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1. 发明申请

WO2011133442A1 NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS 审中-公开
标题翻译：噻唑烷二酮化合物的新合成
公开(公告)号：WO2011133442A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/032822
申请日：2011-04-18
申请人： METABOLIC SOLUTIONS DEVELOPMENT COMPANY , ZELLER, James, R. , TANIS, Steven, P. , LARSEN, Scott, D. , ARTMAN, Gerald, D.
发明人： ZELLER, James, R. , TANIS, Steven, P. , LARSEN, Scott, D. , ARTMAN, Gerald, D.
IPC分类号： C07D213/51 , C07D277/34
CPC分类号： C07D277/34 , C07D213/50 , C07D213/51 , C07F7/1896
摘要： The present invention provides novel methods for synthesizing PPARy sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
摘要翻译：本发明提供了可用于预防和/或治疗诸如糖尿病，肥胖症，高血压和炎性疾病的代谢性疾病的PPARγ保留化合物例如噻唑烷二酮的新方法。

2. 发明申请

WO2006109729A1 ピリジルメチルスルホン誘導体审中-公开
标题翻译：吡啶衍生物衍生物
公开(公告)号：WO2006109729A1
公开(公告)日：2006-10-19
申请号：PCT/JP2006/307464
申请日：2006-04-07
申请人：第一製薬株式会社 , 宮内智 , 窪田秀樹 , 本木佳代子 , 伊藤昌之
发明人：宮内智 , 窪田秀樹 , 本木佳代子 , 伊藤昌之
IPC分类号： C07D213/61 , A61K31/4409 , A61P25/28 , C07D213/48 , C07D213/79 , C07D213/81 , C07D401/04
CPC分类号： C07D213/79 , C07D213/51 , C07D213/61 , C07D213/81 , C07D401/06 , C07D405/12
摘要： Disclosed is a novel compound having an effect of inhibiting the production/secretion of ß-amyloid protein. A compound represented by the general formula (1) or a salt or a solvate of the compound or the salt; and a pharmaceutical agent comprising the compound, salt or solvate.
摘要翻译：公开了具有抑制β-淀粉样蛋白生成/分泌作用的新型化合物。由通式（1）表示的化合物或化合物或其盐的盐或溶剂合物; 和包含该化合物，盐或溶剂合物的药剂。

3. 发明申请

WO02076974A3 PROCESS FOR THE PREPARATION OF TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF 审中-公开
标题翻译：制备四唑基咪唑衍生物及其新型结晶结构的方法
公开(公告)号：WO02076974A3
公开(公告)日：2003-02-13
申请号：PCT/US0205419
申请日：2002-02-22
申请人： ORTHO MCNEIL PHARM INC
发明人： ZHONG HUA , DUBBERKE SILKE , MULLER STEFAN , ROSSLER ARMIN , SCHULTZ THOMAS W , KOREY DANIEL J , OTTEN THOMAS , WALKER DONALD G , ABDEL-MAGID ABDEL
IPC分类号： C07D213/40 , C07D213/51 , C07D401/04
CPC分类号： C07D401/04 , C07D213/51
摘要： The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R , R , R and R are as defined in the specification below.The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).
摘要翻译：本发明涉及制备通式（I）的四取代咪唑衍生物的方法，其中R 1，R 2，R 3和R 4如下面的说明书所定义。本发明还涉及制备式（II）化合物和式（II）化合物的新结晶结构的方法。

4. 发明申请

WO2016200870A1 ORGANIC ANOLYTE MATERIALS FOR FLOW BATTERIES 审中-公开
标题翻译：用于流动电池的有机非离子材料
公开(公告)号：WO2016200870A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036336
申请日：2016-06-08
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： SANFORD, Melanie, S. , SEVOV, Christo, Slavov , BROONER, Rachel , CHENARD, Etienne
IPC分类号： C07D213/04 , C07D213/06 , C07D213/51 , A61K31/44 , A61K31/4402
CPC分类号： H01M8/188 , C07D213/51 , C07D213/55 , C07D213/56 , C07D213/89 , C07F5/022 , H01M2/14 , H01M4/368 , H01M4/9008 , H01M10/0567 , H01M10/0569 , H01M2300/0028 , Y02E60/528
摘要： Organic anolyte materials for redox flow batteries and redox flow batteries containing organic anolyte materials are disclosed.
摘要翻译：公开了用于氧化还原液流电池和含有有机阳极电解质材料的氧化还原电池的有机阳极电解质材料。

