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1. 发明申请

WO2007031098A1 CELL-PERMEABLE PEPTIDE INHIBITORS OF THE JNK SIGNAL TRANSDUCTION PATHWAY 审中-公开
标题翻译： JNK信号转导途径的细胞渗透性肽抑制剂
公开(公告)号：WO2007031098A1
公开(公告)日：2007-03-22
申请号：PCT/EP2005/009782
申请日：2005-09-12
申请人： XIGEN S.A. , BONNY, Christophe
发明人： BONNY, Christophe
IPC分类号： C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2319/10 , C12N7/00 , C12N2740/16322 , C12N2740/16371
摘要： The present invention refers to protein kinase inhibitors and more specifically to inhibitors of the protein kinase c-Jun amino terminal kinase. Additionally, the present invention provides JNK inhibitor sequences, chimeric peptides, nucleic acids encoding same as well as pharmaceutical compositions for treating pathophysiologies associated with JNK signaling.
摘要翻译：本发明涉及蛋白激酶抑制剂，更具体地涉及蛋白激酶c-Jun氨基末端激酶的抑制剂。此外，本发明提供了JNK抑制剂序列，嵌合肽，编码它们的核酸以及用于治疗与JNK信号传导相关的病理生理学的药物组合物。

2. 发明申请

WO2004065578A3 MICROPARTICLES COMPRISING POLYNUCLEOTIDE ADSORBED ON THE SURFACE OF OR ENTRAPPED WITHIN THE MICROPARTICLES 审中-公开
标题翻译：包含在微生物表面或被微生物表面吸附的多核苷酸的微球
公开(公告)号：WO2004065578A3
公开(公告)日：2004-09-30
申请号：PCT/US2004000923
申请日：2004-01-14
申请人： CHIRON CORP
发明人： O'HAGAN DEREK , SINGH MANMOHAN
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K31/7088 , A61K39/00 , A61K48/00 , C12N20060101
CPC分类号： A61K47/34 , A61K9/14 , A61K9/1647 , A61K9/167 , A61K31/7088 , A61K39/21 , A61K2039/55511 , C12N7/00 , C12N2740/16022 , C12N2740/16371
摘要： Microparticles with adsorbed polynucleotide-containing species, compositions containing the same, methods of making such microparticles, and uses thereof are disclosed. The microparticles comprise (a) a biodegradable polymer, such as a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, (b) a cationic surfactant such as cetyltrimethylammonium bromide, (c) and a polynucleotide-containing species adsorbed on the surface of the microparticles, wherein the polynucleotide-containing species constitutes at least 5 percent of the total weight of said microparticles. Examples of polynucleotide-containing species include polynucleotide-containing immunological adjuvants, such as CpG oligonucleotides, and polynucleotide-containing species that encode polypeptide-containing antigens, such as RNA and DNA vector constructs. Use of said composition for the manufacture of a medicament for delivering a therapeutic amount of a polynucleotide-containing species to host animal, stimulating an immune response, treating a host animal having a pathogenic organism infection,
摘要翻译：公开了具有吸附的含多核苷酸的微粒，含有它们的组合物，制备这种微粒的方法及其用途。微粒包括（a）可生物降解的聚合物，例如多羟基丁酸，聚己内酯，聚原酸酯，聚酐或聚氰基丙烯酸酯，（b）阳离子表面活性剂如十六烷基三甲基溴化铵，（c）和含多核苷酸的物质吸附在微粒表面上，其中含多核苷酸的物质占所述微粒总重量的至少5％。含多核苷酸的物质的实例包括含多核苷酸的免疫佐剂，例如CpG寡核苷酸，以及编码含多肽的抗原的含多核苷酸的物种，例如RNA和DNA载体构建体。所述组合物用于制备用于将治疗量的含多核苷酸的物质递送至宿主动物，刺激免疫应答，治疗具有致病性生物体感染的宿主动物的药物的用途，

3. 发明申请

WO2007031280A3 CELL-PERMEABLE PEPTIDE INHIBITORS OF THE JNK SIGNAL TRANSDUCTION PATHWAY 审中-公开
标题翻译： JNK信号转导途径的细胞渗透性肽抑制剂
公开(公告)号：WO2007031280A3
公开(公告)日：2007-05-24
申请号：PCT/EP2006008882
申请日：2006-09-12
申请人： XIGEN SA , BONNY CHRISTOPHE
发明人： BONNY CHRISTOPHE
IPC分类号： C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2319/10 , C12N7/00 , C12N2740/16322 , C12N2740/16371
摘要： The present invention refers to protein kinase inhibitors and more specifically to inhibitors of the protein kinase c-Jun amino terminal kinase. Additionally, the present invention provides JNK inhibitor sequences, chimeric peptides, nucleic acids encoding same as well as pharmaceutical compositions for treating pathophysiologies associated with JNK signaling.
摘要翻译：本发明涉及蛋白激酶抑制剂，更具体涉及蛋白激酶c-Jun氨基末端激酶的抑制剂。此外，本发明提供了JNK抑制剂序列，嵌合肽，编码它们的核酸以及用于治疗与JNK信号传导相关的病理生理学的药物组合物。

