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1. 发明申请

WO2021030808A1 PHOSPHATIDYLSERINE BINDING MOLECULES BLOCK IMMUNE SUPPRESSION OF TUMOR ASSOCIATED EXOSOMES 审中-公开
公开(公告)号：WO2021030808A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/046712
申请日：2020-08-17
申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK , MOLECULAR TARGETING TECHNOLOGIES, INC. , IMMUNE MODULATORY THERAPIES LLC
发明人： BANKERT, Richard B. , PAK, Koon Yan , GRAY, Brian D. , BALU-IYER, Sathy V. , KELLEHER, Raymond , SHENOY, Gautam , BHATTA, Maulasri
IPC分类号： A61K31/045 , A61K31/047 , A61K31/075 , C07C31/00 , C07C31/18 , C07C31/24
摘要： The present disclosure provides compounds that bind phosphatidylserine (PS). Also provided are compositions comprising the compounds and methods of using the compounds and/or compositions. The compounds and compositions may be used to treat an individual having or suspected of having cancer(s), infectious disease(s), chronic inflammation, and/or autoimmune condition(s).

2. 发明申请

WO2019106424A1 DIANHYDROGALACTITOL FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS 审中-公开
公开(公告)号：WO2019106424A1
公开(公告)日：2019-06-06
申请号：PCT/IB2018/001357
申请日：2018-11-02
申请人： DEL MAR PHARMACEUTICALS (BC) LIMITED
发明人： STEINO, Anne , BACHA, Jeffrey, A. , BROWN, Dennis, M.
IPC分类号： A61K31/336 , A61K31/047 , A61P35/00 , C07C31/24 , C07D303/14 , C07D303/22
摘要： Methods for treating diffuse intrinsic pontine glioma (DIPG) comprising administration of a therapeutically effective amount of an alkylating hexitol (such as dianhydrogalacitol, diacetyldianhydrogalacitol, and dibromodulcitol) are disclosed. Such methods may further comprise administration of other anti-cancer agents. In preferred embodiments, the secondary anti-cancer agent is an inhibitor of Weel tyrosine kinase (such as adavosertib). Methods of treating malignancies in general comprising administration of a combination of an alkylating hexitol and an inhibitor of Weel tyrosine kinase are also disclosed.

3. 发明申请

WO2010108840A1 STABILISIERUNG VON POLYOLEN 审中-公开
标题翻译：稳定多元醇
公开(公告)号：WO2010108840A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053507
申请日：2010-03-18
申请人： LANXESS Deutschland GmbH , HEUER, Lutz
发明人： HEUER, Lutz
IPC分类号： C07C29/94 , C07C31/18 , C07C31/20 , C07C31/22 , C07C31/24 , C07C35/08 , C07C43/11 , C08G63/16
CPC分类号： C08G63/12 , C07C29/94 , C07C41/58 , C07C2601/14 , C08G63/133 , C08G63/16 , C08G63/19 , C08G63/193 , C08G63/20 , C08G63/672 , C08G63/78 , C08K5/13 , C08K5/36 , C08K5/375 , C07C31/20 , C07C35/14 , C07C31/202 , C07C31/207 , C07C31/245 , C07C31/22 , C08L71/02 , C07C43/303 , C08L67/00 , C08L67/02
摘要： Die Erfindung betrifft ein Verfahren zur Stabilisierung von Polyolen sowie Mischungen enthaltend Polyole und Stabilisatoren. Als Stabilisatoren werden Verbindungen der Formel (I) oder (II) verwendet, in denen n für 1, 2, 3 oder 4 steht m für 1, 2 oder 3 steht p für 2 steht Q für Schwefel oder C 1 C 4 -Alkylen steht und R 1 jeweils unabhängig von gegebenenfalls vorhandenen anderen Resten R 1 für C 1 -C 8 - Alkyl oder C 1 -C 8 -Alkoxy steht, wobei weiterhin zumindest eine ortho-Position der beiden Phenylringe gemäß Formel (II) bzw. des Phenylrings gemäß Formel (I) mit einem sekundären oder tertiären Rest substituiert sein muss.
摘要翻译：本发明涉及多元醇与含有多元醇的和稳定剂的混合物的稳定化的方法。作为稳定剂，使用式（I）或（II）的化合物，其中n是1，2，3或4，m为1，2或3，p是2，Q是分别硫或C 1 -C 4 - 亚烷基且R 1， R1是C1-C8烷基或C1-C8烷氧基，无论任选其它部分的，其特征在于，另外的至少一种式I的苯环的邻位（II）或式（I）化合物与仲或叔苯基环的剩余的被取代。

