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1. 发明申请

WO2018209223A1 BIOCHEMICAL MOTIF IN CDR3 OF ANTIBODY SEQUENCES DIAGNOSIS AND PATIENTS WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS 审中-公开
公开(公告)号：WO2018209223A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/032304
申请日：2018-05-11
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： OSTMEYER, Jared , COWELL, Lindsay , CHRISTLEY, Scott , ROUNDS, William , TOBY, Inmary , MONSON, Nancy , GREENBERG, Benjamin
IPC分类号： C07K9/00 , C07K16/00 , C12Q1/68 , C12Q1/06 , G01N33/68
CPC分类号： C07K14/70503 , C07K16/2803 , C07K2317/565 , C12Q1/06 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , G01N33/563 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/68 , G01N33/6896 , G01N2800/285 , G01N2800/50
摘要： The present disclosure relates to the identification and application of adaptive immune receptor sequences that indicate an elevated risk of developing an adaptive immune receptor-related disease, such as an autoimmune disease ( e.g ., multiple sclerosis). The biomarkers and methods can further aid in the prophylaxis and treatment of such diseases.

2. 发明申请

WO1984004169A1 REMOVAL OF SELF-BINDING AND STAPH A CROSS-REACTIVITY OF ANTI-STREP ANTIBODY 审中-公开
标题翻译：去除抗结核抗体和抗结核抗体的交叉反应
公开(公告)号：WO1984004169A1
公开(公告)日：1984-10-25
申请号：PCT/US1983001877
申请日：1983-11-28
申请人： QUIDEL
发明人： QUIDEL , KATZ, David, H. , CHANG, Shung-Ho
IPC分类号： G01N33/54
CPC分类号： G01N33/531 , G01N33/563 , G01N33/56944 , G01N33/6857
摘要： An improved diagnostic method and reagent for the assay of Streptococcus Group A, and other antigen containing organisms, in which the high background resulting from cross-reaction of Anti-Streptococcal Group A or the reaction with Staphylococcus is eliminated.
摘要翻译：用于测定链球菌A组和其他含抗原的生物体的改进的诊断方法和试剂，其中消除了抗链球菌A组交叉反应或与葡萄球菌反应产生的高背景。

3. 发明申请

WO0248388A3 METHOD OF INHIBITING INFECTION BY HCV, OTHER FLAVIVIRIDAE VIRUSES, AND ANY OTHER VIRUS THAT COMPLEXES TO LOW DENSITY LIPOPROTEIN OR TO VERY LOW DENSITY LIPOPROTEIN IN BLOOD PREVENTING VIRAL ENTRY INTO A CELL 审中-公开
标题翻译：抑制HCV感染，其他FLAVIVIRIDAV病毒的方法以及与低密度脂蛋白复合物或非常低密度脂蛋白的任何其他病毒，防止预防病毒进入细胞
公开(公告)号：WO0248388A3
公开(公告)日：2005-09-15
申请号：PCT/US0150701
申请日：2001-10-24
申请人： AGNELLO VINCENT
发明人： AGNELLO VINCENT
IPC分类号： A61K45/00 , A61K38/00 , A61K38/17 , A61K38/46 , A61K39/395 , A61P31/12 , C07K14/705 , C07K16/28 , C12Q1/44 , G01N33/563 , G01N33/569 , G01N33/92 , A61K39/42 , C07K1/00 , C12N5/06 , C12Q1/70
CPC分类号： G01N33/92 , A61K38/177 , A61K38/465 , A61K2039/505 , C07K16/28 , C07K2317/54 , C07K2317/76 , C07K2317/77 , C12Q1/44 , G01N33/563 , G01N33/56983
摘要： A method of inhibiting infection by Flaviviridae viruses including HCV, GBC/HGV, and BVD in addition to VSV and any other virus capable of forming a complex with a lipoportein strategies: preventing formation of a complex should one form, altering the conforamtion of such a complex to prevent its interacton with the cell receptor, blocking the cell receptor for the complex using an antibody to the receptor, blocking binding of the lipoprotein complex to the cell receptor using soluble lipoprotein receptor or framents thereof, or downregulating the LDL receptor activity of the cells.
摘要翻译：一种抑制黄曲病毒病毒（包括HCV，GBC / HGV和BVD）感染的方法，除了VSV和能够与脂蛋白结合形成复合物的任何其他病毒策略之外：策略：防止复合物的形成，改变这种形式复合物以防止其与细胞受体的相互作用，使用受体的抗体阻断复合物的细胞受体，使用可溶性脂蛋白受体或其构架阻断脂蛋白复合物与细胞受体的结合，或下调LDL受体活性细胞。