5. 发明申请

WO2004072026A3 PROCESS FOR PREPARING PYRIDINE-SUBSTITUTED AMINO KETAL DERIVATIVES 审中-公开
标题翻译：制备吡啶取代的氨基酮衍生物的方法
公开(公告)号：WO2004072026A3
公开(公告)日：2004-09-30
申请号：PCT/EP2004000640
申请日：2004-01-27
申请人： AVENTIS PHARMA GMBH
发明人： FLEMMING HANS-WOLFRAM , KORB GERHARD , MUELLER-LEHAR JUERGEN , WEBER WALTER
IPC分类号： C07D213/51 , C07D213/53 , C07D213/50 , C07D213/38
CPC分类号： C07D213/53 , C07D213/51
摘要： The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1, 1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
摘要翻译：本发明涉及一种制备式（I）的1-（吡啶基）-1,1-二烷氧基-2-氨基乙烷的衍生物的有效方法，式（I）化合物可以以高纯度制备，产率和游离碱的形式，而无需从作为固体的安全角度分离作为关键产物的式（Ⅺ）的乙酰基吡啶肟。

6. 发明申请

WO2004072026B1 PROCESS FOR PREPARING PYRIDINE-SUBSTITUTED AMINO KETAL DERIVATIVES 审中-公开
标题翻译：制备吡啶取代的氨基酮衍生物的方法
公开(公告)号：WO2004072026B1
公开(公告)日：2004-11-18
申请号：PCT/EP2004000640
申请日：2004-01-27
申请人： AVENTIS PHARMA GMBH
发明人： FLEMMING HANS-WOLFRAM , KORB GERHARD , MUELLER-LEHAR JUERGEN , WEBER WALTER
IPC分类号： C07D213/51 , C07D213/53 , C07D213/50 , C07D213/38
CPC分类号： C07D213/53 , C07D213/51
摘要： The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1, 1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
摘要翻译：本发明涉及用于制备式（I）的1-（吡啶基）-1,1-二烷氧基-2-氨基乙烷的衍生物的有效方法，式（I）的化合物可以以高纯度制备并且产率和游离碱形式，而无需分离式（XI）的乙酰基吡啶肟，从安全的观点来看，它是一种重要产物，为固体。

7. 发明申请

WO2004072026A2 PROCESS FOR PREPARING PYRIDINE-SUBSTITUTED AMINO KETAL DERIVATIVES 审中-公开
标题翻译：制备吡啶取代的氨基酮衍生物的方法
公开(公告)号：WO2004072026A2
公开(公告)日：2004-08-26
申请号：PCT/EP2004/000640
申请日：2004-01-27
申请人： AVENTIS PHARMA DEUTSCHLAND GMBH
发明人： FLEMMING, Hans-Wolfram , KORB, Gerhard , MUELLER-LEHAR, Juergen , WEBER, Walter
IPC分类号： C07D
CPC分类号： C07D213/53 , C07D213/51
摘要： The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1, 1-dialkoxy-2-aminoethane of the formula (I), with which compounds of the formula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
摘要翻译：本发明涉及用于制备式（I）的1-（吡啶基）-1,1-二烷氧基-2-氨基乙烷的衍生物的有效方法，通式（I）的化合物）可以以高纯度和产率制备并且以游离碱的形式制备，无需分离式（XI）的乙酰基吡啶肟，从安全的观点来看，该化合物是固体的关键产物。

8. 发明申请

WO2009026720A1 PROCESSES AND INTERMEDIATES FOR PREPARING FUSED HETEROCYCLIC KINASE INHIBITORS 审中-公开
标题翻译：制备融合型杂环激酶抑制剂的方法和中间体
公开(公告)号：WO2009026720A1
公开(公告)日：2009-03-05
申请号：PCT/CA2008/001543
申请日：2008-08-29
申请人： METHYLGENE INC. , RAEPPEL, Franck , ISAKOVIC, Ljubomir , CLARIDGE, Stephen William , MANNION, Michael , ZHAN, Lijie , GRANGER, Marie-Claude , VAISBURG, Arkadii , NANTEL, Miguel
发明人： RAEPPEL, Franck , ISAKOVIC, Ljubomir , CLARIDGE, Stephen William , MANNION, Michael , ZHAN, Lijie , GRANGER, Marie-Claude , VAISBURG, Arkadii , NANTEL, Miguel
IPC分类号： C07D495/04 , A61K31/4365
CPC分类号： C07D495/04 , C07D213/38 , C07D213/51 , C07D213/61
摘要： The invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, particularly at an industrial level The processes are aimed at ultimately forming compounds of the formula (A) where M is thieno[3,2,b]pyridinyl as shown, the group D is a ring or ring system, preferably pyridine, and the group Z, Ar, and G are as defined herein Such compounds can act to inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling.
摘要翻译：本发明涉及制备稠合杂环型激酶抑制剂化合物如噻吩并吡啶类化合物的方法和中间体，以及用于制备可用于制备稠合杂环型激酶抑制剂化合物的中间体的方法和中间体，特别是在工业水平该方法旨在最终形成式（A）的化合物，其中M是噻吩并[3,2，b]吡啶基，如D所示，基团D是环或环系，优选吡啶，基团Z，Ar 和G如本文所定义。这样的化合物可以起到抑制生长因子受体的蛋白酪氨酸激酶活性的作用，导致受体信号传导的抑制，例如VEGF受体信号传导和HGF受体信号传导的抑制。

