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1. 发明申请

WO2015017788A1 METHOD FOR PREDICTING CANCER SENSITIVITY 审中-公开
标题翻译：预测癌症敏感性的方法
公开(公告)号：WO2015017788A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/049420
申请日：2014-08-01
申请人： EUTROPICS PHARMACEUTICALS, INC.
发明人： CARDONE, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/57496 , C07K16/40 , C07K2317/622 , G01N33/574 , G01N33/57488 , G01N2333/96466 , G01N2800/52
摘要： The present invention relates to methods of determining cancer cell sensitivity to treatment by using antibodies to detect the presence of heterodimers comprising Bcl-2 proteins or caspase-IAP proteins in the cell. The invention also provides a method of predicting therapeutic efficacy in a cancer patient.
摘要翻译：本发明涉及通过使用抗体来检测细胞中包含Bcl-2蛋白或半胱天冬酶-IAP蛋白的异二聚体的存在来确定癌细胞对治疗的敏感性的方法。本发明还提供了一种预测癌症患者的治疗功效的方法。

2. 发明申请

WO2019143947A1 METHODS FOR PREDICTING CANCER DRUG RESPONSIVENESS 审中-公开
公开(公告)号：WO2019143947A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/014208
申请日：2019-01-18
申请人： EUTROPICS PHARMACEUTICALS, INC.
发明人： CARDONE, Michael
IPC分类号： G01N33/574 , G01N33/15 , G01N33/50
摘要： The present disclosure relates to compositions and methods of determining cancer cell sensitivity to treatment using antibodies that detect heterodimers comprising Bcl-2 proteins. The disclosure also provides methods for predicting a cancer patient's sensitivity to the cancer treatment.

3. 发明申请

WO2015066305A1 METHODS FOR DETERMINING CHEMOSENSITIVITY AND CHEMOTOXICITY 审中-公开
标题翻译：用于测定化学感受性和生物毒性的方法
公开(公告)号：WO2015066305A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063121
申请日：2014-10-30
申请人： EUTROPICS PHARMACEUTICALS, INC.
发明人： PIERCEALL, William E. , CARDONE, Michael H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/025 , C12Q1/6886 , C12Q2600/106 , G01N2500/10
摘要： The present disclosure relates to diagnostic methods that are relevant to various cancers and which comprise BH3 profiling diagnostics for, among others, predication of an adverse patient response to a cancer treatment.
摘要翻译：本公开涉及与各种癌症相关的诊断方法，其包括BH3分析诊断，其中包括对患者对癌症治疗的不利患者反应的预测。

4. 发明申请

WO2016154380A1 SURROGATE FUNCTIONAL BIOMARKER FOR SOLID TUMOR CANCER 审中-公开
标题翻译：用于固体肿瘤癌的特征性功能生物标志物
公开(公告)号：WO2016154380A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023896
申请日：2016-03-24
申请人： EUTROPICS PHARMACEUTICALS, INC. , CARDONE, Michael H. , DETTMAN, Elisha J.
发明人： CARDONE, Michael H. , DETTMAN, Elisha J.
IPC分类号： C12Q1/04 , G01N33/50 , G01N33/53 , G01N33/573
CPC分类号： G01N33/57484 , G01N33/15 , G01N33/5005 , G01N33/5017 , G01N33/57496 , G01N2800/52 , G01N2800/7028
摘要： The present invention relates to diagnostic methods that are relevant to various solid tumor cancers that are not amenable to traditional BIH3 profiling diagnostic methods. In some embodiments, the methods described herein are useful in the evaluation of a patient, for example, for evaluating diagnosis, prognosis, and response to treatment. In various aspects, the present disclosure includes evaluating a solid tumor or cancer. In various embodiments, the evaluation may be selected from diagnosis, prognosis, and response to treatment. In various embodiments, the present disclosure directs the treatment of a cancer patient, including, for example, what type of treatment should be administered or withheld. In some embodiments, the present disclosure includes the measurement of a tumor cell, sample, and/or specimen, including biopsy or surgical specimen samples.
摘要翻译：本发明涉及与不适于传统BIH3分析诊断方法的各种实体瘤癌相关的诊断方法。在一些实施方案中，本文所述的方法可用于评估患者，例如用于评估诊断，预后和对治疗的反应。在各方面，本公开包括评估实体瘤或癌症。在各种实施方案中，评估可以选自诊断，预后和对治疗的反应。在各种实施方案中，本公开引导癌症患者的治疗，包括例如应该施用或禁止哪种类型的治疗。在一些实施方案中，本公开内容包括肿瘤细胞，样品和/或标本的测量，包括活组织检查或外科标本样品。

