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1. 发明申请

WO2011143238A3 PROSTHETIC HEART VALVE 审中-公开
公开(公告)号：WO2011143238A3
公开(公告)日：2011-11-17
申请号：PCT/US2011/035952
申请日：2011-05-10
申请人： EDWARDS LIFESCIENCES CORPORATION , CAO, Hengchu , CONKLIN, Brian, S. , SCHMIDT, Paul, A. , KIM, Grace, Myong , DAVIDSON, James, A. , TRAN, Hoa, Trinh , TAM, Kristy, Luong
发明人： CAO, Hengchu , CONKLIN, Brian, S. , SCHMIDT, Paul, A. , KIM, Grace, Myong , DAVIDSON, James, A. , TRAN, Hoa, Trinh , TAM, Kristy, Luong
IPC分类号： A61F2/24 , A61M29/02 , A61L27/04 , A61B17/32
摘要： Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.

2. 发明申请

WO2007138499A2 DISPENSING SYSTEM FOR DISPENSING WARM WET WIPES 审中-公开
标题翻译：用于分配温暖湿巾的分配系统
公开(公告)号：WO2007138499A2
公开(公告)日：2007-12-06
申请号：PCT/IB2007/051684
申请日：2007-05-04
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , SOSALLA, Gerald , SCHMIDT, Paul R. , MILNER, James Dell , JOSEPH, Wael R. , MCDONALD, Duane Lyle
发明人： SOSALLA, Gerald , SCHMIDT, Paul R. , MILNER, James Dell , JOSEPH, Wael R. , MCDONALD, Duane Lyle
IPC分类号： A47K10/32 , A47K10/42
CPC分类号： A47K10/421 , A47K2010/3286 , A47K2010/3293 , A61F7/032 , F28D20/023 , Y02E60/145
摘要： In a dispensing system for dispensing wet wipes, a wet wipe has an aqueous solution and microencapsulated delivery vehicles including a temperature agent, and is disposed in a wet wipe container. A cartridge is held in assembly with the wet wipe container and has an activating device that facilitates rupturing of the microencapsulated delivery vehicles as the wet wipe is removed from the dispensing system to allow contact between the temperature change agent and the aqueous solution of the wet wipe to thereby dispense a warm or cooled wet wipe. In another embodiment, the wet wipe has an aqueous solution and a lotion having the microencapsulated heat delivery vehicles disposed in the cartridge free from contact with the wet wipe. The cartridge also has an applicator that is operable to apply the lotion to the wet wipe as the wet wipe is removed from the wet wipe container.
摘要翻译：在用于分配湿巾的分配系统中，湿巾具有包含温度剂的水溶液和微胶囊化递送载体，并且设置在湿擦拭容器中。墨盒与湿擦拭容器保持组装，并且具有启动装置，其有助于在从分配系统移除湿擦拭物的同时促进微胶囊化递送载体的破裂，以允许温度变化剂与湿擦拭物的水溶液之间的接触从而分配温暖或冷却的湿擦拭物。在另一个实施方案中，湿擦拭物具有水溶液和洗剂，其中微胶囊化传热载体布置在盒中，与湿擦拭物无接触。该墨盒还具有一个可操作的涂抹器，用于将湿擦拭物从湿擦拭容器移除时将洗剂施加到湿巾上。

