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    • 7. 发明申请
    • COATED SENNA EXTRACT GRANULES
    • 涂层SENNA提取物颗粒
    • WO2011014976A2
    • 2011-02-10
    • PCT/CL2010000029
    • 2010-08-05
    • GARDEN HOUSE FARMACEUTICA S A LAB
    • PERAINO HORACIO JORGE
    • A23L21/10
    • A61K36/482
    • Coated senna extract granules are described, which comprise senna extract with 20% sennosides, Eudragit® L-100 and Eudragit® L30 D-55. The granulation process comprises processing the senna extract with Eudragit® L-100 solution in isopropyl alcohol, this solution being prepared twice, in equal quantities each time, and each solution is divided into 2 equal parts. The senna extract granulate is obtained by mixing the extract with one of said solutions, kneading and drying the granules. The resulting dry granules are mixed, again, with another of the Eudragit® L-100 solutions, kneaded and dried. This operation is repeated until all the solutions are used up. The resulting final granules are coated with a solution of Eudragit® L30 D-55 and polyethylene glycol and a solution of talc in purified water. Furthermore, the preparation of a jelly formulation that comprises the coated granules is described.
    • 描述了涂覆的番泻奈萃取物颗粒,其包含具有20%sennosides,Eudragit L-100和Eudragit L30 D-55的番泻叶提取物。 造粒方法包括用异丙醇中的E-L-100溶液处理番泻叶提取物,该溶液每次等量制备两次,每个溶液分成2等份。 番泻奈提取物颗粒通过将提取物与所述溶液之一混合,捏合和干燥颗粒而获得。 将所得干颗粒再次与另一种L-100溶液混合并捏合并干燥。 重复此操作,直到所有解决方案都用尽。 所得到的最终颗粒用Eudragit L30D-55和聚乙二醇的溶液和滑石粉在纯净水中的溶液涂覆。 此外,描述了包含包衣颗粒的胶冻制剂的制备。