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1. 发明申请

WO2004112590A2 METHODS OF ENHANCING RADIATION EFFECTS WITH METAL NANOPARTICLES 审中-公开
标题翻译：用金属纳米粒子增强辐射效应的方法
公开(公告)号：WO2004112590A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/007402
申请日：2004-03-11
申请人： HAINFELD, James, F. , SLATKIN, Daniel, N.
发明人： HAINFELD, James, F. , SLATKIN, Daniel, N.
IPC分类号： A61B
CPC分类号： A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radition in therapeutic regimes ob ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo .
摘要翻译：本发明提供了使用直径为0.5-400nm的金属纳米粒子的方法，以增强X射线或其它种类的辐射在治疗方案中的剂量和效力，从而消除诸如肿瘤的靶组织。金属纳米颗粒可以静脉内，动脉内或局部施用，以实现靶组织内和周围的特异性负载。金属纳米颗粒也可以连接到特异性结合靶组织的化学和/或生物化学部分。增强的辐射方法也可用于离体消融不需要的组织或细胞。

2. 发明申请

WO2008109617A1 SITE-SPECIFIC ENZYMATIC DEPOSITION OF METAL IN SITU 审中-公开
标题翻译： SITE特殊的金属沉积在金属
公开(公告)号：WO2008109617A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/055823
申请日：2008-03-04
申请人： NANOPROBES, INC. , HAINFELD, James, F. , LIU, Wenqiu
发明人： HAINFELD, James, F. , LIU, Wenqiu
IPC分类号： C12N9/00
CPC分类号： C12Q1/28 , C12N9/0065 , C12P3/00 , C12Q1/001 , C12Q1/26 , C12Q1/6827 , G01N33/543 , G01N33/54306 , G01N33/5438 , G01N33/581 , G01N2458/10 , G01N2800/52 , Y10S435/975 , C12Q2563/125 , C12Q2563/113
摘要： The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to linking of metals to enzyme substrates, control of enzymatic metal deposition and applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.
摘要翻译：本发明提供用于进行允许生物酶直接作用于金属和金属颗粒的方法的制品的组合物，试剂盒，制品组合和方法。特别地，本发明涉及使用酶来选择性地将金属沉积到靶分子附近。本发明还涉及金属与酶底物的连接，酶金属沉积的控制和酶金属沉积的应用以灵敏和选择性地检测靶分子，例如各种生物样品中的生物标志物，例如通过使用原位生物显色免疫组织化学（IHC）检测明场光学显微镜。

3. 发明申请

WO2006086631A2 METHODS FOR IMPLEMENTING MICROBEAM RADIATION THERAPY 审中-公开
标题翻译：实施微波辐射治疗的方法
公开(公告)号：WO2006086631A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004734
申请日：2006-02-10
申请人： BROOKHAVEN SCIENCE ASSOCIATES , DILMANIAN, Avraham, F. , MORRIS, Gerard, M. , HAINFELD, James, F. , ANSCHEL, David, J. , ROMANELLI, P.
发明人： DILMANIAN, Avraham, F. , MORRIS, Gerard, M. , HAINFELD, James, F. , ANSCHEL, David, J. , ROMANELLI, P.
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1017 , A61N5/1084 , A61N2005/1091 , A61N2005/1098
摘要： A method of performing microbeam radiation therapy (MRT) includes delivering a dose only to selected tissue in a target volume with continuous broad beam, first, by interleaving arrays of microplanar beams only at the target. Administered contrast agents can supplement the effect by preferentially increasing the target dose relative to dose in normal tissue. A broad beam effect is alternatively created using non-interleaving microbeam array(s) with scattering agents administered to selected tissue that preferentially increase valley dose within target to approximate broad beam. The methods of interleaving microbeams are also applied to treat diseases and conditions by ablating at least a portion of selected tissue, or by damaging blood-brain barrier for efficient drug and/or cell administration. A system for performing interlaced microbeam radiosurgery preferably includes two orthogonal radiation source arms for producing and interleaving microbeam arrays at the target volume. The methods treat tumors, pain, epilepsy, and neurological diseases.
摘要翻译：执行微束放射治疗（MRT）的方法包括仅在具有连续宽波束的目标体积中向选定的组织输送剂量，首先通过仅在目标处交错微平面波束阵列。施用的造影剂可以通过相对于正常组织中的剂量优先增加目标剂量来补充该作用。交替地使用非交错微束阵列产生广泛的束效应，其具有施用于选定组织的散射剂，其优先地增加靶内的谷值以接近宽束。交织微束束的方法也适用于通过消融选定组织的至少一部分，或通过损害血脑屏障以有效的药物和/或细胞给药来治疗疾病和病症。用于执行交织微束放射外科的系统优选地包括用于在目标体积处产生和交织微束阵列的两个正交辐射源臂。该方法治疗肿瘤，疼痛，癫痫和神经系统疾病。

