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1. 发明申请

WO2018017435A1 HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF 审中-公开
标题翻译：用作抑制剂的杂原子化合物，组合物和应用
公开(公告)号：WO2018017435A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/042283
申请日：2017-07-15
申请人： ZHANG, Xiaohu , ACCRO BIOSCIENCE INC.
发明人： ZHANG, Xiaohu , MA, Haikuo , ZHENG, Jiyue , HE, Sudan
IPC分类号： A61K31/428 , C07D513/04
摘要： The present disclosure provides heteroaryl compounds of formulas (I), (Ia) and (Ib), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis. (Formula (I)).
摘要翻译：本公开提供了式（I），（Ia）和（Ib）的杂芳基化合物，其制备方法，含有它们的药物组合物，以及它们在治疗疾病和病症中的用途，来自或与坏死有关。（式（I））。

2. 发明申请

WO2020146858A1 HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME 审中-公开
公开(公告)号：WO2020146858A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/013258
申请日：2020-01-11
申请人： ZHANG, Xiaohu , ACCRO BIOSCIENCE INC.
发明人： ZHANG, Xiaohu , HE, Sudan , MA, Haikuo
IPC分类号： A61K31/4162 , A61K31/41 , A61P35/00 , C07D403/04
摘要： The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis. Formula (I) is shown below:

3. 发明申请

WO2018237370A1 HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND METHOD USING THE SAME 审中-公开
公开(公告)号：WO2018237370A1
公开(公告)日：2018-12-27
申请号：PCT/US2018/039180
申请日：2018-06-23
申请人： ZHANG, Xiaohu , ACCRO BIOSCIENCE INC.
发明人： ZHANG, Xiaohu , MA, Haikuo , ZHENG, Jiyue , HE, Sudan
IPC分类号： C07D401/04 , C07D403/04 , C07D405/04
摘要： The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis. Formula (I) is shown below:

4. 发明申请

WO2009076406A1 ESTIMATING TV AD IMPRESSIONS 审中-公开
标题翻译：估计电视广告印象
公开(公告)号：WO2009076406A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/086169
申请日：2008-12-10
申请人： GOOGLE INC. , VOLOVICH, Yaroslav , SMITH, Geoffrey, R. , ZIGMOND, Daniel, J. , ZHANG, Xiaohu , BHAMBANI, Ajoy , MERRICK, Iain
发明人： VOLOVICH, Yaroslav , SMITH, Geoffrey, R. , ZIGMOND, Daniel, J. , ZHANG, Xiaohu , BHAMBANI, Ajoy , MERRICK, Iain
IPC分类号： H04H60/46 , H04H60/33 , H04N7/08
CPC分类号： H04H60/66 , G06Q30/02 , G06Q30/0203 , H04H60/64
摘要： The subject matter of this specification can be embodied in, among other things, a method that includes receiving cluster information comprising categories and total numbers of media receivers (e.g. television (TV) viewers) associated with the categories and receiving sample data comprising numbers of advertisements (ads) displayed to sampled receivers (e.g., TV viewers) that are classified within the categories. The method also includes calculating probabilities for numbers of ads displayed to the total numbers of receivers associated with the categories, wherein the calculation is based on the cluster information and the sample data, merging the calculated probabilities associated with two or more of the categories, and outputting an estimated number of ads displayed based on the merged probabilities.
摘要翻译：本说明书的主题可以包括接收包括与类别相关联的媒体接收器（例如电视（TV）观众）的类别和总数的群集信息的方法，并接收包括广告数量的样本数据（广告）显示给分类在类别中的采样接收器（例如，电视观众）。该方法还包括计算显示给与类别相关联的总数的广告数量的概率，其中该计算基于该群集信息和该样本数据，合并计算出的两个或多个类别的概率，以及输出基于合并概率显示的估计数量的广告。

5. 发明申请

WO2019060860A1 HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME 审中-公开
公开(公告)号：WO2019060860A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/052503
申请日：2018-09-24
申请人： SUZHOU YUNXUAN YIYAO KEJI YOUXIAN GONGSI , ZHANG, Xiaohu
发明人： ZHANG, Xiaohu , ZHENG, Jiyue , MA, Haikuo
IPC分类号： A61K31/444 , C07D401/14 , A61P11/00 , A61P35/00
摘要： The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.

