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    • 9. 发明申请
    • PEROXIDASE-ACTIVATING ORAL COMPOSITIONS
    • 过氧化物酶活性口服组合物
    • WO1997007777A1
    • 1997-03-06
    • PCT/US1996013240
    • 1996-08-15
    • MONTGOMERY, Robert, Eric
    • A61K07/20
    • A61Q11/00A61K8/11A61K8/20A61K8/22A61K8/41A61K9/0058A61K2800/412
    • An oral care composition and method of activating peroxidase in the oral cavity of an animal is provided. The composition includes a non-enzymatic water-soluble hydrogen peroxide precursor. This precursor is capable of releasing hydrogen peroxide upon contact with water to activate the peroxidase system. The composition further contains a pH-adjusting agent to produce a selected pH that facilitates the rapid release of hydrogen peroxide from the precusor which then is available to activate the peroxidase system in the oral cavity. The method involves the administration of a mixture of a non-enzymatic water-soluble hydrogen peroxide precursor and pH adjusting agent. A process for manufacturing an oral care product is also provided that utilizes an alkali metal percarbonate as hydrogen peroxide precursor.
    • 提供了一种在动物口腔中活化过氧化物酶的口腔护理组合物和方法。 该组合物包括非酶水溶性过氧化氢前体。 该前体能够在与水接触时释放过氧化氢以活化过氧化物酶体系。 所述组合物还含有pH调节剂以产生选择的pH,其有利于过氧化氢从预处理物中的快速释放,所述过氧化氢然后可用于活化口腔中的过氧化物酶体系。 该方法包括施用非酶水溶性过氧化氢前体和pH调节剂的混合物。 还提供了一种利用碱金属过碳酸盐作为过氧化氢前体的口腔护理产品的制造方法。