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1. 发明申请

WO1992003153A1 HEMOGLOBIN-OLIGOMER BASED COMPOSITION AND METHOD TO MAKE SAME 审中-公开
标题翻译：基于HEMOGLOBIN-OLIGOMER的组合物及其制备方法
公开(公告)号：WO1992003153A1
公开(公告)日：1992-03-05
申请号：PCT/US1991005799
申请日：1991-08-15
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NELSON, Deanna, J. , HAI, Ton, That , SRNAK, Ana
IPC分类号： A61K37/14
CPC分类号： C07K14/805 , A61K38/00
摘要： A non-immunogenic mixture of hemoglobin based modified monomers and oligomers produced by the polymerization of a hemoglobin based solution in the presence of a three membered heterocyclic ring, i.e. polyether oxirane. The modified hemoglobin composition has a P50 of at least equivalent to the P50 of human red blood cell hemoglobin.
摘要翻译：通过在三元杂环（即聚醚环氧乙烷）存在下聚合基于血红蛋白的溶液产生的血红蛋白基改性单体和寡聚物的非免疫原性混合物。改性血红蛋白组合物的P50至少等于人红细胞血红蛋白的P50。

2. 发明申请

WO1988000055A1 MACROMOLECULAR CONJUGATES OF HEMOGLOBIN, THEIR PREPARATION, METHOD AND THEIR APPLICATIONS 审中-公开
标题翻译： HEMOGLOBIN的大分子结合体，其制备方法及其应用
公开(公告)号：WO1988000055A1
公开(公告)日：1988-01-14
申请号：PCT/FR1987000262
申请日：1987-07-02
申请人： INSTITUT MERIEUX , LEONARD, Michèle , DELLACHERIE, Edith , NEEL, Jean, Maurice, Léon , VIGNERON, Claude , LABRUDE, Pierre
发明人： INSTITUT MERIEUX
IPC分类号： A61K37/14
CPC分类号： C07K14/805 , A61K38/00
摘要： Water-soluble macromolecular conjugate of hemoglobin, characterised in that it is comprised of, on the one hand, hemoglobin, and on the other hand a water-soluble polymer P comprising polar groups which macromolecular conjugate has sites Z attached to the P polymer and containing at least 1 negative charge carried for example by sulfate groups, the polymer P being connected to the hemoglobin on the one hand through at least a band established between one at least of the Z sites carried by the polymer and the hemoglobin, and on the other hand through at least one covalent band established between the polymer and the hemoglobin, or between one at least the sites Z carried by the polymer and the hemoglobin. The macromolecular conjugates according to the invention present for oxygen an affinity lower than that of free hemoglobin.
摘要翻译：血红蛋白的水溶性大分子缀合物，其特征在于，一方面由血红蛋白构成，另一方面是包含极性基团的水溶性聚合物P，大分子缀合物具有与P聚合物连接的位置Z，并含有至少1个负电荷例如由硫酸基团携带，聚合物P一方面通过至少一个由聚合物携带的至少一个Z位点与血红蛋白之间建立的带和另一个所连接的带通过建立在聚合物和血红蛋白之间的至少一个共价带，或至少一个至少由聚合物携带的位点Z和血红蛋白之间。对于氧而言，本发明的大分子缀合物的亲和力低于游离血红蛋白的亲和力。

3. 发明申请

WO1992020369A1 USE OF HEMOGLOBIN IN A METHOD FOR THE TREATMENT OF TUMORS WITH CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：在用化学治疗剂治疗肿瘤的方法中使用HEMOGLOBIN
公开(公告)号：WO1992020369A1
公开(公告)日：1992-11-26
申请号：PCT/US1992004068
申请日：1992-05-14
申请人： DANA FARBER CANCER INSTITUTE , BIOPURE CORPORATION
发明人： DANA FARBER CANCER INSTITUTE , BIOPURE CORPORATION , TEICHER, Beverly, A. , RAUSCH, Carl, W. , HOPKINS, Robert, E., II
IPC分类号： A61K37/14
CPC分类号： A61K38/42 , Y10S514/908 , Y10S530/829 , A61K31/195 , A61K31/675 , A61K31/505 , A61K33/24 , A61K31/17 , A61K2300/00
摘要： A method is disclosed treating a tumor in a host by administering an ultrapurified polymerized hemoglobin solution to the host and also administering a chemotherapeutic agent to the host. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.
摘要翻译：公开了一种通过向主体施用超纯化聚合血红蛋白溶液并且向主体施用化学治疗剂来治疗宿主中的肿瘤的方法。在特别优选的实施方案中，血红蛋白是牛血红蛋白。