4. 发明申请

WO2004094474A1 CLOSTRIDIUM DIFFICILE FOCUSSED ANTIBODIES 审中-公开
标题翻译：胶原蛋白聚糖抗体
公开(公告)号：WO2004094474A1
公开(公告)日：2004-11-04
申请号：PCT/GB2004/001619
申请日：2004-04-14
申请人： NEUTEC PHARMA PLC , BURNIE, James, Peter , MATTHEWS, Ruth, Christine
发明人： BURNIE, James, Peter , MATTHEWS, Ruth, Christine
IPC分类号： C07K16/12
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/565 , G01N33/563 , G01N33/56911 , G01N2333/33 , Y02A90/26
摘要： The present invention is concerned with antibodies specific for and which confer immunity against infection by C. difficile or against a vaccine, methods of identifying same, methods of manufacture of medicaments, and methods of treatment of patients using same. Also provided is a method for determining the efficacy of a vaccine, together with methods of vaccinating a patient, diagnostic test methods and diagnostic test kits.
摘要翻译：本发明涉及对艰难梭菌或针对疫苗的感染具有特异性且赋予其抗体的抗体，鉴定其的方法，药物的制备方法和使用其的患者的治疗方法。还提供了用于确定疫苗的功效的方法，以及疫苗接种患者的方法，诊断测试方法和诊断测试试剂盒。

5. 发明申请

WO0248388A9 METHOD OF INHIBITING INFECTION BY HCV, OTHER FLAVIVIRIDAE VIRUSES, AND ANY OTHER VIRUS THAT COMPLEXES TO LOW DENSITY LIPOPROTEIN OR TO VERY LOW DENSITY LIPOPROTEIN IN BLOOD PREVENTING VIRAL ENTRY INTO A CELL 审中-公开
标题翻译：抑制HCV感染，其他FLAVIVIRIDAV病毒的方法以及与低密度脂蛋白复合物或非常低密度脂蛋白的任何其他病毒，防止预防病毒进入细胞
公开(公告)号：WO0248388A9
公开(公告)日：2003-01-23
申请号：PCT/US0150701
申请日：2001-10-24
申请人： AGNELLO VINCENT
发明人： AGNELLO VINCENT
IPC分类号： A61K45/00 , A61K38/00 , A61K38/17 , A61K38/46 , A61K39/395 , A61P31/12 , C07K14/705 , C07K16/28 , C12Q1/44 , G01N33/563 , G01N33/569 , G01N33/92 , C12Q
CPC分类号： G01N33/92 , A61K38/177 , A61K38/465 , A61K2039/505 , C07K16/28 , C07K2317/54 , C07K2317/76 , C07K2317/77 , C12Q1/44 , G01N33/563 , G01N33/56983
摘要： A method of inhibiting infection by Flaviviridae viruses including HCV, GBC/HGV, and BVD in addition to VSV and any other virus capable of forming a complex with a lipoportein strategies: preventing formation of a complex should one form, altering the conforamtion of such a complex to prevent its interacton with the cell receptor, blocking the cell receptor for the complex using an antibody to the receptor, blocking binding of the lipoprotein complex to the cell receptor using soluble lipoprotein receptor or framents thereof, or downregulating the LDL receptor activity of the cells.
摘要翻译：一种抑制黄曲病毒病毒（包括HCV，GBC / HGV和BVD）感染的方法，除了VSV和能够与脂蛋白结合形成复合物的任何其他病毒策略之外：策略：防止复合物的形成，改变这种形式复合物以防止其与细胞受体的相互作用，使用受体的抗体阻断复合物的细胞受体，使用可溶性脂蛋白受体或其构架阻断脂蛋白复合物与细胞受体的结合，或下调LDL受体活性细胞。

