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1. 发明申请

WO2016038194A1 VACCINE FOR USE IN PROTECTING A PIG AGAINST PORCINE ENDEMIC DIARRHEA VIRUS 审中-公开
标题翻译：用于保护PIGCINE内分泌病毒的疫苗的疫苗
公开(公告)号：WO2016038194A1
公开(公告)日：2016-03-17
申请号：PCT/EP2015/070849
申请日：2015-09-11
申请人： INTERVET INTERNATIONAL B.V. , INTERVET INC. , UNIVERSITEIT UTRECHT HOLDING B.V.
发明人： BORN VAN DEN, Erwin , BOSCH, Berend, Jan , ROTTIER, Peter
IPC分类号： A61K39/215 , C07K14/165 , A61K39/39
CPC分类号： A61K39/225 , A61K39/215 , A61K39/39 , A61K2039/5252 , A61K2039/545 , A61K2039/552 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , C07K14/08 , C07K14/165 , C07K16/10 , C12N7/00 , C12N2770/20034
摘要： The invention pertains to a vaccine for use in protecting a pig against an infection with porcine endemic diarrhea virus (PEDV), the vaccine comprising non-live PEDV antigen and a non-metabolizable oil containing adjuvant, wherein the total amount of oil in the vaccine is less than 50% v/v, by administration of a dose of the antigen corresponding to at least 3.0E6 TCID50 killed whole PEDV. The invention also pertains to a method of protecting a pig against an infection with porcine endemic diarrhea virus.
摘要翻译：本发明涉及一种用于保护猪免受猪流行性腹泻病毒（PEDV）感染的疫苗，该疫苗包含非活性PEDV抗原和不含代谢油的佐剂，其中疫苗中的总油量通过给予相当于至少3.0E6 TCID50的全部PEDV的抗原剂量，小于50％v / v。本发明还涉及一种保护猪免受猪流行性腹泻病毒感染的方法。

2. 发明申请

WO2016007955A1 INACTIVATED VACCINE FOR PORCINE EPIDEMIC DIARRHEA VIRUS (PEDV) 审中-公开
标题翻译： PORCINE EPIDEMIC DIARRHEA VIRUS灭活疫苗（PEDV）
公开(公告)号：WO2016007955A1
公开(公告)日：2016-01-14
申请号：PCT/US2015040181
申请日：2015-07-13
申请人： MERIAL INC
发明人： ANBALAGAN SRIVISHNUPRIYA , COLLIN EMILY , HAUSE BENJAMIN MATTHEW
IPC分类号： A61K39/225 , C07K14/08 , C12N7/06
CPC分类号： A61K39/215 , A61K39/225 , A61K2039/5252 , C12N7/00 , C12N2770/18034 , C12N2770/18071 , C12N2770/20021 , C12N2770/20034
摘要： The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing inactivated PEDV. The invention also encompasses epitopes or immunogens which can be used to protect porcine animals against PEDV.
摘要翻译：本发明包括猪流行性腹泻病毒（PEDV）疫苗或组合物。疫苗或组合物可以是含有灭活的PEDV的疫苗或组合物。本发明还包括可用于保护猪动物免受PEDV的表位或免疫原。

3. 发明申请

WO2015179412A1 RECOMBINANT SPIKE PROTEIN SUBUNIT BASED VACCINE FOR PORCINE EPIDEMIC DIARRHEA VIRUS (PEDV) 审中-公开
标题翻译：用于PORCINE EPIDEMIC DIARRHEA VIRUS（PEDV）的重组SPIKE蛋白亚基疫苗
公开(公告)号：WO2015179412A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/031596
申请日：2015-05-19
申请人： MERIAL, INC.
发明人： LAWRENCE, Paulraj , BEY, Russell
IPC分类号： A61K39/12 , A61K39/215
CPC分类号： A61K39/215 , A61K39/225 , A61K2039/5256 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/14041 , C12N2770/20034
摘要： The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.
摘要翻译：本发明包括猪流行性腹泻病毒（PEDV）疫苗或组合物。疫苗或组合物可以是含有PEDV抗原的疫苗或组合物。本发明还包括编码和表达可用于保护猪动物抵抗PEDV的PEDV抗原，表位或免疫原的重组载体。