4. 发明申请

WO1986004240A1 PLASMA SUBSTITUTE 审中-公开
标题翻译：等离子体替代品
公开(公告)号：WO1986004240A1
公开(公告)日：1986-07-31
申请号：PCT/EP1985000589
申请日：1985-11-04
申请人： BATTELLE - INSTITUT e.V. , GUDJONS, Jürgen , WIESERT, Peter , REINER, Roland
发明人： BATTELLE - INSTITUT e.V.
IPC分类号： A61K37/14
CPC分类号： C07K14/805 , A61K38/42
摘要： A plasma substitute is comprised of a water-soluble polymer which is biocompatible with phosphate, sulphate and/or sulphonate groups. These products are obtained by coupling the polymer with compounds containing phosphate, sulphate and sulphonate groups, which compounds are capable of fixing the hemoglobine by adsorption. Preferably, dextrane is used as polymer constituent and inositolhexaphosphate is used as hemoglobine-related compound.

5. 发明申请

WO1993016721A1 INHIBITION OF NITRIC OXIDE-MEDIATED HYPOTENSION AND SEPTIC SHOCK WITH IRON-CONTAINING HEMOPROTEIN 审中-公开
标题翻译：氮氧化物介导的羟基磷灰石抑制氧化还原和分离性休克
公开(公告)号：WO1993016721A1
公开(公告)日：1993-09-02
申请号：PCT/US1993001288
申请日：1993-02-16
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , DUKE UNIVERSITY , APEX BIOSCIENCE, INC.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , DUKE UNIVERSITY , APEX BIOSCIENCE, INC. , KILBOURN, Robert, G. , DE ANGELO, Joseph , BONAVENTURA, Joseph
IPC分类号： A61K37/14
CPC分类号： A61K38/42 , Y02A50/411
摘要： The invention is directed to a method for the prophylaxis or treatment of an animal for deleterious physiological effects such as systemic hypotension caused by nitric oxide production induced by a biological response modifier. Examples of such biological response modifiers include but are not limited to a cytokine and an endotoxin. The invention is also directed to a method for the treatment of septic shock.

6. 发明申请

WO1992020368A1 USE OF POLYMERIZED HEMOGLOBIN TO INCREASE THE ANTITUMOR EFFECT OF THE IONIZING RADIATION 审中-公开
标题翻译：使用聚合的HEMOGLOBIN增加放射性辐射的抗肿瘤效应
公开(公告)号：WO1992020368A1
公开(公告)日：1992-11-26
申请号：PCT/US1992004067
申请日：1992-05-14
申请人： DANA FARBER CANCER INSTITUTE , BIOPURE CORPORATION
发明人： DANA FARBER CANCER INSTITUTE , BIOPURE CORPORATION , TEICHER, Beverly, A. , RAUSCH, Carl, W. , HOPKINS, Robert, E., II.
IPC分类号： A61K37/14
CPC分类号： A61K38/42 , A61K2121/00
摘要： A method is disclosed treating a tumor in a host by administering an ultrapurified polymerized hemoglobin solution to the host and thereafter administering ionizing radiation, such as x-ray, to the tumor. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.

7. 发明申请

WO1992008477A1 THERAPEUTIC AGENT FOR CORNEAL LESION 审中-公开
标题翻译：角膜溃疡治疗药物
公开(公告)号：WO1992008477A1
公开(公告)日：1992-05-29
申请号：PCT/JP1991001539
申请日：1991-11-08
申请人： SANTEN PHARMACEUTICAL CO., LTD. , BIO SERAE LABORATOIRES S.A. , MITA, Shiro , HIKIDA, Mitsushi , DEGRE, Michel, François
发明人： SANTEN PHARMACEUTICAL CO., LTD. , BIO SERAE LABORATOIRES S.A.
IPC分类号： A61K37/14
CPC分类号： A61K38/44 , A61K9/0048 , A61K38/40 , Y10S514/912 , Y10S514/915 , Y10S530/832 , A61K2300/00
摘要： A therapeutic agent for corneal lesion, containing lactoferrin and/or lactoperoxidase as the active ingredient. Lactoferrin and lactoperoxidase are proteins contained in the milk and tear of man, bovine, etc., and having an antibacterial activity and a pharmacological activity such as promotion of the growth of lymphocites. However they have been scarcely applied to the ophthalmological field. The invention is based on the finding that they have a new pharmacological activity applicable to this field and are useful as a therapeutic agent for corneal lesion, because they have an excellent activity of promoting the growth of corneal parenchymal cells.

