, or R and R together form (CH2)n wherein n is 3 or 4, and Ar is naphthyl, anthryl or phenanthryl, which may be substituted by from 1 to 3 substituents selected from the group consisting of halogen, nitro, C1-C6 alkyl, C3-C7 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C7-C11 aralkyl, C6-C10 aryl, C1-C6 alkoxy and styrene polymer substituents.
摘要翻译：式（I）的光学活性β-氨基烷氧基硼烷配合物，其中R 1是C 1 -C 8烷基，C 3 -C 7环烷基，C 7 -C 11芳烷基或C 6 -C 10芳基，R 2是氢，C 1 -C 8烷基，C 3 -C 7环烷基或C 7 -C 11芳烷基，或R 1和R 2一起形成（CH 2）n，其中n为3或4，Ar为萘基，蒽基或菲基，其可以被1 至3个选自卤素，硝基，C 1 -C 6烷基，C 3 -C 7环烷基，C 2 -C 6烯基，C 2 -C 6炔基，C 7 -C 11芳烷基，C 6 -C 10芳基，C 1 -C 6烷氧基和苯乙烯聚合物取代。

5. 发明申请

WO1993009123A1 HETEROCYCLIC AMINO-BORANES 审中-公开
标题翻译：杂环氨基硼烷
公开(公告)号：WO1993009123A1
公开(公告)日：1993-05-13
申请号：PCT/US1992009271
申请日：1992-10-29
申请人： BORON BIOLOGICALS, INC.
发明人： BORON BIOLOGICALS, INC. , SPIELVOGEL, Bernard, F. , SOOD, Anup , HALL, Iris, H.
IPC分类号： C07F05/02
CPC分类号： C07F5/022 , C07F5/027
摘要： Heterocyclic amine-borane compounds of formula (I) wherein: A is a heterocyclic amine moiety; R1 is selected from H, alkyl, alkylaryl, aryl, and arylalkyl; and R2 is selected from CN, COOH, COOR3, and CONHR3 where R3 is selected from H, alkyl, alkylaryl, aryl, aralkyl. The heterocyclic amine-borane compounds of the invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and anti-hyperlipidemic activity. The invention also comprehends a method of inhibiting enzyme activity (e.g., DNA topoisomerase II, PRPP amidotransferase, IMP dehydrogenase, dihydrofolate reductase, and/or ribonucleotide reductase) in an in vitro or in vivo system, comprising administering to the system an enzyme-inhibitingly effective amount of a Lewis-base borane adduct, such as a heterocyclic amine-borane compound of the foregoing formula.

6. 发明申请

WO1984003885A1 ASYMMETRICALLY MODIFIED BORON HYDRIDE COMPOUNDS, PROCESS FOR ITS PREPARATION, AND PROCESS FOR PREPARING OPTICALLY ACTIVE ALCOHOL DERIVATIVE USING SAME 审中-公开
标题翻译：非对称改性的硼氢化合物，其制备方法和使用其制备光学活性醇衍生物的方法
公开(公告)号：WO1984003885A1
公开(公告)日：1984-10-11
申请号：PCT/JP1984000161
申请日：1984-04-03
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED , YONEYOSHI, Yukio , SUZUKAMO, Gohfu , HAMADA, Kazuhiko , NISHIOKA, Toshio
发明人： SUMITOMO CHEMICAL COMPANY, LIMITED
IPC分类号： C07F05/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07F5/022
摘要： Asymmetrically modified boron hydride compounds to be used for preparing optically active alcohol derivatives by asymmetrical reduction of ketone compounds are prepared by reacting an acid salt of an optically active amino alcohol of formula (I) with boron hydride or by reacting the optically active amino alcohol with borane in the presence of an inert solvent at -78 to 100oC. The compounds are used for asymmetrically reducing an azole type ketone of formula (II) to prepare an optically active alcohol derivative useful as a fungicide, herbicide or plant growth regulator and represented by formula (III).

7. 发明申请

WO1996031519A1 WEAKLY NUCLEOPHILIC ANIONS 审中-公开
标题翻译：微弱的核酸阴离子
公开(公告)号：WO1996031519A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004712
申请日：1996-04-05
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF COLORADO
发明人： BOARD OF REGENTS OF THE UNIVERSITY OF COLORADO , MICHL, Josef , KING, Benjamin , JANOUS¿EK, Zbynek
IPC分类号： C07F05/02
CPC分类号： C07F5/027
摘要： Substituted borate and carborate anions having unusual properties of being exceptionally weakly nucleophilic and being soluble in non-polar solvents. One-electron oxidation of the anions yields the corresponding radicals. The compounds are useful, e.g., as electrolytes, catalysts, and electrochromic materials.
摘要翻译：具有非常弱的亲核性并且可溶于非极性溶剂的不寻常的特性的取代硼酸盐和碳化硼阴离子。阴离子的一电子氧化产生相应的自由基。这些化合物是有用的，例如电解质，催化剂和电致变色材料。

