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1. 发明申请

WO2014106731A1 THE CLEANING OF ANIMAL BODY PARTS 审中-公开
标题翻译：动物身体部位的清洁
公开(公告)号：WO2014106731A1
公开(公告)日：2014-07-10
申请号：PCT/GB2013/053333
申请日：2013-12-18
申请人： GENUS PLC
发明人： KING, Andrew
IPC分类号： A01J7/04
CPC分类号： A01K13/001 , A01J7/04
摘要： A method of disinfecting or cleaning a body part of an animal comprising the steps of: impregnating a web of material with a disinfectant liquid and capable of generating a foam; causing the liquid within the web to foam; applying foaming liquid to the body part with the web including wiping the animal body part with the impregnated web; allowing the foaming liquid thus applied to the body part to evaporate from the body part.
摘要翻译：一种对动物的身体部位进行消毒或清洁的方法，包括以下步骤：用消毒液浸渍材料网并且能够产生泡沫; 使得网内的液体发泡; 将泡沫液体施加到身体部分，其中所述网包括用所述浸渍的纤维网擦拭所述动物体部分; 使得如此施加到身体部位的发泡液体从身体部分蒸发。

2. 发明申请

WO2013142697A1 CYB5 AND CYP17 MUTATIONS FOR ALTERATION OF 16-ANDROSTENE STEROID SYNTHESIS AND REDUCED BOAR TAINT IN PIGS 审中-公开
标题翻译： CYB5和CYP17突变体，用于改变16位安慰剂甾体合成和减少血小板
公开(公告)号：WO2013142697A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/033316
申请日：2013-03-21
申请人： E.J. SQUIRES, LTD. , GENUS, PLC , SQUIRES, E. James
发明人： SQUIRES, E. James
IPC分类号： C07K14/435
CPC分类号： C12N9/0085 , A01K67/0275 , A01K2227/108 , C12N9/004 , C12N15/8509 , C12Q1/6883 , C12Q2600/156 , C12Y106/02002 , C12Y401/0203
摘要： Novel mutations in cytochrome P450C17 (CYP17) and cytochrome b5 (CYB5) affecting 16-androstene steroid synthesis are disclosed. The novel mutations result in alterations in production of critical intermediaries in the synthesis of 16-androstene steroids. Altering the activity of these enzymes may be useful in enhancing reducing androstenone synthesis and reducing boar taint. The identification of these novel mutations also allows for the development of transgenic pigs bearing mutations in these enzymes or for genetic screening to identify pigs on the basis of their CYP17 and/or CYB5 genotype. Pigs having these mutations may be selected and bred to produce pigs that have a lower incidence of boar taint.
摘要翻译：公开了影响16-雄烯类固醇合成的细胞色素P450C17（CYP17）和细胞色素b5（CYB5）的新突变。新型突变导致关键中间体在合成16-雄烯甾类固醇中的生产变化。改变这些酶的活性可用于增强还原和雄烯酮合成和减少野猪污点。这些新突变的鉴定还允许开发在这些酶中具有突变的转基因猪或用于遗传筛选以基于其CYP17和/或CYB5基因型鉴定猪的转基因猪。可以选择并育种具有这些突变的猪，以产生具有较低的野猪污染发生率的猪。

