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1. 发明申请

WO2009060440A1 ANTI-MEASLES CANCER IMMUNOTHERAPY 审中-公开
标题翻译：抗肿瘤癌免疫治疗
公开(公告)号：WO2009060440A1
公开(公告)日：2009-05-14
申请号：PCT/IL2008/001453
申请日：2008-11-05
申请人： MOR RESEARCH APPLICATIONS LTD. , ARIAD, Shmuel , GOPAS, Jacob , BENHARROCH, Daniel , LAZAREV, Irina
发明人： ARIAD, Shmuel , GOPAS, Jacob , BENHARROCH, Daniel , LAZAREV, Irina
IPC分类号： A61K39/165 , G01N33/574
CPC分类号： G01N33/57423 , A61K39/165 , A61K45/06 , A61K2039/525 , A61K2039/53 , A61K2039/54 , A61K2039/57 , A61K2039/585 , A61N5/10 , C07K14/005 , C12N7/00 , C12N2760/18422 , C12N2760/18432 , C12N2760/18434 , G01N1/30 , G01N33/57415 , G01N2333/12 , G01N2800/52
摘要： The present invention provides methods for treating specific populations of cancer patients by immunotherapy. The methods comprise administering an immunogenic composition eliciting an immune response to measles virus to patients having measles virus-immunoreactive cancer cells.
摘要翻译：本发明提供了通过免疫治疗来治疗癌症患者的特定群体的方法。所述方法包括向具有麻疹病毒免疫反应性癌细胞的患者施用引发针对麻疹病毒的免疫应答的免疫原性组合物。

2. 发明申请

WO2016035099A1 A FLOW THROUGH DEVICE FOR DETECTION OF MULTIPLE BIOANALYTES AND A PROCESS THEREOF 审中-公开
标题翻译：用于检测多生物素的流动装置及其过程
公开(公告)号：WO2016035099A1
公开(公告)日：2016-03-10
申请号：PCT/IN2015/000347
申请日：2015-09-07
申请人： MERIL DIAGNOSTICS PRIVATE LIMITED
发明人： MINOCHA, Pramod Kumar , VYAS, Rajnikant Gandalal , PARAB, Shailesh Yashwant , LAD, Nilay Mohanlal
IPC分类号： G01N33/558 , G01N33/569
CPC分类号： G01N33/558 , G01N33/569 , G01N33/56983 , G01N2333/02 , G01N2333/035 , G01N2333/04 , G01N2333/045 , G01N2333/075 , G01N2333/12 , G01N2333/135 , G01N2333/16 , G01N2333/186 , G01N2333/20 , G01N2333/285
摘要： The present invention discloses a flow through device for detection and differentiation of multiple bioanalytes from a single sample and a process thereof. The device is a visual, rapid, sensitive and reliable immunoassay analyzer for the differential detection of multiple bioanalytes in biological fluids like human blood, serum or plasma by immobilizing the respective disease specific bio-molecules i.e. antigen, antibody, peptides, synthetic peptides or recombinant proteins derived from disease causing microorganisms on the immunofilteration reaction membrane.
摘要翻译：本发明公开了一种用于从单个样品中检测和分化多种生物分析物的流通装置及其方法。该装置是一种视觉，快速，灵敏和可靠的免疫测定分析仪，用于通过将各种疾病特异性生物分子（即抗原，抗体，肽，合成肽或重组体）固定化来差异检测生物流体如人血液，血清或血浆中的多种生物分析物衍生自免疫反应膜上引起微生物的疾病的蛋白质。

3. 发明申请

WO2012098465A1 PVRL4 (NECTIN 4) IS A RECEPTOR FOR MEASLES VIRUS 审中-公开
标题翻译： PVRL4（NECTIN 4）是测量病毒的受体
公开(公告)号：WO2012098465A1
公开(公告)日：2012-07-26
申请号：PCT/IB2012/000183
申请日：2012-01-17
申请人： DALHOUSIE UNIVERSITY , RICHARDSON, Christopher, D.
发明人： RICHARDSON, Christopher, D.
IPC分类号： A61K35/76 , A61K31/713 , A61K39/155 , A61K39/395 , A61P37/04 , C12N5/09 , C12Q1/68 , C12Q1/70 , G01N33/48 , G01N33/53 , G06F19/20 , C12N7/00
CPC分类号： A61K39/42 , A61K31/713 , A61K35/76 , A61K35/768 , C12N2760/18432 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/574 , G01N2333/12 , G01N2333/70503 , A61K2300/00
摘要： PVRL4 is a tumor marker that is highly expressed on the surfaces of many carcinomas. Disclosed herein are compositions and methods that provide impetus for using measles virus as an oncolytic agent against PVRL4+ carcinomas and use of PVRL4-binding agents to interfere with viral infection.
摘要翻译： PVRL4是一种在许多癌细胞表面高表达的肿瘤标记物。本文公开的是提供使用麻疹病毒作为抗PVRL4 +癌症的溶瘤药物以及使用PVRL4结合剂来干扰病毒感染的动力的组合物和方法。

