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1. 发明申请

WO2016139625A1 COMPOSITIONS FOR USE IN THE TREATMENT OF TUMORS RESISTANT TO CHEMOTHERAPY 审中-公开
标题翻译：用于治疗抗肿瘤的肿瘤的组合物
公开(公告)号：WO2016139625A1
公开(公告)日：2016-09-09
申请号：PCT/IB2016/051216
申请日：2016-03-04
申请人： PROBIOTICAL S.P.A.
发明人： MOGNA, Giovanni
IPC分类号： A61K31/136 , A61K31/337 , A61K31/365 , A61K31/4741 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K36/28 , A61K36/29 , A61K36/66 , A61P35/00
CPC分类号： A61K36/28 , A61K31/136 , A61K31/337 , A61K31/365 , A61K31/4741 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K36/29 , A61K36/66 , A61K2300/00
摘要： The present invention relates to the use of at least one flavonoid of natural or synthetic origin in association with cyclophosphamide and/or methotrexate to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors, in particular in case of resistance to the chemotherapeutic agents currently in use; said at least one flavonoid is selected from the group comprising or, alternatively, consisting of rutin, oxerutin, diosmin, troxerutin and hesperidin.
摘要翻译：本发明涉及与环磷酰胺和/或甲氨蝶呤联合使用的至少一种天然或合成来源的类黄酮，以增加人和兽医用于治疗肿瘤的化学治疗的有效性，特别是在抗药性的情况下涉及目前使用的化学治疗剂; 所述至少一种类黄酮选自包含或替代地由芦丁，氧尿素，二糖苷，曲塞菌素和橙皮苷组成的组。

2. 发明申请

WO2015149393A1 一种治疗慢性胃炎的中药及其制备方法审中-公开
公开(公告)号：WO2015149393A1
公开(公告)日：2015-10-08
申请号：PCT/CN2014/075340
申请日：2014-04-15
申请人：袁志贤
发明人：袁志贤
IPC分类号： A61K36/9064 , A61K36/8994 , A61K36/899 , A61K36/898 , A61K36/8905 , A61K36/889 , A61K36/752 , A61K36/704 , A61K36/66 , A61K36/539 , A61K36/535 , A61K36/53 , A61K36/488 , A61K36/284 , A61K36/28 , A61K36/236 , A61K36/185 , A61P1/04
CPC分类号： A61K36/185 , A61K36/236 , A61K36/284 , A61K36/48 , A61K36/488 , A61K36/53 , A61K36/535 , A61K36/539 , A61K36/66 , A61K36/704 , A61K36/71 , A61K36/752 , A61K36/889 , A61K36/8905 , A61K36/898 , A61K36/899 , A61K36/8994 , A61K36/9064 , A61K2300/00 , A61K36/536
摘要：一种治疗慢性胃炎的中药及其制备方法，该制剂是由广藿香、紫苏叶、白术、大腹皮、甘葛、苍术、白蒺藜、豆蔻、枳实、香附、川芎、橘皮、虎杖、元胡、薏苡仁、黄芩、大血藤、白芨和小米经过粉碎、煎煮、乙醇提取及混合等工序制备成的液态制剂。

3. 发明申请

WO2015142611A1 PRE-OPERATIVE BEVERAGES 审中-公开
标题翻译：营养饮料
公开(公告)号：WO2015142611A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/020133
申请日：2015-03-12
申请人： SANTÉ, LLC
发明人： POPITZ, Michael
IPC分类号： A01N43/04
CPC分类号： A61K9/0095 , A23L2/38 , A23L2/385 , A23L2/39 , A23L2/52 , A23L2/56 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/28 , A61K36/288 , A61K36/48 , A61K36/534 , A61K36/54 , A61K36/63 , A61K36/66 , A61K36/73 , A61K36/752 , A61K36/88 , A61K36/899 , A61K36/9064 , A61K36/9068 , A61K2300/00
摘要： The invention provides a formulated beverage composition that can be administered to a patient, prior to anesthesia, sedation and/or surgical or dental operation, to reduce the risk of aspiration pneumonia while simultaneously improving the well-being of the patient. The beverage composition is designed to be taken orally, by a patient, within a specified short period of time prior to administration of an anesthesia and/or sedative/analgesic. Further described herein is the method of using the beverage composition. The method may include providing a written label of instructions affixed to the beverage container which instructions positively direct the patient's ingestion of the beverage composition.
摘要翻译：本发明提供配制的饮料组合物，其可以在麻醉，镇静和/或手术或牙科手术之前施用于患者，以减少吸入性肺炎的风险，同时改善患者的健康。饮料组合物被设计成在施用麻醉和/或镇静/镇痛之前的特定短时间内由患者口服。本文进一步描述的是使用饮料组合物的方法。该方法可以包括提供固定到饮料容器的指令的书签标签，该指令积极地指导患者对饮料组合物的摄取。

