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1. 发明申请

WO2012026712A2 ＮＯＤ２의 아고니스트를 처리한 줄기세포 또는 그 배양물을 포함하는 면역질환 또는 염증질환의 예방 또는 치료용 약학조성물 审中-公开
标题翻译：用于预防或治疗免疫疾病或炎性疾病的药物组合物，其包含用NOD2激动剂或其培养物处理的干细胞
公开(公告)号：WO2012026712A2
公开(公告)日：2012-03-01
申请号：PCT/KR2011/006109
申请日：2011-08-19
申请人： 주식회사 강스템홀딩스 , 강경선 , 김형식
发明人： 강경선 , 김형식
IPC分类号： A61K38/03 , A61K38/05 , A61K35/12 , A61P37/00
CPC分类号： A61K35/28 , A61K35/545 , A61K38/05 , C12N5/0665 , C12N2501/02 , C12N2501/05 , C12N2501/052 , C12N2501/054
摘要： 본 발명은 NOD2를 발현하는 줄기세포에 NOD2의 아고니스트를 첨가하여 배양한 줄기세포 또는 그 배양물을 포함하는 면역질환 및 염증질환의 예방 또는 치료용 약학조성물에 관한 것으로, 보다 상세하게는 상기 약학조성물, 상기 상기 줄기세포 또는 그 배양물을 피험체에 투여하는 단계를 포함하는 피험체의 면역반응 또는 염증반응을 억제하는 방법, 상기 줄기세포 또는 그 배양물을 이용하여 면역억제제 또는 항염증제의 제조 방법, NOD2를 발현하는 줄기세포에 NOD2의 아고니스트를 첨가하여 배양하는 단계를 포함하는 PGE 2 또는 TGF-β1의 제조 방법, NOD2를 발현하는 줄기세포 및 NOD2의 아고니스트를 포함하는 이식체, 상기 이식체의 제조방법, NOD2를 발현하는 줄기세포 및 NOD2의 아고니스트를 포함하는 복합체 및 NOD2를 발현하는 줄기세포에 NOD2의 아고니스트를 첨가하여 얻은 배양물에 관한 것이다.
摘要翻译：
本发明茎通过在表达NOD2细胞或免疫疾病，包括根据用于所述的药物组合物中的培养和炎症性疾病的预防或治疗的干细胞在添加NOD2的激动剂的培养到，使用和更特别是药物组合物，其中所述的干细胞或培养用于抑制受试者中的免疫应答或炎症，其包括向受治疗者施用的方法，其中所述的干细胞或培养生产PGE 2或TGF-β1的方法包括通过向培养基中加入NOD2激动剂培养表达NOD2的干细胞，生产NOD2的方法干细胞和NOD2激动剂，生产移植物的方法，包含表达NOD2的干细胞和NOD2激动剂的复合物以及表达NOD2的干细胞 NOD2激动剂。

2. 发明申请

WO2012026712A4 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING STEM CELLS TREATED WITH NOD2 AGONIST OR CULTURED PRODUCT THEREOF 审中-公开
标题翻译：用于预防或治疗免疫缺陷病毒或炎症性疾病的药物组合物，含有NOD2激动剂或其培养产物的干细胞
公开(公告)号：WO2012026712A4
公开(公告)日：2012-08-23
申请号：PCT/KR2011006109
申请日：2011-08-19
申请人： KANG STEM HOLDINGS CO LTD , KANG KYUNG SUN , KIM HYUNG SIK
发明人： KANG KYUNG SUN , KIM HYUNG SIK
IPC分类号： A61K38/03 , A61K35/12 , A61K38/05 , A61P37/00
CPC分类号： A61K35/28 , A61K35/545 , A61K38/05 , C12N5/0665 , C12N2501/02 , C12N2501/05 , C12N2501/052 , C12N2501/054
摘要： The present invention relates to a pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing the stem cells which are obtained by adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, or cultured product thereof, and more specifically, to a method for suppressing the immune diseases or inflammatory diseases of a subject, comprising the step of administering the pharmaceutical composition, the stem cell or a cultured product thereof to a subject, a method for preparing an immunosuppressive drug or an anti-inflammatory drug using the stem cells or a cultured product thereof, a method for preparing PGE2 or TGF-ß1, comprising the step of adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, a graft comprising stem cells which express NOD2 and an NOD2 agonist, a preparation method of the graft, a composite comprising stem cells which express NOD2 and an NOD2 agonist, and a cultured product obtained by adding an NOD2 agonist to stem cells which express NOD2.
摘要翻译：本发明涉及一种预防或治疗免疫疾病或炎性疾病的药物组合物，其含有通过向表达NOD2的干细胞培养NOD2激动剂或其培养产物，更具体地提供的干细胞涉及抑制受试者的免疫疾病或炎症性疾病的方法，包括向受试者施用药物组合物，干细胞或其培养物的步骤，制备免疫抑制药物或抗炎药物的方法使用干细胞或其培养产物，制备PGE2或TGF-β1的方法，包括向表达NOD2的干细胞和培养干细胞的干细胞中加入NOD2激动剂的步骤，包含表达NOD2的干细胞和 NOD2激动剂，移植物的制备方法，包含表达NOD2和NOD2激动剂的干细胞的复合物，以及培养物通过向表达NOD2的干细胞中加入NOD2激动剂获得的红色产物。