5. 发明申请

WO2013192423A2 METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES 审中-公开
标题翻译：用于治疗涉及具有喹啉衍生物的BCL-2家族蛋白的疾病的方法和组合物
公开(公告)号：WO2013192423A2
公开(公告)日：2013-12-27
申请号：PCT/US2013/046826
申请日：2013-06-20
申请人： EUTROPICS PHARMACEUTICALS, INC.
发明人： CARDONE, Michael H. , RICHARD, David
IPC分类号： A61K31/5377
CPC分类号： A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/5377 , A61K31/573 , A61K31/69 , A61K38/05 , A61K45/06 , G01N33/5011 , G01N33/5079 , G01N2333/82 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要： The present invention relates to compositions and methods for cancer treatment comprising compounds of Formulae I, II, and III. In some aspects, the invention relates to the treatment of B-cell Lymphoma or other hematopoietic cancers. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as, for example, B-cell lymphoma, using a combination of one or more compounds of Formulae I, II, and III. Combination therapy with, for example, 26S proteasome inhibitors, such as, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formulae I, II, and III. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.
摘要翻译：本发明涉及包含式I，II和III化合物的用于癌症治疗的组合物和方法。在一些方面，本发明涉及B细胞淋巴瘤或其他造血癌的治疗。在其它方面，本发明提供了使用一种或多种式I，II和III化合物的组合来治疗特定类型的造血细胞癌例如B细胞淋巴瘤的方法。还包括与例如26S蛋白酶体抑制剂例如硼替佐米的组合治疗。另一方面，本发明涉及用式I，II和III化合物进行的自身免疫治疗。在另一方面，本发明涉及用于鉴定化合物的方法，例如BH3类似物的化合物，其具有预测B细胞淋巴瘤肿瘤和其他癌症以及自身免疫疾病的体内功效的体外特性。

6. 发明申请

WO2015010094A1 DIFFERENTIAL BH3 MITOCHONDRIAL PROFILING 审中-公开
标题翻译：差异BH3 MITOCHONDRIAL Profiling
公开(公告)号：WO2015010094A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/047307
申请日：2014-07-18
申请人： EUTROPICS PHARMACEUTICALS, INC.
发明人： CARDONE, Michael
IPC分类号： C07K14/47
CPC分类号： G01N33/5011 , A61K49/0008 , G01N33/5079 , G01N2333/47 , G01N2800/52
摘要： The present invention relates to methods of determining cancer cell sensitivity to treatment by correlating the pattern of sensitivity of the cell to a panel of BH3 domain peptides. The invention also provides a method applying an algorithm to said pattern to predict therapeutic efficacy and of monitoring the shift in cell sensitivity to a therapeutic during treatment.
摘要翻译：本发明涉及通过将细胞的灵敏度与一组BH3结构域肽相关联来确定癌细胞对治疗的敏感性的方法。本发明还提供了一种将所述模式应用于所述模式以预测治疗功效并监测治疗期间治疗剂对细胞敏感性的变化的方法。