4. 发明申请

WO2013106068A3 THERAPEUTIC COMPOSITIONS OF SPECIFIED HERBAL FORMULATIONS AND USES THEREOF 审中-公开
标题翻译：指定草药制剂的治疗组合物及其用途
公开(公告)号：WO2013106068A3
公开(公告)日：2014-01-09
申请号：PCT/US2012037974
申请日：2012-05-15
申请人： HAUS BIOCEUTICALS INC , YESUDAS TOMY , ALEX PHILIP , CENTOLA MICHAEL , PAYNE ADAM JOSHUA
发明人： YESUDAS TOMY , ALEX PHILIP , CENTOLA MICHAEL , PAYNE ADAM JOSHUA
IPC分类号： A61K36/185 , A61K36/22 , A61K36/23 , A61K36/24 , A61K36/28 , A61K36/29 , A61K36/31 , A61K36/35 , A61K36/48 , A61K36/49 , A61K36/66 , A61K36/71 , A61K36/76 , A61K36/80 , A61K36/808 , A61K36/899 , A61K36/90 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/02 , A61P43/00
CPC分类号： A61K36/90 , A61K36/185 , A61K36/22 , A61K36/23 , A61K36/24 , A61K36/27 , A61K36/28 , A61K36/29 , A61K36/31 , A61K36/35 , A61K36/48 , A61K36/66 , A61K36/68 , A61K36/71 , A61K36/76 , A61K36/77 , A61K36/808 , A61K36/899 , A61K2300/00
摘要： Disclosed herein are herbal formulations developed for the management of acute and chronic inflammatory conditions and infectious diseases. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.
摘要翻译：本文公开的是用于治疗急性和慢性炎性病症和感染性疾病的草药制剂。制剂还可以与活性或非活性药物成分和/或药学上可接受的赋形剂组合。

5. 发明申请

WO2013027245A1 インフルエンザウイルス感染抑制剤审中-公开
标题翻译：流感病毒感染抑制剂
公开(公告)号：WO2013027245A1
公开(公告)日：2013-02-28
申请号：PCT/JP2011/004701
申请日：2011-08-24
申请人：株式会社ロッテ , 石塚智和 , 清野宏 , 國澤純 , 吉田圭司郎 , 志村進
发明人：石塚　智和 , 清野　宏 , 國澤　純 , 吉田　圭司郎 , 志村　進
IPC分类号： A61K36/18 , A23L1/30 , A61P31/16
CPC分类号： A61K36/66 , A21D2/36 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2200/00 , A61K2236/00 , A23V2200/324 , A23V2250/21
摘要：　インフルエンザウイルスの感染抑制効果を有する組成物の提供。ヒナゲシを水を用いて、抽出し、その抽出液を凍結乾燥して精製することにより得た抽出物を有効成分とすることを特徴とする抗インフルエンザウイルス剤。　
摘要翻译：提供对流感病毒感染具有抑制作用的组合物。一种抗流感病毒剂，其特征在于，含有通过用水提取罂粟植物而产生的提取物作为活性成分，然后冻干所述提取物，从而净化所述提取物。

