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1. 发明申请

WO02086475A3 METHOD AND APPARATUS FOR DETECTION OF MOLECULAR EVENTS USING TEMPERATURE CONTROL OF DETECTION ENVIRONMENT 审中-公开
标题翻译：检测环境温度控制检测分子活性的方法与装置
公开(公告)号：WO02086475A3
公开(公告)日：2003-08-07
申请号：PCT/US0112694
申请日：2001-04-18
申请人： SIGNATURE BIOSCIENCE INC
发明人： CHAPMAN ROBERT G , HEFTI JOHN J , BARTELL BARRETT J , RHODES MARK A , ZHAO MIN , PALMER TYLER
IPC分类号： G01N22/00
CPC分类号： G01N22/00
摘要： The present invention provides a method for detecting a molecular event, comprising (1) applying an electromagnetic test signal to a sample in which a molecular event is being detected, whereby the sample interacts with and modulates the test signal to produce a modulated test signal to produce a modulated test signal, and (2) detecting the modulated test signal, wherein the applying and detecting take place in a temperature-controlled environment, wherein the temperature-controlled environment comprises the sample, a radiating portion of a signal generating circuit, and a receiving portion of a signal detection circuit and wherein the applying and detecting take place in the environment at a temperature controlled to within +/-0.5 DEG C.
摘要翻译：本发明提供了一种用于检测分子事件的方法，包括：（1）向检测到分子事件的样品施加电磁测试信号，由此样品与测试信号相互作用并调制测试信号，以产生调制的测试信号产生调制测试信号，和（2）检测调制的测试信号，其中施加和检测发生在温度控制的环境中，其中温度控制环境包括样本，信号发生电路的辐射部分，以及信号检测电路的接收部分，其中施加和检测在控制在+/- 0.5℃的温度下在环境中进行。

2. 发明申请

WO02066983A3 BIOASSAY DEVICE FOR DETECTING MOLECULAR EVENTS 审中-公开
标题翻译：用于检测分子活动的生物仪器
公开(公告)号：WO02066983A3
公开(公告)日：2003-05-01
申请号：PCT/US0203143
申请日：2002-01-30
申请人： SIGNATURE BIOSCIENCE INC
发明人： PENG HONG , PHODES MARK A , KRAMER KURT D , FULLER CHRISTOPHER K
IPC分类号： B01L3/00 , C12Q1/00 , C40B60/14 , G01N22/00 , G01N33/543 , B01J19/00 , G01N27/22
CPC分类号： G01N22/00 , B01J2219/00317 , B01J2219/00585 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01L3/502715 , B01L3/508 , B01L2300/0645 , B01L2300/0877 , C12Q1/00 , C40B60/14 , G01N33/5438
摘要： A bioassay device operable to detect the presence or absence of molecular events within a test sample is presented in four embodiments: a coplanar waveguide detector, a stripline detector, a magic-t detector, and a microstrip detector. The coplanar waveguide detector includes a center gap operable to contact the sample and to electromagnetically couple an incident test signal between the sample and transmission line. The stripline detector includes a sample chamber operable to contain at least a portion of the supplied sample and to electromagnetically couple an incident at least a portion of the supplied sample and to electromagnetically couple an incident test signal between the contained sample and the transmission line. The magic-t detector includes a magic-t coupler and first and second test sample loads electromagnetically coupled thereto. The microstrip detector includes a transmission line, ground plane metallization and a flow channel formed between, and vertically aligned with, the transmission line and ground plane.
摘要翻译：可以在四个实施例中提供可操作以检测测试样品中分子事件的存在或不存在的生物测定装置：共面波导检测器，带状线检测器，魔术探测器和微带检测器。共面波导检测器包括可操作以接触样品并在样品和传输线之间电磁耦合入射测试信号的中心间隙。带状线检测器包括样品室，其可操作以容纳所提供的样品的至少一部分，并且将所提供的样品的至少一部分电磁耦合并且将所接收的样品和传输线之间的入射测试信号电磁耦合。魔术t检测器包括魔术耦合器和与其电磁耦合的第一和第二测试样本负载。微带检测器包括传输线，接地平面金属化和在传输线和接地平面之间形成并垂直对齐的流动通道。

