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1. 发明申请

WO2016114839A2 APPARATUS FOR IN-SITU NMR SPECTROSCOPY OF METAL-AIR AND METAL-FREE AIR BATTERIES 审中-公开
标题翻译：金属空气和无金属空气电池的核磁共振光谱仪器
公开(公告)号：WO2016114839A2
公开(公告)日：2016-07-21
申请号：PCT/US2015057794
申请日：2015-10-28
申请人： UNIV FLORIDA STATE RES FOUND
发明人： ZHENG JIAN-PING , SHELLIKERI ANNADANESH
IPC分类号： G01R31/36 , H01M12/08
CPC分类号： G01R31/3606 , G01N24/08 , H01M10/4285 , H01M12/08 , Y02E60/128
摘要： An apparatus for the in situ NMR monitoring of a battery including an anode, a separator and an air cathode is provided. The apparatus includes a non-metallic anode container portion, a non-metallic cathode container portion, and non-metallic connecting structure and sealing structure for connecting and sealing the anode container portion and the cathode container portion to define a hermetically sealed interior space for containing the battery with an anode of the battery adjacent the anode container portion and an air cathode of the battery adjacent the cathode container portion. The cathode container portion includes an air chamber portion with an air inlet and an air outlet. The air chamber portion can be adjacent to the air cathode such that air flowing from the air inlet to the air outlet will contact the air cathode. A method of evaluating an air cathode battery and a battery assembly for the NMR spectroscopy of an air cathode battery are also disclosed.
摘要翻译：提供了一种用于原子核磁共振监测包括阳极，分离器和空气阴极的电池的装置。该装置包括非金属阳极容器部分，非金属阴极容器部分和用于连接和密封阳极容器部分和阴极容器部分的非金属连接结构和密封结构，以限定密封的内部空间，用于容纳具有与阳极容器部分相邻的电池的阳极的电池和与阴极容器部分相邻的电池的空气阴极。阴极容器部分包括具有空气入口和空气出口的空气室部分。空气室部分可以与空气阴极相邻，使得从空气入口流到空气出口的空气将接触空气阴极。还公开了一种评估空气阴极电池和用于空气阴极电池的NMR光谱的电池组件的方法。

2. 发明申请

WO2016010601A2 ADAPTIVE NONLINEAR MODEL PREDICTIVE CONTROL USING A NEURAL NETWORK AND INPUT SAMPLING 审中-公开
标题翻译：基于神经网络和输入采样的自适应非线性模型预测控制
公开(公告)号：WO2016010601A2
公开(公告)日：2016-01-21
申请号：PCT/US2015027319
申请日：2015-04-23
申请人： UNIV FLORIDA STATE RES FOUND , COLLINS EMMANUEL , REESE BRANDON , DUNLAP DAMION
发明人： COLLINS EMMANUEL , REESE BRANDON , DUNLAP DAMION
IPC分类号： G06F7/76
CPC分类号： G05B13/027 , G05B2219/33039 , G06N3/0436 , G06N3/084
摘要： A novel method for adaptive Nonlinear Model Predictive Control (NMPC) of multiple input, multiple output (MIMO) systems, called Sampling Based Model Predictive Control (SBMPC) that has the ability to enforce hard constraints on the system inputs and states. However, unlike other NMPC methods, it does not rely on linearizing the system or gradient based optimization. Instead, it discretizes the input space to the model via pseudo-random sampling and feeds the sampled inputs through the nonlinear plant, hence producing a graph for which an optimal path can be found using an efficient graph search method.
摘要翻译：一种用于多输入多输出（MIMO）系统的自适应非线性模型预测控制（NMPC）的新方法称为基于抽样的模型预测控制（SBMPC），其能够对系统输入和状态施加强硬约束。但是，与其他NMPC方法不同，它不依赖线性化系统或基于梯度的优化。相反，它通过伪随机采样将输入空间离散到模型，并通过非线性设备输入采样的输入，从而生成一个图形，使用高效的图形搜索方法可以找到最佳路径。

