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1. 发明申请

WO9843618A3 THERAPEUTIC INHIBITOR OF VASCULAR SMOOTH MUSCLE CELLS 审中-公开
标题翻译：血管平滑肌细胞的治疗抑制剂
公开(公告)号：WO9843618A3
公开(公告)日：1998-11-05
申请号：PCT/US9806322
申请日：1998-03-31
申请人： NEORX CORP
发明人： KUNZ LAWRENCE L , KLEIN RICHARD A , RENO JOHN M
IPC分类号： A61K9/00 , A61K31/00 , A61K31/04 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/48 , A61L31/08 , A61L31/14 , A61L31/16 , A61P7/00 , A61P9/00 , A61P43/00
CPC分类号： A61K31/403 , A61K9/0024 , A61K9/0051 , A61K31/00 , A61K31/04 , A61K31/131 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/17 , A61K31/337 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/407 , A61K31/519 , A61K31/551 , A61K31/704 , A61K47/34 , A61K47/51 , A61K47/6803 , A61K47/6809 , A61K47/6817 , A61K47/6831 , A61K47/6843 , A61K47/6923 , A61K47/6927 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/432 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61L2300/63 , G01N2800/323
摘要： Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.

2. 发明申请

WO0075333A9 STREPTAVIDIN EXPRESSED GENE FUSIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译： STREPTAVIDIN EXPRESSED GENE FUSIONS及其使用方法
公开(公告)号：WO0075333A9
公开(公告)日：2002-06-20
申请号：PCT/US0015595
申请日：2000-06-05
申请人： NEORX CORP , GOSHORN STEPHEN CHARLES , GRAVES SCOTT STOLL , SCHULTZ JOANNE ELAINE , LIN YUKANG , SANDERSON JAMES ALLEN , RENO JOHN M
发明人： GOSHORN STEPHEN CHARLES , GRAVES SCOTT STOLL , SCHULTZ JOANNE ELAINE , LIN YUKANG , SANDERSON JAMES ALLEN , RENO JOHN M
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K47/48 , A61K48/00 , A61P35/00 , C07K14/36 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/31 , C12Q1/02 , G01N33/574 , A61K39/395 , C12N15/62 , C12N15/72
CPC分类号： B82Y5/00 , A61K39/00 , A61K47/665 , C07K14/36 , C07K16/2896 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/22
摘要： The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genomic streptavidin are provided as are vectors encoding the same. Also provided, are methods of using the fusion proteins of the present invention, and in particular, the use of scFvSA fusion proteins as diagnostic markers or as a cell specific targeting agents.
摘要翻译：本发明提供用于表达基因组链霉亲和素融合盒的载体。在各种实施方案中，提供了由这些载体产生的融合蛋白。在具体实施方案中，提供包含单链抗体和基因组链霉抗生物素蛋白的融合蛋白，如同编码它们的载体。还提供了使用本发明的融合蛋白的方法，特别是使用scFvSA融合蛋白作为诊断标记物或作为细胞特异性靶向剂。

3. 发明申请

WO9912968A3 CHEMOKINE PEPTIDES, VARIANTS, DERIVATIVES AND ANALOGS, THEIR USE IN METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE 审中-公开
标题翻译：化学药物，变体，衍生物和类似物，它们用于抑制或损害炎症反应的方法
公开(公告)号：WO9912968A3
公开(公告)日：1999-07-29
申请号：PCT/US9819052
申请日：1998-09-11
申请人： NEORX CORP , GRAINGER DAVID J , TATALICK LAUREN MARIE , KANALY SUZANNE T
发明人： GRAINGER DAVID J , TATALICK LAUREN MARIE , KANALY SUZANNE T
IPC分类号： A61K38/00 , A61K31/16 , A61K45/06 , A61K47/48 , A61P3/14 , A61P9/10 , A61P17/02 , A61P17/06 , A61P31/12 , A61P33/00 , A61P33/06 , A61P35/00 , A61P37/02 , C07K7/06 , C07K14/52 , A61K38/19 , C07C229/30 , C07C237/22 , C07K5/08 , C07K7/64
CPC分类号： C07K14/523 , A61K38/00 , A61K45/06 , A61K47/68 , C07K14/522
摘要： Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
摘要翻译：提供分离和纯化的趋化因子肽，变体和衍生物，以及趋化因子肽类似物。

