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1. 发明申请

WO2009035644A1 ATTENUATED MYCOPLASMA GALLISEPTICUM STRAINS 审中-公开
标题翻译：衰老的MYCOPLASMA GALLISEPTICUM菌株
公开(公告)号：WO2009035644A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/010630
申请日：2008-09-10
申请人： WYETH , KUMAR, Mahesh , KHAN, Muhammad, Ayub
发明人： KUMAR, Mahesh , KHAN, Muhammad, Ayub
IPC分类号： A61K39/02 , C12N1/36 , C12R1/35
CPC分类号： C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12R1/35
摘要： The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.
摘要翻译：本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。在某些实施方案中，相对于野生型M，减毒细菌可另外显示出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质的表达降低胆汁败霉菌还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的在鸡中

2. 发明申请

WO2004006851A2 MYCOPLASMA GALLISEPTICUM FORMULATION 审中-公开
标题翻译： MYCOPLASMA GALLISEPICUM配方
公开(公告)号：WO2004006851A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/022011
申请日：2003-07-10
申请人： THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , KLEVEN, Stanley, H. , FERGUSON, Naola
发明人： KLEVEN, Stanley, H. , FERGUSON, Naola
IPC分类号： A61K
CPC分类号： C12R1/35 , A61K39/0241 , A61K2039/541 , A61K2039/543 , A61K2039/544 , A61K2039/552
摘要： The present invention provides a protective formulation that prevents virulent Mycoplasma gallisepticum infection in birds of the order Galliformes. The formulation comprises a protective amount of live MG strain K5054 or derivatives thereof in a pharmaceutically acceptable carrier. A vaccine that prevents virulent Mycoplasma gallisepticum infection in birds of the order Galliformes is also presented. Methods for administering the formulation and vaccine are also presented.
摘要翻译：本发明提供一种保护性制剂，其可以防止鸡尾草杆菌中的毒性毒蕈碱性支原体感染。制剂包含保护量的活MG菌株K5054或其药学上可接受的载体中的衍生物。还提出了一种能够预防鸡尾草属鸡的毒性支原体感染疫苗。还提供了施用制剂和疫苗的方法。

3. 发明申请

WO2010132932A1 A TEMPERATURE SENSITIVE VACCINE STRAIN OF MYCOPLASMA HYOPNEUMONIAE AND USES THEREOF 审中-公开
标题翻译： MYCOPLASMA HYOPNEUMONIAE的温度敏感性疫苗菌株及其用途
公开(公告)号：WO2010132932A1
公开(公告)日：2010-11-25
申请号：PCT/AU2010/000590
申请日：2010-05-19
申请人： BIOPROPERTIES PTY LTD , THE UNIVERSITY OF MELBOURNE , YOUIL, Rima , ABS EL-OSTA, Youssef , BROWNING, Glenn , MARKHAM, Phillip
发明人： YOUIL, Rima , ABS EL-OSTA, Youssef , BROWNING, Glenn , MARKHAM, Phillip
IPC分类号： A61K39/02 , A61P31/04 , C12N1/20 , C12N1/36
CPC分类号： A61K39/0241 , A61K2039/522 , A61K2039/543 , A61K2039/552 , C12R1/35
摘要： The present invention relates to a Mycoplasma hyopneumoniae vaccine strain comprising a mutation in at least one of the genes listed or as deposited with the National Measurements Institute (Australia) under accession number NM04/41259, which strain is temperature sensitive and attenuated, a vaccine comprising such strains and methods and uses thereof.
摘要翻译：本发明涉及猪肺炎支原体疫苗菌株，其包含在国家测量研究所（澳大利亚）列出或保藏的至少一个基因中的突变，登录号NM04 / 41259，该菌株是温度敏感性和减毒性的疫苗，其包含这种菌株及其方法和用途。

4. 发明申请

WO2010085611A3 Mycoplasma gallisepticum formulation 审中-公开
标题翻译：基于米曲霉GALLISEPTICUM的组成
公开(公告)号：WO2010085611A3
公开(公告)日：2010-11-25
申请号：PCT/US2010021749
申请日：2010-01-22
申请人： UNIV GEORGIA , KLEVEN STANLEY H , FERGUSON NAOLA M
发明人： KLEVEN STANLEY H , FERGUSON NAOLA M
IPC分类号： C12N1/20 , A61K39/04 , C12R1/32
CPC分类号： A61K39/0241 , A61K39/12 , A61K2039/522 , A61K2039/552 , C12N2760/18134 , C12R1/35
摘要： The present invention provides a formulation that prevents virulent Mycoplasma galHsepticum infection in birds of the order GaIHf ormes. The formulation comprises live Mycoplasma galHsepticum strain K5831 or derivatives thereof in a pharmaceutically acceptable carrier. A vaccine that prevents virulent Mycoplasma galHsepticum infection in birds of the order Galliformes is also presented. Methods for administering the formulation and vaccine are also presented.
摘要翻译：本发明涉及一种用于预防鸡形目鸟类中毒力型鸡毒支原体感染的组合物。该组合物含有活的支原体（菌株K5831鸡毒支原体）或其衍生物在药学上可接受的赋形剂中。本发明还涉及在鸡形目鸟类中防止鸡毒支原体的病毒感染的疫苗，以及施用所述组合物和所述疫苗的方法。