6. 发明申请

WO2008012666A2 METHODS FOR TREATING AND PREVENTING MUCOSITIS 审中-公开
标题翻译：治疗和预防肌瘤的方法
公开(公告)号：WO2008012666A2
公开(公告)日：2008-01-31
申请号：PCT/IB2007002147
申请日：2007-07-27
申请人： INDENA SPA , BOMBARDELLI EZIO , MORAZZONI PAOLO
发明人： BOMBARDELLI EZIO , MORAZZONI PAOLO
IPC分类号： A61K31/352 , A61K31/7048 , A61K36/45 , A61K36/66 , A61K36/87 , A61P1/04
CPC分类号： A61K31/7048 , A61K31/352 , A61K36/28 , A61K36/45 , A61K36/51 , A61K36/66
摘要： Methods for treating and preventing mucositis, in particular mucositis following the administration of chemotherapy drugs or a combination of said drugs with radiotherapy, are disclosed herein. More specifically, disclosed herein is the administration of a therapeutically effective amount of at least one of an anthocyanoside, a proanthocyanidin, or an extract containing at least one of an anthocyanoside or a proanthocyanidin for the treatment or prevention of mucositis. The therapeutically effective amount of the anthocyanoside, proanthocyanidin or extract can be administered alone or in combination with a therapeutically effective amount of at least one of an anti¬ inflammatory agent, immunomodulating agent, analgesic, antimicrobial agent or antifungal agent. Also disclosed herein are pharmaceutical compositions for treating and preventing mucositis.
摘要翻译：在本文中公开了治疗和预防粘膜炎，特别是在施用化疗药物或所述药物与放射疗法的组合之后的粘膜炎的方法。更具体地，本文公开了施用治疗有效量的花青素，原花青素或含有花色素苷或原花青素中的至少一种的提取物中的至少一种，用于治疗或预防粘膜炎。花色素苷，原花色素或提取物的治疗有效量可以单独施用或与治疗有效量的抗炎剂，免疫调节剂，止痛剂，抗微生物剂或抗真菌剂中的至少一种组合施用。本文还公开了用于治疗和预防粘膜炎的药物组合物。

7. 发明申请

WO2006047279A3 IN SITU CONTROLLED RELEASE DRUG DELIVERY SYSTEM 审中-公开
标题翻译：原位控制释放药物递送系统
公开(公告)号：WO2006047279A3
公开(公告)日：2006-08-10
申请号：PCT/US2005037872
申请日：2005-10-21
申请人： UNIV IOWA RES FOUND , LIM TAE-HONG , PARK JOON B , LEE JIN WHAN
发明人： LIM TAE-HONG , PARK JOON B , LEE JIN WHAN
IPC分类号： A61F2/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/1647 , A61K9/5031 , A61K9/5084 , A61K31/137 , A61K31/192 , A61K31/439 , A61K31/44 , A61K31/445 , A61K31/4741 , A61K31/485 , A61K31/55 , A61K31/60 , A61K31/606 , A61K31/655 , A61K36/66 , A61K45/06 , A61K47/36
摘要： A system is described for long-term controlled release delivery of a drug or a therapeutic agent. According to the invention, one or more drugs or therapeutic agents contained in microspheres are mixed with a temperature sensitive hydrogel which is then introduced directly to the desired situs of the drug or therapeutic agent. The temperature sensitive hydrogel may also contain a drug or a therapeutic agent, for example, a pain relieving drug, for a short-term controlled release. The temperature sensitive hydrogel is in liquid state at room temperature, but upon injection, shortly becomes gelatinous. This system is particularly suitable for treatment of diseases, disorders, or conditions, for example, tumors, discogenic back pain, or arthritis, warranting localized administration of a drug or a therapeutic agent. In addition, the specification provides a method for production of a drug- or therapeutic agent-containing microspheres.
摘要翻译：描述了用于长期控制释放递送药物或治疗剂的系统。根据本发明，包含在微球体中的一种或多种药物或治疗剂与温度敏感性水凝胶混合，然后将其直接引入药物或治疗剂的所需部位。温度敏感性水凝胶还可以含有药物或治疗剂，例如止痛药，用于短期控制释放。温度敏感性水凝胶在室温下为液态，但注射后很快变成凝胶状。该系统特别适用于治疗疾病，病症或病症，例如肿瘤，致discogenic背痛或关节炎，需要局部给药药物或治疗剂。另外，说明书提供了用于生产含有药物或治疗剂的微球体的方法。

8. 发明申请

WO2006063716A1 COMPOSITIONS COMPRISING EXTRACTS FROM SANGUINARIA OR MACLEAYA 审中-公开
标题翻译：包含从SANGUINARIA或MACLEAYA提取物的组合物
公开(公告)号：WO2006063716A1
公开(公告)日：2006-06-22
申请号：PCT/EP2005/013047
申请日：2005-12-06
申请人： INDENA S.P.A. , BOMBARDELLI, Ezio , RONCHI, Massimo , DI NICOLO, Paola
发明人： BOMBARDELLI, Ezio , RONCHI, Massimo , DI NICOLO, Paola
IPC分类号： A61K36/00
CPC分类号： A61K31/47 , A61K36/28 , A61K36/66 , A61K36/758 , A61K2300/00
摘要： Compositions containing: 1. Anthocyanosides, and/or 2. Procyanidins, 3. Isoquinoline alkaloids extracted from Sanguinaria canadensis, Macleaya cordata or Macleaya microcarpa, and optionally 4. a Zanthoxylum bungeanum and/or Echinacea angustifolia lipophilic extract.
摘要翻译：含有：花青素和/或原花青素的组合物，3.从加拿大血统，马鞭草或马鞭草微藻提取的异喹啉生物碱，以及任选的花椒（Zanthoxylum bungeanum）和/或紫锥菊（Echinacea angustifolia）亲脂性提取物。

