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1. 发明申请

WO2007019575A3 METHODS FOR TREATING B-CELL MALIGNANCIES USING TACI-IG FUSION MOLECULE 审中-公开
标题翻译：使用TACI-IG融合分子治疗B细胞恶性肿瘤的方法
公开(公告)号：WO2007019575A3
公开(公告)日：2007-06-21
申请号：PCT/US2006031277
申请日：2006-08-09
申请人： ZYMOGENETICS INC , ARES TRADING SA , MAYO FOUNDATION , BROLY HERVE , SIEVERS ERIC , YTHIER ARNAUD , BUSBY SHARON J , ANSELL STEPHEN M , OEHRSTROEM JAN , NESTOROV IVAN
发明人： BROLY HERVE , SIEVERS ERIC , YTHIER ARNAUD , BUSBY SHARON J , ANSELL STEPHEN M , OEHRSTROEM JAN , NESTOROV IVAN
IPC分类号： A61K38/17 , A61P35/00 , C07K14/705
CPC分类号： A61K49/0008 , A61K38/177 , A61K47/6835 , C07K2319/30
摘要： The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BIyS and APRIL.
摘要翻译：本发明提供了用于治疗B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法和组合物，其包括向需要治疗的患者施用足以抑制BIyS和APRIL增殖诱导功能的TACI-Ig融合分子。

2. 发明申请

WO2007053732A3 PROMOTER POLYMORPHISMS OF THE BLYS GENE AND USE IN DIAGNOSTIC METHODS 审中-公开
标题翻译： BLY基因的促进多态性和用于诊断方法
公开(公告)号：WO2007053732A3
公开(公告)日：2007-12-21
申请号：PCT/US2006042766
申请日：2006-11-01
申请人： MAYO FOUNDATION , ANSELL STEPHEN M , NOVAK ANNE J
发明人： ANSELL STEPHEN M , NOVAK ANNE J
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/6834 , C12Q2565/501 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The present invention provides an isolated polynucleotide comprising at least one polymorphic nucleotide sequence, for example, at position -871 from the promoter region of the BLyS gene, and diagnostic assays for detecting the presence of this polymorphism associated with a condition associated with BLyS activity, such as hematological malignancy including B cell malignancies. The diagnostic assays are useful in predicting an individual's likelihood of developing a condition associated with BLyS activity, such as hematological malignancies, and for methods for treating an individual clinically diagnosed with a condition associated with BLyS activity, such as prediction of a patient's likelihood to respond to a specific drug treatment. The invention also provides an array of nucleic acid molecules immobilized on a solid surface, where at least one of the nucleic acid molecules comprises a BLyS polymorphic nucleic acid molecule. The nucleic acid arrays of the invention allow rapid detection of hybridizing nucleic acid-molecules, in a nucleic acid sample from an individual, of a BLyS polymorphism associated with hematological malignancy.
摘要翻译：本发明提供了一种分离的多核苷酸，其包含至少一个多核苷酸序列，例如在BLyS基因的启动子区-871位置，以及用于检测与与BLyS活性相关的病症相关的该多态性的存在的诊断测定，如血液恶性肿瘤，包括B细胞恶性肿瘤。诊断测定可用于预测个体发展与BLyS活性相关的病症（例如血液恶性肿瘤）的可能性，以及用于治疗临床诊断患有与BLyS活性相关的病症的个体的方法，例如预测患者的响应可能性到一个具体的药物治疗。本发明还提供固定在固体表面上的核酸分子的阵列，其中至少一个核酸分子包含BLyS多态核酸分子。本发明的核酸阵列允许在来自个体的核酸样品中快速检测与血液恶性肿瘤相关的BLyS多态性的杂交核酸分子。

3. 发明申请

WO2009073511A3 POLYMORPHISMS OF THE BLYS GENE AND USE IN DIAGNOSTIC METHODS 审中-公开
标题翻译： BLYS基因的多态性和用于诊断方法
公开(公告)号：WO2009073511A3
公开(公告)日：2009-07-23
申请号：PCT/US2008084854
申请日：2008-11-26
申请人： MAYO FOUNDATION , NOVAK ANNE J , ANSELL STEPHEN M
发明人： NOVAK ANNE J , ANSELL STEPHEN M
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides an isolated polynucleotide comprising at least one polymorphic nucleotide sequence, for example, the major alleles of the SNPs described as rs12583006, rs1224141, and rs12428930 and diagnostic assays for detecting the presence of these polymorphism associated with a condition associated with BLyS activity, such as hematological malignancy including B cell malignancies. The diagnostic assays are useful in predicting an individual's likelihood of developing a condition associated with BLyS activity, such as hematological malignancies, and for methods for treating an individual clinically diagnosed with a condition associated with BLyS activity, such as prediction of a patient's likelihood to respond to a specific drug treatment. The invention also provides an array of nucleic acid molecules immobilized on a solid surface, where at least one of the nucleic acid molecules comprises a BLyS polymorphic nucleic acid molecule. The nucleic acid arrays of the invention allow rapid detection of hybridizing nucleic acid-molecules, in a nucleic acid sample from an individual, of a BLyS polymorphism associated with hematological malignancy.
摘要翻译：本发明提供了分离的多核苷酸，其包含至少一个多核苷酸序列，例如描述为rs12583006，rs1224141和rs12428930的SNP的主要等位基因，以及用于检测与与BLyS活性相关的病症相关的这些多态性的存在的诊断测定，如血液恶性肿瘤，包括B细胞恶性肿瘤。诊断测定可用于预测个体发展与BLyS活性相关的病症（例如血液恶性肿瘤）的可能性，以及用于治疗临床诊断患有与BLyS活性相关的病症的个体的方法，例如预测患者的响应可能性针对具体药物治疗。本发明还提供固定在固体表面上的核酸分子阵列，其中至少一个核酸分子包含BLyS多态性核酸分子。本发明的核酸阵列允许在来自个体的核酸样品中快速检测与血液恶性肿瘤相关的BLyS多态性的杂交核酸分子。

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