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1. 发明申请

WO2016154498A1 DEVICES AND METHODS FOR LEFT ATRIAL APPENDAGE CLOSURE 审中-公开
标题翻译：用于左侧附件关闭的装置和方法
公开(公告)号：WO2016154498A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/024117
申请日：2016-03-24
申请人： SENTREHEART, INC.
发明人： FUNG, Gregory, W. , BRADLEY, Alan, L. , CLARK, Robert, L. , PONG, Russell
IPC分类号： A61B17/00 , A61B17/04 , A61B17/10 , A61B17/12
CPC分类号： A61B17/12013 , A61B90/361 , A61B2017/00243 , A61B2017/00309 , A61B2017/00358
摘要： Surgical and percutaneous devices for closing tissue, for example, the left atrial appendage, may have an elongate body with a stiffened proximal portion, a flexible middle portion, a distal portion, a closure element with a loop having a continuous aperture therethrough, and a suture loop. The closure devices may have a malleable member attached to the elongate body that may be configured to retain a curve after a force is applied to the malleable member. System and methods for closing the left atrial appendage may utilize a closure device and a curved guide device, and the closure device and curved guide device may be self-orienting.
摘要翻译：用于闭合组织的外科手术和经皮装置，例如左心耳，可以具有细长体，其具有加强的近端部分，柔性中间部分，远端部分，具有穿过其中的连续孔的环的闭合元件，以及缝线回路。闭合装置可以具有连接到细长主体的可延展构件，该延展构件可构造成在将力施加到可延展构件之后保持曲线。用于关闭左心耳的系统和方法可以利用闭合装置和弯曲的引导装置，并且闭合装置和弯曲引导装置可以是自定向的。

2. 发明申请

WO2015066549A8 DEVICES AND METHODS FOR LEFT ATRIAL APPENDAGE CLOSURE 审中-公开
标题翻译：用于左侧附件关闭的装置和方法
公开(公告)号：WO2015066549A8
公开(公告)日：2016-06-23
申请号：PCT/US2014063570
申请日：2014-10-31
申请人： SENTREHEART INC
发明人： FUNG GREGORY W , LEE RANDALL J , PONG RUSSEL , CLARK ROBERT L III , ESCANO ARNOLD M
IPC分类号： A61B17/04
CPC分类号： A61B18/1492 , A61B17/12013 , A61B2017/00243 , A61B2017/00477 , A61B2017/00876 , A61B2018/0016 , A61B2018/0022 , A61B2018/00357 , A61B2018/00577 , A61B2018/141 , A61B2018/142
摘要： Described here are devices, systems, and methods for closing the left atrial appendage. The methods described here utilize a closure device for closing the left atrial appendage and guides or expandable elements with ablation or abrading elements to ablate or abrade the left atrial appendage. In general, these methods include positioning a balloon at least partially within the atrial appendage, positioning a closure assembly of a closure device around an exterior of the atrial appendage, inflating the balloon, partially closing the closure assembly, ablating the interior tissue of the atrial appendage with the inflated balloon, removing the balloon from the atrial appendage, and closing the atrial appendage with the closure assembly.
摘要翻译：这里描述的是关闭左心耳的装置，系统和方法。这里描述的方法利用闭合装置来闭合左心耳和具有消融或研磨元件的引导或可扩张元件以消融或磨擦左心耳。通常，这些方法包括至少部分地将气囊定位在心房附近内，将闭合装置的闭合组件定位在心房附近的周围，使气囊膨胀，部分闭合闭合组件，消融心房的内部组织用充气球囊附着物，从气囊移除气球，并用闭合组件关闭心房附件。