3. 发明申请

WO2007138498A2 WET WIPE DISPENSING SYSTEM 审中-公开
标题翻译：湿抹布分配系统
公开(公告)号：WO2007138498A2
公开(公告)日：2007-12-06
申请号：PCT/IB2007051671
申请日：2007-05-03
申请人： KIMBERLY CLARK CO , AMUNDSON JOHN DAVID , ABUTO FRANK P , CLARE TIMOTHY P , FOLEY EDWARD JOHN , WINDER ERIC MICHAEL , SCHMIDT PAUL R , JOSEPH WAEL R , MCDONALD DUANE LYLE
发明人： AMUNDSON JOHN DAVID , ABUTO FRANK P , CLARE TIMOTHY P , FOLEY EDWARD JOHN , WINDER ERIC MICHAEL , SCHMIDT PAUL R , JOSEPH WAEL R , MCDONALD DUANE LYLE
CPC分类号： A47K10/421 , A47K2010/328 , A47K2010/3293 , A61F7/032 , A61F2007/0098 , A61F2007/0292 , F28D20/023 , Y02E60/145
摘要： The present disclosure relates to wet wipe dispensing systems for dispensing wet wipes capable of changing temperature upon use. In one embodiment, the dispensing system includes a wet wipe container and a lotion container that is held in assembly with the wet wipe container that contains a lotion that is kept separate from the wet wipes until the wet wipe is dispensed from the wet wipe container. The lotion includes a microencapsulated delivery vehicle that contains a temperature change agent that is capable of generating a temperature change upon contact with an aqueous solution. Once the wet wipe is dispensed from the system, an applicating device can apply the lotion to the wet wipe to facilitate contact between the temperature change agent in the microencapsulated delivery vehicle and the aqueous solution of the wet wipe.
摘要翻译：本公开涉及用于分配使用时能够改变温度的湿巾的湿抹布分配系统。在一个实施方案中，分配系统包括湿擦拭容器和洗涤剂容器，所述洗涤剂容器与湿擦拭容器保持组合，所述湿擦拭容器包含与湿擦拭物分离的洗剂，直到从湿擦拭容器分配湿擦拭物。洗液包括微胶囊化递送载体，其含有能够在与水溶液接触时产生温度变化的温度变化剂。一旦从系统分配湿擦拭物，施用装置可以将洗剂施加到湿擦拭物，以便于微胶囊化输送载体中的温度变化剂与湿擦拭物的水溶液之间的接触。

4. 发明申请

WO2006104638A3 DYNAMIC SUPPRESSION AND RECREATION OF SUPPRESSED DATA 审中-公开
公开(公告)号：WO2006104638A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/007523
申请日：2006-03-02
申请人： CISCO TECHNOLOGY, INC. , SELLENTIN, Uwe , BALES, Scott, A. , BORDONARO, Frank, G. , FUSSELL, John, P. , PEARCE, Bernie, P. , SCHMIDT, Paul, A.
发明人： SELLENTIN, Uwe , BALES, Scott, A. , BORDONARO, Frank, G. , FUSSELL, John, P. , PEARCE, Bernie, P. , SCHMIDT, Paul, A.
IPC分类号： H04L12/66
摘要： A method for communicating data is provided that includes receiving a plurality of bits associated with a communications flow and determining whether one or more samples included in the flow should be suppressed. The method also includes suppressing a selected one or more of the samples if the selected samples are similar to previously received samples. In a more particular embodiment, the method also includes positioning unique samples that are included in the flow in a super-frame to be communicated to a next destination. Additionally, the method may include receiving the unique samples and evaluating the unique samples in order to restore a plurality of bits associated with the communications flow.

5. 发明申请

WO2004091494A3 METHOD FOR PREPARATION OF SITE-SPECIFIC PROTEIN CONJUGATES 审中-公开
标题翻译：制备特异性蛋白质结合蛋白的方法
公开(公告)号：WO2004091494A3
公开(公告)日：2006-02-09
申请号：PCT/US2004010995
申请日：2004-04-08
申请人： PR PHARMACEUTICALS INC , HINDS KENNETH , LEWIS DANNY , SCHMIDT PAUL , CAMPBELL KATHLEEN M
发明人： HINDS KENNETH , LEWIS DANNY , SCHMIDT PAUL , CAMPBELL KATHLEEN M
IPC分类号： A61K20060101 , A61K31/00 , A61K38/28
CPC分类号： A61K47/60 , A61K9/5031 , A61K38/28 , A61K47/48215 , C07K14/62
摘要： The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB 1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.
摘要翻译：本发明涉及用于快速且有效地制备包括胰岛素 - 聚合物缀合物的蛋白质 - 聚合物缀合物的单步方法。根据本发明的方法，蛋白质和亲水性聚合物在至少一种有机溶剂和至少一种金属螯合剂的存在下，在促进蛋白质和聚合物的缀合物形成的条件下接触。因此，本发明涉及在残基PheB 1上与聚（乙二醇）一起选择的蛋白质（例如胰岛素）的位点特异性修饰。本发明还提供用于将缀合物包封在可生物降解的聚合物中的药物制剂。