5. 发明申请

WO2010085611A2 MYCOPLASMA GALLISEPTICUM FORMULATION 审中-公开
标题翻译：基于组成鸡毒支原体
公开(公告)号：WO2010085611A2
公开(公告)日：2010-07-29
申请号：PCT/US2010/021749
申请日：2010-01-22
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , KLEVEN, Stanley, H. , FERGUSON, Naola, M.
发明人： KLEVEN, Stanley, H. , FERGUSON, Naola, M.
IPC分类号： C12N1/20 , A61K39/04 , C12R1/32
CPC分类号： A61K39/0241 , A61K39/12 , A61K2039/522 , A61K2039/552 , C12N2760/18134 , C12R1/35
摘要： The present invention provides a formulation that prevents virulent Mycoplasma galHsepticum infection in birds of the order GaIHf ormes. The formulation comprises live Mycoplasma galHsepticum strain K5831 or derivatives thereof in a pharmaceutically acceptable carrier. A vaccine that prevents virulent Mycoplasma galHsepticum infection in birds of the order Galliformes is also presented. Methods for administering the formulation and vaccine are also presented.
摘要翻译：本发明涉及预防败血支原体感染病毒在鸡形目鸟的组合物。此组合物含有支原体（鸡毒支原体菌株K5831）在药学上可接受的赋形剂住或其衍生物。的所述组合物和所述疫苗本发明还涉及一种疫苗预防与败血支原体感染病毒在鸡形目鸟，以及给药的方法。

6. 发明申请

WO2004006851A3 MYCOPLASMA GALLISEPTICUM FORMULATION 审中-公开
标题翻译：扁桃体炎球菌配方
公开(公告)号：WO2004006851A3
公开(公告)日：2004-03-18
申请号：PCT/US0322011
申请日：2003-07-10
申请人： UNIV GEORGIA RES FOUND , KLEVEN STANLEY H , FERGUSON NAOLA
发明人： KLEVEN STANLEY H , FERGUSON NAOLA
IPC分类号： A61K39/00 , A61K20060101 , A61K39/02 , A61K39/38 , A61K39/385 , A61P11/00 , A61P31/00 , C12N1/21 , C12R1/35
CPC分类号： C12R1/35 , A61K39/0241 , A61K2039/541 , A61K2039/543 , A61K2039/544 , A61K2039/552
摘要： The present invention provides a protective formulation that prevents virulent Mycoplasma gallisepticum infection in birds of the order Galliformes. The formulation comprises a protective amount of live MG strain K5054 or derivatives thereof in a pharmaceutically acceptable carrier. A vaccine that prevents virulent Mycoplasma gallisepticum infection in birds of the order Galliformes is also presented. Methods for administering the formulation and vaccine are also presented.
摘要翻译：本发明提供了一种保护性配制剂，其在鸡形目鸟类中预防有毒的鸡毒支原体感染。该制剂包含保护量的活性MG菌株K5054或其衍生物在药学上可接受的载体中。还介绍了一种能够防止鸡形鸡毒支原体感染的疫苗。还提供了用于施用制剂和疫苗的方法。

7. 发明申请

WO0210343A3 TEMPERATURE-SENSITIVE LIVE VACCINE FOR MYCOPLASMA HYOPNEUMONIAE 审中-公开
标题翻译：用于MYCOPLASMA HYOPNEUMONIAE的温度敏感的活体疫苗
公开(公告)号：WO0210343A3
公开(公告)日：2002-10-10
申请号：PCT/US0123663
申请日：2001-07-27
申请人： UNIV MINNESOTA , PIJOAN CARLOS
发明人： PIJOAN CARLOS
IPC分类号： C12N1/20 , A61K39/00 , A61K39/02 , A61K39/12 , A61P11/00 , A61P31/04 , C12N20060101 , C12N1/36 , C12R1/35
CPC分类号： C12R1/35 , A61K39/0241 , A61K2039/522 , A61K2039/552
摘要： The present invention provides a live temperature-sensitive vaccine for Mycoplasma hyopneumoniae . The present invention also provides methods of vaccinating a swine against colonization or infection of Mycoplasma hypneumoniae .
摘要翻译：本发明提供了用于猪肺炎支原体的活的温度敏感的疫苗。本发明还提供了接种猪以抵抗肺炎支原体的定植或感染的方法。

