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1. 发明申请

WO2016064896A1 TISSUE SAMPLE PROCESSING SYSTEM AND ASSOCIATED METHODS 审中-公开
标题翻译：组织样品加工系统及相关方法
公开(公告)号：WO2016064896A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/056494
申请日：2015-10-20
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
发明人： GALE, Bruce, K. , CARRELL, Douglas, T. , MURPHY, Kristin , HOTALING, Jim , SON, Jiyoung
IPC分类号： C12M1/00 , A61D19/02 , C12N5/076
CPC分类号： C12M47/04 , A61B17/435 , A61D19/00 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , C12M23/16 , C12N5/0612 , G01N30/0005 , G01N2030/002
摘要： A tissue sample processing system and associated methods is disclosed and described. The tissue sample processing system (100) can include a microfluidic separating system (110). The microfluidic separating system (110) can include a fluid channel to receive a carrier fluid (104) and a tissue sample (102), and a plurality of outlets. Flow of the carrier fluid (104) and the tissue sample (102) in the fluid channel can facilitate segregation of materials in the tissue sample (102) based on size into a plurality of size fractions, such that each one of the plurality of outlets receives a different size fraction of the materials in the tissue sample. In addition, the sample processing system (100) can comprise a cryopreservation system (120) associated with at least one of the plurality of outlets to freeze the material in the tissue sample (102) associated with the at least one of the plurality of outlets.
摘要翻译：公开并描述了组织样品处理系统和相关方法。组织样品处理系统（100）可以包括微流体分离系统（110）。微流体分离系统（110）可以包括用于接收载体流体（104）和组织样品（102）的流体通道以及多个出口。流体通道中的载体流体（104）和组织样品（102）的流动可以促进基于尺寸将组织样品（102）中的材料分离成多个尺寸部分，使得多个出口接收组织样本中材料的不同尺寸分数。此外，样品处理系统（100）可以包括与多个出口中的至少一个出口相关联的冷冻保存系统（120），以冷冻与多个出口中的至少一个出口相关联的组织样品（102）中的材料。

2. 发明申请

WO2015178556A1 깊이 정보를 이용한 동물의 머리 탐지 시스템 및 그 탐지 방법 审中-公开
标题翻译：使用深度信息检测动物头的系统及其检测方法
公开(公告)号：WO2015178556A1
公开(公告)日：2015-11-26
申请号：PCT/KR2014/011603
申请日：2014-12-01
申请人： 고려대학교 산학협력단
发明人： 정용화 , 김진한 , 최동휘 , 김희곤 , 박대희 , 정연우 , 김석 , 장홍희
IPC分类号： A61D19/00
CPC分类号： A61D19/00
摘要： 본 발명은 깊이 정보를 이용한 동물의 머리 탐지 시스템 및 그 탐지 방법에 관한 것으로, 더욱 상세하게는 깊이 카메라를 이용하여 탐지공간의 깊이 정보를 획득하는 정보 획득부(100) 및 상기 정보 획득부(100)로부터 전달받은 깊이 정보를 분석하여 탐지공간 내의 동물의 머리 높이 정보를 산출하고, 상기 머리 높이 정보가 기설정된 설정값과 비교하여 상이할 경우, 동물의 승가 여부를 판단하는 판단부(200)를 포함하여 구성되는 것을 특징으로 하는 깊이 정보를 이용한 동물의 머리 탐지 시스템에 관한 것이다.
摘要翻译：本发明涉及一种使用深度信息检测动物头部的系统及其检测方法，更具体地说，涉及一种使用深度信息检测动物头部的系统，该系统包括：信息获取单元（100 ），用于使用深度摄像机获取检测空间的深度信息; 以及确定单元（200），用于通过分析从信息获取单元（100）接收的深度信息来计算在检测空间内的动物头部的高度的信息，并且当关于头部的高度的信息不同从基于比较的预定设定值，确定动物是否被安装。