6. 发明申请

WO2005060614A2 OIL FILTRATION SYSTEM 审中-公开
标题翻译：油过滤系统
公开(公告)号：WO2005060614A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/041156
申请日：2004-12-09
申请人： KOMATSU AMERICA CORP. , SCHMIDT, Paul, Wayne , BOATMAN, Robert, Murray
发明人： SCHMIDT, Paul, Wayne , BOATMAN, Robert, Murray
IPC分类号： B01D36/02 , F16N7/38 , F16N39/06
CPC分类号： F16N7/38 , B01D36/02 , F16N39/06
摘要： An oil filtration system includes three separate tanks. A first of these tanks is to receive oil from a wheel motor of the mining or construction vehicle. A second of these tanks is to receive the oil from the first tank after the oil in the first tank has been suffficiently heated so as to remove moisture therefrom. And, a third of these tanks is to receive the oil from the second tank after the oil has been sufficiently filtered so as to remove particles and debris therefrom. The third tank can hold the filtered oil therein until it is ready to be supplied back to the wheel motor.
摘要翻译：油过滤系统包括三个独立的油箱。这些坦克中的第一个是从采矿或建筑车辆的车轮电机接收油。这些坦克中的第二个是在第一个坦克中的油已经被充分加热之后，从第一个坦克接收油，从而从中除去水分。而且，三分之一的这些坦克是在油被充分过滤之后从第二个坦克接收油，以从中除去颗粒和碎屑。第三个罐可以将过滤的油保持在其中，直到它准备被送回到车轮马达。

7. 发明申请

WO2005044692A1 PACKAGE FOR SEGREGATING AND MIXING SUBSTANCES 审中-公开
标题翻译：分离和混合物质的包装
公开(公告)号：WO2005044692A1
公开(公告)日：2005-05-19
申请号：PCT/US2004/013181
申请日：2004-04-28
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , SCHMIDT, Paul, R. , MURPH, Nefetari, B. , BRUNNER, Michael, S. , LINDON, Jack
发明人： SCHMIDT, Paul, R. , MURPH, Nefetari, B. , BRUNNER, Michael, S. , LINDON, Jack
IPC分类号： B65D81/32
CPC分类号： B65D81/3266
摘要： The present invention relates to a package that includes an enclosure (11) having a first substance (14) and a second substance (15) within the enclosure. The package further includes a plastic zipper (18) which segregates the first substance from the second substance within the enclosure such that opening the plastic zipper (18) allows the first substance and the second substance to be mixed together inside the enclosure. In another aspect, the package includes a gas-permeable enclosure and first and second solid substances stored within the enclosure. A mechanism, such as a plastic zipper, segregates the first and second solid substances. Opening the mechanism allows a user to mix the first and second solid substances inside the enclosure to produce a gas. The package permits the gas that is produced to permeate through the gas-permeable enclosure for distribution throughout an area.
摘要翻译：本发明涉及一种包装盒，其包括在外壳内具有第一物质（14）和第二物质（15）的外壳（11）。该包装还包括塑料拉链（18），该塑料拉链将第一物质与外壳内的第二物质隔开，使得打开塑料拉链（18）允许第一物质和第二物质在外壳内混合在一起。在另一方面，包装包括气体可渗透的外壳和存储在外壳内的第一和第二固体物质。诸如塑料拉链的机构分离第一和第二固体物质。打开机构允许用户将第一和第二固体物质混合在外壳内以产生气体。该包装允许产生的气体渗透通过气体可渗透的外壳以分布在整个区域中。

8. 发明申请

WO2003092585A2 CONTROLLED RELEASE COMPOSITIONS OF ESTRADIOL METABOLITES 审中-公开
标题翻译： ESTRADIOL代谢物的控制释放组成
公开(公告)号：WO2003092585A2
公开(公告)日：2003-11-13
申请号：PCT/US2003/012727
申请日：2003-04-25
申请人： PR PHARMACEUTICALS, INC. , ALLISON, Dean, S. , SCHMIDT, Paul, G. , HUDNUT, Paul, S.
发明人： ALLISON, Dean, S. , SCHMIDT, Paul, G. , HUDNUT, Paul, S.
IPC分类号： A61K
CPC分类号： A61K9/5153 , A61K9/145 , A61K9/1647 , A61K9/7038 , A61K31/56 , A61K31/565 , A61K47/10
摘要： The present invention provides improved sustained release formulations of estradiol metabolites, including 2-hydroxyestradiol, 2-methoxyestradiol, 4-hydroxyestradiol and 4-methoxyestradiol, useful for therapeutic treatments. The invention also provides methods of producing sustained release forms of estradiol metabolites. The compositions of the present invention include microparticles, nanoparticles, patches, crystals, gels, rods, stints, pellets, discs, lozenges, wafers, capsules, films, microcapsules, nanocapsules, hydrogels, liposomes, implants and vaginal rings. Compositions also include formulations for transdermal and intravenous delivery of estradiol metabolites. The present invention provides numerous improvements over previous forms of estradiol metabolites, such advantages including the sustained release of normally short half-life compounds to maintain therapeutic blood levels.
摘要翻译：本发明提供可用于治疗性治疗的改进的雌二醇代谢物的缓释制剂，包括2-羟基雌二醇，2-甲氧基雌二醇，4-羟基雌二醇和4-甲氧基雌二醇。本发明还提供了产生雌二醇代谢物的持续释放形式的方法。本发明的组合物包括微粒，纳米颗粒，贴剂，晶体，凝胶，棒，钉，丸，盘，锭剂，晶片，胶囊，膜，微胶囊，纳米胶囊，水凝胶，脂质体，植入物和阴道环。组合物还包括用于经皮和静脉内递送雌二醇代谢物的制剂。本发明提供了与先前形式的雌二醇代谢物相比的许多改进，包括持续释放通常短的半衰期化合物以维持治疗血液水平的优点。