4. 发明申请

WO8911877A3 CONJUGATES FOR BONE IMAGING AND BONE CANCER THERAPY 审中-公开
标题翻译：骨骼成像和骨癌治疗结合
公开(公告)号：WO8911877A3
公开(公告)日：1990-03-08
申请号：PCT/US8902510
申请日：1989-06-08
申请人： NEORX CORP
发明人： FRITZBERG ALAN R , VANDERHEYDEN JEAN-LUC E , KASINA SUDHAKAR , FITZNER JEFFREY N
IPC分类号： A61K51/00 , A61K51/04 , A61P35/00 , C07F1/08 , C07F1/12 , C07F9/38 , C07F13/00 , A61K49/02
CPC分类号： C07F13/005 , A61K51/0497 , A61K2121/00 , A61K2123/00 , C07F9/3873
摘要： The present invention provides conjugates formed from calcified tissues targeting agents and radiolabeled compounds. One such conjugate comprises a chelate and a targeting agent that is capable of associating with calcified tissue, wherein the chelate contains at least four atoms selected from nitrogen atoms or sulfur atoms or combinations thereof as the donor atoms. Another aspect of the invention provides conjugates for diagnostic and therapeutic purposes, including those related to bone cancer.

5. 发明申请

WO0042071A3 COMPOUNDS AND METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE 审中-公开
标题翻译：化合物和方法抑制或损害炎症反应
公开(公告)号：WO0042071A3
公开(公告)日：2001-05-31
申请号：PCT/US0000821
申请日：2000-01-12
申请人： NEORX CORP , GRAINGER DAVID J , TATALICK LAUREN MARIE
发明人： GRAINGER DAVID J , TATALICK LAUREN MARIE
IPC分类号： G01N33/50 , A61K31/198 , A61K31/4015 , A61K31/437 , A61K31/4375 , A61K31/45 , A61K31/472 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/515 , A61K31/7052 , A61K38/00 , A61K47/48 , A61P9/00 , A61P9/10 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/10 , A61P29/00 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/416 , C07D211/88 , C07D217/24 , C07D457/04 , C07D457/06 , C07D459/00 , C07D471/04 , C07K5/08 , C07K5/097 , C07K14/52 , G01N33/15 , A61K31/435 , A61K38/19 , C07C229/30 , C07C237/22
CPC分类号： C07D457/04 , A61K31/4375 , A61K31/45 , A61K31/472 , A61K31/475 , A61K31/515 , A61K38/00 , A61K47/6898 , B82Y5/00 , C07D211/88 , C07D457/06 , C07D459/00 , C07K14/521 , G01N33/6863 , G01N2500/02
摘要： Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
摘要翻译：提供分离和纯化的趋化因子肽，变体和衍生物，以及趋化因子肽类似物。