3. 发明申请

WO2013122864A1 FEEDER-FREE METHOD FOR CULTURE OF BOVINE AND PORCINE SPERMATOGONIAL STEM CELLS 审中-公开
标题翻译：用于培养牛肝细胞干细胞培养物的无免费方法
公开(公告)号：WO2013122864A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/025537
申请日：2013-02-11
申请人： WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION , OATLEY, Jon Michael , OATLEY, Melissa Joan
发明人： OATLEY, Jon Michael , OATLEY, Melissa Joan
IPC分类号： C12N5/076 , A61K35/52 , C12N15/873 , C12N5/071
CPC分类号： C12N5/061 , A01K67/0271 , A01K2207/12 , A01K2227/101 , A01K2227/108 , A01K2267/02 , A61B17/425 , A61D19/00 , A61K35/52 , C12M21/00 , C12N5/0602 , C12N5/0603 , C12N5/0656 , C12N5/0683 , C12N15/873 , C12N2500/05 , C12N2500/24 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/13 , C12N2501/21 , C12N2501/727 , C12N2502/13 , C12N2502/246 , C12N2510/04 , C12N2533/90
摘要： The present invention relates to the production and culture of undifferentiated spermatogonial stem cells that can be maintained long term and are feeder free. The resultant feeder-free populations can be used in any of a number of protocols including the generation of progeny bulls. The present invention includes novel methods required for the successful enrichment of bovine spermatogonial stem cells, novel cell lines and other components used for the same, as well as the resultant stem cell compositions.
摘要翻译：本发明涉及可以长期保持并且不含饲料的未分化精原干细胞的生产和培养。所得的无饲料种群可以用于许多方案中的任一种，包括产生后代公牛。本发明包括成功富集牛精原干细胞，新型细胞系和用于其的其它组分所需的新方法，以及所得的干细胞组合物。

4. 发明申请

WO2011143752A8 USE OF AROMATASE INHIBITORS FOR SYNCHRONIZING OVULATION, INDUCING SUPEROVULATION OR DOUBLE OVULATION AND IMPROVING TWINNING AND FERTILITY IN A MAMMAL 审中-公开
标题翻译：使用芳香酶抑制剂进行同步蒸煮，诱导超滤或双重蒸发，并改善牛肉中的双重和有效性
公开(公告)号：WO2011143752A8
公开(公告)日：2012-02-16
申请号：PCT/CA2011000578
申请日：2011-05-19
申请人： UNIV SASKATCHEWAN , PIERSON ROGER , ADAMS GREGG
发明人： PIERSON ROGER , ADAMS GREGG
IPC分类号： A61K31/5575 , A61D19/02 , A61K31/4196 , A61P15/08
CPC分类号： A61K31/4196 , A61D19/00 , A61D19/02 , A61K31/5575 , A61K38/09 , A61K38/24
摘要： Described herein is the use of an aromatase inhibitor (i.e. lezotrole) for synchronizing ovulation (i.e. follicular wave emergence, ovulation) in a herd or a single mammal. Also described is the use of said aromatase inhibitor at the beginning of a follicular wave emergence for inducing multiple ovulation or improving the response to ovarian superstimulation. Treatment with aromatase inhibitor early in the follicular wave will induce follicular co-dominance and increase the incidence of double ovulation and twin pregnancy. Aromatase inhibitor treatment may be used before or soon after insemination (early estrus to early diestrus) for improving fertility in a mammal.
摘要翻译：本文描述的是使用芳香酶抑制剂（即，lezotrole）在群体或单一哺乳动物中同步排卵（即滤泡出血，排卵）。还描述了在滤泡波出现开始时所述芳香酶抑制剂用于诱导多次排卵或改善对卵巢超刺激的反应的用途。在卵泡波早期用芳香酶抑制剂治疗将诱发滤泡共同作用，并增加双排卵和双胎妊娠的发生率。芳香酶抑制剂治疗可以在授精之前或之后（早期发情到早期发情）使用，以改善哺乳动物的生育能力。

