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1. 发明申请

WO2019108903A1 METHODS OF TREATING SKIN LESIONS 审中-公开
公开(公告)号：WO2019108903A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/063261
申请日：2018-11-30
申请人： SCIODERM, INC.
发明人： NARDI, Ronald V. , REHA, Allen , BARTH, Jay
IPC分类号： A61K47/06 , A61K8/06 , A61K19/00
摘要： The present disclosure provides methods of treating skin lesions, e.g., of Epidermolysis bullosa (EB), in a subject in need thereof. In some embodiments, the methods comprise topically administering, at least once daily, to a skin area affected by the lesions of EB: a pharmaceutical composition comprising or consisting essentially of an emollient, an emulsifier, a pH modifier, a viscosity agent, a solubilizing agent, a preservative, a chelating agent, and an antioxidant. In some embodiments, the composition comprises less than 0.5% allantoin or 0% allantoin.

2. 发明申请

WO2019030240A1 ANTIBODIES BINDING TO A LINEAR HUMAN CS1 EPITOPE 审中-公开
公开(公告)号：WO2019030240A1
公开(公告)日：2019-02-14
申请号：PCT/EP2018/071429
申请日：2018-08-07
申请人： NBE-THERAPEUTICS AG , THE SCRIPPS RESEARCH INSTITUTE
发明人： HELLMANN, Ina , BEERLI, Roger , GRAWUNDER, Ulf , RADER, Christoph , HAIYONG, Peng
IPC分类号： A61K19/00
摘要： An antibody or antigen-binding fragment thereof, or a chimeric antigen receptor (CAR), which competes for binding to a linear human CS1 epitope comprising an amino acid sequence according to SEQ ID NO. 1 with an antibody having a heavy chain/light chain amino acid sequence pair according to any one selected from the following pairs SEQ ID NO. 3 / SEQ ID NO. 4; SEQ ID NO. 5 / SEQ ID NO. 6; SEQ ID NO. 7 / SEQ ID NO. 8; SEQ ID NO. 9 / SEQ ID NO. 10; SEQ ID NO. 11/ SEQ ID NO. 12; SEQ ID NO. 13/ SEQ ID NO. 14, and/or SEQ ID NO. 15 / SEQ ID NO. 16.

3. 发明申请

WO2021030374A1 MODIFIED INTERLEUKIN 2 (IL-2) POLYPEPTIDES, CONJUGATES AND USES THEREOF 审中-公开
公开(公告)号：WO2021030374A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/045810
申请日：2020-08-11
申请人： CYTIMM THERAPEUTICS, INC.
发明人： XU, Xiao , HUANG, Haining , FENG, Yu , MOGNOL, Giuliana , JIN, Can , GUIMET, Diana
IPC分类号： C07K14/55 , A61K38/00 , A61K19/00
摘要： This disclosure relates to modified interleukin 2 (IL-2) polypeptides, polynucleotides, e.g. , DNA, RNA or viral vector, that encode the modified IL-2 polypeptides and are configured to express said modified IL-2 polypeptides in vitro and/or in vivo , conjugates comprising the modified IL-2 polypeptides, and uses thereof.

4. 发明申请

WO00025831A1 A NEW COMPOSITION AND METHOD FOR INCREASING PRODUCTION YIELD OF AGRICULTURALLY USEFUL SPECIES 审中-公开
标题翻译：一种增加农业生产有效物种的新组合物和方法
公开(公告)号：WO00025831A1
公开(公告)日：2000-05-11
申请号：PCT/IL1999/000585
申请日：1999-11-03
IPC分类号： A61K39/00 , A61K47/48 , C07K19/00 , A61K19/00 , A61K38/22 , C07K4/12
CPC分类号： C07K19/00 , A61K39/0005 , A61K47/643 , A61K2039/6081
摘要： An economically effective method and composition thereof, for enhancing the production yield of agriculturally useful animals, in particular mammals such as sheep and poultry such as chickens, through the administration of a novel composition for fertility enhancement which contains substantially low concentrations of an immunogen, which is a conjugated inhibin or a fragment thereof. These concentrations are preferably in the range of from about 5 to about 500 micrograms immunogen per ml of composition, and more preferably in the range of from about 20 to about 300 micrograms immunogen per ml of composition. The fertility-enhancing is useful for mammals, in particular sheep, and for poultry animals, in particular chickens, and is effective under commercial farm conditions. The composition features inhibin or a fragment thereof, linked to a carrier protein emulsified with an adjuvant. Preferably, the immunogen includes the N-terminal sequence (amino acids 1-29) of the alpha sub-unit of bovine inhibin conjugated to keyhole limpet hemocyanin (KLH) at a ratio of 1:40 peptide/KLH.
摘要翻译：一种经济上有效的方法和组合物，用于通过施用含有基本上低浓度的免疫原的生育力增强的新组合物来提高农业上有用的动物，特别是哺乳动物如绵羊和家禽如鸡的产量，其中是缀合的抑制素或其片段。这些浓度优选在每ml组合物约5至约500微克免疫原的范围内，更优选在每毫升组合物约20至约300微克免疫原的范围内。生殖力增强对哺乳动物，特别是羊，以及禽类动物，特别是鸡有用，并且在商业农场条件下是有效的。该组合物具有与用佐剂乳化的载体蛋白连接的抑制素或其片段。优选地，免疫原包括以1:40肽/ KLH的比例缀合至匙孔血蓝蛋白（KLH）的牛抑制素的α亚单元的N-末端序列（氨基酸1-29）。

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