3. 发明申请

WO2003016894A3 COPLANAR WAVEGUIDE BIOSENSOR FOR DETECTING MOLECULAR OR CELLULAR EVENTS 审中-公开
公开(公告)号：WO2003016894A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/025693
申请日：2002-08-12
申请人： SIGNATURE BIOSCIENCE, INC.
发明人： HEFTI, John , BARTELL, Barrett, J. , RHODES, Mark, A. , KRAMER, Kurt, D.
IPC分类号： G01N22/00
摘要： A coplanar waveguide biosensor and method of use include a coplanar waveguide transmission line and a sample containment structure. The coplanar waveguide transmission line is operable to support the propagation of an electromagnetic signal and includes a signal line and one or more spaced apart ground elements. The signal line is configured to conduct a time-varying voltage, and the one or more ground elements are configured to maintain a time-invariant voltage, a detection region being formed between a portion of the signal line and a portion of at least one of the one or more ground elements. The sample containment structure intersects the detection region of the coplanar waveguide transmission line and includes a cavity configured to hold 1 ml or less of sample solution within the detection region.

4. 发明申请

WO2001020329A3 TEST SYSTEMS AND SENSORS FOR DETECTING MOLECULAR BINDING EVENTS 审中-公开
公开(公告)号：WO2001020329A3
公开(公告)日：2001-03-22
申请号：PCT/US2000/020470
申请日：2000-07-27
申请人： SIGNATURE BIOSCIENCE, INC.
发明人： HEFTI, John
IPC分类号： G01N22/00
摘要： A bio-assay test system includes a test fixture, a measurement system, and a computer. The test fixture includes a bio-assay device having a signal path and a retaining structure configured to place a sample containing molecular structures in electromagnetic communication with the signal path. The measurement system is configured to transmit test signals to and to receive test signals from the signal path at one or more predefined frequencies. The computer is configured to control the transmission and reception of the test signals to and from the measurement system.

5. 发明申请

WO02101367A3 PIPETTE-LOADED BIOASSAY ASSEMBLY FOR DETECTING MOLECULAR OR CELLULAR EVENTS 审中-公开
标题翻译：用于检测分子细胞活动的PIPETTE负载生物仪器组件
公开(公告)号：WO02101367A3
公开(公告)日：2003-03-20
申请号：PCT/US0218449
申请日：2002-06-10
申请人： SIGNATURE BIOSCIENCE INC
发明人： BODNER KEVIN S , SANDHAM ANDREW P
IPC分类号： G01N33/543 , G01N33/487 , G01N22/00 , G01N33/483
CPC分类号： G01N22/00 , G01N33/54373 , Y10T436/11 , Y10T436/119163
摘要： A pipette-loaded bioassay includes a measurement probe and a pipette tip. The measurement probe includes a probe head configured to launch an incident test signal and a connecting end configured to receive the incident test signal form a signal source. The pipette tip includes a sample interrogation region which is electromagnetically coupled to the probe head, the sample interrogation region configured to retain a plug of sample solution and constructed from a material which is substantially transparent to the incident test signal. The incident test signal electromagnetically couples through the sample interrogation region and to the molecular or cellular events occurring within the sample solution. The interaction of the incident test signal with the molecular or cellular events produces a modulated test signal which can be recovered and used to identify the molecular events occurring in a subsequently tested sample.
摘要翻译：移液管装载的生物测定包括测量探针和移液管尖。测量探头包括配置成发射入射测试信号的探头和被配置为从信号源接收入射测试信号的连接端。移液管尖端包括电磁耦合到探针头的样品询问区域，样品询问区域被配置为保持样品溶液塞并由对入射的测试信号基本透明的材料构成。事件测试信号通过样品询问区域电磁耦合到样品溶液中发生的分子或细胞事件。事件测试信号与分子或细胞事件的相互作用产生调制的测试信号，其可被回收并用于鉴定随后测试样品中发生的分子事件。