4. 发明申请

WO02092827A2 CORONA-VIRUS-LIKE PARTICLES COMPRISING FUNCTIONALLY DELETED GENOMES 审中-公开
标题翻译：包含功能性删除基因的COR A病毒颗粒
公开(公告)号：WO02092827A2
公开(公告)日：2002-11-21
申请号：PCT/NL0200318
申请日：2002-05-17
申请人： UNIV UTRECHT , STICHTING TECH WETENSCHAPP , ROTTIER PETRUS JOSEPHUS MARIE , DE HAAN CORNELIS ALEXANDER MAR , HAIJEMA BERT JAN , BOSCH BEREND JAN
发明人： ROTTIER PETRUS JOSEPHUS MARIE , DE HAAN CORNELIS ALEXANDER MAR , HAIJEMA BERT JAN , BOSCH BEREND JAN
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K39/215 , A61K39/225 , A61K39/395 , A61K48/00 , A61K49/00 , A61P1/16 , A61P7/00 , A61P7/04 , A61P7/06 , A61P11/00 , A61P31/00 , A61P31/12 , A61P31/16 , A61P31/20 , A61P31/22 , A61P35/02 , A61P37/04 , C07K14/165 , C12N5/06 , C12N5/16 , C12N7/00 , C12N7/04 , C12N15/86 , C12P21/06 , C12Q1/68 , C12Q1/70 , G01N33/569
CPC分类号： A61K39/215 , A61K38/00 , A61K39/12 , A61K39/225 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/12034 , C12N2710/16034 , C12N2740/13034 , C12N2750/14334 , C12N2760/16034 , C12N2770/20021 , C12N2770/20022 , C12N2770/20023 , C12N2770/20034 , C12N2770/20043 , C12N2800/204 , G01N33/56983 , G01N2333/165
摘要： The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. The invention provides replicative coronaviruses and replicative virus-like particles (VLPs) from which large parts of their genome are (at least functionally) deleted without abolishing their replicative capacities. Said deletion is preferably resulting in at least a functional deletion in that the corresponding gene is not or only partly expressed whereby the resulting gene product is dysfunctional or at least functionally distinct from a corresponding wild-type gene product. One striking result seen with VLPs provided with deletions as provided herein is that said deleted VLP, albeit capable of replication in vitro and in vivo, are in general well attenuated, in that they do not cause disease in the target host, making them very suitable for therapeutic use, said as a delivery vehicle for genes and other cargo (whereby specific targeting may be provided as well when desired), and for use as a vaccine, being attenuated while carrying important immunogenic determinants that help elicit an immune response.
摘要翻译：本发明涉及冠状病毒和诊断领域，治疗用途及其衍生的疫苗。本发明提供复制性冠状病毒和复制病毒样颗粒（VLP），其基因组的大部分（至少在功能上）被删除，而不消除其复制能力。所述缺失优选导致至少一个功能缺失，因为相应的基因不是或仅部分表达，由此得到的基因产物在相应的野生型基因产物中功能失调或至少在功能上是不同的。如本文提供的具有缺失的VLP所见到的一个引人注目的结果是所述缺失的VLP虽然在体外和体内都能复制，但通常很好地减弱，因为它们不会在靶宿主中引起疾病，使得它们非常合适被称为用于基因和其他货物的递送载体（因此，当需要时也可以提供特异性靶向），并且用作疫苗，同时减毒，同时携带有助于引发免疫应答的重要的免疫原性决定簇。