3. 发明申请

WO2017019996A4 METHOD OF BREEDING COWS FOR IMPROVED MILK YIELD 审中-公开
标题翻译：饲喂改良牛奶制品的方法
公开(公告)号：WO2017019996A4
公开(公告)日：2017-03-09
申请号：PCT/US2016044824
申请日：2016-07-29
申请人： GENUS PLC
发明人： DATTILO KATRINA , ZARE YALDA , MARQUEZ BETZ GABRIELA CAROLINA , STEPHAN KALEENA , STARKENBURG RYAN , VERGARA CRISTIAN
IPC分类号： A01K67/02
CPC分类号： A01K67/02
摘要： Applicants have identified that three critical phenotypic/genetic measures are highly correlated with transition period health and may be used in selection and breeding protocols and/or in combination with traditional breeding and marker assisted selection methods to improve predictability of transition period health. According to the invention genetic evaluations for mastitis, ketosis, and metritis have been found to be highly predictive of overall transition health. The genetic evaluations are produced by directly measuring thousands of clinical cases of mastitis, ketosis, and metritis in ancestors of a particular animal and using this data in selection. Applicant's selection criteria and quickly impact a breeders population by reducing transition cow disease incidence in the initial population and in progeny.
摘要翻译：申请人已经确定三个关键的表型/遗传措施与过渡期健康高度相关，并可用于选择和育种方案和/或与传统育种和标记辅助选择方法相结合，以提高过渡期健康的可预测性。根据本发明，已经发现乳腺炎，酮症和子宫炎的遗传学评估是对整体转移健康的高度预测。遗传评估是通过直接测量数千种特定动物的祖先中的乳腺炎，酮症和子宫炎的临床病例并使用该数据进行选择产生的。申请人的选择标准，并通过减少初始种群和后代中牛群的转变，迅速影响育种人口。

4. 发明申请

WO2017019996A1 METHOD OF BREEDING COWS FOR IMPROVED MILK YIELD 审中-公开
标题翻译：饲喂奶牛的方法以提高奶产量
公开(公告)号：WO2017019996A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044824
申请日：2016-07-29
申请人： GENUS, PLC
发明人： DATTILO, Katrina , ZARE, Yalda , MARQUEZ BETZ, Gabriela Carolina , STEPHAN, Kaleena , STARKENBURG, Ryan , VERGARA, Cristian
IPC分类号： A01K67/02
CPC分类号： A01K67/02
摘要： Applicants have identified that three critical phenotypic/genetic measures are highly correlated with transition period health and may be used in selection and breeding protocols and/or in combination with traditional breeding and marker assisted selection methods to improve predictability of transition period health. According to the invention genetic evaluations for mastitis, ketosis, and metritis have been found to be highly predictive of overall transition health. The genetic evaluations are produced by directly measuring thousands of clinical cases of mastitis, ketosis, and metritis in ancestors of a particular animal and using this data in selection. Applicant's selection criteria and quickly impact a breeders population by reducing transition cow disease incidence in the initial population and in progeny.
摘要翻译：申请人已经鉴定了三种关键的表型/遗传测量与转换期健康高度相关，并且可以用于选择和育种方案和/或与传统育种和标记辅助选择方法组合以提高可预测性过渡期健康。根据本发明，已经发现对乳腺炎，酮症和子宫炎的遗传评估高度预测整体转变健康。通过直接测量特定动物的祖先中数以千计的乳腺炎，酮症和子宫炎的临床病例并在选择中使用这些数据来产生遗传评估。申请人的选择标准并通过减少初始群体和后代中的转型奶牛发病率来快速影响育种群体。

5. 发明申请

WO2017009713A2 CRYOPRESERVING UNGULATE EMBRYOS 审中-公开
公开(公告)号：WO2017009713A2
公开(公告)日：2017-01-19
申请号：PCT/IB2016/001112
申请日：2016-07-13
申请人： GENUS PLC
发明人： SANCHES, Bruno, Valente
IPC分类号： A61D19/04 , C12N5/073
CPC分类号： A61D19/04 , A01N1/0268 , A01N1/0284
摘要： Technologies for cryopreserving ungulate embryos for implantation into recipient females are described.
摘要翻译：描述了用于将有蹄类动物胚胎低温保存植入受体雌性的技术。

6. 发明申请

WO2021224599A1 METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163 审中-公开
公开(公告)号：WO2021224599A1
公开(公告)日：2021-11-11
申请号：PCT/GB2021/051060
申请日：2021-05-04
申请人： GENUS PLC
发明人： CIGAN, Andrew Mark , LIGHTNER, Jonathan Edward , CULBERTSON, Matthew Scott , CHRISTIANSON, William Thomas , BEATON, Benjamin , BURGER, Brian , BARNES, Dylan , CAMPBELL, Matthew
IPC分类号： A01K67/027 , C07K14/705 , C12N15/877 , C12N15/90 , C12Q1/68
摘要： The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties

7. 发明申请

WO2016077693A1 HYBRID DAIRY CATTLE AND SYSTEMS FOR MAXIMIZING HYBRID ADVANTAGE 审中-公开
标题翻译：混合奶酪和系统，以最大限度地发挥混合优势
公开(公告)号：WO2016077693A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/060576
申请日：2015-11-13
申请人： GENUS PLC
发明人： LIGHTNER, Jon , WILLIAMS, Richard
IPC分类号： A01K67/02 , A61D19/02 , A61K35/52 , A61K35/54
CPC分类号： A01K67/02 , A61D19/02 , A61D19/04 , A61K35/52 , A61K35/54
摘要： Systems for selecting, generating, and breeding hybrid dairy cattle are described, as are methods for maintaining herds of hybrid cattle.
摘要翻译：描述了用于选择，产生和繁殖杂交奶牛的系统，以及用于保持杂种牛群的方法。

8. 发明申请

WO2019043656A1 METHODS AND SYSTEMS FOR ASSESSING AND/OR QUANTIFYING SEX SKEWED SPERM CELL POPULATIONS 审中-公开
公开(公告)号：WO2019043656A1
公开(公告)日：2019-03-07
申请号：PCT/IB2018/056710
申请日：2018-09-03
申请人： GENUS PLC
发明人： ROTI-ROTI, Elon , CRAY, Nicole , WAGNER, Matthias , BOTTS, Michael Reid
IPC分类号： C12Q1/6879
CPC分类号： C12Q1/6879 , C12Q1/6841 , C12Q2600/124 , C12Q2600/16 , C12Q2600/166
摘要： Technologies for assessing, quantifying and isolating sperm cell populations and/or subpopulations having specific genetic signatures are provided, as well as methods and systems to assess the efficacy of chromosomal differentiation processes. Compositions for identification and differentiation of X-chromosomes and Y-chromosomes in DNA are also provided.

9. 发明申请

WO2019090237A1 SELECTIVELY TARGETED DNA EDITS IN LIVESTOCK 审中-公开
公开(公告)号：WO2019090237A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/059232
申请日：2018-11-05
申请人： GENUS PLC
发明人： EDGAR, Cassandra Joan , CIGAN, Andrew Mark
IPC分类号： A01K67/027 , A61K39/12 , C07K14/705 , C12N5/10 , C12N15/85
摘要： The invention comprises a means for reducing infection and/or transmission of viral diseases in mammals. Gene editing complexes, comprising a nuclease and at least one nucleotide directing where the nuclease should act in the genome, are loaded onto nanoparticles. The gene editing bundle-nanoparticle complex is then administered into the mammal and passes through cell membranes to enter the cell, where DNA is edited. Once inside the cells, the gene editing complex edits the DNA. This edit results in the alteration of the expression of the targeted gene in these cells. This invention uses nanoparticles which increase solubility in the cell membrane to deliver the gene editing complex directly into the cell, resulting in non-heritable genetic changes which confer disease resistance.

10. 发明申请

WO2017009713A3 CRYOPRESERVING UNGULATE EMBRYOS 审中-公开
标题翻译：冷冻保存结合的胚胎
公开(公告)号：WO2017009713A3
公开(公告)日：2017-03-16
申请号：PCT/IB2016001112
申请日：2016-07-13
申请人： GENUS PLC
发明人： SANCHES BRUNO VALENTE
IPC分类号： A61D19/04 , C12N5/073
CPC分类号： A61D19/04 , A01N1/0284
摘要： Technologies for cryopreserving ungulate embryos for implantation into recipient females are described.
摘要翻译：描述了用于冷冻有蹄动物胚胎以植入受体雌性动物的技术。

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