专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010113647A1 ボルナ病ウイルスを利用するベクター及びその利用审中-公开
标题翻译：使用BORNA疾病病毒的VECTOR及其用途
公开(公告)号：WO2010113647A1
公开(公告)日：2010-10-07
申请号：PCT/JP2010/054600
申请日：2010-03-17
申请人：国立大学法人大阪大学 , 朝長啓造 , 大東卓史 , 本田知之
发明人：朝長　啓造 , 大東　卓史 , 本田　知之
IPC分类号： C12N15/09 , C12N7/00
CPC分类号： C12N15/86 , C12N15/111 , C12N2310/121 , C12N2310/123 , C12N2310/128 , C12N2330/51 , C12N2760/00043 , C12N2760/00045 , C12N2800/80 , C12N2810/6072 , C12N2810/6081
摘要：　（ａ）ボルナ病ウイルスゲノムにおける少なくともＮ遺伝子、Ｘ遺伝子、Ｐ遺伝子及びＬ遺伝子を、ボルナ病ウイルスゲノムにおける順序と同じ順序で有し、前記Ｐ遺伝子の翻訳領域の下流に連結する非翻訳領域内に外来性遺伝子が挿入された配列を有する組換えウイルスＲＮＡのｃＤＮＡ、（ｂ）リボザイムをコードするＤＮＡ及び（ｃ）プロモーター配列を含み、該（ａ）の上流及び下流に（ｂ）が配置され、かつ（ａ）及び（ｂ）が（ｃ）の下流に配置されていることを特徴とするウイルスベクター。
摘要翻译：一种病毒载体，其特征在于包含：（a）具有如下序列的重组病毒RNA的cDNA，所述重组病毒RNA具有以下顺序：伯氏病病毒基因组中所含的至少N个基因，X基因，P基因和L基因的排列顺序与在博尔纳病病毒和外源基因插入到与P基因的翻译区的下游相连的非翻译区; （b）编码核酶的DNA; 和（c）启动子序列，其中所述DNA（b）位于所述cDNA（a）的上游和所述DNA（b）的下游，并且其中所述cDNA（a）和所述DNA（b）位于启动子序列（c）。

2. 发明申请

WO1995027044A1 ALPHAVIRUS cDNA VECTORS 审中-公开
公开(公告)号：WO1995027044A1
公开(公告)日：1995-10-12
申请号：PCT/SE1995000343
申请日：1995-03-30
申请人： BIOPTION AB , LILJESTRÖM, Peter , GAROFF, Henrik
发明人： BIOPTION AB
IPC分类号： C12N07/01
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/86 , C12N2310/111 , C12N2310/123 , C12N2770/36143 , C12N2830/52
摘要： The present invention is related to polynucleotide molecules and to their use for production of desired products after introduction into human or animal cells. In addition, the present invention is concerned with pharmaceutical compositions comprising said polynucleotide molecules and their use in prophylactic or therapeutic treatment methods. The present invention is also related to use of such polynucleotide molecules in animals to achieve expression of desired products, which can be recovered from the animal but do not give rise to any beneficial, e.g. therapeutical, activity in the said animal. More specifically, the present invention is directed to alphavirus cDNA vectors comprised of recombinant cDNA consisting of cDNA derived from an alphavirus and heterologous, i.e. foreign, cDNA coding for a desired substance.
摘要翻译：本发明涉及多核苷酸分子及其在引入人或动物细胞后产生所需产物的用途。此外，本发明涉及包含所述多核苷酸分子的药物组合物及其在预防或治疗方法中的用途。本发明还涉及在动物中使用这种多核苷酸分子以实现所需产物的表达，其可以从动物中回收，但不产生任何有益的，例如，所述动物的治疗活性。更具体地，本发明涉及包含由源自甲病毒属的cDNA和异源（即外来的）编码所需物质的cDNA的cDNA组成的重组cDNA的甲病毒cDNA载体。