5. 发明申请

WO01039797A2 INFECTIOUS CLONES 审中-公开
标题翻译：感染性克隆
公开(公告)号：WO01039797A2
公开(公告)日：2001-06-07
申请号：PCT/EP2000/012063
申请日：2000-11-30
IPC分类号： C12N15/09 , A61K35/74 , A61K35/76 , A61K39/00 , A61K39/225 , A61K39/395 , A61K48/00 , A61P1/00 , A61P11/00 , A61P29/00 , A61P31/00 , A61P31/12 , C07K14/08 , C12N1/21 , C12N7/00 , C12N7/04 , C12N15/50 , C12N15/70 , C12N15/86
CPC分类号： C12N7/00 , A61K39/12 , A61K39/225 , A61K2039/525 , A61K2039/5256 , A61K2039/53 , A61K2039/541 , C07K14/005 , C12N15/70 , C12N15/86 , C12N2770/20034 , C12N2770/20043 , C12N2770/20062 , C12N2800/204 , C12N2800/80
摘要： The present invention relates to methods of preparing a DNA comprising steps, wherein (a) a DNA comprising a full length copy of the genomic RNA (gRNA) or an RNA virus; or (b) a DNA comprising one or several fragments of a gRNA of an RNA virus, which fragments code for an RNA dependent RNA polymerase and at least one structural or non-structural protein; or (c) a DNA having a homology of at least 60% to the sequences of (a) or (b); is cloned into a bacterial artificial chromosome (BAC). Additionally, DNAs are provided, which comprise sequences derived from the genomic RNA (gRNA) of a coronavirus which sequences have a homology of at least 60% to the natural sequence of the virus and code for an RNA dependent RNA polymerase and at least one structural or no-structural protein, wherein a fragment of said DNA is capable of being transcribed into RNA which RNA can be assembled to a virion. Further, the use of these nucleic acids for preparation of viral RNA or virions as well as pharmaceutical preparations comprising these DNAs, viral RNAs or virions is disclosed.
摘要翻译：本发明涉及制备DNA的方法，包括步骤，其中（a）包含基因组RNA（gRNA）或RNA病毒的全长拷贝的DNA; 或（b）包含RNA病毒的gRNA的一个或几个片段的DNA，其对于RNA依赖性RNA聚合酶和至少一种结构或非结构蛋白的片段编码; 或（c）与（a）或（b）的序列具有至少60％的同源性的DNA; 被克隆到细菌人造染色体（BAC）中。此外，提供了DNA，其包含衍生自冠状病毒的基因组RNA（gRNA）的序列，该序列与病毒的天然序列具有至少60％的同源性，并编码RNA依赖性RNA聚合酶和至少一种结构或无结构蛋白，其中所述DNA的片段能够被转录成RNA，所述RNA可以组装成病毒粒子。此外，公开了使用这些核酸来制备病毒RNA或病毒粒子以及包含这些DNA，病毒RNA或病毒粒子的药物制剂。

6. 发明申请

WO2018188639A1 猪流行性腹泻病毒S蛋白及其亚单位疫苗及其制备方法和应用审中-公开
公开(公告)号：WO2018188639A1
公开(公告)日：2018-10-18
申请号：PCT/CN2018/082908
申请日：2018-04-13
申请人：浙江海隆生物科技有限公司
发明人：钱泓 , 吴有强 , 卞广林 , 张强 , 徐玉兰 , 白志军 , 吴素芳 , 车影 , 吕洋萍 , 查银河
IPC分类号： C07K14/17 , A61K39/225 , A61K38/16 , A61P1/12
CPC分类号： A61K38/16 , A61K39/225 , A61P1/12 , C07K14/17
摘要：本发明提供了一种猪流行性腹泻病毒S蛋白以及亚单位疫苗及其制备方法和应用。该疫苗包含30～200μg重组猪流行性腹泻病毒S蛋白以及药学上可接受的ISA 201 VG佐剂。制备方法包括以下步骤：(1)重组猪流行性腹泻病毒S蛋白基因的克隆；(2) S蛋白的表达和纯化；(3)将纯化后的S蛋白制备成水相；(4)将水相与ISA 201 VG佐剂按照体积比46:54的比例乳化，得到疫苗。该疫苗成功构建并筛选了悬浮稳定高效表达PEDV-S蛋白的CHO细胞株，该细胞株表达PEDV-S蛋白的产量能够达到1g/L。

7. 发明申请

WO2016126853A1 VACCINES FOR PORCINE EPIDEMIC DIARRHEA VIRUS INFECTIONS 审中-公开
标题翻译： PORCINE EPIDEMIC DIARRHEA病毒感染疫苗
公开(公告)号：WO2016126853A1
公开(公告)日：2016-08-11
申请号：PCT/US2016/016417
申请日：2016-02-03
申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
发明人： CHANG, Kyeong-Ok , KIM, Yunjeong , HESSE, Richard
IPC分类号： A61K39/215 , A61K39/225 , A61K39/12
CPC分类号： A61K39/225 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2770/18034
摘要： Isolated porcine epidemic diarrhea virus (PEDV) deposited under ATCC Accession No. PTA-121847, and attenuated strains generated by serial passage in culture of the deposited strain. Immunogenic compositions for reducing the incidence or severity of clinical symptoms from PEDV infection, and methods of making and using the same.
摘要翻译：以ATCC登录号PTA-121847保藏的分离的猪流行性腹泻病毒（PEDV）和通过连续传代在沉积菌株的培养中产生的减毒菌株。用于降低PEDV感染的临床症状的发生率或严重程度的免疫原性组合物及其制备和使用方法。