4. 发明申请

WO2005090390A1 NOVEL ASSAY FOR THE SEPARATION AND QUANTIFICATION OF HEMAGGLUTININ ANTIGENS 审中-公开
标题翻译：用于分离和定量HEMAGGLUTININ抗原的新方法
公开(公告)号：WO2005090390A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/050957
申请日：2005-03-03
申请人： CRUCELL HOLLAND B.V. , LAGERWERF, Fija , KAPTEYN, Johan
发明人： LAGERWERF, Fija , KAPTEYN, Johan
IPC分类号： C07K14/01
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2760/16122 , C12N2760/16151 , C12N2760/16222 , C12N2760/16251 , C12N2760/16322 , C12N2760/16351 , G01N33/68 , G01N33/6842 , G01N2333/11 , G01N2333/12
摘要： The present invention relates to novel methods for separating hemagglutinin (HA) antigens, comprising the steps of applying a reduced and derivatized antigen preparation comprising solubilized HA antigens and a detergent in a pH controlled solution, on a Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) column; and eluting the HA antigens from the column with an ion pairing agent in an organic mobile phase. The invention further relates to quantifying methods using the methods for separating the antigens with the further step of measuring the peak area of the eluted antigen in a chromatogram resulting from the elution step.
摘要翻译：本发明涉及用于分离血凝素（HA）抗原的新方法，包括以下步骤：将反应型高效液相色谱法（pH值控制溶液中的溶解的HA抗原和洗涤剂）的还原和衍生抗原制剂 RP-HPLC）柱; 并用离子对试剂在有机流动相中从柱中洗脱HA抗原。本发明还涉及使用分离抗原的方法的定量方法，其中进一步的步骤是在洗脱步骤得到的色谱图中测定洗脱抗原的峰面积。

5. 发明申请

WO1997038011A1 NON-DENDRITIC BACKBONE PEPTIDE CARRIER 审中-公开
标题翻译：非脱落肽胶囊载体
公开(公告)号：WO1997038011A1
公开(公告)日：1997-10-16
申请号：PCT/DK1997000146
申请日：1997-04-03
申请人： PEPRESEARCH A/S , HEEGAARD, Peter, Mikael, Helweg , JAKOBSEN, Palle, Hoy
发明人： PEPRESEARCH A/S
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K39/385 , A61K2039/6031 , A61K2039/627 , G01N33/56977 , G01N2333/12 , G01N2333/35 , G01N2333/445 , G01N2333/545 , G01N2333/57 , G01N2333/96486 , Y02A50/412
摘要： The present invention relates to a non-dendritic peptide designed for use as a carrier of an immunogenic substance and/or an immune mediator, a construct of said carrier carrying an immunogenic substance and/or an immune mediator, a process for the preparation of immunogens with high and predictable immunogenicity which comprise said non-dendritic peptide carrier, use of such immunogens for the production of vaccines and vaccines comprising an immunogenic substance and/or an immune mediator on the peptide carrier. The invention also relates to diagnostic or therapeutic embodiments using the non-dendritic peptide carrier, to diagnostic or therapeutic compositions and to methods for the use thereof in diagnosis of diseases and pregnancy as well as in therapy. The non-dendritic peptide carrier according to the invention comprises 10-50 amino acids capable of forming a secondary structure in a benign buffer after liberation from the solid phase.
摘要翻译：本发明涉及设计用作免疫原性物质和/或免疫介体的载体的非树突状肽，携带免疫原性物质的所述载体的构建体和/或免疫介体，制备免疫原的方法具有高和可预测的免疫原性，其包含所述非树突状肽载体，在肽载体上使用这种免疫原来生产疫苗和包含免疫原性物质和/或免疫介体的疫苗。本发明还涉及使用非树突状肽载体，诊断或治疗组合物的诊断或治疗实施方案以及用于诊断疾病和妊娠以及在治疗中的方法。根据本发明的非树枝状肽载体包含10-50个氨基酸，其能够在从固相释放出来之后在良性缓冲液中形成二级结构。

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