9. 发明申请

WO02056121A2 SAMPLE TRACKING SYSTEMS 审中-公开
标题翻译：样本跟踪系统
公开(公告)号：WO02056121A2
公开(公告)日：2002-07-18
申请号：PCT/GB0105578
申请日：2001-12-17
申请人： SCHMIDT PAUL , PRELLER KOBUS
发明人： SCHMIDT PAUL , PRELLER KOBUS
IPC分类号： A61B5/117 , A61B5/15 , G05B19/12 , G05B
CPC分类号： A61B5/411 , A61B5/117 , A61B5/15003 , A61B5/150389 , A61B5/150503 , A61B5/150793 , A61B5/150854 , A61B5/154 , A61B2562/08 , G05B19/12 , G05B2219/31095 , G05B2219/31162 , G05B2219/33192 , G05B2219/45092
摘要： A method of tracking and controlling the passage of samples through test procedures, which comprising the follwing steps. Introducing a sample (10) into a sample carrier (12) provided with a memory chip (14) that can store and provide tat that can be retrieved wirelessly. Programming sample specific data, such as the origin of the sample and the tests to be done, onto the chip (14). Introdicing the sample carrier and sample to testing appratus with chip reading means, and then elelctronically reading data on the chip (14). Performing appropriate processing and sorting on the sample. Loading at least partial details concerning the tests onto the memory chip (14) and finally using the sample specific data to return the test results and other data to a person who requested the test. The invention also includes sample carriers for use with such a method.
摘要翻译：跟踪和控制样本通过测试程序的方法，包括以下步骤。将样本（10）引入到设有存储器芯片（14）的样本载体（12）中，所述存储器芯片（14）可以存储并提供可以无线地检索的文本。将样本特定的数据（例如样本的来源和要进行的测试）编程到芯片（14）上。使用芯片读取装置将样本载体和样本输送到测试设备，然后以电流方式读取芯片上的数据（14）。对样品进行适当的处理和分类。将至少部分关于测试的细节加载到存储器芯片（14）上，最后使用样本特定数据将测试结果和其他数据返回给请求测试的人。本发明还包括用于这种方法的样品载体。

10. 发明申请

WO1998018480A1 VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) NUCLEIC ACID LIGAND COMPLEXES 审中-公开
标题翻译：血管内皮生长因子（VEGF）核酸配体复合物
公开(公告)号：WO1998018480A1
公开(公告)日：1998-05-07
申请号：PCT/US1997018944
申请日：1997-10-17
申请人： NEXSTAR PHARMACEUTICALS, INC. , JANJIC, Nebojsa , GOLD, Larry , SCHMIDT, Paul, G. , VARGEESE, Chandra , WILLIS, Michael
发明人： NEXSTAR PHARMACEUTICALS, INC.
IPC分类号： A61K37/22
CPC分类号： C12N15/115 , A61K9/0019 , A61K9/0048 , A61K9/127 , A61K38/00 , A61K47/544 , C07H21/00 , C07K14/52 , C12N15/88 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3521
摘要： This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.
摘要翻译：本发明公开了一种通过使用SELEX方法鉴定VEGF核酸配体来制备由VEGF核酸配体和非免疫原性，高分子量化合物或亲脂性化合物组成的复合物的方法，并将VEGF核酸配体与非 - 免疫原性，高分子量化合物或亲脂性化合物。本发明还公开了包含与非免疫原性，高分子量化合物或亲脂性化合物结合的一种或多种VEGF核酸配体的复合物。本发明还包括含有VEGF核酸配体或复合物的脂质构建物及其制备方法。

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