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1. 发明申请

WO2020077322A1 NOVEL METHOD AND COMPOUNDS FOR TREATMENT OF COGNITIVE LOSS ASSOCIATED WITH ADULT ONSET LEUKODYSTROPHY WITH AXONAL SPHEROIDS AND PIGMENTED GLIA (ALSP) AND OTHER NEURODEGENERATIVE DISEASES INVOLVING REDUCED COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) SIGNALING 审中-公开
公开(公告)号：WO2020077322A1
公开(公告)日：2020-04-16
申请号：PCT/US2019/056019
申请日：2019-10-13
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
发明人： STANLEY, Richard E. , CHLITU, Violeta
IPC分类号： A61K39/395 , A61K38/18 , A61K39/00 , A61P25/28 , C07K14/475
摘要： Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is caused by dominant inactivating mutations in the colony stimulating factor receptor 1 (CSF1R) kinase domain. GM-CSF haploinsufficiency corrects olfactory, cognitive and emotional functions lost in Csflr+/- mice. This correlates with the correction of microgliosis and microglial functions resulting in improvement of myelination and rescue of neurogenesis. However, GM-CSF haploinsufficiency fails to correct the motor deficits of Csflr+/- mice and cerebellar microgliosis. The present invention discloses methods and compositions using GM-CSF as a suitable therapeutic target to inhibit in amelioration of the cognitive impairments in ALSP and other in conditions involving inflammatory activation of microglia and macrophages, such as AD, ALS, multiple sclerosis, and hippocampal inflammation following radiation therapy. Treatment with GM-CSF inhibitors is beneficial in ALSP, as adult neurogenesis is important for memory, olfaction and prevention of anxiety/depression and early initiation of such treatment in carriers of CSF1R mutations may increase effectiveness. Balancing the actions of CSF-1R and GM- CSF signaling are necessary to preserve olfaction, cognition and emotional balance in aged mice. This balance is likely altered in many neurodegenerative diseases in which activated microglia contribute to the pathology.

2. 发明申请

WO2018156464A1 CHARACTERIZATION OF S-ADENOSYL-L-METHIONINE-CONSUMING ENZYMES WITH 1-STEP EZ-MTASE: A UNIVERSAL COUPLED-ASSAY 审中-公开
公开(公告)号：WO2018156464A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/018654
申请日：2018-02-20
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
发明人： BURGOS, Emmanuel, Sebastien , SHECHTER, David
IPC分类号： C12Q1/48 , C12Q1/34
CPC分类号： C12Q1/48 , C12Q1/34 , G01N33/573 , G01N33/582 , G01N2333/91011 , G01N2333/978
摘要： Methods and kits are disclosed for measuring activity of a methyltransferase or a radical SAM enzyme or for screening for an inhibitor of a methyltransferase or a radical SAM enzyme, where the methods and kits comprise, respectively, deaminase TM0936 for a MTase coupled assay and deaminase PA3170 for a radical SAM coupled assay.

3. 发明申请

WO2018140298A1 CO-LOCALIZATION AT MOLECULAR RESOLUTION OF MULTIPLE FLUORESCENCE CHANNELS ACQUIRED USING OPTICAL MICROSCOPY 审中-公开
公开(公告)号：WO2018140298A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/014313
申请日：2018-01-19
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
发明人： SINGER, Robert, H. , ELISCOVICH, Carolina , SHENOY, Shailesh, M.
IPC分类号： G01N21/64 , G01N33/533 , G02B21/16 , G02B21/02
摘要： A method for improving the performance of a fluorescence microscopy imaging system and for correcting chromatic aberration of an optical objective in a fluorescence microscopy system.

4. 发明申请

WO2018136831A1 PSEUDOKNOT COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D 审中-公开
公开(公告)号：WO2018136831A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014579
申请日：2018-01-19
申请人： VITRISA THERAPEUTICS, INC. , ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
发明人： ERICKSON, Carl , RUSCONI, Christopher P. , MCLURE, Kevin G. , LEVY, Matthew , BHOWMICK, Arijit
IPC分类号： C12N15/115 , A61K31/7088
CPC分类号： C12N15/115 , A61K31/7088 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3517 , C12N2310/3521 , C12N2310/3533
摘要： The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, the compositions include aptamers having a pseudoknot secondary structure for the inhibition of fD.

5. 发明申请

WO2018136827A1 STEM-LOOP COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D 审中-公开
公开(公告)号：WO2018136827A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014573
申请日：2018-01-19
申请人： VITRISA THERAPEUTICS, INC. , ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
发明人： ERICKSON, Carl , RUSCONI, Christopher P. , MCLURE, Kevin G. , LEVY, Matthew , BHOWMICK, Arijit
IPC分类号： C12N15/115 , A61K31/7088
摘要： The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, stem-loop aptamers are provided for the inhibition of Factor D.