3. 发明申请

WO2014145302A3 SYNTHESIS OF ENT-PROGESTERONE AND INTERMEDIATES THEREOF 审中-公开
标题翻译：耳 - 孕酮的合成及其中间体
公开(公告)号：WO2014145302A3
公开(公告)日：2014-11-27
申请号：PCT/US2014030040
申请日：2014-03-15
申请人： UNIV FLORIDA STATE RES FOUND , PREVACUS INC
发明人： CRAN JOHN W , HAN YINGLIN , ZHANG FALIANG
IPC分类号： B01J23/46 , C07J75/00
CPC分类号： C07J1/00 , C07C17/16 , C07C17/361 , C07C21/14 , C07C21/22 , C07C45/41 , C07C45/59 , C07C2601/10 , C07D317/72 , C07F7/0801 , C07F7/0809 , C07F7/0812 , C07F7/1852 , C07F7/1868 , C07F9/5022 , C07F9/5059 , C07F9/5442 , C07F9/5456 , C07F9/65517 , C07J5/0053 , C07J15/005 , C07J61/00 , C07C47/20 , C07C49/647
摘要： The present invention relates to the synthesis of ent-progesterone and intermediates thereof.
摘要翻译：本发明涉及对黄体酮及其中间体的合成。

4. 发明申请

WO2014033627A3 SIMPLIFIED EXTRACTION METHODS FOR THE RAPID DETERMINATION OF SPECIES CONTENT OF ADIPOSE TISSUE BASED ON THE DETECTION OF TNI IN IMMUNOASSAYS 审中-公开
标题翻译：基于TNI检测免疫球蛋白快速检测ADIPOSE组织物种含量的简化提取方法
公开(公告)号：WO2014033627A3
公开(公告)日：2014-04-24
申请号：PCT/IB2013058019
申请日：2013-08-27
申请人： UNIV FLORIDA STATE RES FOUND
发明人： HSIEH YUN-HWA PEGGY
IPC分类号： C07K1/14 , C07K1/34 , G01N33/48 , G01N33/68
CPC分类号： C07K1/145
摘要： A method for extracting protein from a fat-containing sample is described comprising the steps of separating solidified fat and solid residues from a centrifuged mixture of protein, fat, other solid materials and aqueous solution of phosphate buffered saline to form an aqueous phase containing the protein. The aqueous phase is then filtered through a filter to separate a clear protein extract from the mixture.
摘要翻译：描述了从含脂肪样品中提取蛋白质的方法，其包括从蛋白质，脂肪，其它固体材料和磷酸盐缓冲盐水溶液的离心混合物中分离固化的脂肪和固体残留物以形成含有蛋白质的水相的步骤。然后将水相通过过滤器过滤以从混合物中分离出澄清的蛋白质提取物。

5. 发明申请

WO2014024173A9 RECOMBINANT HUMAN FIBROBLAST GROWTH FACTOR-1 AS A NOVEL THERAPEUTIC FOR ISCHEMIC DISEASES AND METHODS THEREOF 审中-公开
标题翻译：重组人成纤维细胞生长因子-1作为治疗疾病的新疗法及其方法
公开(公告)号：WO2014024173A9
公开(公告)日：2014-04-17
申请号：PCT/IB2013056533
申请日：2013-08-09
申请人： UNIV FLORIDA STATE RES FOUND
发明人： BLABER MICHAEL
IPC分类号： A61K38/18 , A61K38/17 , A61P9/00
CPC分类号： C07K14/50 , C07K2319/21

6. 发明申请

WO2010028051A3 SUBSTITUTED HETEROCYCLIC MERCAPTOSULFONAMIDE METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：取代的杂环羧甲基磺酰胺金属蛋白酶抑制剂
公开(公告)号：WO2010028051A3
公开(公告)日：2010-07-08
申请号：PCT/US2009055742
申请日：2009-09-02
申请人： UNIV FLORIDA STATE RES FOUND , SCHWARTZ MARTIN A , JIN YONGHAO , SANG QING-XIANG AMY
发明人： SCHWARTZ MARTIN A , JIN YONGHAO , SANG QING-XIANG AMY
IPC分类号： C07D207/327 , A61K31/415 , A61P35/00 , C07D207/16 , C07D237/02 , C07D237/12 , C07D265/06
CPC分类号： C07D207/14 , A61K31/415 , C07D403/12
摘要： The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These compounds are designed to be potent selective inhibitors of matrix metalloproteinases (MMPs), including, for example, gelatinases, collagenases, matrilysins, metalloelastase, stromelysin, and membrane-type 1 matrix metalloproteinase. These inhibitors may be used for the control of physiological and pathological processes and disease conditions in which MMPs are believed to play significant functions.
摘要翻译：本发明一般涉及取代的杂环巯基磺酰胺化合物，前体和衍生物，以及制备这些化合物和包含这些化合物的药物组合物的方法。这些化合物被设计为基质金属蛋白酶（MMP）的有效选择性抑制剂，包括例如明胶酶，胶原酶，基质溶素，金属弹性蛋白酶，溶基质素和膜型1基质金属蛋白酶。这些抑制剂可用于控制MMPs被认为起重要作用的生理和病理过程和疾病状态。