3. 发明申请

WO2011129894A3 METHODS AND DEVICES FOR ACCESSING AND DELIVERING DEVICES TO A HEART 审中-公开
公开(公告)号：WO2011129894A3
公开(公告)日：2011-10-20
申请号：PCT/US2011/000677
申请日：2011-04-13
申请人： SENTREHEART, INC. , FUNG, Gregory, W. , SEIBER, Russell, A. , STRASSER, Robert , HELMUTH, Ryan, Douglas
发明人： FUNG, Gregory, W. , SEIBER, Russell, A. , STRASSER, Robert , HELMUTH, Ryan, Douglas
IPC分类号： A61B17/34
摘要： Described here are devices, methods, and systems for accessing and delivering devices to a heart. Systems used to provide access to the heart via the left atrial appendage comprise a first access element with a first alignment member, a second access element with a second alignment member, a piercing element, an exchange element and may further comprise a left atrial appendage stabilization device. Methods of accessing and delivering devices to the heart via the left atrial appendage may comprise advancing a first access element into the left atrial appendage by an intravascular pathway and advancing a second access element towards the left atrial appendage through the pericardial space. The first and second alignment members form an attachment through the wall of the left atrial appendage so that the first and second access elements are aligned.

4. 发明申请

WO2019191316A8 DEVICES AND METHODS FOR LEFT ATRIAL APPENDAGE CLOSURE 审中-公开
公开(公告)号：WO2019191316A8
公开(公告)日：2019-10-03
申请号：PCT/US2019/024413
申请日：2019-03-27
申请人： SENTREHEART, INC.
发明人： FUNG, Gregory W. , CLARK, Robert L., III , SEIBER, Russell A. , PONG, Russell , ESCANO, Arnold M.
IPC分类号： A61B17/12 , A61B17/04 , A61B17/132 , A61M25/10
摘要： Tissue stabilizing devices and methods for stabilizing, and optionally closing, a target tissue, such as the left atrial appendage, generally include an elongate body with a first lumen and a second lumen, a suction tip coupled to the elongate body, and an injection tip coupled to the elongate body proximal of the suction tip. The suction tip may define a suction aperture and the suction aperture may be in fluid communication with the first lumen to apply suction to the target tissue. The injection tip may be in fluid communication with the second lumen to dispense a contrast fluid.

5. 发明申请

WO2014182859A2 TISSUE LIGATION DEVICES AND METHODS THEREFOR 审中-公开
标题翻译：组织注射装置及其方法
公开(公告)号：WO2014182859A2
公开(公告)日：2014-11-13
申请号：PCT/US2014/037217
申请日：2014-05-07
申请人： SENTREHEART, INC.
发明人： PONG, Russell , CLARK, Robert, L. , FUNG, Gregory, W. , ESCANO, Arnold, M.
IPC分类号： A61B17/12
CPC分类号： A61B17/12013 , A61B2017/00243
摘要： Described here are closure devices and methods for ligating tissue, such as the left atrial appendage. The closure devices may comprise a snare loop assembly comprising a snare and a suture loop releasably attached thereto, and a snare control. The closure devices may further comprise one or more reference markings, wherein the relative positioning between a portion of the snare control and the reference markings provides an indication of the diameter of the snare loop assembly. In some variations, when the snare loop assembly is closed around a tissue such as the left atrial appendage, the measured diameter of the snare loop assembly may help a user determine whether the snare loop assembly has been properly positioned relative to the tissue, as well as the approximate size that a suture loop may have when released from the snare loop assembly.
摘要翻译：这里描述了用于结扎组织的闭合装置和方法，例如左心耳。闭合装置可以包括圈套组件，其包括可释放地附接到其上的圈套和缝合线环以及圈套控制。闭合装置还可以包括一个或多个参考标记，其中圈套控制部分和参考标记之间的相对定位提供了圈套环组件的直径的指示。在一些变型中，当围绕诸如左心耳的组织围绕圈套环组件时，圈套环组件的测量直径可以帮助用户确定圈圈组件是否已经相对于组织正确定位作为当从圈套环组件释放时缝合线圈可能具有的大致尺寸。