9. 发明申请

WO2005002608A1 HERBAL COMPOSITION 审中-公开
标题翻译：草本成分
公开(公告)号：WO2005002608A1
公开(公告)日：2005-01-13
申请号：PCT/AU2004/000895
申请日：2004-07-02
申请人： HILTERMAN, Karina, Anna
发明人： HILTERMAN, Karina, Anna
IPC分类号： A61K35/78
CPC分类号： A61K36/28 , A61K36/13 , A61K36/185 , A61K36/48 , A61K36/66 , A61K36/86 , A61K2300/00
摘要： The invention relates to a herbal composition comprising extracts from Thuja, Poke, Sweet violet, Red clover, Greater celandine and Calendula; formulations containing the herbal composition; and use of the herbal composition for preventing and/or treating skin conditions and/or abnormalities.
摘要翻译：本发明涉及一种草药组合物，其中含有从Thuja，Poke，甜紫，红三叶草，大白ine和金盏花提取物; 含有草药组合物的制剂; 以及使用草药组合物来预防和/或治疗皮肤病症和/或异常。

10. 发明申请

WO03057133A9 HERBAL COMPOSITION FOR TREATING VARIOUS DISORDERS INCLUDING PSORIASIS, A PROCESS FOR PREPARATION THEREOF AND METHOD FOR TREATMENT OF SUCH DISORDERS 审中-公开
标题翻译：用于治疗各种疾病的草本组合物，包括PSORIASIS，其制备方法和用于治疗这种疾病的方法
公开(公告)号：WO03057133A9
公开(公告)日：2004-08-12
申请号：PCT/IN0300008
申请日：2003-01-10
申请人： LUPIN LTD , ARORA SUDERSHAN K , NARENDAR SANGANABHATLA , SRIVASTAVA VANDITA , SARAF DINESH BALAKRISHNA , GUPTA LAVLEEN KUMAR
发明人： ARORA SUDERSHAN K , NARENDAR SANGANABHATLA , SRIVASTAVA VANDITA , SARAF DINESH BALAKRISHNA , GUPTA LAVLEEN KUMAR
IPC分类号： A61K9/06 , A61K20060101 , A61K9/08 , A61K9/10 , A61K9/20 , A61K9/48 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/66 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40 , A61K47/44 , A61P1/04 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P37/02 , A61P37/08 , A61P43/00 , A61K35/78
CPC分类号： A61K36/23 , A61K36/66 , A61K2300/00
摘要： The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum, which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, NEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.
摘要翻译：本发明提供了一种新颖的草药组合物，其含有茄科植物的叶子和/或茎的提取物，任选地含有孜然的果实的提取物，其显示出有用的体外和有趣的免疫学和药理学活性; 其制备方法; 以及通过施用所述新型草药组合物治疗牛皮癣和相关免疫学和生物学疾病的方法。茄科植物的叶子和/或茎的提取物和级分表现的有用的体外，体内和有趣的免疫学和药理学活性包括免疫抑制，淋巴细胞增殖抑制，细胞因子调节如IL-2抑制，IFNγ抑制，IL- 10诱导，角质形成细胞增殖抑制，角质酶活性，内皮细胞增殖抑制，细胞粘附分子表达的抑制，例如ICAM-1，NEST抑制和酶抑制如p60src酪氨酸激酶，已知其参与抗牛皮癣活性。新型草药组合物可用于治疗各种疾病，例如牛皮癣，包括斑块性牛皮癣，胃肠牛皮癣，脓疱性牛皮癣和指甲银屑病; 皮炎和硬皮病; 湿疹; 炎症性疾病和其他自身免疫性疾病如牛皮癣关节炎，类风湿性关节炎，克罗恩病，多发性硬化，肠易激综合征，强直性脊柱炎，系统性红斑狼疮和干燥综合征; 过敏如哮喘和慢性阻塞性肺疾病，是安全，耐受良好，无毒的，具有最小和可逆的不良反应或副作用，最重要的是，在治疗方案完成后，疾病的复发或复发最少。本发明还描述了在孜然植物的水果，乙醇或乙醇提取物中磷酸二酯酶（III，IV和V）抑制和5-脂氧合酶抑制的存在。

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