8. 发明申请

WO1993011219A1 NOVEL ADHERENT AND INVASIVE MYCOPLASMA 审中-公开
标题翻译：新的独立和入侵MYCOPLASMA
公开(公告)号：WO1993011219A1
公开(公告)日：1993-06-10
申请号：PCT/US1992010163
申请日：1992-12-01
申请人： AMERICAN REGISTRY OF PATHOLOGY
发明人： AMERICAN REGISTRY OF PATHOLOGY , LO, Shyh-Ching , WANG, Richard, Yuan-Hu , HAYES, Michael, MacGregor
IPC分类号： C12N01/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0241 , C07K14/30 , C12N2740/16011 , C12R1/35 , G01N33/56933 , G01N33/56988 , Y10S435/87 , Y10S435/974 , Y10S435/975
摘要： The present invention relates to a novel mycoplasma isolated from the urine of patients with AIDS. The mycoplasma has unique morphological and pathobiological properties. The invention also relates to the antigens and antibodies of the novel mycoplasma, and methods of detection utilizing these antigens and antibodies. Antigenically and genetically, the mycoplasma is distinct from all other known mycoplasmas. The invention further relates to the DNA sequence of the novel mycoplasma and vaccines against the mycoplasma infection.
摘要翻译：本发明涉及从艾滋病患者的尿中分离的新型支原体。支原体具有独特的形态和病理特性。本发明还涉及新型支原体的抗原和抗体，以及利用这些抗原和抗体的检测方法。抗原和遗传上的支原体与所有其他已知的支原体不同。本发明还涉及新型支原体的DNA序列和针对支原体感染的疫苗。

9. 发明申请

WO2014009586A2 CEPAS MUTANTES DE MYCOPLASMA HYOPNEUMONIAE 审中-公开
标题翻译： MYCOPLASMA HYOPNEUMONIAE的突变菌株
公开(公告)号：WO2014009586A2
公开(公告)日：2014-01-16
申请号：PCT/ES2013/070492
申请日：2013-07-09
申请人： LABORATORIOS HIPRA, S.A.
发明人： GONZALEZ GONZALEZ, Luis , PIÑOL RIBAS, Jaume , MONTANE GIRALT, Jordi , CAMATS MALET, Maria , QUEROL MURILLO, Enrique , SITJA ARNAU, Marta
IPC分类号： C12N15/74
CPC分类号： A61K39/0241 , A61K2039/522 , A61K2039/552 , C12N1/20 , C12N15/00 , C12N15/63 , C12N15/64 , C12N15/74 , C12N2800/70 , C12N2820/55 , C12R1/35
摘要： La presente invención se refiere a cepas mutantes de Mycoplasma hyopneumoniae y a un procedimiento para prepararlas. También se refiere a vectores portadores que se emplean en dicho procedimiento, a composiciones vacunales y a kits de vacunación que las comprenden contra la neumonía enzoótica porcina y otras enfermedades porcinas. También se refiere al empleo de M. hyopneumoniae como huésped para la expresión de proteínas recombinantes y de otras secuencias de ADN de interés.
摘要翻译：本发明涉及猪肺炎支原体突变菌株及其制备方法。它还涉及用于所述方法的载体，疫苗组合物和疫苗试剂盒，所述疫苗试剂盒包含用于抗猪酸性肺炎和其它猪疾病的所述菌株。本发明还涉及猪肺炎支原体作为用于表达重组蛋白和感兴趣的其它DNA序列的宿主的用途。

10. 发明申请

WO2009058833A2 MYCOPLASMA BOVIS VACCINE AND METHODS OF USE THEREOF 审中-公开
标题翻译： MYCOPLASMA BOVIS VACCINE及其使用方法
公开(公告)号：WO2009058833A2
公开(公告)日：2009-05-07
申请号：PCT/US2008081545
申请日：2008-10-29
申请人： BOEHRINGER INGELHEIM VETMED , BECK MICHAEL , KNITTEL JEFFREY
发明人： BECK MICHAEL , KNITTEL JEFFREY
IPC分类号： C12N1/20 , A61K39/02 , C12N1/02
CPC分类号： C12N1/36 , A61K39/0241 , A61K2039/522 , A61K2039/54 , A61K2039/543 , A61K2039/552 , C12R1/35
摘要： The present invention relates to new attenuated M. bovis bacteria strains. Moreover, the present invention also provides immunogenic compositions comprising live bacteria of an of those attenuated M. bovis bacteria strain, their manufacture and use for the treatment and prophylaxis of M. bovis infections.
摘要翻译：本发明涉及新的减毒牛分枝杆菌菌株。此外，本发明还提供包含那些减毒的牛分枝杆菌细菌菌株的活细菌的免疫原性组合物，其制备和用于治疗和预防牛分枝杆菌感染的用途。

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