6. 发明申请

WO2011130456A1 METHODS AND DEVICES FOR PERICARDIAL ACCESS 审中-公开
标题翻译： PERICARDIAL访问的方法和设备
公开(公告)号：WO2011130456A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032382
申请日：2011-04-13
申请人： SENTREHEART, INC. , FUNG, Gregory, W. , SEIBER, Russell, A. , SAGER, Eduardo, A. , ESCANO, Arnold, M. , HELMUTH, Ryan, Douglas
发明人： FUNG, Gregory, W. , SEIBER, Russell, A. , SAGER, Eduardo, A. , ESCANO, Arnold, M. , HELMUTH, Ryan, Douglas
IPC分类号： A61M25/00
CPC分类号： A61B17/3478 , A61B17/3415 , A61B17/3421 , A61B2017/00247 , A61B2017/00309 , A61B2017/00331 , A61B2017/00946 , A61B2017/22038 , A61B2017/22044 , A61B2017/320064 , A61B2017/3488 , A61B2018/00392
摘要： Devices and methods for accessing the pericardial space of a heart are described here. Access devices may generally comprise a tissue-engaging member, a tissue-piercing member, and a guide element. The access device may be introduced to the surface of a pericardium, where the tissue-engaging member may be deployed to engage a portion of the pericardium without engaging the epicardial surface of the heart. Once the access device has engaged the pericardium, the device may manipulate the pericardium to increase the distance between a portion of the pericardium and the epicardial surface of the heart. Once a sufficient space has been created, the tissue-piercing member may be advanced to pierce the pericardium and enter the pericardial space. The guide element may then be introduced into the pericardial space to provide an access pathway to the heart for other devices.
摘要翻译：这里描述了用于访问心脏心包空间的装置和方法。通路装置通常可以包括组织接合构件，组织刺穿构件和引导元件。进入装置可以被引入到心包的表面，其中可以将组织接合构件展开以接合心包的一部分而不与心脏的心外膜表面接合。一旦进入装置接合心包，该装置可以操纵心包以增加心包的一部分与心脏的心外膜表面之间的距离。一旦创建了足够的空间，组织穿刺构件可以前进以刺穿心包并进入心包空间。引导元件然后可以被引入心包空间中以提供到其他装置的心脏的通路。

7. 发明申请

WO2005034802A3 APPARATUS AND METHOD FOR THE LIGATION OF TISSUE 审中-公开
标题翻译：用于组织结构的装置和方法
公开(公告)号：WO2005034802A3
公开(公告)日：2007-06-07
申请号：PCT/US2004033459
申请日：2004-10-11
申请人： SENTREHEART INC , LIDDICOAT JOHN R , COHN WILLIAM E , LAHAM ROGER
发明人： LIDDICOAT JOHN R , COHN WILLIAM E , LAHAM ROGER
IPC分类号： A61B17/10 , A61B17/00 , A61B17/12 , A61B19/00 , A61F20060101 , A61F2/01 , A61M29/00
CPC分类号： A61B17/12013 , A61B17/00234 , A61B17/0467 , A61B17/12009 , A61B17/30 , A61B2017/00243 , A61B2017/00867 , A61B2017/00876 , A61B2017/12018 , A61B2017/308 , A61B2090/0811 , A61B2090/3966 , A61B2576/023 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/0108 , A61M25/0127 , A61M25/10 , A61M29/02
摘要： A catheter-based system which ligates the left atrial appendage (LAA) on the outside of the heart, preferably using a combination of catheters and/or instruments, e.g., a guide catheter positioned inside the left atrial appendage which may assist in the optimal placement of a ligature on the outside of the appendage, and a ligating catheter and/or instrument outside the heart in the pericardial space to set a ligating element at the neck of the left atrial appendage.
摘要翻译：基于导管的系统，其将心脏外侧的左心耳（LAA）结合，优选地使用导管和/或器械的组合，例如位于左心耳内的引导导管，其可以协助最佳放置在附件外侧的结扎，以及在心包空间内的心脏外的结扎导管和/或器械，以将结扎元件设置在左心耳的颈部。