8. 发明申请

WO1984001290A1 LECTIN-CONTAINING ANTI-VIRAL VACCINES FOR DOMESTIC ANIMALS AND METHOD OF PREPARATION 审中-公开
标题翻译：含国内动物的反病毒疫苗及其制备方法
公开(公告)号：WO1984001290A1
公开(公告)日：1984-04-12
申请号：PCT/US1983001457
申请日：1983-09-23
申请人： IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
发明人： IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , GOUGH, Patricia, Marie , PLATT, Kenneth, B.
IPC分类号： A61K39/12
CPC分类号： A61K39/39 , A61K39/12 , A61K39/225 , A61K39/245 , A61K2039/525 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , C12N2710/16734 , C12N2770/20034
摘要： Anti-viral vaccines for domestic animals are prepared from glycoprotein envelope whole virus or antigenic glycoprotein obtained therefrom by complexing the glycoprotein antigenic agent with a lectin, which is preferably a mitogenic lectin. The recovery of the immunizing agent from an aqueous solution or suspension is facilitated since the lectin-glycoprotein complex is readily recoverable. The mitogenic lectin administered in the vaccine with the glycoprotein antigen can enhance the anamnestic response, in effect, acting as an adjuvant.

9. 发明申请

WO2015124594A1 SWINE VIRUS VACCINES THAT ARE LIQUID STABLE 审中-公开
标题翻译：蛇毒疫苗，液体稳定
公开(公告)号：WO2015124594A1
公开(公告)日：2015-08-27
申请号：PCT/EP2015/053364
申请日：2015-02-18
申请人： INTERVET INTERNATIONAL B.V. , INTERVET INC.
发明人： O'CONNELL, Kevin , QIAO, Zhisong , EDDY, Brad , STRAIT, Erin
IPC分类号： A61K39/12
CPC分类号： A61K47/26 , A61K9/0019 , A61K39/12 , A61K39/145 , A61K39/225 , A61K47/183 , A61K47/32 , A61K2039/5254 , A61K2039/552 , C12N2760/16034 , C12N2770/10034 , C12N2770/20034
摘要： The present invention is drawn to liquid stable swine vaccines that comprise a live porcine virus. The invention is also drawn to the manufacture of such vaccines and methods of vaccinating animal subjects with these vaccines.
摘要翻译：本发明涉及包含活猪病毒的液体稳定的猪疫苗。本发明还涉及这些疫苗的制造和用这些疫苗接种动物受试者的方法。

10. 发明申请

WO2005063801A2 CORONA-VIRUS-LIKE PARTICLES COMPRISING FUNCTIONALLY DELETED GENOMES 审中-公开
标题翻译：包含功能性删除基因的COR A病毒颗粒
公开(公告)号：WO2005063801A2
公开(公告)日：2005-07-14
申请号：PCT/NL2004/000924
申请日：2004-12-30
申请人： Universiteit Utrecht Holding B.V. , Universiteit Utrecht , ROTTIER, Petrus, Josephus, Marie , BOSCH, Berend, Jan
发明人： ROTTIER, Petrus, Josephus, Marie , BOSCH, Berend, Jan
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/215 , A61K39/225 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , C07K16/10 , C12N7/00 , C12N15/86 , C12N2770/20021 , C12N2770/20022 , C12N2770/20023 , C12N2770/20034 , C12N2800/204 , G01N33/56983 , G01N2333/165
摘要： The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. Methods are shown for at least in part inhibiting anti-parallel coiled coil formation of a coronavirus spike protein comprising decreasing the contact between heptad repeat regions of said protein. The invention provides a peptide comprising a heptad repeat region of a corona viral spike protein and/or a functional fragment and/or an derivative thereof. The invention also provides antibodies and compounds inhibiting corona viral infection of cells, and/or cell-to-cell fusion. The invention also discloses heptad repeat regions and a fusion peptide of SARS-CoV.
摘要翻译：本发明涉及冠状病毒和诊断领域，治疗用途及其衍生的疫苗。显示了至少部分抑制冠状病毒尖峰蛋白的抗平行线圈形成的方法，包括减少所述蛋白质的七重复区域之间的接触。本发明提供了包含电晕病毒尖峰蛋白和/或其功能片段和/或其衍生物的七重复重复区的肽。本发明还提供了抑制细胞的电晕病毒感染和/或细胞与细胞融合的抗体和化合物。本发明还公开了七倍体重复区和SARS-CoV的融合肽。

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