8. 发明申请

WO1996026945A1 AQUEOUS SPECTINOMYCIN BORATE SOLUTIONS 审中-公开
标题翻译：水性白蛋白溶液
公开(公告)号：WO1996026945A1
公开(公告)日：1996-09-06
申请号：PCT/EP1996000816
申请日：1996-02-27
申请人： RHONE MERIEUX , HOPPONEN, Raymond, E. , MACY, Lowell, R.
发明人： RHONE MERIEUX
IPC分类号： C07F05/02
CPC分类号： C07F5/025
摘要： Aqueous pharmaceutical compositions containing more than 10 % spectinomycin, prepared by the reaction of the ketone hydrate of spectinomycin with boric acid to form the boron compound, and with a base such as sodium hydroxyde to form the stable salt of the compound. Method for preparing same and new boron compound of spectinomycin and salt thereof.
摘要翻译：含有超过10％的壮观霉素的水性药物组合物通过观察壮观霉素的酮水合物与硼酸反应形成硼化合物，并与碱如氢氧化钠反应形成化合物的稳定盐。其制备方法以及壮观霉素及其盐的新硼化合物。

9. 发明申请

WO1996005206A1 NOVEL PROCESS FOR THE PREPARATION OF DIISOPINOCAMPHEYLCHLOROBORANE 审中-公开
标题翻译：二氯硝基胆碱的制备新方法
公开(公告)号：WO1996005206A1
公开(公告)日：1996-02-22
申请号：PCT/US1995009921
申请日：1995-08-07
申请人： MERCK & CO., INC. , KING, Anthony, On-Ping , LARSEN, Robert, D. , VERHOEVEN, Thomas, R. , ZHAO, Mangzhu
发明人： MERCK & CO., INC.
IPC分类号： C07F05/02
CPC分类号： C07D495/04 , C07D215/14 , C07D215/18 , C07F5/027 , Y02P20/55
摘要： The present invention relates to an improved process for the in situ preparation of diisopinocampheylchloroborane which comprises reacting sodium borohydride and boron trichloride with alpha -pinene. The diisopinocampheylchloroborane thus obtained may be used, without isolation, to reduce prochiral ketones to their corresponding alcohols in high optical purity.
摘要翻译：本发明涉及一种二异蒎烷基氯代硼烷的原位制备改进方法，其包括使硼氢化钠和三氯化硼与α-蒎烯反应。这样得到的二蒎烯yl yl chlor chlor ob or or may。。。。。。。，，，。。。。。。。。。。。。。

10. 发明申请

WO1995026353A1 NEW IODIZED BORON COMPOUNDS USEFUL AS X-RAY CONTRASTING AGENTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型碘化合物可用作X射线对比剂，以及含有它们的药物组合物
公开(公告)号：WO1995026353A1
公开(公告)日：1995-10-05
申请号：PCT/ES1994000034
申请日：1994-03-25
申请人： CENTRO INVESTIGACION JUSTESA IMAGEN, S.A.
发明人： CENTRO INVESTIGACION JUSTESA IMAGEN, S.A. , MARTIN JIMENEZ, José L. , SPECK, Ulrich , CARRETERO COLON, José María , MARTINEZ SANZ, Antonio , BOHLE, Florian , KRAUSE, Werner
IPC分类号： C07F05/02
CPC分类号： C07F5/027 , A61K41/0095 , A61K49/0433
摘要： The invention relates to new organic boron compounds having a monomer structure (I): [BxCyH(x+y-t-w)ItZw], 2/rQ and a dimer structure (II): {[B12H(12-t-w)ItZw]-N(R)-[B12H(12-t-w)ItZw]}, 4/rQ, characterized in that they contain a high molar percentage of iodine, and are useful as radio-opaque agents in uroangiography, cardioangiography, etc., as well as for selectively visualizing organs or body systems such as the liver, the spleen or the lymphatic system. The compounds having the general formulas (I) and (II) are also useful in the selective therapy of tumors. The invention also relates to pharmaceutical preparations which contain the claimed compounds having the general formulas (I) and (II).
摘要翻译：本发明涉及具有单体结构（I）的新的有机硼化合物：[BxCyH（x + ytw）ItZw]，2 / rQ和二聚体结构（II）：{[B12H（12-tw）ItZw] -N（ R） - [B12H（12-tw）ItZw]}，4 / rQ，其特征在于它们含有高摩尔百分比的碘，并且可用作尿路造影，心脏血管造影等中的不透射线剂，以及选择性地观察器官或身体系统如肝脏，脾脏或淋巴系统。具有通式（I）和（II）的化合物也可用于肿瘤的选择性治疗。本发明还涉及含有所要求保护的具有通式（I）和（II）的化合物的药物制剂。

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