3. 发明申请

WO2013096866A3 PROCESSES USING VLPS WITH CAPSIDS RESISTANT TO HYDROLASES 审中-公开
标题翻译：使用具有抗水解胶胨的VLPS的工艺
公开(公告)号：WO2013096866A3
公开(公告)日：2013-10-03
申请号：PCT/US2012071419
申请日：2012-12-21
申请人： APSE LLC , ARHANCET JUAN PEDRO HUMBERTO , ARHANCET JUAN P , DELANEY KIMBERLY , HALL KATHLEEN B , SUMMERS NEENA
发明人： ARHANCET JUAN PEDRO HUMBERTO , ARHANCET JUAN P , DELANEY KIMBERLY , HALL KATHLEEN B , SUMMERS NEENA
IPC分类号： C12N7/00 , C07H21/00
CPC分类号： C12N7/00 , A01N25/26 , A01N25/28 , C07K14/005 , C07K14/01 , C12N7/04 , C12N15/111 , C12N15/113 , C12N2310/121 , C12N2310/123 , C12N2310/128 , C12N2310/14 , C12N2310/16 , C12N2330/51 , C12N2795/18122 , C12N2795/18123 , C12N2795/18142 , A01N43/70 , A01N47/40 , A01N57/12 , A01N57/14 , A01N57/30 , C12N2310/531
摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides.
摘要翻译：描述了使用对水解酶具有抗性的病毒衣壳蛋白制备病毒样颗粒以包封并随后分离和纯化包括诸如siRNA's和shRNA以及小肽的核酸的感兴趣的目标货物分子的新颖方法和组合物。

4. 发明申请

WO1996022368A1 RIBOZYMES TARGETING THE RETROVIRAL PACKAGING SEQUENCE EXPRESSION CONSTRUCTS AND RECOMBINANT RETROVIRUSES CONTAINING SUCH CONSTRUCTS 审中-公开
标题翻译：重组包装序列表达构建体和包含这些构建体的重组逆转录酶的RIBOZYMES
公开(公告)号：WO1996022368A1
公开(公告)日：1996-07-25
申请号：PCT/AU1996000022
申请日：1996-01-18
申请人： GENE SHEARS PTY. LTD. , SYMONDS, Geoffrey, P. , SUN, Lun-Quan
发明人： GENE SHEARS PTY. LTD.
IPC分类号： C12N15/11
CPC分类号： C12N15/1132 , A61K38/00 , C12N15/1131 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/13 , C12N2799/027
摘要： This invention is directed to a synthetic non-naturally occurring oligonucleotide compound which comprises nucleotides whose sequence defines a conserved catalytic region and nucleotides whose sequence is capable of hybridizing with a predetermined target sequence within a packaging sequence of an RNA virus. Preferably, the viral packaging sequence is a retrovirus packaging sequence or the HIV-1 Psi packaging sequence. The RNA virus may be HIV-1, Feline Leukemia Virus, Feline Immunodeficiency Virus or one of the viruses listed in Table (I). The conserved catalytic region may be derived from a hammerhead ribozyme, a hairpin ribozyme, a hepatitis delta ribozyme, an RNAase P ribozyme, a group (I) intron, a group (II) intron. The invention is also directed to multiple ribozymes, combinations of ribozymes, with or without antisense, and combinations of ribozymes, with antisense, and TAR decoys, polyTARs and RRE decoys targeted against the RNA virus. Vectors are also described. Further, methods of treatment and methods of use both in vivo and ex vivo are described.
摘要翻译：本发明涉及合成的非天然存在的寡核苷酸化合物，其包含其序列限定保守催化区的核苷酸和其序列能够与RNA病毒的包装序列内的预定靶序列杂交的核苷酸。优选地，病毒包装序列是逆转录病毒包装序列或HIV-1 Psi包装序列。 RNA病毒可以是HIV-1，猫白血病病毒，猫免疫缺陷病毒或表（I）中列出的病毒之一。保守的催化区域可以衍生自锤头核酶，发夹核酶，戊型肝炎核酶，RNA酶P核酶，组（I）内含子，组（II）内含子。本发明还涉及多种核酶，具有或不具有反义的核酶的组合，以及核酶与反义和TAR诱饵，针对RNA病毒靶向的多核苷酸和RRE诱饵的组合。还描述了载体。此外，描述了体内和体外的治疗方法和使用方法。