6. 发明申请

WO0076556A2 HIGH DOSE RADIONUCLIDE COMPLEXES FOR BONE MARROW SUPPRESSION 审中-公开
标题翻译：用于骨髓抑制的高剂量放射性核素复合物
公开(公告)号：WO0076556A2
公开(公告)日：2000-12-21
申请号：PCT/US0016052
申请日：2000-06-12
申请人： NEORX CORP , ABRAMS PAUL G , TATALICK LAUREN M , THOELKE KENT R , BRYAN JAMES KYLE , JOHN ELIZABETH K , HYLARIDES MARK D , FRITZBERG ALAN R
发明人： ABRAMS PAUL G , TATALICK LAUREN M , THOELKE KENT R , BRYAN JAMES KYLE , JOHN ELIZABETH K , HYLARIDES MARK D , FRITZBERG ALAN R
IPC分类号： A61K45/00 , A61K31/192 , A61K31/198 , A61K31/375 , A61K31/555 , A61K31/664 , A61K31/675 , A61K31/711 , A61K48/00 , A61K51/00 , A61K51/04 , A61P5/28 , A61P7/00 , A61P31/00 , A61P31/04 , A61P31/06 , A61P35/00 , A61P35/02 , A61P35/04 , A61P39/06 , A61P43/00
CPC分类号： A61K51/0482 , A61K51/0478 , A61K51/0489 , Y10S514/836
摘要： The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid.
摘要翻译：本发明涉及一种抑制骨髓（BM）的治疗方法，并且治疗在诸如癌症，骨髓增生性疾病，自身免疫性疾病，传染病，代谢疾病或遗传疾病之类的骨附近或附近产生的病症，组合物具有作为其活性成分的组合物与螯合剂如大环氨基膦酸络合的放射性核素。

7. 发明申请

WO9843678B1 TETRAAZA- OR N2S2- COMPLEXANTS, AND THEIR USE IN RADIODIAGNOSTICS OR RADIOTHERAPY 审中-公开
标题翻译：四氮芥或N2S2-复合物及其在放射免疫或放射治疗中的应用
公开(公告)号：WO9843678B1
公开(公告)日：1999-04-01
申请号：PCT/US9805858
申请日：1998-03-26
申请人： NEORX CORP
发明人： KASINA SUDHAKAR
IPC分类号： A61K51/00 , A61K51/04 , A61K51/08 , A61P35/00 , C07C229/16 , C07C229/18 , C07C323/34 , C07D257/10 , C07D265/32 , C07D285/00 , C07D333/36 , C07D495/04 , C07D495/14 , C07F5/00 , C07F9/22 , C07F9/38 , C07F9/6524 , C07F9/6553 , C07F9/6561 , C07F13/00
CPC分类号： C07F13/005 , A61K51/04 , A61K51/0478 , A61K51/0482 , A61K51/0489 , A61K51/0497 , A61K51/087 , A61K51/088 , C07B2200/05 , C07C229/16 , C07C323/34 , C07D257/10 , C07D265/32 , C07D285/00 , C07D333/36 , C07D495/04 , C07D495/14 , C07F9/3817 , C07F9/6524 , C07F9/655345 , C07F9/6561
摘要： The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds. Another aspect of the invention provides for the use of the chelation compounds described above in methods for diagnostic and therapeutic purposes. A diagnostic method is described for detecting the presence or absence of a target site within a mammalian host. This method comprises providing to cells a diagnostically effective dose of a compound of the present invention which contains a metal radionuclide, such as Tc and/or In, and detecting the biodistribution of the radionuclide. A therapeutic method is described for delivering a radionuclide, such as Re/ Re, Y, and Sm, to a target site within a mammalian host. This method comprises providing to cells a therapeutically effective dose of a chelate compound of the present invention.
摘要翻译：本发明提供了取代的金属螯合化合物，其中至少两个螯合原子是直接连接到芳族环上的氮，并且一个或多个这些氮原子连接有除氢之外的取代基，以及制备和使用方法这些化合物。本发明的另一方面提供了用于诊断和治疗目的的方法中上述螯合化合物的用途。描述了用于检测哺乳动物宿主内目标位点的存在或不存在的诊断方法。该方法包括向细胞提供含有金属放射性核素（例如99m Tc和/或111 In）的诊断有效剂量的本发明化合物，并检测放射性核素的生物分布。描述了用于将放射性核素例如186 Re / 188 Re，<90> Y和<153> Sm的递送至哺乳动物宿主内的靶位点的治疗方法。该方法包括向细胞提供治疗有效剂量的本发明的螯合物。