8. 发明申请

WO1989012456A1 METHOD OF PURIFYING CROSS-LINKED HEMOGLOBIN 审中-公开
标题翻译：净化交联HEMOGLOBIN的方法
公开(公告)号：WO1989012456A1
公开(公告)日：1989-12-28
申请号：PCT/US1989001489
申请日：1989-04-10
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , ESTEP, Timothy, N. , WALDER, Joseph, A. , HAI, Ton-That
IPC分类号： A61K37/14
CPC分类号： C07K14/805 , A61K38/00
摘要： A method of purifying cross-linked hemoglobin which is mixed with non-cross-linked hemoglobin, which comprises heating the hemoglobin mixture at a temperature of about 60 degrees to 85 degrees C for a time sufficient to cause the precipitation of a substantial amount of the non-cross-linked hemoglobin present. Thereafter, one separates the precipitate thus formed from the cross-linked hemoglobin.
摘要翻译：一种纯化与非交联血红蛋白混合的交联血红蛋白的方法，该方法包括在约60摄氏度至85摄氏度的温度下加热所述血红蛋白混合物足够的时间，以使沉淀出大量的非交联血红蛋白存在。然后，将由此形成的沉淀物与交联血红蛋白分离。

9. 发明申请

WO1995003820A1 TRANSGENIC, CROSS-LINKED HEMOGLOBIN 审中-公开
标题翻译：转基因，交联HEMOGLOBIN
公开(公告)号：WO1995003820A1
公开(公告)日：1995-02-09
申请号：PCT/US1994008433
申请日：1994-07-26
申请人： THE UAB RESEARCH FOUNDATION
发明人： THE UAB RESEARCH FOUNDATION , TOWNES, Tim, M. , McCUNE, Steven, L.
IPC分类号： A61K37/14
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A61K38/00 , C07K14/805
摘要： Transgenic, recombinantly cross-linked polymeric human hemoglobins suitable as cell-free blood substitutes have been produced. A plurality of DNA constructs have been designed for efficient expression of modified human hemoglobins in the erythrocytes of the non-human transgenic animals. Substantially pure, non-immunogenic, artificial human hemoglobins are then easily obtained from the erythroid cells of the transgenic animals.
摘要翻译：已经生产了适合作为无细胞血液代用品的转基因重组交联聚合人血红蛋白。已经设计了多个DNA构建体用于在非人转基因动物的红细胞中有效表达修饰的人血红蛋白。然后可以从转基因动物的红细胞容易地获得基本上纯的，非免疫原性的人造血红蛋白。

10. 发明申请

WO1993008831A1 EXPRESSION OF RECOMBINANT HEMOGLOBIN AND HEMOGLOBIN VARIANTS IN YEAST 审中-公开
标题翻译：重组人血红蛋白和HEMOGLOBIN变体在YEAST中的表达
公开(公告)号：WO1993008831A1
公开(公告)日：1993-05-13
申请号：PCT/US1991008108
申请日：1991-10-30
申请人： STROHTECH, INC.
发明人： STROHTECH, INC. , DE ANGELO, Joseph , MOTWANI, Nalini, M. , BAJWA, Wajeeh
IPC分类号： A61K37/14
CPC分类号： C07K14/805 , A61K38/00 , Y02A50/473
摘要： The invention is directed to certain substantially pure hemoglobins comprising certain globin chains. The globin chain may be an alpha-like globin chain or a beta-like globin chain, or variants thereof. The invention is further directed to an expression vector which specifically comprises DNA sequences encoding a certain globin chain or heme-binding fragment thereof operably linked to a yeast promoter. The invention is also directed to methods for producing certain hemoglobins in yeast. The substantially pure hemoglobins of the present invention and the hemoglobins produced by methods of the present invention may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or as in a plasma expander.
摘要翻译：本发明涉及包含某些珠蛋白链的某些基本上纯的血红蛋白。球蛋白链可以是α样球蛋白链或β样球蛋白链，或其变体。本发明进一步涉及表达载体，其特异性地包含编码与酵母启动子连接的某种珠蛋白链或血红素结合片段的DNA序列。本发明还涉及在酵母中产生某些血红蛋白的方法。本发明的基本上纯的血红蛋白和通过本发明的方法产生的血红蛋白可以用于需要生理性氧载体的应用中，例如在血液替代溶液中，或在等离子体扩张器中。

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