5. 发明申请

WO1995013378A1 BASE-MODIFIED ENZYMATIC NUCLEIC ACID 审中-公开
标题翻译：碱改性的酶促核酸
公开(公告)号：WO1995013378A1
公开(公告)日：1995-05-18
申请号：PCT/US1994012806
申请日：1994-11-07
申请人： RIBOZYME PHARMACEUTICALS, INC.
发明人： RIBOZYME PHARMACEUTICALS, INC. , USMAN, Nassim , BEIGELMAN, Leonid , McSWIGGEN, James, A.
IPC分类号： C12N15/52
CPC分类号： C07K14/005 , C07H19/06 , C07H21/00 , C12N15/113 , C12N15/85 , C12N15/86 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2770/00022 , C12N2770/28122 , C12Q1/6811 , C12Q1/701 , C12Q2541/101 , C12Q2521/337
摘要： Method to produce a more active ribozyme by introducting a modified base into a substrate binding arm of the ribozyme or its catalytic core.
摘要翻译：通过将修饰的碱基引入核酶或其催化核心的底物结合臂来产生更有活性的核酶的方法。

6. 发明申请

WO1994002595A1 METHOD AND REAGENT FOR TREATMENT OF ANIMAL DISEASES 审中-公开
标题翻译：用于治疗动物疾病的方法和试剂
公开(公告)号：WO1994002595A1
公开(公告)日：1994-02-03
申请号：PCT/US1993006316
申请日：1993-07-02
申请人： RIBOZYME PHARMACEUTICALS, INC.
发明人： RIBOZYME PHARMACEUTICALS, INC. , SULLIVAN, Sean, M. , DRAPER, Kenneth, G.
IPC分类号： C12N05/22
CPC分类号： C12N15/113 , A61K38/00 , C07K14/4702 , C12N9/6491 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development of maintenance of an inflammatory disease, an arthritic condition, a stenotic condition, or a cardiovascular condition.
摘要翻译：与维持炎性疾病，关节炎病症，狭窄状况或心血管病症的发展相关的mRNA的酶RNA分子。

7. 发明申请

WO1993023057A1 METHOD AND REAGENT FOR INHIBITING CANCER DEVELOPMENT 审中-公开
标题翻译：抑制癌症发展的方法和试剂
公开(公告)号：WO1993023057A1
公开(公告)日：1993-11-25
申请号：PCT/US1993004573
申请日：1993-05-13
申请人： RIBOZYME PHARMACEUTICALS, INC.
发明人： RIBOZYME PHARMACEUTICALS, INC. , THOMPSON, James, D. , DRAPER, Kenneth, G.
IPC分类号： A61K31/70
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/53
摘要： An enzymatic RNA molecule which specifically cleaves mRNA encoded by an mdr-1 gene, or associated with development or maintenance of chronic myelogenous leukemia, promyelocytic leukemia, Burkitt's lymphoma or acute lymphocytic leukemia, follicular lymphoma, B-cell acute lymphocytic leukemia, breast cancer, colon carcinoma, neuroblastoma, and lung cancer.
摘要翻译：特异性切割由mdr-1基因编码的mRNA，或与慢性骨髓性白血病，早幼粒细胞白血病，伯基特淋巴瘤或急性淋巴细胞性白血病，滤泡淋巴瘤，B细胞急性淋巴细胞性白血病，乳腺癌，结肠癌，成神经细胞瘤和肺癌。