4. 发明申请

WO2009099679A2 TREATMENT OF DISEASE CONDITIONS VIA ADMINISTRATION OF DNA REPAIR ENZYME 审中-公开
标题翻译：通过DNA修复酶的治疗来治疗疾病状况
公开(公告)号：WO2009099679A2
公开(公告)日：2009-08-13
申请号：PCT/US2009000889
申请日：2009-02-09
申请人： UNIV SOUTH ALABAMA , WILSON GLENN , LEDOUX SUSAN , ALEXEYER MIKHAIL , SHOKOLENKO INNA , GILLESPIE MARK N
发明人： WILSON GLENN , LEDOUX SUSAN , ALEXEYER MIKHAIL , SHOKOLENKO INNA , GILLESPIE MARK N
IPC分类号： A61K47/48 , A61K38/43 , A61P39/00
CPC分类号： C12N9/2497 , A61K38/00 , A61K47/62 , C07K14/005 , C07K14/435 , C07K2319/07 , C07K2319/10 , C12N7/00 , C12N9/22 , C12N9/88 , C12N2740/16371 , C12Y301/21005 , C12Y302/02023 , C12Y402/99018
摘要： The present invention is directed to compositions and methods of preserving viability of islets of Langerhans for transplantation, and treating various diseases and other abnormal or pathological conditions, including inflammatory bowel disease, ischemic heart disease, acute lung injury, acute respiratory distress syndrome and radiation- induced brain injury, with DNA repair enzymes that are directed to the mitochondria.
摘要翻译：本发明涉及保存用于移植的朗格汉斯胰岛的存活力的组合物和方法，以及治疗各种疾病和其它异常或病理状况，包括炎症性肠病，缺血性心脏病，急性肺损伤，急性呼吸窘迫综合征和放射线 - 诱导脑损伤，DNA修复酶被导向线粒体。

5. 发明申请

WO2004065578A2 MICROPARTICLES WITH ADSORBED POLYNUCLEOTIDE-CONTAINING SPECIES 审中-公开
标题翻译：含有多聚核苷酸的物种的微生物
公开(公告)号：WO2004065578A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/000923
申请日：2004-01-14
申请人： CHIRON CORPORATION
发明人： O'HAGAN, Derek , SINGH, Manmohan
IPC分类号： C12N
CPC分类号： A61K47/34 , A61K9/14 , A61K9/1647 , A61K9/167 , A61K31/7088 , A61K39/21 , A61K2039/55511 , C12N7/00 , C12N2740/16022 , C12N2740/16371
摘要： Microparticles with adsorbed polynucleotide-containing species, compositions containing the same, methods of making such microparticles, and uses thereof are disclosed. The microparticles comprise (a) a biodegradable polymer, such as a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, (b) a cationic surfactant such as cetyltrimethylammonium bromide, (c) and a polynucleotide-containing species adsorbed on the surface of the microparticles, wherein the polynucleotide-containing species constitutes at least 5 percent of the total weight of said microparticles. Examples of polynucleotide-containing species include polynucleotide-containing immunological adjuvants, such as CpG oligonucleotides, and polynucleotide-containing species that encode polypeptide-containing antigens, such as RNA and DNA vector constructs. Methods of delivering a therapeutic amount of a polynucleotide-containing species to host animal, methods of stimulating an immune response, methods of treating a host animal having a pathogenic organism infection, methods of immunizing a host animal against infection by a pathogenic organism, and uses of the microparticle compositions for vaccines are also provided.
摘要翻译：公开了具有吸附的含多核苷酸的微粒，含有它们的组合物，制备这种微粒的方法及其用途。微粒包括（a）可生物降解的聚合物，例如多羟基丁酸，聚己内酯，聚原酸酯，聚酐或聚氰基丙烯酸酯，（b）阳离子表面活性剂如十六烷基三甲基溴化铵，（c）和含多核苷酸的物质吸附在微粒表面上，其中含多核苷酸的物质占所述微粒总重量的至少5％。含多核苷酸的物质的实例包括含多核苷酸的免疫佐剂，例如CpG寡核苷酸，以及编码含多肽的抗原的含多核苷酸的物种，例如RNA和DNA载体构建体。将治疗量的含多核苷酸的物种递送至宿主动物的方法，刺激免疫应答的方法，治疗具有致病性生物体感染的宿主动物的方法，免疫宿主动物免受致病性生物体感染的方法和使用的疫苗微粒组合物。