6. 发明申请

WO2018136575A1 PXR AGONISTS AND USES THEREOF FOR GUT BARRIER DYSFUNCTION TREATMENT AND PREVENTION 审中-公开
公开(公告)号：WO2018136575A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014129
申请日：2018-01-18
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. , DREXEL UNIVERSITY , PALACKY UNIVERSITY OLOMOUC
发明人： MANI, Sridhar , KOPP, Felix , DVORAK, Zdenek , KORTAGERE, Sandhya , KARUNARATNE, Chamini
IPC分类号： A61K45/06 , A61P25/28 , C07C57/03 , C07C57/30
摘要： Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to intestines, or leaky intestinal (gut) syndrome in a subject.

7. 发明申请

WO2018106667A1 BROAD-SPECTRUM INHIBITORS OF FILOVIRUSES 审中-公开
公开(公告)号：WO2018106667A1
公开(公告)日：2018-06-14
申请号：PCT/US2017/064675
申请日：2017-12-05
申请人： MICROBIOTIX, INC. , ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. , THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY
发明人： BOWLIN, Terry, L. , MOIR, Donald, T. , CHANDRAN, Kartik , DYE, John M, Jr. , WILLIAMS, John, D. , ARON, Zachary, D. , BARBOR, Katherine, S. , LIVELY, Kelly, N. , NASH, Peter, J. , MILLS, Debra, M. , BASU, Arnab
IPC分类号： A61K31/551 , C07D401/04
摘要： The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C 1 (NPCl) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.

8. 发明申请

WO2018013954A1 PERSISTANCE AND LINKING OF ANALYTIC PRODUCTS IN BIG DATA ENVIRONMENTS 审中-公开
标题翻译：大数据环境下分析产品的持续性和连接性
公开(公告)号：WO2018013954A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/042182
申请日：2017-07-14
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. , FRANZ, INC.
发明人： MIRHAJI, Parsa , AASMAN, Jannes
IPC分类号： G06F17/00
摘要： Persistence and linking of analytic products is provided. Information regarding a plurality of analytic methods is collected. A first process node is generated in a network. The first process node corresponds to a first analytic method. Information is collected regarding a plurality of executions of the first analytic method. A plurality of session nodes is generated in the network corresponding to the plurality of executions. Each of the plurality of session nodes is linked to the first process node. Metadata regarding the plurality of executions is associated with the plurality of session nodes. At least one product node is generated corresponding to a product. The product integrates a result value of at least one of the plurality of executions. The at least one product node is linked to the session node of the plurality of session nodes corresponding to the at least one of the plurality of executions.
摘要翻译：
提供分析产品的持久性和链接。收集关于多种分析方法的信息。第一个过程节点在网络中生成。第一个过程节点对应于第一个分析方法。收集关于第一分析方法的多个执行的信息。在与多次执行相对应的网络中生成多个会话节点。多个会话节点中的每一个都链接到第一处理节点。关于多个执行的元数据与多个会话节点相关联。至少有一个产品节点是根据产品生成的。该产品集成了多个执行中的至少一个执行的结果值。该至少一个产品节点被链接到与多个执行中的至少一个相对应的多个会话节点中的会话节点。

9. 发明申请

WO2017201131A1 VARIANT PD-L1 POLYPEPTIDES, T-CELL MODULATORY MULTIMERIC POLYPEPTIDES, AND METHODS OF USE THEREOF 审中-公开
标题翻译：变体PD-L1多肽，T细胞调节性多细胞多肽及其使用方法
公开(公告)号：WO2017201131A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033042
申请日：2017-05-17
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
发明人： GARRETT-THOMSON, Sarah, C. , ALMO, Steven, C. , SEIDEL, Ronald, D.
IPC分类号： A61K39/395 , C07K14/705 , C07K16/28
摘要： The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T- cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
摘要翻译：本公开内容提供了变体PD-L1免疫调节多肽和包含变体免疫调节肽的融合多肽。本公开提供了T细胞调节多聚体多肽和包含其的组合物，其中所述T细胞调节多聚体多肽包含本公开的变体免疫调节多肽。本公开内容提供了包含编码T细胞调节多聚体多肽的核苷酸序列的核酸以及包含该核酸的宿主细胞。本公开提供了调节T细胞活性的方法; 该方法包括使T细胞与本公开的T细胞调节性多聚多肽接触。

10. 发明申请

WO2017070076A1 THERAPEUTIC TNFR-1B TARGETS AND USES THEREOF 审中-公开
标题翻译：治疗性TNFR-1B靶标及其用途
公开(公告)号：WO2017070076A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/057469
申请日：2016-10-18
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
发明人： GARRETT-THOMSON, Sarah , ALMO, Steven, C. , SIEDEL, Ron
IPC分类号： A61K38/18 , A61K38/19 , A61P19/04 , A61P37/02 , A61P37/06
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7151 , C07K2319/30 , G01N2333/525 , G01N2333/70575 , G01N2500/04
摘要： Disclosed are tumor necrosis factor receptor 1B (TNFR-1B) signaling targets and TNFR-1B mutants and their uses for treatment of diseases and disorders.
摘要翻译：公开了肿瘤坏死因子受体1B（TNFR-1B）信号传导靶标和TNFR-1B突变体及其用于治疗疾病和病症的用途。

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