4. 发明申请

WO00058246A1 A FORMALDEHYDE AND FORMATE REDUCED POLYOL PROCESS 审中-公开
标题翻译：甲醛和甲醛减少多元醇方法
公开(公告)号：WO00058246A1
公开(公告)日：2000-10-05
申请号：PCT/SE2000/000509
申请日：2000-03-20
IPC分类号： C07C29/14 , C07C29/38 , C07C31/18 , C07C31/22 , C07C31/24
CPC分类号： C07C29/38 , C07C29/14 , C07C31/205 , C07C31/20 , C07C31/22 , C07C31/245
摘要： Formaldehyde and formate reduced process for preparation of a di, tri or polyalcohol from formaldehyde and a second aldehyde in the presence of an alkaline catalyst. The process comprises an aldol condensation yielding a methylolaldehyde and a subsequent crossed Cannizzaro reaction yielding said di, tri or polyalcohol and formate. The Cannizzaro reaction comprises reacting said methylolaldehyde with formaldehyde at a molar ratio said methylolaldehyde to said formaldehyde of 1:0.3-0.9 in the presence of 0.3-0.9 mole of OH on 1 mole of said methylolaldehyde. The Cannizzaro reaction is interrupted when 0.2-0.8 mole of HCOO is generated on 1 mole of said methylolaldehyde and obtained reaction mixture is in a subsequent step subjected to a transfer hydrogenation in the presence of an effective amount of at least one transfer hydrogenation catalyst.
摘要翻译：在碱性催化剂存在下，由甲醛和第二醛制备二，三或多元醇的甲醛和甲酸酯还原方法。该方法包括产生羟甲醛的醛醇缩合物和随后的交叉的Cannizzaro反应，产生所述二，三或多元醇和甲酸盐。坎尼扎罗反应包括在1摩尔所述羟甲基醛中，在0.3-0.9摩尔OH存在下，使所述羟甲醛与甲醛以所述羟甲醛与所述甲醛为1:0.3-0.9的摩尔比反应。当在1摩尔所述羟甲基醛上产生0.2-0.8摩尔HCOO时，坎尼扎罗反应中断，所得反应混合物在随后的步骤中，在有效量的至少一种转移氢化催化剂存在下进行转移氢化。

5. 发明申请

WO2020067963A1 PROCESS FOR PRODUCTION OF PENTAERYTHRITOL WITH AN INCREASED YIELD OF DI-PENTAERYTHRITOL 审中-公开
公开(公告)号：WO2020067963A1
公开(公告)日：2020-04-02
申请号：PCT/SE2019/050883
申请日：2019-09-19
申请人： PERSTORP AB
发明人： MÅNSSON, Christoffer , FINNHULT, Daniel
IPC分类号： C07C29/38 , B01J23/30 , C07C31/24
摘要： The present invention refers to a process for production of pentaerythritol with an increased yield of di-pentaerythritol, wherein acetaldehyde, formaldehyde, calcium hydroxide and a formose inhibitor are reacted in an aqueous solution.

6. 发明申请

WO2017115939A1 직쇄형 폴리글리세롤의 제조방법 审中-公开
标题翻译：生产直链聚甘油的方法
公开(公告)号：WO2017115939A1
公开(公告)日：2017-07-06
申请号：PCT/KR2016/005415
申请日：2016-05-23
申请人： 한국과학기술연구원
发明人： 이현주 , 김민수 , 이상득 , 이제승 , 한태열 , 박서경
IPC分类号： C07C29/128 , C07C29/14 , C07C29/48 , C07C31/18 , C07C31/22 , C07C31/24 , B01J31/12
CPC分类号： B01J31/12 , C07C29/128 , C07C29/14 , C07C29/48 , C07C31/18 , C07C31/22 , C07C31/24
摘要： 본 발명은 직쇄형 폴리글리세롤의 제조방법에 관한 것으로 글리세롤을 주촉매 및 조촉매 하에서 반응시켜 직쇄형 폴리글리세롤을 생성하는 단계를 포함함으로써, 용매를 사용하지 않는 친환경적인 방법으로 반응을 수행할 수 있다. 또한, 주촉매의 높은 활성을 조절할 수 있는 조촉매를 사용하여 부반응을 억제시킴으로써 높은 수율 및 높은 선택도로 직쇄형 폴리글리세롤, 특히 디글리세롤 및 트리글리세롤을 생성할 수 있다.
摘要翻译：
本发明是通过将甘油状态的催化剂和助催化剂作为直链聚甘油涉及一种用于制造的方法，不使用溶剂中反应生成直链聚甘油环保该反应可以以相同的方式进行。另外，也可以使用助催化剂，可以调整主催化剂的高活性，以产生高收率和高选择性线性聚甘油，通过抑制副反应尤其二甘油和三甘油。