6. 发明申请

WO99056126A3 IMMUNO-ADSORPTION MATRIX, A METHOD FOR THE PRODUCTION THEREOF, AND THE UTILIZATION THEREOF 审中-公开
标题翻译： IMMUNADSORPTIONSMATRIX，其制造方法相同，它们的用途
公开(公告)号：WO99056126A3
公开(公告)日：2000-01-13
申请号：PCT/DE1999/001228
申请日：1999-04-24
IPC分类号： A61K35/14 , C07K17/00 , G01N33/543 , G01N33/563 , C07K16/28 , G01N33/538
CPC分类号： B01J20/3202 , B01D15/3809 , B01J20/3274 , C07K1/107 , C07K1/22 , C07K16/4283 , C07K17/00 , C07K2317/23 , C07K2317/55 , G01N33/54353 , G01N33/563
摘要： The invention relates to a novel immuno-adsorption matrix, a method for the production thereof, and the utilization thereof for therapeutic, diagnostic, preparative, analytic and medicine technological purposes. By coupling to a supporting material, antigen binding structures are derivatized and/or activated while protecting the antigen binding site with functional groups which are suited for coupling to a chemically activated matrix or which represent an activated group themselves.
摘要翻译：本发明涉及一种新Immunadsorptionsmatrix，它们的制备方法以及它们用于治疗，诊断，制备和分析和医学目的的用途。使用耦合到载体材料的抗原结合结构保护抗原结合位点是适合于耦合到一化学活化的基质的官能团或本身构成的活化基团，衍生的和/或活化。

7. 发明申请

WO9956126A2 IMMUNO-ADSORPTION MATRIX, A METHOD FOR THE PRODUCTION THEREOF, AND THE UTILIZATION THEREOF 审中-公开
标题翻译： IMMUNADSORPTIONSMATRIX，其制造方法相同，它们的用途
公开(公告)号：WO9956126A2
公开(公告)日：1999-11-04
申请号：PCT/DE9901228
申请日：1999-04-24
申请人： AFFINA IMMUNTECHNIK GMBH , ROENSPECK WOLFGANG , GEBAUER FRANK
发明人： ROENSPECK WOLFGANG , GEBAUER FRANK
IPC分类号： A61K35/14 , C07K17/00 , G01N33/543 , G01N33/563 , G01N33/48
CPC分类号： B01J20/3202 , B01D15/3809 , B01J20/3274 , C07K1/107 , C07K1/22 , C07K16/4283 , C07K17/00 , C07K2317/23 , C07K2317/55 , G01N33/54353 , G01N33/563
摘要： The invention relates to a novel immuno-adsorption matrix, a method for the production thereof, and the utilization thereof for therapeutic, diagnostic, preparative, analytic and medicine technological purposes. By coupling to a supporting material, antigen binding structures are derivatized and/or activated while protecting the antigen binding site with functional groups which are suited for coupling to a chemically activated matrix or which represent an activated group themselves.
摘要翻译：本发明涉及一种新Immunadsorptionsmatrix，它们的制备方法以及它们用于治疗，诊断，制备和分析和医学目的的用途。使用耦合到载体材料的抗原结合结构保护抗原结合位点是适合于耦合到一化学活化的基质的官能团或本身构成的活化基团，衍生的和/或活化。

8. 发明申请

WO1983002285A1 BISPECIFIC ANTIBODY DETERMINANTS 审中-公开
标题翻译：双重抗体决定因子
公开(公告)号：WO1983002285A1
公开(公告)日：1983-07-07
申请号：PCT/US1982001766
申请日：1982-12-20
申请人： BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC.
发明人： BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC. , PAULUS, Henry, P.
IPC分类号： C12M01/34
CPC分类号： C08L35/04 , C07K16/468 , C08L55/02 , C08L65/00 , C12Q1/003 , G01N33/563 , Y10S435/805 , Y10S435/81 , Y10S435/817 , Y10S435/962 , Y10S435/964 , Y10S435/966 , Y10S435/969 , Y10S436/808 , C08L2666/02 , C08L2666/04
摘要： Echantillon homogène de déterminants d'anticorps bispécifiques identiques, chaque déterminant étant composé de deux demi-molécules LH liées par des liaisons bisulfures, chaque demi-molécule LH étant spécifique pour un déterminant antigénique différent et comprenant au moins la partie F(ab')2 d'un anticorps IgG monoclonique. Les déterminants d'anticorps bispécifiques sont utiles, par exemple, dans la formation d'assemblages multilamellaires et d'électrodes enzymatiques.

