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1. 发明申请

WO2014053246A1 VACCINATION AGAINST JAPANESE ENCEPHALITIS, MEASLES, MUMPS AND RUBELLA 审中-公开
标题翻译：日本消费者，日本消费者，消费者和消费者
公开(公告)号：WO2014053246A1
公开(公告)日：2014-04-10
申请号：PCT/EP2013/002981
申请日：2013-10-03
申请人： SANOFI PASTEUR
发明人： FEROLDI, Emmanuel , BOUCKENOOGHE, Alain
IPC分类号： A61K39/295 , A61P31/14
CPC分类号： A61K39/0015 , A61K39/12 , A61K39/25 , A61K2039/5254 , A61K2039/5256 , A61K2039/55 , A61K2039/70 , C12N7/00 , C12N2710/16734 , C12N2760/18434 , C12N2760/18471 , C12N2760/18734 , C12N2760/18771 , C12N2770/24134 , C12N2770/24143 , C12N2770/24171 , C12N2770/36234 , C12N2770/36271 , Y02A50/388 , Y02A50/39
摘要： The invention relates to a method of vaccinating against Japanese encephalitis (JE), measles, mumps and rubella which comprises co-administering to a patient in need, MMR vaccine and a live attenuated or inactivated cell culture derived JE vaccine.
摘要翻译：本发明涉及针对日本脑炎（JE），麻疹，腮腺炎和风疹疫苗的方法，其包括向有需要的患者，MMR疫苗和活减毒或灭活的细胞培养物JE疫苗共同施用。

2. 发明申请

WO2013152352A8 LIVE, ATTENUATED RUBELLA VECTOR TO EXPRESS VACCINE ANTIGENS 审中-公开
标题翻译：活的，减毒的RUBELLA载体，以表达疫苗抗原
公开(公告)号：WO2013152352A8
公开(公告)日：2013-11-07
申请号：PCT/US2013035634
申请日：2013-04-08
申请人： US HEALTH
发明人： BERKOWER IRA , VIRNIK KONSTANTIN
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N15/86 , C12N2740/15034 , C12N2740/16034 , C12N2740/16134 , C12N2770/36221 , C12N2770/36234 , C12N2770/36243 , C12N2770/36271
摘要： Disclosed herein are isolated rubella viral vector constructs that include a rubella non structural protein open reading frame (ORF) without an in-frame deletion, a rubella structural protein ORF, and a heterologous antigenic insert. In one example, the heterologous antigenic insert is positioned within the rubella structural protein ORF. In some examples, the heterologous antigenic insert is positioned in the rubella structural protein ORF in between a gene encoding structural protein E2 and a gene encoding structural protein El. Exemplary antigenic inserts include HIV, SIV, RSV or hepatitis B surface antigens. In some examples, the HIV antigenic insert is a Gag antigenic insert, a gp41 antigenic insert or a gpl20 antigenic insert. Also disclosed are uses of the isolated rubella viral vector, such as to induce an immune response to a particular virus, such as HIV-1, testing sensitivity to neutralizing antibodies, or screening antiviral drugs (such as protease inhibitors).
摘要翻译：本文公开了分离的风疹病毒载体构建体，其包括没有框内缺失的风疹非结构蛋白开放阅读框（ORF），风疹结构蛋白ORF和异源抗原插入片段。在一个实例中，异源抗原插入物位于风疹结构蛋白ORF内。在一些实例中，异源抗原插入物位于编码结构蛋白E2的基因和编码结构蛋白E1的基因之间的风疹结构蛋白ORF中。示例性的抗原插入物包括HIV，SIV，RSV或乙型肝炎表面抗原。在一些实例中，HIV抗原插入物是Gag抗原插入物，gp41抗原插入物或gp120抗原插入物。还公开了分离的风疹病毒载体的用途，例如诱导针对特定病毒如HIV-1的免疫应答，检测对中和抗体的敏感性或筛选抗病毒药物（例如蛋白酶抑制剂）。

3. 发明申请

WO2013152352A1 LIVE, ATTENUATED RUBELLA VECTOR TO EXPRESS VACCINE ANTIGENS 审中-公开
标题翻译： LIVE，衰减的RUBELLA VECTOR TO EXPRESS VACCINE ANTIGENS
公开(公告)号：WO2013152352A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/035634
申请日：2013-04-08
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
发明人： BERKOWER, Ira , VIRNIK, Konstantin
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N15/86 , C12N2740/15034 , C12N2740/16034 , C12N2740/16134 , C12N2770/36221 , C12N2770/36234 , C12N2770/36243 , C12N2770/36271
摘要： Disclosed herein are isolated rubella viral vector constructs that include a rubella non structural protein open reading frame (ORF) without an in-frame deletion, a rubella structural protein ORF, and a heterologous antigenic insert. In one example, the heterologous antigenic insert is positioned within the rubella structural protein ORF. In some examples, the heterologous antigenic insert is positioned in the rubella structural protein ORF in between a gene encoding structural protein E2 and a gene encoding structural protein El. Exemplary antigenic inserts include HIV, SIV, RSV or hepatitis B surface antigens. In some examples, the HIV antigenic insert is a Gag antigenic insert, a gp41 antigenic insert or a gpl20 antigenic insert. Also disclosed are uses of the isolated rubella viral vector, such as to induce an immune response to a particular virus, such as HIV-1, testing sensitivity to neutralizing antibodies, or screening antiviral drugs (such as protease inhibitors).
摘要翻译：本文公开了分离的风疹病毒载体构建体，其包含没有帧内缺失的风疹非结构蛋白质开放阅读框（ORF），风疹结构蛋白ORF和异源抗原插入物。在一个实例中，异源抗原插入物位于风疹结构蛋白ORF内。在一些实例中，异源抗原插入物位于编码结构蛋白E2的基因和编码结构蛋白E1的基因之间的风疹结构蛋白ORF中。示例性抗原插入物包括HIV，SIV，RSV或乙型肝炎表面抗原。在一些实例中，HIV抗原插入物是Gag抗原插入片段，gp41抗原插入物或gp120抗原插入物。还公开了分离的风疹病毒载体的用途，例如诱导对特定病毒（例如HIV-1）的免疫应答，测试对中和抗体的敏感性，或筛选抗病毒药物（例如蛋白酶抑制剂）。

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