4. 发明申请

WO0207846A8 EXTENDED ORGANIC COBALT AND NICKEL MAGNETIC COMPLEXES 审中-公开
标题翻译：扩展有机钴和镍磁性复合材料
公开(公告)号：WO0207846A8
公开(公告)日：2002-07-25
申请号：PCT/US0122832
申请日：2001-07-20
申请人： HAINFELD JAMES F
发明人： HAINFELD JAMES F
IPC分类号： A61K49/00 , G01R33/28 , A66B5/055 , G01N24/00
CPC分类号： G01R33/5601 , A61K49/16 , A61K49/1866 , A61K49/1875 , B82Y5/00
摘要： A method for in vivo imaging tissue of a individual, by performing magnetic resonance imaging utilizing an extended cobalt complex as a contrast enhancement agent. The extended cobalt complex is comprised of cobalt atoms, a carboxylate ligand, an amine ligand, and a multidentate thiol-containing organic ligand, the cobalt atoms being linked to thiol groups and counter ions. Also, a method for visually detecting the presence of an antigen in a sample using an antibody being coupled to an extended cobalt complex.
摘要翻译：通过使用扩展的钴络合物作为对比度增强剂进行磁共振成像来体内成像个体的组织的方法。扩展的钴络合物包括钴原子，羧酸盐配体，胺配体和多齿硫醇的有机配体，钴原子连接到硫醇基团和抗衡离子。另外，使用与延伸的钴络合物偶联的抗体来目视检测样品中抗原的存在的方法。

5. 发明申请

WO0006244A3 LOADING METAL PARTICLES INTO CELL MEMBRANE VESICLES AND METAL PARTICLE USE FOR IMAGING AND THERAPY 审中-公开
标题翻译：将金属颗粒加载到细胞膜和金属颗粒中用于成像和治疗
公开(公告)号：WO0006244A3
公开(公告)日：2000-06-15
申请号：PCT/US9917181
申请日：1999-07-29
申请人： HAINFELD JAMES F
发明人： HAINFELD JAMES F
IPC分类号： A61B6/00 , A61K41/00 , A61K47/48 , A61K49/22 , A61N1/40 , A61N5/00 , A61N5/06 , A61N5/10 , A61K49/04 , A61K49/00
CPC分类号： A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Delivery of metal particles to living tissue, then applying external energy that interacts with the metal particles, is found to selectively increase the energy deposition and interaction surrounding the metal particles. The method is useful to improve treatment of various conditions, since targeted cells may be selectively altered or killed. Metal particles are also loaded into cells or membrane vesicles by placing metal seed particles into the cells or vesicles, then chemically depositing additional metal on the metal seed particles. The metal particles are useful to improve imaging and therapies by their interaction with externally applied energy.
摘要翻译：发现金属颗粒向活体组织递送，然后施加与金属颗粒相互作用的外部能量，选择性地增加金属颗粒周围的能量沉积和相互作用。该方法可用于改善各种病症的治疗，因为靶细胞可被选择性地改变或杀死。通过将金属种子颗粒放入细胞或囊泡中，然后在金属种子颗粒上化学沉积另外的金属，将金属颗粒也加载到细胞或膜囊泡中。金属颗粒通过与外部施加的能量的相互作用来改善成像和治疗是有用的。

6. 发明申请

WO2006086631A3 METHODS FOR IMPLEMENTING MICROBEAM RADIATION THERAPY 审中-公开
标题翻译：实施微波辐射治疗的方法
公开(公告)号：WO2006086631A3
公开(公告)日：2006-10-12
申请号：PCT/US2006004734
申请日：2006-02-10
申请人： BROOKHAVEN SCIENCE ASS LLC , DILMANIAN AVRAHAM F , MORRIS GERARD M , HAINFELD JAMES F , ANSCHEL DAVID J , ROMANELLI P
发明人： DILMANIAN AVRAHAM F , MORRIS GERARD M , HAINFELD JAMES F , ANSCHEL DAVID J , ROMANELLI P
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1017 , A61N5/1084 , A61N2005/1091 , A61N2005/1098
摘要： A method of performing microbeam radiation therapy (MRT) includes delivering a dose only to selected tissue in a target volume (10) with continuous broad beam, first, by interleaving arrays of microplanar beams (30,36) only at the target (10). Administered contrast agents can supplement the effect by preferentially increasing the target dose relative to dose in normal tissue. A broad beam effect is alternatively created using non-interleaving microbeam array(s) with scattering agents administered to selected tissue that preferentially increase valley dose (69) within target to approximate broad beam. The methods of interleaving microbeams are also applied to treat diseases and conditions by ablating at least a portion of selected tissue, or by damaging blood-brain barrier for efficient drug and/or cell administration. A system for performing interlaced microbeam radiosurgery preferably includes two orthogonal radiation source arms (102) for producing and interleaving microbeam arrays (30,36) at the target volume (10). The methods treat tumors, pain, epilepsy, and neurological diseases.
摘要翻译：一种执行微束放射治疗（MRT）的方法包括：仅向具有连续宽束的目标体积（10）中的选定组织递送剂量，首先，仅通过在靶（10）上交错微平面波束（30,36）的阵列，。施用的造影剂可以通过相对于正常组织中的剂量优先增加目标剂量来补充该作用。交替地使用非交错微束阵列产生广泛的束效应，其具有施用于选定组织的散射剂，其优先地增加靶内的谷剂量（69）以接近宽束。交织微束束的方法也适用于通过消融选定组织的至少一部分，或通过损害血脑屏障以有效的药物和/或细胞给药来治疗疾病和病症。用于执行交织微束放射外科的系统优选地包括用于在目标体积（10）处产生和交织微束阵列（30,36）的两个正交辐射源臂（102）。该方法治疗肿瘤，疼痛，癫痫和神经系统疾病。

7. 发明申请

WO2004112590A3 METHODS OF ENHANCING RADIATION EFFECTS WITH METAL NANOPARTICLES 审中-公开
公开(公告)号：WO2004112590A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/007402
申请日：2004-03-11
申请人： HAINFELD, James, F. , SLATKIN, Daniel, N.
发明人： HAINFELD, James, F. , SLATKIN, Daniel, N.
IPC分类号： A61N5/00
摘要： The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radition in therapeutic regimes ob ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo .

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