9. 发明申请

WO2016128348A1 METHOD OF ASSESSING RHEUMATOID ARTHRITIS BY MEASURING ANTI-CCP AND ANTI-PIK3CD 审中-公开
标题翻译：通过测量抗CCP和抗PIK3CD来评估炎症性角膜炎的方法
公开(公告)号：WO2016128348A1
公开(公告)日：2016-08-18
申请号：PCT/EP2016/052610
申请日：2016-02-08
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： ANDRES, Herbert , WEISER, Stefan , KARL, Johann , KUNERT, Ursula , GRUPP, Florian
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N33/563 , G01N33/58 , G01N2333/91215 , G01N2800/102
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis ("RA"). The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and anti-PIK3CD and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and anti-PIK3CD and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and anti-PIK3CD in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention. Further the invention relates to the use of a marker panel comprising anti-CCP and anti-PIK3CD to differentiate RA from other autoimmune diseases, preferably osteoarthritis (OA).
摘要翻译：本发明涉及帮助评估类风湿性关节炎（“RA”）的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。该方法例如通过分析生物化学标记来实施，包括在样品中测量抗CCP和抗PIK3CD的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和抗PIK3CD一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和抗PIK3CD的标记物在诊断类风湿性关节炎中的用途，并且教导了用于实施本发明方法的试剂盒。此外，本发明涉及包含抗CCP和抗PIK3CD的标记物块在其它自身免疫性疾病，优选骨关节炎（OA））中的区别。

10. 发明申请

WO2002048388A2 METHOD OF INHIBITING INFECTION BY HCV, OTHER FLAVIVIRIDAE VIRUSES, AND ANY OTHER VIRUS THAT COMPLEXES TO LOW DENSITY LIPOPROTEIN OR TO VERY LOW DENSITY LIPOPROTEIN IN BLOOD PREVENTING VIRAL ENTRY INTO A CELL 审中-公开
标题翻译：抑制HCV感染，其他FLAVIVIRIDAV病毒的方法以及与低密度脂蛋白复合物或非常低密度脂蛋白的任何其他病毒，防止预防病毒进入细胞
公开(公告)号：WO2002048388A2
公开(公告)日：2002-06-20
申请号：PCT/US2001/050701
申请日：2001-10-24
申请人： AGNELLO, Vincent
发明人： AGNELLO, Vincent
IPC分类号： C12Q
CPC分类号： G01N33/92 , A61K38/177 , A61K38/465 , A61K2039/505 , C07K16/28 , C07K2317/54 , C07K2317/76 , C07K2317/77 , C12Q1/44 , G01N33/563 , G01N33/56983
摘要： A method of inhibiting infection by Flaviviridae viruses including HCV, GBC/HGV, and BVD in addition to VSV and any other virus capable of forming a complex with a lipoportein strategies: preventing formation of a complex should one form, altering the conforamtion of such a complex to prevent its interacton with the cell receptor, blocking the cell receptor for the complex using an antibody to the receptor, blocking binding of the lipoprotein complex to the cell receptor using soluble lipoprotein receptor or framents thereof, or downregulating the LDL receptor activity of the cells.
摘要翻译：一种抑制黄曲病毒病毒（包括HCV，GBC / HGV和BVD）感染的方法，除了VSV和能够与脂蛋白结合形成复合物的任何其他病毒策略之外：策略：防止复合物的形成，改变这种形式复合物以防止其与细胞受体的相互作用，使用受体的抗体阻断复合物的细胞受体，使用可溶性脂蛋白受体或其构架阻断脂蛋白复合物与细胞受体的结合，或下调LDL受体活性细胞。

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