8. 发明申请

WO1991004319A1 THERAPEUTIC RIBOZYME COMPOSITIONS AND EXPRESSION VECTORS 审中-公开
标题翻译：治疗RIBOZYME组合物和表达载体
公开(公告)号：WO1991004319A1
公开(公告)日：1991-04-04
申请号：PCT/US1990005450
申请日：1990-09-25
申请人： INNOVIR LABORATORIES, INC.
发明人： INNOVIR LABORATORIES, INC. , GOLDBERG, Allan, R. , GEORGE, Shaji, T. , ROBERTSON, Hugh, D.
IPC分类号： C12N07/01
CPC分类号： C12N15/1132 , A61K38/00 , A61K47/6901 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/123 , C12N2730/10122 , C12N2730/10134 , C12N2740/16043 , C12N2740/16122 , C12N2740/16222 , C12N2760/10122 , C12N2760/10134
摘要： Hepatitis delta is used as a vector for inhibition of viral infection and to express proteins in vivo in a cell-specific manner. The scope of delta's use as a vector is broadened in the present invention in several important ways. For example, a delta RNA genome capable of self-replication is enlarged to carry additional information, either coding for messenger RNA for a protein, or for a targeted ribozyme, which can be delivered to liver cells using delta's normally infectious properties, or to other cell types using chimeric delta viral agents carrying altered surface proteins. In another embodiment, the delta vector is made self-limiting, so that its role in delivering targeted information is separated from its viral property of unlimited infectious replication. Targeting is achieved through the use of sequences flanking the delta sequences that have affinity for sites on RNA to be cleaved.

9. 发明申请

WO2013096866A2 PROCESSES USING VLPS WITH CAPSIDS RESISTANT TO HYDROLASES 审中-公开
标题翻译：使用VLPS与抗血清抑制剂的方法
公开(公告)号：WO2013096866A2
公开(公告)日：2013-06-27
申请号：PCT/US2012/071419
申请日：2012-12-21
申请人： APSE, LLC , ARHANCET, Juan Pedro Humberto , ARHANCET, Juan P. , DELANEY, Kimberly , HALL, Kathleen B. , SUMMERS, Neena
发明人： ARHANCET, Juan Pedro Humberto , ARHANCET, Juan P. , DELANEY, Kimberly , HALL, Kathleen B. , SUMMERS, Neena
CPC分类号： C12N7/00 , A01N25/26 , A01N25/28 , C07K14/005 , C07K14/01 , C12N7/04 , C12N15/111 , C12N15/113 , C12N2310/121 , C12N2310/123 , C12N2310/128 , C12N2310/14 , C12N2310/16 , C12N2330/51 , C12N2795/18122 , C12N2795/18123 , C12N2795/18142 , A01N43/70 , A01N47/40 , A01N57/12 , A01N57/14 , A01N57/30 , C12N2310/531
摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides.
摘要翻译：描述了新的方法和组合物，其使用对水解酶具有抗性的病毒衣壳蛋白，以制备病毒样颗粒以包围并随后分离和纯化目标载体分子，包括核酸如siRNA和shRNA以及小肽。

10. 发明申请

WO2011005799A2 SELF REPLICATING RNA MOLECULES AND USES THEREOF 审中-公开
标题翻译：自我更新RNA分子及其用途
公开(公告)号：WO2011005799A2
公开(公告)日：2011-01-13
申请号：PCT/US2010/041113
申请日：2010-07-06
申请人： NOVARTIS AG , GEALL, Andrew , HEKELE, Armin , MANDL, Christian
发明人： GEALL, Andrew , HEKELE, Armin , MANDL, Christian
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K2039/53 , A61K2039/55555 , C12N15/113 , C12N15/86 , C12N2310/123 , C12N2770/36143
摘要： This application discloses self-replicating RNA molecules that contain modified nucleotides, compositions that contain the self-replicating RNA molecules, and methods for using the self-replicating RNA molecules, for example, to raise an immune response.
摘要翻译：本申请公开了含有修饰的核苷酸的自我复制的RNA分子，含有自我复制的RNA分子的组合物，以及使用自我复制的RNA分子的方法，例如提高免疫应答。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式