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1. 发明申请

WO01036371A1 CARBONIC ACID DERIVATIVES AND THEIR USE AS ECTOPARASITICIDAL COMPOSITION 审中-公开
标题翻译：碳酸衍生物及其作为ECTOPARASIIDIDAL组合物的用途
公开(公告)号：WO01036371A1
公开(公告)日：2001-05-25
申请号：PCT/EP2000/011470
申请日：2000-11-17
IPC分类号： C07C69/65 , C07C69/96 , C07C233/20 , C07C255/45 , C07C255/55 , C07C257/08 , A01N33/00 , A01N37/06
CPC分类号： C07C69/96 , C07C69/65 , C07C233/20 , C07C255/45 , C07C255/55 , C07C257/08
摘要： There are described new compounds of formula (I) wherein, when n is 0, at least one of the two phenyl rings is substituted; R1 and R2 are each independently of the other hydrogen, halogen, cyano, nitro, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4 haloalkoxy or benzyl; A is oxygen, sulfur or -N(R6)-, wherein R6 is C1-4alkyl, phenylthio or tolylthio; B is -C(O)-, -O-C(O)- or -C(N-R6)-, wherein n is 0 or 1 and R6 is hydrogen of C1-4alkyl; p is an integer from 1 to 10; R3, R4 and R5 are each independently of the others hydrogen, halogen, cyano, nitro, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy or C1-4haloalkoxy; or R3 and R4 are adjacent to one another and together with the phenyl ring to which they are bonded form a naphthyl group; m is 0, 1, 2 or 3; and Z is C1-6 alkyl, phenyl or halogen; in free form or in the form of physiologically tolerable salts. Also described is the preparation of those substances and their use in controlling ectoparasites on domestic animals, productive livestock and pets, as well as ectoparasiticidal compositions for use on such animals.
摘要翻译：描述了新的式（I）化合物，其中当n为0时，两个苯环中的至少一个被取代; R 1和R 2各自独立地为氢，卤素，氰基，硝基，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基，C 1-4卤代烷氧基或苄基; A是氧，硫或-N（R6） - ，其中R6是C1-4烷基，苯硫基或甲苯基硫基; B是-C（O） - ， - O-C（O） - 或-C（N-R6） - ，其中n是0或1，R6是C1-4烷基的氢; p是1至10的整数; R 3，R 4和R 5各自独立地为氢，卤素，氰基，硝基，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基或C 1-4卤代烷氧基; 或者R 3和R 4彼此相邻并与它们所键合的苯环一起形成萘基; m为0,1,2或3; Z为C 1-6烷基，苯基或卤素; 以游离形式或以生理上可耐受的盐的形式。还描述了这些物质的制备及其在控制家畜，生产性家畜和宠物中的外寄生物的用途以及用于这些动物的杀寄生虫杀伤组合物。

2. 发明申请

WO1995024381A1 CYANO COMPOUNDS AND PREPARATIONS THEREOF 审中-公开
标题翻译：氰化合物及其制备方法
公开(公告)号：WO1995024381A1
公开(公告)日：1995-09-14
申请号：PCT/US1995002965
申请日：1995-03-08
申请人： SMITHKLINE BEECHAM CORPORATION , BORDAS-NAGY, Joseph , GORYCKI, Peter , WEBB, Kevin, Scott
发明人： SMITHKLINE BEECHAM CORPORATION
IPC分类号： C07C253/30
CPC分类号： C07C253/30 , C07C255/45 , C07C2601/08 , C07C2601/14
摘要： This invention relates to compounds of formula (I) which are useful as PDE IV inhibitors and for treating diseases related thereto.
摘要翻译：本发明涉及可用作PDE IV抑制剂并用于治疗与之相关疾病的式（I）化合物。

3. 发明申请

WO2010010174A1 1,1'-DIADAMANTYL CARBOXYLIC ACIDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE 审中-公开
标题翻译： 1,1'-DIADAMANTYL CARBOXYLIC ACIDS，含有这些化合物的药物及其使用
公开(公告)号：WO2010010174A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059573
申请日：2009-07-24
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , ECKHARDT, Matthias , HAMILTON, Bradford, S. , HIMMELSBACH, Frank
发明人： ECKHARDT, Matthias , HAMILTON, Bradford, S. , HIMMELSBACH, Frank
IPC分类号： C07C229/46 , C07C233/58 , C07C233/60 , C07C255/47 , C07C259/08 , C07C261/04 , C07C271/24 , C07C62/06 , C07C62/38 , C07C69/00 , C07C69/753 , C07D217/04 , A61K31/19 , A61P3/04 , A61P3/10
CPC分类号： C07D295/185 , C07C62/06 , C07C62/38 , C07C69/00 , C07C69/753 , C07C211/35 , C07C233/32 , C07C233/57 , C07C233/58 , C07C233/60 , C07C255/45 , C07C271/24 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D209/08 , C07D209/44 , C07D211/56 , C07D213/64 , C07D217/04 , C07D223/16 , C07D235/16 , C07D239/74 , C07D241/04 , C07D257/04 , C07D263/56 , C07D271/06
摘要： The present invention relates to compounds defined by formula (I) wherein the group R is defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases.
摘要翻译：本发明涉及由式（I）定义的化合物，其中基团R如权利要求1所定义，具有有价值的药理学活性。特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制如代谢疾病影响的疾病。

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