6. 发明申请

WO2003016887A3 METHOD FOR ANALYZING CELLULAR EVENTS IN A SAMPLE BY MEASURING TRANSMITTED AND/OR REFLECTED ELECTROMAGNETIC TEST SIGNALS IN A FREQUENCY RANGE FROM 500 KHZ TO 1000 GHZ 审中-公开
公开(公告)号：WO2003016887A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/025689
申请日：2002-08-12
申请人： SIGNATURE BIOSCIENCE, INC.
发明人： LIU, Vivian, F. , BHAGAVATULA, Prasanthi , DO, Uyen, T. , HEFTI, John, J. , PITCHFORD, Simon
IPC分类号： G01N22/00
摘要： The invention makes it possible to detect cellular activity without knowing specifically what activity is being detected, although detection of specific activity is possible. The assay comprises coupling an electromagnetic test signal in the specified frequency range to a sample in which a cellular event is being detected, whereby the sample interacts with and modulates the test signal to produce a modulated test signal; detecting the modulated test signal; and analyzing the modulated test signal to detect said cellular event. The invention is useful in the detection of cellular activity induced by the presence of a test substance in the medium in which a cell is located and provides advantages for lead optimization in the drug discovery field.

7. 发明申请

WO2002103358A1 SYSTEM AND METHOD FOR DETECTING AND IDENTIFYING MOLECULAR EVENTS IN A SAMPLE USING A RESONANT TEST STRUCTURE 审中-公开
标题翻译：使用共振测试结构在样品中检测和鉴定分子活性的系统和方法
公开(公告)号：WO2002103358A1
公开(公告)日：2002-12-27
申请号：PCT/US2001/043629
申请日：2001-11-13
申请人： SIGNATURE BIOSCIENCE, INC.
发明人： HEFTI, John , HONG, Peng
IPC分类号： G01N33/53
CPC分类号： G01N33/487 , G01N22/00
摘要： A system and method for detecting a molecular event in a test sample using a resonant test structure is presented. The method includes providing a resonant test structure having a resonant response associated therewith. Next, a first resonant response of the resonant test structure is obtained when the resonant test structure is electromagnetically coupled to a reference sample, the reference sample having a known composition. A second resonant response is also obtained when the resonant test structure is electromagnetically coupled to the test sample, the test sample having an unknown composition. Subsequently, one or more first electrical parameters, such as the q-factor of the resonator, are derived from the first resonant response. One or more second electrical parameters are similarly derived from the second resonant response. The similarity or difference between the first and second electrical parameters are analyzed to determine the presence or absence of the molecular event in the test sample.
摘要翻译：提出了一种使用共振测试结构检测测试样品中的分子事件的系统和方法。该方法包括提供具有与其相关联的谐振响应的谐振测试结构。接下来，当谐振测试结构与参考样品电磁耦合时，获得谐振测试结构的第一谐振响应，参考样品具有已知组成。当共振测试结构与测试样品电磁耦合时，也可获得第二谐振响应，测试样品具有未知的组成。随后，从第一谐振响应导出一个或多个第一电参数，例如谐振器的q因子。类似地，从第二谐振响应导出一个或多个第二电参数。分析第一和第二电参数之间的相似性或差异以确定测试样品中分子事件的存在或不存在。

8. 发明申请

WO2002077605A3 REENTRANT CAVITY BIOASSAY FOR DETECTING MOLECULAR OR CELLULAR EVENTS 审中-公开
公开(公告)号：WO2002077605A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/008368
申请日：2002-03-18
申请人： SIGNATURE BIOSCIENCE, INC.
发明人： BARTELL, Barrett, J. , HEANUE, Joseph, A. , RHODES, Mark, A.
IPC分类号： G01N33/543
摘要： A reentrant cavity bioassay includes a reentrant cavity and a sample retaining structure. The reentrant cavity includes a reentrant post extending from a first interior surface and terminating proximate to a second interior surface, the gap between the termination of the reentrant post and the second interior surface defining a detection region. The sample retaining structure is configured to retain the sample in the detection region, wherein at least a portion of the sample retaining structure is located within the detection region.