3. 发明申请

WO2014053596A1 A NOD2-DEPENDENT PATHWAY OF CYTOPROTECTION OF STEM CELLS 审中-公开
标题翻译：一种NOD2依赖性干细胞移植途径
公开(公告)号：WO2014053596A1
公开(公告)日：2014-04-10
申请号：PCT/EP2013/070620
申请日：2013-10-03
申请人： INSTITUT PASTEUR
发明人： SANSONETTI, Philippe , NIGRO, Giulia
IPC分类号： A61K38/05 , C12N5/074
CPC分类号： A61K38/14 , A61K38/05 , C12N5/068 , C12N2501/054 , G01N33/502 , G01N33/5073 , G01N33/5076 , G01N2333/904
摘要： The present invention is directed to an agonist of NOD2 for use in therapy for increasing the autonomous capacity of survival of vertebrate adult stem cells, without loss of their capacity to multiply and differentiate, and preferably the capacity of survival of intestinal stem cells, especially in response to a stress. The invention also concerns the use of an agonist of Nod2 for increasing in vitro or ex vivo the autonomous capacity of survival, without loss of multiplication and differentiation capacity of mammalian adult stem cell. The invention also discloses different media and support for mammalian adult stem cells. The invention also concerns an in vitro screening process for identifying molecules capable increasing, in response to a stress, the autonomous capacity of survival, without loss of multiplication and differentiation capacity of mammalian adult stem cells.
摘要翻译：本发明涉及NOD2的激动剂，其用于治疗以提高脊椎动物成体干细胞的自主生存能力，而不损失其增殖和分化的能力，优选肠道干细胞的存活能力，特别是在应对压力。本发明还涉及Nod2的激动剂用于增加体外或离体存活的自主能力，而不损失哺乳动物成体干细胞的增殖和分化能力。本发明还公开了哺乳动物成体干细胞的不同培养基和载体。本发明还涉及用于识别能够响应于应激而增加生存的自主能力并且不损失哺乳动物成体干细胞的增殖和分化能力的分子的体外筛选方法。

4. 发明申请

WO2012026712A3 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING STEM CELLS TREATED WITH NOD2 AGONIST OR CULTURED PRODUCT THEREOF 审中-公开
标题翻译：用于预防或治疗免疫疾病或炎性疾病的药物组合物，含有用NOD2激动剂或其培养产物处理的干细胞
公开(公告)号：WO2012026712A3
公开(公告)日：2012-05-24
申请号：PCT/KR2011006109
申请日：2011-08-19
申请人： KANG STEM HOLDINGS CO LTD , KANG KYUNG SUN , KIM HYUNG SIK
发明人： KANG KYUNG SUN , KIM HYUNG SIK
IPC分类号： A61K38/03 , A61K35/12 , A61K38/05 , A61P37/00
CPC分类号： A61K35/28 , A61K35/545 , A61K38/05 , C12N5/0665 , C12N2501/02 , C12N2501/05 , C12N2501/052 , C12N2501/054
摘要： The present invention relates to a pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing the stem cells which are obtained by adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, or cultured product thereof, and more specifically, to a method for suppressing the immune diseases or inflammatory diseases of a subject, comprising the step of administering the pharmaceutical composition, the stem cell or a cultured product thereof to a subject, a method for preparing an immunosuppressive drug or an anti-inflammatory drug using the stem cells or a cultured product thereof, a method for preparing PGE2 or TGF-ß1, comprising the step of adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, a graft comprising stem cells which express NOD2 and an NOD2 agonist, a preparation method of the graft, a composite comprising stem cells which express NOD2 and an NOD2 agonist, and a cultured product obtained by adding an NOD2 agonist to stem cells which express NOD2.
摘要翻译：本发明涉及用于预防或治疗免疫疾病或炎性疾病的药物组合物，其含有通过向表达NOD2的干细胞添加NOD2激动剂并培养干细胞获得的干细胞或其培养产物，更具体地涉及用于抑制受试者的免疫疾病或炎性疾病的方法，该方法包括将药物组合物，干细胞或其培养产品给予受试者的步骤，制备免疫抑制药物或抗炎药物的方法使用干细胞或其培养产物制备PGE2或TGF-β1的方法，包括向表达NOD2的干细胞中加入NOD2激动剂并培养干细胞的步骤，包含表达NOD2的干细胞的移植物和 NOD2激动剂，移植物的制备方法，包含表达NOD2和NOD2激动剂的干细胞的复合物以及培养物通过向表达NOD2的干细胞添加NOD2激动剂而获得红色产物。

5. 发明申请

WO1991012316A1 METHOD FOR PREPARING BLOOD DERIVATIVES AND DERIVATIVES THEREBY OBTAINED 审中-公开
标题翻译：制备血液衍生物和衍生物的方法
公开(公告)号：WO1991012316A1
公开(公告)日：1991-08-22
申请号：PCT/FR1991000090
申请日：1991-02-06
申请人： FONDATION NATIONALE DE TRANSFUSION SANGUINE , BARTHOLEYNS, Jacques
发明人： FONDATION NATIONALE DE TRANSFUSION SANGUINE
IPC分类号： C12N05/00
CPC分类号： C12N5/0645 , A61K35/15 , A61K38/00 , A61L27/52 , A61L27/54 , A61L2300/414 , C07K14/475 , C07K14/52 , C07K14/811 , C12N2500/32 , C12N2500/38 , C12N2501/02 , C12N2501/052 , C12N2501/054 , C12N2501/24 , C12N2501/82
摘要： A method for preparing blood cell derivatives wherein monocytes or leukocytes are isolated from the blood and treated in a culture medium. The method is characterized in that the monocytes or leukocytes are treated in a culture medium which contains at least 1 g/l of amino-acid(s), at least 3 g/l of glucose and at least 10 mg/l of vitamins placed in a gas-permeable pocket.

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