6. 发明申请

WO2015023824A2 CELL PERMEABLE INHIBITORS OF THE SCAFFOLD PROTEIN PLENTY OF SH3 DOMAINS (POSH) OR SH3RFL 审中-公开
标题翻译： SH3域（POSH）或SH3RFL的SCAFF蛋白质细胞的细胞渗透性抑制剂
公开(公告)号：WO2015023824A2
公开(公告)日：2015-02-19
申请号：PCT/US2014051019
申请日：2014-08-14
申请人： UNIV MISSOURI
发明人： DANIELS MARK
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K38/00 , A61K47/48246 , A61K47/64 , C07K7/08 , C07K14/005 , C07K14/47 , C07K2319/00 , C07K2319/10 , C12N7/00 , C12N2740/16322 , C12N2740/16371
摘要： Here, we identify Plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multi-protein scaffold network for TCR-mediated JNK1 activation in CD8+ T-cells. Disruption of the POSH/JIP-1 complex led to profound defects in the activation of JNK1, as well as deficient activation or induction of the transcription factors c-Jun, T-bet and Eomesodermin. Furthermore, disruption of the POSH/JIP complex in CD8+ T-cells resulted in impaired proliferation, decreased cytokine expression and the inability to control tumors. Collectively, these data identify a mechanism for the specific regulation of TCR-dependent JNK1 activation and function that is key for CD8+ T-cell responses. The present invention describes a group of compounds that individually or in concert target a common set of biological pathways important in T cell function, activation of innate inflammation, ischemic reperfusion injury, HIV release and oncogenesis.
摘要翻译：在这里，我们确定了大量SH3（POSH）和JNK相互作用蛋白1（JIP-1）作为CD8 + T细胞中TCR介导的JNK1激活的多蛋白支架网络。 POSH / JIP-1复合物的破坏导致JNK1激活的深刻缺陷，以及转录因子c-Jun，T-bet和Eomesodermin的活化或诱导不足。此外，CD8 + T细胞中POSH / JIP复合物的破坏导致增殖受损，细胞因子表达降低，以及不能控制肿瘤。总的来说，这些数据确定了TCR依赖性JNK1激活和功能的特异性调节机制，这是CD8 + T细胞应答的关键。本发明描述了一组化合物，其单独地或一致地靶向在T细胞功能，先天性炎症的激活，缺血再灌注损伤，HIV释放和肿瘤发生中重要的常见生物学途径。

7. 发明申请

WO2007031280A2 CELL-PERMEABLE PEPTIDE INHIBITORS OF THE JNK SIGNAL TRANSDUCTION PATHWAY 审中-公开
标题翻译： JNK信号传输途径的细胞渗透肽抑制剂
公开(公告)号：WO2007031280A2
公开(公告)日：2007-03-22
申请号：PCT/EP2006/008882
申请日：2006-09-12
申请人： XIGEN S.A. , BONNY, Christophe
发明人： BONNY, Christophe
IPC分类号： C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2319/10 , C12N7/00 , C12N2740/16322 , C12N2740/16371
摘要： The present invention refers to protein kinase inhibitors and more specifically to inhibitors of the protein kinase c-Jun amino terminal kinase. Additionally, the present invention provides JNK inhibitor sequences, chimeric peptides, nucleic acids encoding same as well as pharmaceutical compositions for treating pathophysiologies associated with JNK signaling.
摘要翻译：本发明涉及蛋白激酶抑制剂，更具体地涉及蛋白激酶c-Jun氨基末端激酶的抑制剂。此外，本发明提供了JNK抑制剂序列，嵌合肽，编码相同的核酸以及用于治疗与JNK信号传导相关的病理生理学的药物组合物。

8. 发明申请

WO2006020071A2 VACCINE CONSTRUCTS AND COMBINATIONS OF VACCINES DESIGNED TO IMPROVE THE BREADTH OF THE IMMUNE RESPONSE TO DIVERSE STRAINS AND CLADES OF HIV 审中-公开
标题翻译：疫苗结构和疫苗的组合设计用于改善免疫应答对多样性病毒和艾滋病毒携带者的免疫应答
公开(公告)号：WO2006020071A2
公开(公告)日：2006-02-23
申请号：PCT/US2005025219
申请日：2005-07-15
申请人： US GOV HEALTH & HUMAN SERV , GENVEC INC , NABEL GARY J , HUANG YUE , XU LING , CHAKRABARTI BIMAL , WU LAN , YANG ZHI-YONG , GALL JASON G D , KING C RICHTER
发明人： NABEL GARY J , HUANG YUE , XU LING , CHAKRABARTI BIMAL , WU LAN , YANG ZHI-YONG , GALL JASON G D , KING C RICHTER
IPC分类号： C07K14/16 , A61K39/21 , A61P31/00
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
摘要翻译：本公开提供了针对人类免疫缺陷病毒引发免疫应答（包括预防性免疫应答）的组合物。该组合物包括编码多个进化枝或菌株的HIV抗原多肽的核酸构建体。还提供了通过将受试者施用组合物引起免疫应答的方法。

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