8. 发明申请

WO2016154488A2 TISSUE LIGATION DEVICES AND METHODS THEREFOR 审中-公开
标题翻译：组织注射装置及其方法
公开(公告)号：WO2016154488A2
公开(公告)日：2016-09-29
申请号：PCT/US2016/024103
申请日：2016-03-24
申请人： SENTREHEART, INC.
发明人： FUNG, Gregory, W. , BRADLEY, Alan, L. , PONG, Russell , CLARK, Robert, L. III , ESCANO, Arnold, M.
IPC分类号： A61B17/12
CPC分类号： A61B17/12013 , A61B17/0487 , A61B2017/00243 , A61B2017/0488
摘要： Described herein are tissue closure devices and methods for ligating a target tissue, such as the left atrial appendage. The tissue closure device may have an elongate body, a snare at least partially housed within the elongate body, a suture at least partially housed within the elongate body, and a tightening element coupled to the suture. The suture may have a suture loop, and the tightening element may be configured to decrease the size of the suture loop when the area of a tissue within the suture loop decreases.
摘要翻译：本文描述了组织闭合装置和用于结合目标组织的方法，例如左心耳。组织闭合装置可以具有细长的主体，至少部分地容纳在细长主体内的网孔，至少部分地容纳在细长主体内的缝线以及联接到缝合线的紧固元件。缝合线可以具有缝线环，并且紧固元件可以被配置为当缝合线环内的组织的面积减小时减小缝合线环的尺寸。

9. 发明申请

WO2014164028A1 TISSUE LIGATION DEVICES AND METHODS THEREFOR 审中-公开
标题翻译：组织注射装置及其方法
公开(公告)号：WO2014164028A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/020030
申请日：2014-03-03
申请人： SENTREHEART, INC.
发明人： CLARK, Robert, L. III , FUNG, Gregory, W. , PONG, Russell , ESCANO, Arnold, M. , LIU, Greg
IPC分类号： A61B17/03 , A61B17/04 , A61B17/06
CPC分类号： A61B17/12013 , A61B17/0218 , A61B90/39 , A61B2017/00243 , A61B2017/00557 , A61B2017/00867 , A61B2017/00876 , A61B2090/3966
摘要： Described here are closure devices and methods for ligating tissue, such as the left atrial appendage. The closure devices may comprise a snare loop assembly comprising a snare and a suture loop releasably attached thereto. The snare may be releasable from an elongate body of the closure device. In some instances, the closure device may comprise one or more markers to allow a user to determine whether the snare loop assembly is twisted.
摘要翻译：这里描述了用于结扎组织的闭合装置和方法，例如左心耳。闭合装置可以包括圈套环组件，其包括可释放地附接到其上的圈套和缝合线环。圈套可以从闭合装置的细长主体释放。在一些情况下，闭合装置可以包括一个或多个标记，以允许使用者确定圈套环组件是否扭曲。

10. 发明申请

WO2010115030A1 TISSUE LIGATION DEVICES AND CONTROLS THEREFOR 审中-公开
标题翻译：组织设备及其控制
公开(公告)号：WO2010115030A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029668
申请日：2010-04-01
申请人： SENTREHEART, INC. , FUNG, Gregory, W. , SEIBER, Russell, A. , SAGER, Eduardo , MILLER, Gary, H. , GARCIA, Maria , HELMUTH, Ryan, Douglas , ESCANO, Arnold, M. , ELLISON, Douglas, Todd , COHN, William, E.
发明人： FUNG, Gregory, W. , SEIBER, Russell, A. , SAGER, Eduardo , MILLER, Gary, H. , GARCIA, Maria , HELMUTH, Ryan, Douglas , ESCANO, Arnold, M. , ELLISON, Douglas, Todd , COHN, William, E.
IPC分类号： A61B17/12
CPC分类号： A61B17/12013 , A61B17/0469 , A61B17/0487 , A61B17/06114 , A61B2017/00243 , A61B2017/003 , A61B2017/00331 , A61B2017/00557 , A61B2017/00867 , A61B2017/0475 , A61B2017/0496 , A61B2017/3445 , A61B2090/037 , A61B2090/0811
摘要： Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess- suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.
摘要翻译：这里描述了用于关闭一个或多个组织的装置，以及用于控制这些装置的手柄。通常，这里描述的装置包括圈套环组件，其中圈套环组件包括圈套和缝合线环以及用于控制圈套环组件的手柄。在一些变型中，圈套环组件可以包括保持构件，该保持构件可将缝线环可释放地连接到圈套。在其他变型中，装置包括一个或多个减小力的缝合线锁，以帮助防止缝合线环从圈套圈组件中无意中脱离。在其他变体中，超缝线管理功能。这里描述的手柄可以被配置为从缝合线环去除多余的缝合线，并且还可以被配置为从缝合环组件释放缝线环。

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