7. 发明申请

WO2009073184A1 COMPOSITIONS FOR INDUCING LABOR AND ASSOCIATED METHODS 审中-公开
标题翻译：用于诱导劳动者和相关方法的组合物
公开(公告)号：WO2009073184A1
公开(公告)日：2009-06-11
申请号：PCT/US2008013317
申请日：2008-12-03
申请人： UNIV FLORIDA STATE RES FOUND , OLCESE JAMES
发明人： OLCESE JAMES
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K45/06 , A61K31/4045 , A61K38/11 , A61K2300/00
摘要： The invention discloses a pharmaceutical composition containing oxytocin and melatonin in amounts therapeutically effective for inducing labor in a pregnant human patient. Preferably, the oxytocin content is reduced to mitigate unwanted side effects and the melatonin content synergistically enhances the oxytocin's labor-inducing effectiveness. Also disclosed is a pharmaceutical composition for treatment of a pregnant human patient experiencing pre-term labor characterized by early expression of melatonin receptors in myometrial cells, the composition containing one or more agents which interfere with melatonin binding to said receptors. Additionally, the invention includes a method of treatment effective in inducing labor in a pregnant human patient, the method comprising coadministering melatonin and oxytocin to the patient and a method of treating pre-term labor in a pregnant human patient manifesting early expression of melatonin receptors in her myometrial tissues, the method comprising administering to the patient an agent effective in blocking melatonin binding to the receptors.
摘要翻译：本发明公开了含有催产素和褪黑激素的药物组合物，其量在治疗有效诱导怀孕的人类患者中的劳动。优选地，减少催产素含量以减轻不希望的副作用，并且褪黑素含量协同地增强催产素的劳动诱导效力。还公开了一种用于治疗经历早期劳动的怀孕人类患者的药物组合物，其特征在于在子宫肌层细胞中早期表达褪黑素受体，所述组合物含有一种或多种干扰褪黑激素结合所述受体的试剂。另外，本发明包括一种在怀孕的人类患者中有效诱导劳动的治疗方法，该方法包括将褪黑激素和催产素共同施用于患者，以及一种在怀孕的人类患者中治疗褪黑激素受体的早期表达的方法她的子宫肌层组织，该方法包括向患者施用有效阻断结合受体的褪黑素的试剂。

8. 发明申请

WO2007016193A3 NANOPARTICLE SYNTHESIS AND ASSOCIATED METHODS 审中-公开
标题翻译：纳米合成及相关方法
公开(公告)号：WO2007016193A3
公开(公告)日：2007-04-05
申请号：PCT/US2006029100
申请日：2006-07-27
申请人： UNIV FLORIDA STATE RES FOUND , STROUSE GEOFFREY F , GERBEC JEFFREY A
发明人： STROUSE GEOFFREY F , GERBEC JEFFREY A
IPC分类号： C30B29/00 , C30B7/00 , C30B30/00
CPC分类号： C30B29/60 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/25 , C01G1/02 , C01G15/00 , C01P2002/72 , C01P2004/64 , C30B7/00 , H01L21/02521 , H01L21/02543 , H01L21/02554 , H01L21/0256 , H01L21/02601 , H01L21/02606
摘要： A method is provided for producing crystalline nanoparticle semiconductor material. The method includes the steps of mixing a precursor in a solvent to form a reaction mixture and subjecting the reaction mixture to microwave dielectric heating at sufficient power to achieve a superheating temperature of the reaction mixture. A growth-phase reaction is permitted to proceed, wherein nanoparticles are formed in the heated reaction mixture. The reaction is then quenched to substantially terminate nanoparticle formation.
摘要翻译：提供了一种用于生产结晶纳米颗粒半导体材料的方法。该方法包括以下步骤：将前体在溶剂中混合以形成反应混合物，并使反应混合物以足够的功率进行微波介电加热以达到反应混合物的过热温度。允许进行生长相反应，其中在加热的反应混合物中形成纳米颗粒。然后将反应淬灭以基本上终止纳米颗粒的形成。