7. 发明申请

WO2010066674A3 METHOD FOR PURIFYING POLYMETHYLOLS 审中-公开
标题翻译：程序对清洁POLYMETHYLOLEN
公开(公告)号：WO2010066674A3
公开(公告)日：2010-12-16
申请号：PCT/EP2009066522
申请日：2009-12-07
申请人： BASF SE , SIRCH TILMAN , STEINIGER MICHAEL , MAAS STEFFEN , RITTINGER STEFAN , SCHLITTER STEPHAN
发明人： SIRCH TILMAN , STEINIGER MICHAEL , MAAS STEFFEN , RITTINGER STEFAN , SCHLITTER STEPHAN
IPC分类号： C07C29/80 , C07C31/20 , C07C31/22 , C07C31/24
CPC分类号： C07C29/141 , C07C29/80 , C08G18/56 , C08G63/16 , C08L67/00 , C08L75/04 , C07C31/245 , C07C31/20 , C07C31/22
摘要： The invention relates to a method for distilling an aqueous polymethylol mixture, comprising a polymethylol of formula (I), where R independently = a further methylol group, or 1 to 22 C alkyl, or a 6 to 22 C aryl or aralkyl group, a tertiary amine, water and the adduct of tertiary amine and formic acid, (amine formate), characterised in that the distillation is carried out in a distillation column connected to an evaporator at the kettle, wherein the kettle temperature is maintained above the boiling point of the mono-ester of formic acid and polymethylol (polymethylol formate) formed during the distillation. The invention further relates to a composition comprising polymethylol and 1 to 10,000 ppm by weight of polymethylol formate and the use thereof.
摘要翻译：本发明涉及一种用于式（I）的羟甲基化合物，其中在每种情况下彼此独立地，R水性PoIymethylolgemisches的蒸馏的过程的进一步羟甲基或具有碳原子数1〜22的烷基或具有6〜22的芳基或芳基装置C原子，叔胺，水和叔胺和甲酸（胺甲酸盐）的加成物，其特征在于，蒸馏是在连接在底部用蒸发器的蒸馏塔，进行，其中上述塔底温度甲酸和羟甲基（Polymethylolformiat）的蒸馏的单酯过程中形成的蒸发温度的位置。此外，本发明还涉及一种组合物，包含羟甲基和1〜10000重量ppm PoIymethylol甲酸盐和它们的用途。

8. 发明申请

WO02027037A1 A MULTISTEP PROCESS FOR RECOVERING BETAINE, ERYTHRITOL, INOSITOL, SUCROSE, MANNITOL, GLYCEROL AND AMINO ACIDS FROM A PROCESS SOLUTION USING A WEAKLY ACID CATION EXCHANGE RESIN 审中-公开
标题翻译：使用弱酸性交换树脂从工艺解决方案中回收BETAINE，ERYTHRITOL，INOSITOL，SUCROSE，MANNITOL，GLYCEROL和氨基酸的多步骤方法
公开(公告)号：WO02027037A1
公开(公告)日：2002-04-04
申请号：PCT/FI2001/000849
申请日：2001-09-28
IPC分类号： G01N30/02 , B01D15/08 , B01J20/281 , B01J20/285 , B01J20/34 , B01J39/04 , B01J39/20 , B01J39/26 , C07C29/76 , C07C31/22 , C07C31/24 , C07C31/26 , C07C35/16 , C07C227/28 , C07C227/40 , C07C227/42 , C07C229/12 , C07H1/06 , C07H3/04 , C13B20/14 , C13B30/02 , C13B35/06 , C13K13/00 , G01N30/26 , G01N30/30 , G01N30/46 , G01N30/64 , G01N30/80 , G01N30/84 , G01N30/88 , C13D3/14 , C13J1/06
CPC分类号： C13B35/06 , B01J39/07 , B01J39/26 , C07C29/76 , C07C227/28 , C07C2601/14 , C13B20/144 , C13B30/02 , C13K13/00 , C07C229/12 , C07C31/225 , C07C31/24 , C07C31/26 , C07C35/16
摘要： The invention relates to a method comprising a multistep process for recovering betaine, erythritol, inositol, sucrose, mannitol, glycerol and amino acids from corresponding starting materials. The invention comprises the use of a weakly acid cation exchange resin in chromatographic column in the multistep process. The starting materials are especially beet molasses, betaine molasses, syrups, thick juices, raw juices, corn steep cane based solutions and glycerol.
摘要翻译：本发明涉及一种方法，该方法包括从相应起始原料中回收甜菜碱，赤藓糖醇，肌醇，蔗糖，甘露糖醇，甘油和氨基酸的多步法。本发明包括在多步骤过程中在色谱柱中使用弱酸阳离子交换树脂。起始材料特别是甜菜糖蜜，甜菜碱糖蜜，糖浆，浓稠果汁，生果汁，玉米枸杞子溶液和甘油。