7. 发明申请

WO2013170176A2 SURROGATE FUNCTIONAL DIAGNOSTICS TEST FOR CANCER 审中-公开
标题翻译：癌症的现场功能诊断测试
公开(公告)号：WO2013170176A2
公开(公告)日：2013-11-14
申请号：PCT/US2013/040585
申请日：2013-05-10
申请人： EUTROPICS PHARMACEUTICALS, INC.
发明人： PIERCEALL, William , CARDONE, Michael H.
IPC分类号： C12Q1/68
CPC分类号： G01N33/57407 , G01N21/6486 , G01N33/574 , G01N33/57426 , G01N2800/52 , G16H50/20
摘要： The present invention relates to diagnostic methods that are relevant to various cancers and which comprise improvements on a BH3 profiling diagnostic method.
摘要翻译：本发明涉及与各种癌症相关的诊断方法，其包括对BH3分析诊断方法的改进。

8. 发明申请

WO2012122370A2 COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES 审中-公开
标题翻译：用于治疗疾病的组合物和方法
公开(公告)号：WO2012122370A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/028263
申请日：2012-03-08
申请人： EUTROPICS PHARMACEUTICALS, INC. , CARDONE, Michael H. , KOLODZIEJ, Andrew F. , RICHARD, David
发明人： CARDONE, Michael H. , KOLODZIEJ, Andrew F. , RICHARD, David
IPC分类号： G06Q10/08
CPC分类号： A61K31/4709 , A61K31/496 , C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention relates to a compositions for and methods of cancer treatment in which compounds of Formula I or Formula II. In some aspects, the treatment of B-cell Lymphoma or other hematopoietic cancers is encompassed. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more compounds of Formula I or Formula II. Combination therapy with, for example, a class of therapeutics known as 26S proteasome inhibitors, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formula I or Formula II. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitrio properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.
摘要翻译：本发明涉及式I或式II化合物的癌症治疗用组合物和方法。在一些方面，包括B细胞淋巴瘤或其他造血癌的治疗。在其它方面，本发明提供了使用一种或多种式I或式II化合物的组合来治疗特定类型的造血细胞癌例如B细胞淋巴瘤的方法。还包括与例如称为26S蛋白酶体抑制剂的一类治疗剂例如硼替佐米的组合疗法。另一方面，本发明涉及用式I或式II化合物进行的自身免疫治疗。在另一方面，本发明涉及用于鉴定化合物的方法，例如BH3类似物的化合物，其具有独特的葡萄糖特性，其预测体内对B细胞淋巴瘤肿瘤和其他癌症以及自身免疫疾病的功效。

9. 发明申请

WO2009137664A1 ANTIBODIES SPECIFIC TO HETERODIMERS OF BCL-2 FAMILY AND USES THEREOF 审中-公开
标题翻译： BCL-2家族特异性抗体及其用途
公开(公告)号：WO2009137664A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/043129
申请日：2009-05-07
申请人： EUTROPICS PHARMACEUTICALS, INC. , CARDONE, Michael, H. , LETAI, Anthony, G.
发明人： CARDONE, Michael, H. , LETAI, Anthony, G.
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , C07K16/18 , C07K2317/622 , G01N33/57492
摘要： Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient.
摘要翻译：特异性结合Bcl-2家族异源二聚体的分离抗体及其用于检测患者Bcl-2异二聚体存在的用途。

10. 发明申请

WO2022140556A1 METHODS AND COMPOSITIONS RELATED TO BCL2 AND BIM HETERODIMER ANTIBODIES 审中-公开
公开(公告)号：WO2022140556A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064882
申请日：2021-12-22
申请人： EUTROPICS PHARMACEUTICALS, INC.
发明人： CARDONE, Michael H. , KINLOCH, Andrew , GILLIES, Stephen
IPC分类号： A61K39/395 , C07K16/30 , C07K16/28
摘要： The present disclosure relates to compositions and methods of determining cancer cell sensitivity to treatment using antibodies that detect heterodimers comprising Bcl-2 proteins selected from Bcl2 and BIM. The disclosure also provides methods for predicting a cancer patient's sensitivity to the cancer treatment.

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