9. 发明申请

WO2004037790A1 PROCESS FOR THE PREPARATION OF ARYL-PIRIDYL COMPOUNDS 审中-公开
标题翻译：制备芳基 - 吡啶化合物的方法
公开(公告)号：WO2004037790A1
公开(公告)日：2004-05-06
申请号：PCT/IT2002/000625
申请日：2002-10-02
申请人： EUTICALS PRIME EUROPEAN THERAPEUTICALS SPA , GIORDANO, Claudio , GIANNINI, Luca
发明人： GIORDANO, Claudio , GIANNINI, Luca
IPC分类号： C07D213/48
CPC分类号： C07D213/51 , C07D213/48
摘要： A method is described for the preparation of aryl-pyridine compounds of formula (I) by cross-coupling reaction, promoted by catalytic systems based on palladium or nickel between compounds of formula (II) and (III) in which: - Met represents Mg or Zn, - Y represents C1, Br, I or acetoxy, - Z represents I, Br, Cl, triflate, sulphonate, phosphate, - R l , R 2 , R 3 , R 4 , which are the same as one another or different, represent hydrogen, a linear and/or branched C l -C 4 alkyl, and/or an aryl, and/or a heteroaryl, or R l and R 2 and/or R 3 and R 4 , taken together, form a C 3 -C 8 ring, an aryl and/or a heteroaryl, - A represents -COR 5 where R 5 represents hydrogen, a linear and/or branched C l -C 4 alkyl, and/or an aryl, and/or a heteroaryl, or - A represents -CR s5 (OR 6 )(OR 7 ) where R 5 has the meaning described above and R 6 and R 7 , which are the same as one another or different, represent a linear and/or branched C 1 -C 4 alkyl, and/or an aryl, and/or a heteroaryl, or R 6 and R 7 , joined together, represent a C 1 -C 8 alkyl or alkenyl.
摘要翻译：描述了通过交叉偶联反应制备式（I）的芳基 - 吡啶化合物的方法，由式（II）和（III）化合物之间的基于钯或镍的催化体系促进，其中：Met表示Mg 或Zn，-Y表示C1，Br，I或乙酰氧基，-Z表示I，Br，Cl，三氟甲磺酸酯，磺酸酯，磷酸酯，-R1，R2，R3，R4彼此相同或不同，表示氢，线性和/或支链C 1 -C 4烷基和/或芳基，和/或杂芳基，或R 1和R 2和/或R 3和R 4一起形成C 3 -C 8环，芳基和/或杂芳基，-A表示-COR 5，其中R 5表示氢，直链和/或支链C 1 -C 4烷基和/或芳基，和/或杂芳基，或-A表示-CR s（OR 6）（OR 7），其中R 5具有上述含义和R 6和R 7彼此相同或不同，表示连接在一起的直链和/或支链C 1 -C 4烷基和/或芳基和/或杂芳基，或R 6和R 7 ，代表C1-C8 烷基或烯基。

10. 发明申请

WO2002076974A2 PROCESS FOR THE PREPARATION OF TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF 审中-公开
标题翻译：制备四唑基咪唑衍生物及其新型结晶结构的方法
公开(公告)号：WO2002076974A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/005419
申请日：2002-02-22
申请人： ORTHO-MCNEIL PHARMACEUTICAL, INC.
发明人： ZHONG, Hua , DUBBERKE, Silke , MULLER, Stefan , ROSSLER, Armin , SCHULTZ, Thomas, W. , KOREY, Daniel, J. , OTTEN, Thomas , WALKER, Donald, G. , ABDEL-MAGID, Abdel
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D213/51
摘要： The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R 1 , R 2 , R 3 and R 4 are as defined in the specification below.The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).
摘要翻译：本发明涉及制备通式（I）的四取代咪唑衍生物的方法，其中R 1，R 2，R 3和R 4如下面的说明书所定义。本发明还涉及制备式（II）化合物和式（II）化合物的新结晶结构的方法。

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