9. 发明申请

WO2022233904A1 METHOD OF PREPARING ALIPHATIC POLYOLS HAVING THREE OR MORE HYDROXY GROUPS AND A TOTAL NUMBER OF CARBON ATOMS OF 5 OR MORE 审中-公开
公开(公告)号：WO2022233904A1
公开(公告)日：2022-11-10
申请号：PCT/EP2022/061908
申请日：2022-05-04
申请人： BASF SE
发明人： GROESSL, Sylvester , LINKE, Stephanie Sybille , BAIER, Grit , TAVARES ANDRE, Rute da Conceicao
IPC分类号： C07C29/149 , C07C31/24 , C07C33/03
摘要： Described are a method of preparing a product comprising one or more product compounds selected from the group consisting of aliphatic polyols having three or more hydroxy groups and a total number of carbon atoms of 5 or more, the use of compounds selected from the group consisting of aliphatic tricarboxylic acids, esters thereof, anhydrides thereof and salts thereof as starting compounds for making said product compounds, and the use of a heterogeneous hydrogenation catalyst in a method of preparing a product comprising one or more of said product compounds.

10. 发明申请

WO2011050424A1 CATALYTIC PROCESS FOR THE PRODUCTION OF ALCOHOLS FROM BIOMASS-RELATED FEEDSTOCK 审中-公开
标题翻译：用于从与生物量相关的饲料生产酒精的催化方法
公开(公告)号：WO2011050424A1
公开(公告)日：2011-05-05
申请号：PCT/BE2010/000073
申请日：2010-10-26
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN , JACOBS, Pierre, Auguste , SELS, Bert, F. , VAN DE VYVER, Stijn
发明人： JACOBS, Pierre, Auguste , SELS, Bert, F. , VAN DE VYVER, Stijn
IPC分类号： C07C31/18 , C07C31/24 , C07C31/26 , C07C29/00 , C07C29/132
CPC分类号： C07C29/00 , C07C29/132 , C07C31/18 , C07C31/24 , C07C31/26
摘要： The present invention pertains generally to a catalytic technology for converting biomass- related feedstock into useful or value-added chemicals. More specifically, this invention relates to a catalytic process for the production of lower alcohols, and preferably for the production of C4 to C6 polyols from polysaccharides with β-glycoside linkages. A particular aspect of the present invention relates to a single-step catalytic process, using a heterogeneous catalyst, to produce C4 to C6 polyols such as sorbitol, mannitol, xylitol and erythritol, mixtures thereof and their partially dehydrated and/or dehydrogenated products such as sorbitan, isosorbide and sorbose from polysaccharides containing β-glycoside functionalities such as in cellulose, chitin and particular bacterial biopolymers. The heterogeneous catalyst which comprises non-noble transition metal(s) and acid carrier(s) is characterized by thermal pretreatment in a carbon-containing atmosphere in order to obtain increased sugar alcohol yields.
摘要翻译：本发明一般涉及将生物质相关原料转化为有用或增值化学品的催化技术。更具体地，本发明涉及用于生产低级醇的催化方法，并且优选用于由具有β-糖苷键的多糖生产C4至C6多元醇。本发明的一个特定方面涉及使用多相催化剂生产C4至C6多元醇如山梨糖醇，甘露糖醇，木糖醇和赤藓糖醇的单步催化方法，其混合物及其部分脱水和/或脱氢产物如脱水山梨糖醇，异山梨醇和山梨糖，其含有β-糖苷官能团的多糖，如纤维素，甲壳素和特定的细菌生物聚合物。包含非贵重过渡金属和酸性载体的非均相催化剂的特征在于在含碳气氛中进行热预处理以获得增加的糖醇产率。

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