5. 发明申请

WO2010122562A9 A SPERM SEPARATION SYSTEM 审中-公开
标题翻译： SPERM分离系统
公开(公告)号：WO2010122562A9
公开(公告)日：2010-12-16
申请号：PCT/IL2010000329
申请日：2010-04-22
申请人： LOTUS BIO NYMPHAEA LTD , SHANY VERED , TAVORI ISSAC
发明人： SHANY VERED , TAVORI ISSAC
IPC分类号： A01N1/02
CPC分类号： A01N1/0263 , A61B10/0058 , A61B10/0096 , A61B17/43 , A61D19/00 , C12N5/0612 , Y10T436/25
摘要： The present invention provides a naturally based Sperm Separation System (SSS) for separation of at least a portion of sperm cell populations (SCP) within an original semen sample, such that an enpched SCP sample is obtained, comprising a a sperm separation device, comprising ?) a first chamber adapted to contain at least a portion of said original semen sample, said first chamber is characterized by predetermined 3D shape and volume, V, said first chamber is bounded by a rim such that said orginal sample is kept below said rim, n) a second chamber in physical communication with said first chamber and said nm, said second chamber is characterized by predetermined 3D shape and volume, V1, said second chamber is adapted to reside said enriched SCP sample, b incubation means, adapted to socket at least one of said cell separation device and to homogeneously thermoregulate the temperature within the same
摘要翻译：本发明提供了一种用于分离原始精液样本中至少一部分精子细胞群体（SCP）的天然精子分离系统（SSS），从而获得包含精子分离装置的加固的SCP样品，其包括：）适于容纳所述原始精液样品的至少一部分的第一室，所述第一室的特征在于预定的3D形状和体积，V，所述第一室由边缘限定，使得所述原始样品保持在所述边缘下方， n）与所述第一室和所述nm物理连通的第二室，所述第二室的特征在于预定的3D形状和体积，V1，所述第二室适于驻留所述富集的SCP样品，b孵育装置，所述细胞分离装置中的至少一个并且使其内的温度均匀地调温

6. 发明申请

WO01051612A1 PROCESS FOR THE PRODUCTION OF NON-HUMAN EMBRYOS OF HIGH-GENETIC VALUE AND OF PREDETERMINED SEX 审中-公开
标题翻译：生产高等遗传价值和预测性非人类胚胎的方法
公开(公告)号：WO01051612A1
公开(公告)日：2001-07-19
申请号：PCT/EP2001/000281
申请日：2001-01-11
IPC分类号： A01K67/027 , A61D19/00 , C12N5/00 , C12N5/071 , C12N5/06 , A01K67/02 , A61K35/52 , G01N33/483
CPC分类号： C12N5/0612 , A01K67/027 , A61D19/00
摘要： The process described herein concerns the production of non-human mammalian embryos of predetermined sex, with high-genetic value. The process uses frozen semen, frozen according to EU regulations, obtained from animals selected for their genetic characteristics at Semen Collection Centres, which is thawed and sexed by flow-cytometry. Sexed spermatozoa are used for the in vitro fertilisation of oocytes of a compatible animal species for the in vitro production of embryos of predetermined sex. The operating conditions of the present process allow the use of frozen semen.
摘要翻译：本文描述的方法涉及具有高遗传价值的预定性别的非人哺乳动物胚胎的产生。该方法使用根据欧盟法规冷冻的精液，从通过流式细胞术解冻和性别的精液收集中心选择的动物中选择的动物获得。性别精子用于体外受精的相容动物物种的卵母细胞体外生产预定性别的胚胎。本方法的操作条件允许使用冷冻精液。

7. 发明申请

WO9938376A8 METHOD FOR THE STIMULATION OF SPERM PRODUCTION AND GONADAL DEVELOPMENT IN ANIMALS 审中-公开
标题翻译：刺激动物生产和发展的方法
公开(公告)号：WO9938376A8
公开(公告)日：2000-10-26
申请号：PCT/US9902520
申请日：1999-02-03
申请人： UNIV MARYLAND , UNIV ARKANSAS , KUENZEL WAYNE J , KIRBY JOHN D
发明人： KUENZEL WAYNE J , KIRBY JOHN D
IPC分类号： A61D19/00 , A01K29/00
CPC分类号： A61D19/00
摘要： Disclosed is a method to stimulate or enhance sperm development in males and gonadal development in females by administration of an agent which results in a transiently lowered level of a thyroid hormone such as T3 and increased gonadotropin levels in the blood.
摘要翻译：公开了通过施用导致甲状腺激素例如T3的瞬时降低的水平和血液中促性腺激素水平升高的药剂来刺激或增强男性的精子发育和性腺发育的方法。