9. 发明申请

WO2002065127A2 A SYSTEM AND METHOD FOR CHARACTERIZING THE PERMITTIVITY OF MOLECULAR EVENTS 审中-公开
标题翻译：用于表征分子活性的允许性的系统和方法
公开(公告)号：WO2002065127A2
公开(公告)日：2002-08-22
申请号：PCT/US2002/004048
申请日：2002-02-11
申请人： SIGNATURE BIOSCIENCE, INC.
发明人： HEFTI, John , PENG, Peng , BALABAN, David , HEANUE, Joseph
IPC分类号： G01N33/543
CPC分类号： G01N33/54373
摘要： A system and method for comparing the permittivities of test and reference samples to detect and identify molecular events is presented. A resonant detector configured to output measurement parameters when the detector is electromagnetically coupled to a supplied sample is provided. One or more permittivity coefficients is defined for the detector. A first output parameter is obtained from the detector when the detector is electromagnetically coupled to a reference sample. A second output parameter is obtained from the detector when the detector is electromagnetically coupled to the test sample. The difference between the first and second output parameters is applied to the one or more permittivity coefficients to compute the relative difference in permitivity between the test sample and reference sample.
摘要翻译：提出了一种用于比较测试和参考样本的介电常数以检测和识别分子事件的系统和方法。提供一种谐振检测器，被配置为当检测器电磁耦合到所提供的样品时输出测量参数。为检测器定义一个或多个介电常数系数。当检测器电磁耦合到参考样品时，从检测器获得第一输出参数。当检测器电磁耦合到测试样品时，从检测器获得第二输出参数。将第一和第二输出参数之间的差应用于一个或多个介电常数系数，以计算测试样本与参考样本之间的相对差异。

10. 发明申请

WO0127610A3 SYSTEM AND METHOD FOR DETECTING AND IDENTIFYING MOLECULAR EVENTS IN A TEST SAMPLE 审中-公开
标题翻译：用于检测和鉴定测试样品中分子事件的系统和方法
公开(公告)号：WO0127610A3
公开(公告)日：2002-03-28
申请号：PCT/US0028491
申请日：2000-10-13
申请人： SIGNATURE BIOSCIENCE INC
发明人： CHAPMAN ROBERT G , HEFTI JOHN J , BARTELL BARRETT J , RHODES MARK A , ZHAO MIN
IPC分类号： G01N22/00 , B01L3/00 , G01N35/08 , G01N37/00 , G01N33/543
CPC分类号： B01L3/50273 , B01L3/502784 , B01L2200/0673 , B01L2300/0645 , B01L2400/0418 , G01N22/00
摘要： A molecular detection system for detecting the presence or absence of a molecular event within a test sample includes a fluid reservoir, a signal source, a measurement probe, and a signal detector. The measurement probe includes a probe head and a connecting end. The probe head is configured to electromagnetically couple an incident test signal to the test sample within the detection region of the fluid reservoir. The interaction of the incident test signal with the test sample produces a modulated test signal, at least a portion of which the probe head is configured to recover. The system further includes a signal detector that is coupled to the connecting end of the measurement probe and configured to recover the modulated test signal.
摘要翻译：用于检测测试样品内是否存在分子事件的分子检测系统包括流体贮存器，信号源，测量探针和信号检测器。测量探头包括探头和连接端。探头被配置为将入射测试信号电磁耦合到流体储存器的检测区域内的测试样本。事件测试信号与测试样本的相互作用产生调制测试信号，探测头的至少一部分被配置为恢复。该系统还包括耦合到测量探针的连接端并被配置为恢复调制的测试信号的信号检测器。

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