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    • 7. 发明申请
    • FAST RESPONSE NANOFIBER ARTICLES WITH TUNABLE WETTABILITY AND BULK PROPERTIES
    • 具有易挥发性和膨胀性的快速响应纳米纤维制品
    • WO2013032859A1
    • 2013-03-07
    • PCT/US2012/052070
    • 2012-08-23
    • UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.SANDIA NATIONAL LABORATORIES, NEW MEXICOSIGMUND, Wolfgang, M.MUTHIAH, PalanikkumaranBOYLE, Tim
    • SIGMUND, Wolfgang, M.MUTHIAH, PalanikkumaranBOYLE, Tim
    • D04H1/544D06M13/282D01F6/04D06M15/333
    • D04H1/728D01D5/0007D01F6/36D01F6/56D04H1/544Y10T442/615Y10T442/626
    • A fibrous properties-switching article comprises a mat consisting of fibers having a fiber diameter of 2 microns or less. The fibers comprise a polymer, copolymer, polymer blend, or polymer network, wherein the fibers have a diameter of 2 μιη or less. The surface and/or bulk property of the mat changes over a range of temperatures, wherein the polymer, copolymer, polymer blend, or polymer network undergoes a structural change over the range of temperatures. The fiber mat is formed by electrospinning. In an exemplary embodiment, a blend of polystyrene and poly((N-isopropyl acrylamide) (bl-PS/PNIPA) in dimethylformamide (DMF) is electrospun to form a mat consisting of fibers with a diameter less than 2 μηι that shows a transition from a superhydrophilic surface to a nearly superhydrophobic surface over a temperature range from 30 °C to 45 °C. A fiber mat formed by electrospinning a DMF solution comprising poly(N-isopropyl acrylamide-co- methacylicacid) (PNIPAMAA), comprises fibers having a diameter less than 2 μιτι and are cross linked after spinning. The crosslinked PNIPAMAA, (xl-PNIPAMAA) fiber mat displays a transition from a hydrophilic surface to a nearly hydrophobic surface over a temperature range from 30 °C to 45 °C.
    • 纤维性质切换制品包括由纤维直径为2微米或更小的纤维组成的垫。 纤维包括聚合物,共聚物,聚合物共混物或聚合物网络,其中纤维的直径为2μΩ 或更少。 垫的表面和/或体积特性在一定温度范围内变化,其中聚合物,共聚物,聚合物共混物或聚合物网络在温度范围内经历结构变化。 纤维垫通过静电纺丝形成。 在一个示例性实施方案中,将聚苯乙烯和聚((N-异丙基丙烯酰胺)(b1-PS / PNIPA))在二甲基甲酰胺(DMF)中的共混物静电纺丝以形成由直径小于2μΩ的纤维组成的垫, 通过静电纺丝包含聚(N-异丙基丙烯酰胺 - 共 - 甲酰甲酸)(PNIPAMAA)的DMF溶液形成的纤维垫,形成由纤维垫组成的纤维垫,其包含: 直径小于2μt·t的纤维,在纺丝后交联,交联的PNIPAMAA(xl-PNIPAMAA)纤维垫在30℃至30℃的温度范围内显示从亲水表面到接近疏水性表面的转变 45°C。
    • 8. 发明申请
    • HOLLOW FIBER MEMBRANE TYPE BLOOD PURIFIER
    • 空心纤维膜式血液净化器
    • WO2007018242A3
    • 2007-05-24
    • PCT/JP2006315763
    • 2006-08-09
    • ASAHI KASEI MEDICAL CO LTDKOMURA RYOKOIZUMI TOSHINORI
    • KOMURA RYOKOIZUMI TOSHINORI
    • A61M1/14A61M1/18B01D63/02B01D65/02B01D71/44B01D71/68D01F6/94
    • D01F6/94A61M1/16B01D65/02B01D65/022B01D67/0088B01D67/009B01D71/68B01D2321/00D01D5/24D01F6/56
    • A hollow fiber membrane type blood purifier packed with hollow fiber membranes comprising a polysulfone resin and polyvinylpyrrolidone. Even when sterilized by irradiation with a radiation, the hollow fiber membrane type blood purifier is less apt to suffer polyvinylpyrrolidone dissolution and can be inhibited from decreasing in blood compatibility. The purifier is of the type called semidry, and is lightweight and has excellent handleability. The hollow fiber membrane type blood purifier comprises a bundle of hollow fiber membranes comprising a polysulfone resin and polyvinylpyrrolidone, a container packed therewith, and a potting agent disposed between each bundle end and the container to hold the bundle and thereby form a hollow-fiber-membrane inside chamber and a hollow-fiber-membrane outside chamber. The purifier has fluid ports connected to the hollow-fiber-membrane inside chamber and a fluid port connected to the hollow-fiber-membrane outside chamber. The hollow fiber membrane type blood purifier is characterized in that the hollow fiber membranes have, adherent thereto, a radical trapping agent in an amount of 80-300% based on the dry weight of the hollow fiber membranes, have a water content of 40-100%, excluding 100%, and have been sterilized with a radiation.
    • 一种中空纤维膜型血液净化器,其中填充有包含聚砜树脂和聚乙烯吡咯烷酮的中空纤维膜。 即使通过放射线照射进行杀菌,中空纤维膜型血液净化器也不易受到聚乙烯吡咯烷酮的溶解,可以抑制血液相容性的降低。 净化器属于半干型,重量轻,操作性好。 中空纤维膜型血液净化器包括一束由聚砜树脂和聚乙烯吡咯烷酮组成的中空纤维膜,一个装在其中的容器,以及一个灌封剂,灌封剂位于每一个束端和容器之间以保持该束并由此形成中空纤维膜型血液净化器, 室内的膜和室外的中空纤维膜。 净化器具有连接到腔室内的中空纤维膜的流体端口和连接到腔室外的中空纤维膜的流体端口。 中空纤维膜型血液净化器的特征在于,中空纤维膜附着有基于中空纤维膜干重80-300%的自由基捕获剂,其含水量为40-90% 100%,不包括100%,并已通过辐射灭菌。