8. 发明申请

WO9325240A3 PRETARGETING METHODS AND COMPOUNDS 审中-公开
标题翻译：预测方法和化合物
公开(公告)号：WO9325240A3
公开(公告)日：1994-02-17
申请号：PCT/US9305406
申请日：1993-06-07
申请人： NEORX CORP
发明人： AXWORTHY DONALD B , THEODORE LOUIS J , GUSTAVSON LINDA M , RENO JOHN M
IPC分类号： A61K39/395 , A61K47/48 , A61K51/00 , A61K51/04 , A61K51/12 , A61P43/00 , C07D495/04 , A61K43/00
CPC分类号： C07D495/04 , A61K47/54 , A61K47/557 , A61K47/665 , A61K47/68 , A61K47/6887 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/1268 , A61K2121/00 , A61K2123/00 , B82Y5/00
摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.
摘要翻译：公开了与诊断和治疗剂的预靶向递送相关的方法，化合物，组合物和试剂盒。特别地，描述了用于生物素的放射性金属标记和改善生物素的放射性卤化的方法以及相关化合物。此外，讨论了清除剂，抗配体靶向部分缀合物，靶细胞保留增强部分和另外的方法。

9. 发明申请

WO9746589A3 HUMANIZED ANTIBODIES THAT BIND TO THE SAME ANTIGEN AS BOUND BY ANTIBODY NR-LU-13, AND THEIR USE IN PRETARGETING METHODS 审中-公开
标题翻译：与抗体NR-LU-13接触的抗体相结合的人体抗体及其在预防方法中的使用
公开(公告)号：WO9746589A3
公开(公告)日：2002-09-19
申请号：PCT/US9710074
申请日：1997-06-06
申请人： NEORX CORP
发明人： GRAVES SCOTT S , RENO JOHN M , MALLET ROBERT W , HYLARIDES MARK D , SEARLE STEPHEN M J , HENRY ANDREW H , PEDERSEN JAN T , REES ANTHONY R
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K47/48 , A61P35/00 , C07K1/113 , C07K16/00 , C07K16/30 , C07K16/46 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/574 , G01N33/577
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/68 , A61K47/6898 , A61K2039/505 , C07K1/1133 , C07K16/00 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
摘要翻译：提供了结合NR-LU-13抗原的人源化抗体，含有这些抗体的缀合物，以及它们在预靶向方法和常规抗体治疗和免疫诊断中的用途。

10. 发明申请

WO9921533A3 DELIVERY VEHICLES FOR BIOACTIVE AGENTS AND USES THEREOF 审中-公开
标题翻译：用于生物活性剂的递送车辆及其用途
公开(公告)号：WO9921533A3
公开(公告)日：1999-07-08
申请号：PCT/US9822552
申请日：1998-10-23
申请人： NEORX CORP , SOUTHERN RES INST , KUNZ LAWRENCE L , TICE THOMAS R , LIBBY RANDELL T , MCDANIEL CHRISTOPHER W
发明人： KUNZ LAWRENCE L , TICE THOMAS R , LIBBY RANDELL T , MCDANIEL CHRISTOPHER W
IPC分类号： A61K9/107 , A61K48/00
CPC分类号： A61K9/1075
摘要： Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically-modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agent.
摘要翻译：用于跨越生物膜运输生物活性剂的组合物包括生物活性剂，油，油不混溶性化合物和非阳离子表面活性剂。组合物可以通过化学微孔处理机制递送生物活性剂，其允许药剂跨细胞，细胞内细胞器和核膜转移。用于核酸递送的组合物包括核酸，油，油不混溶性化合物，非阳离子表面活性剂和基本上不含阳离子脂质，或包括核酸，油，油不混溶性化合物和两种非阳离子表面活性剂。核酸可以是疏水改性的，并且可以与油，油不混溶的化合物和至少一种表面活性剂组合。该组合物可以用于基因递送至细胞，以及递送其他治疗剂。

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