8. 发明申请

WO2019049163A1 REPRODUCTION OF FISH BY INDUCED SPAWNING WITH AN INJECTION CONTAINING BOTH BUSERELIN AND DOMPERIDONE 审中-公开
公开(公告)号：WO2019049163A1
公开(公告)日：2019-03-14
申请号：PCT/IN2018/000011
申请日：2018-02-06
申请人： SUDARSANAM, Korapati
发明人： SUDARSANAM, Korapati
IPC分类号： A61K38/00 , A61K38/09 , A61K38/24
CPC分类号： A61D19/00 , A61K38/00
摘要： The present process comprises injecting a high quality and an effective fish hormone for increased and Improved reproduction and high quality production in various species of fish with a combination of products composed of GnRH agonists as BUSERELIN and dopamine receptor antagonists as Domperidone allowing reliable induction and synchronization of maturation, ovulation-and spawning. The synthetic stimulators yield spawn of much higher quality than the pituitary extracts used in controlled fish reproduction. The process helps In significantly advancing maturation without affecting viability or fecundity; advances the spawning season and coordinates spawning dates and helps overcome problems of arrested maturation.

9. 发明申请

WO2017083663A1 AUTOMATIC SYSTEM AND METHOD FOR DELIVERING A SUBSTANCE TO AN ANIMAL 审中-公开
标题翻译：向动物提供物质的自动系统和方法
公开(公告)号：WO2017083663A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061548
申请日：2016-11-11
申请人： KARIMPOUR, Ramin
发明人： KARIMPOUR, Ramin
IPC分类号： A61D1/02 , A61D7/00
CPC分类号： A01K45/00 , A61B5/0033 , A61B5/43 , A61B5/70 , A61B2503/40 , A61B2576/00 , A61D7/00 , A61D17/00 , A61D19/00 , G06F19/00 , G16H50/20 , Y02A90/26
摘要： A system and method for automatically delivering a substance to an animal including a positioning system that positions each animal singularly, a sensor that detects the location of a predetermined targeted area on the animal and an image processor. The system further includes a delivery device having a plurality of delivery outlets for delivering a substance to the targeted area. The sensor, image processor and delivery device are in communication with a computer processor. The sensor activates the image processor which takes at least one image of the animal positioned singularly. The image is communicated to the computer processor and analyzed. The computer processor activates the delivery outlet proximate the predetermined target area on the animal which delivers an effective dosage of substance to the predetermined targeted area.
摘要翻译：用于向动物自动传递物质的系统和方法，包括单独定位每个动物的定位系统，检测动物上预定目标区域的位置的传感器和图像处理器。该系统还包括具有用于将物质递送到目标区域的多个递送出口的递送装置。传感器，图像处理器和传送装置与计算机处理器通信。传感器启动图像处理器，该图像处理器至少拍摄一张单独定位的动物图像。图像被传送到计算机处理器并进行分析。计算机处理器启动靠近动物预定目标区域的递送出口，其将有效剂量的物质递送到预定目标区域。

10. 发明申请

WO2016163646A1 쌍각 자궁을 갖는 동물의 번식 방지 장치 审中-公开
标题翻译：用于预防传播具有双歧杆菌的动物的装置
公开(公告)号：WO2016163646A1
公开(公告)日：2016-10-13
申请号：PCT/KR2016/002177
申请日：2016-03-04
申请人： 엄태현
发明人： 엄태현
IPC分类号： A61D19/00 , A61F6/14
CPC分类号： A61D19/00 , A61F6/14
摘要： 본 발명은, 본체; 상기 본체로부터 연장되는 한 쌍의 암부; 및 상기 본체에 설치되는 구리체를 포함하고, 상기 암부는 외측면에 돌출되는 외측돌기와 내측면에 돌출되는 내측돌기를 구비하는, 쌍각 자궁을 갖는 동물의 번식 억제 장치를 제공한다.
摘要翻译：本发明提供一种用于抑制具有双子宫的动物的繁殖的装置，该装置包括：主体; 一对从主体延伸的臂部; 以及安装在所述主体上的铜体，其中，所述臂部具有在其外表面上突出的外部突起，以及在其内表面上突出的内侧突起。

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