9. 发明申请

WO2004042026A2 NUCLEIC ACID AND ALLERGENIC POLYPEPTIDES ENCODED THEREBY IN CASHEW NUTS (Anacardium occidentale) 审中-公开
标题翻译：在CASHEW NUTS（西葫芦）中编码的核酸和过敏多肽
公开(公告)号：WO2004042026A2
公开(公告)日：2004-05-21
申请号：PCT/US0334960
申请日：2003-11-04
申请人： UNIV FLORIDA STATE RES FOUND , UNIV CALIFORNIA , ROUX KENNETH H PH D , TEUBER SUZANNE S M D , SATHE SHRIDHAR K PH D , ROBOTHAM JASON M B S
发明人： ROUX KENNETH H PH D , TEUBER SUZANNE S M D , SATHE SHRIDHAR K PH D , ROBOTHAM JASON M B S
IPC分类号： C07K14/415 , G01N33/68 , C12N
CPC分类号： G01N33/6854 , C07K14/415 , Y10S435/81
摘要： The invention describes an isolated nucleic acid sequence comprising the nucleotide sequence of SEQ ID NO:1 or a degenerate variant of SEQ ID NO:1. The nucleic acid sequence encodes an Ig-E binding immunogenic polypeptide the amino acid sequence of which comprises at least one sequence selected from SEQ ID NOS:4-25. The invention additionally provides an in vitro diagnostic test for detecting anti-cashew IgE in a patient. The test comprises reacting the patient's serum with a purified polypeptide the amino acid sequence of which comprises at least one sequence selected from SEQ ID NOS:3-25; separating the polypeptide from unreacted patient serum; reacting the polypeptide with a labeled human IgE-reactive agent after separating from unreacted patient serum; separating the polypeptide from unreacted labeled human IgE-reactive agent; and detecting labeled human IgE-reactive agent bound to the polypeptide after separating from unreacted agent to thereby indicate presence in the patient's serum of anti-cashew IgE.
摘要翻译：本发明描述了分离的核酸序列，其包含SEQ ID NO：1的核苷酸序列或SEQ ID NO：1的简并变体。核酸序列编码Ig-E结合免疫原性多肽，其氨基酸序列包含至少一个选自SEQ ID NO：4-25的序列。本发明另外提供用于检测患者抗腰果IgE的体外诊断试验。测试包括使患者的血清与纯化的多肽反应，其纯化多肽的氨基酸序列包含至少一个选自SEQ ID NO：3-25的序列; 将多肽与未反应的患者血清分离; 在从未反应的患者血清中分离后，使多肽与标记的人IgE反应剂反应; 将多肽与未反应的标记的人IgE反应剂分离; 以及在从未反应剂分离后检测与多肽结合的标记的人IgE反应剂，从而指示患者血清中抗腰果IgE的存在。

10. 发明申请

WO2015036972A3 SELECTIVE DOPAMINE D4 RECEPTOR AGONISTS FOR TREATMENT OF WORKING MEMORY DEFICITS 审中-公开
标题翻译：选择性DOPAMINE D4受体激素治疗工作记忆缺陷
公开(公告)号：WO2015036972A3
公开(公告)日：2015-08-06
申请号：PCT/IB2014064470
申请日：2014-09-12
申请人： UNIV FLORIDA STATE RES FOUND , GEN HOSPITAL CORP
发明人： BHIDE PRADEEP G , ZHU JINMIN , BIEDERMAN JOSEPH , SPENCER THOMAS J
IPC分类号： A61K31/496 , A61K31/4545 , A61K31/495 , A61P25/00 , A61P25/28
CPC分类号： A61K31/495 , A61K9/0019 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/4825 , A61K31/4545
摘要： Working memory deficits are treated and working memory is improved with a composition that comprises a therapeutically effective amount of one or more respective selective dopamine D4 receptor agonists and/or pharmaceutically acceptable analogs, salts or hydrates of the respective one or more selective dopamine D4 receptor agonists. This composition can be administered to a subject to improve the subject's working memory.
摘要翻译：处理工作记忆缺陷并且使用包含治疗有效量的相应的一种或多种选择性多巴胺D4受体激动剂的一种或多种相应的选择性多巴胺D4受体激动剂和/或药学上可接受的类似物，盐或水合物的组合物来改善工作记忆缺陷。可以将该组合物施用于受试者以改善受试者的工作记忆。

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