6. 发明申请

WO2014113191A1 HEDGEHOG PATHWAY SIGNALING INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF 审中-公开
标题翻译： HEDGEHOG PATHWAY信号抑制剂及其治疗应用
公开(公告)号：WO2014113191A1
公开(公告)日：2014-07-24
申请号：PCT/US2013/077305
申请日：2013-12-20
申请人： ZHANG, Xiaohu
发明人： ZHANG, Xiaohu
IPC分类号： A61K31/395
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04 , C07D513/04
摘要： The hedgehog (Hh) signaling pathway is a pathway which regulates patterning, growth and cell migration during embryonic development, but in adulthood is limited to tissue maintenance and repair. Mutational inactivation of the inhibitory pathway components leads to constitutive ligand-independent activation of the Hh signaling pathway, results in cancers such as basal cell carcinoma and medulloblastoma. Ligand-dependent activation of Hh signaling is involved in prostate cancer, pancreatic cancer, breast cancer and blood cancers. Therefore, inhibition of the aberrant Hh signaling represents a promising approach toward novel anticancer therapy. The invention provides novel molecules of formula I that inhibit hedgehog pathway signaling and provides therapeutic applications for the treatment of malignancies (basal cell carcinoma, medulloblastoma, glioblastoma, non-small cell lung cancer, prostate cancer, pancreatic cancer, blood cancers, mesenchymal cancers, etc.), prevention of tumor regrowth, sensitization of radio-chemo therapies, and other diseases (inflammation, fibrosis and immune disorders).
摘要翻译：刺猬（Hh）信号通路是调控胚胎发育过程中的图案，生长和细胞迁移的途径，但成年期限于组织维持和修复。抑制性途径组分的突变失活导致Hh信号通路的组成型配体非依赖性激活，导致癌症如基底细胞癌和成神经管细胞瘤。 Hh信号传导的配体依赖性激活涉及前列腺癌，胰腺癌，乳腺癌和血液癌。因此，抑制异常Hh信号代表了一种有希望的新型抗癌治疗方法。本发明提供抑制刺猬蛋白通路信号传导的新型分子式I，并提供用于治疗恶性肿瘤（基底细胞癌，成神经管细胞瘤，成胶质细胞瘤，非小细胞肺癌，前列腺癌，胰腺癌，血癌，间充质癌，等等），预防肿瘤再生长，放射化学疗法的敏化和其他疾病（炎症，纤维化和免疫疾病）。

7. 发明申请

WO2013064445A1 IMIDAZOPYRIDAZINE COMPOUNDS 审中-公开
标题翻译：咪唑吡嗪化合物
公开(公告)号：WO2013064445A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071337
申请日：2012-10-29
申请人： F. HOFFMANN-LA ROCHE AG , HERMANN, Johannes Cornelius , KUGLSTATTER, Andreas , LUCAS, Matthew C. , PADILLA, Fernando , WANNER, Jutta , ZHANG, Xiaohu
发明人： HERMANN, Johannes Cornelius , KUGLSTATTER, Andreas , LUCAS, Matthew C. , PADILLA, Fernando , WANNER, Jutta , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/5025 , A61P29/00 , A61P19/02 , A61P17/06 , A61P3/10 , A61P37/00 , A61P11/06 , A61P25/28 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K31/625 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of novel compounds of formula (I): wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译：本发明涉及式（I）的新化合物的用途：其中所有可变取代基如本文所述定义，其为SYK抑制剂，并且可用于治疗自身免疫和炎性疾病。

8. 发明申请

WO2013030138A1 PYRROLOPYRAZINE KINASE INHIBITORS 审中-公开
标题翻译：吡咯啉激酶抑制剂
公开(公告)号：WO2013030138A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066567
申请日：2012-08-27
申请人： F. HOFFMANN-LA ROCHE AG , CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
发明人： CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5025 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译：本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中所述变量如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。

9. 发明申请

WO2012098068A1 PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS 审中-公开
标题翻译： PYRAZOLO PYRIMIDINES作为DYRK1A和DYRK1B抑制剂
公开(公告)号：WO2012098068A1
公开(公告)日：2012-07-26
申请号：PCT/EP2012/050545
申请日：2012-01-16
申请人： F. HOFFMANN-LA ROCHE AG , LIU, Wenjian , LUK, Kin-Chun Thomas , ZHANG, Xiaohu
发明人： LIU, Wenjian , LUK, Kin-Chun Thomas , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , A61P35/00
CPC分类号： C07D487/04
摘要： Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.
摘要翻译：本发明描述了式及其药学上可接受的盐的化合物，以及含有所述化合物及其药学上可接受的盐的药物组合物，以及所述化合物和药物组合物用于治疗，控制或改善增殖性疾病（包括癌症）Down 综合征或早发性阿尔茨海默氏病。

10. 发明申请

WO2008124530A1 ADJUSTING FOR UNCERTAINTY IN ADVERTISMENT IMPRESSION DATA 审中-公开
标题翻译：调整广告印象数据中的不确定性
公开(公告)号：WO2008124530A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/059302
申请日：2008-04-03
申请人： GOOGLE INC. , ZIGMOND, Daniel J. , BAYER, Jason , ZHANG, Xiaohu
发明人： ZIGMOND, Daniel J. , BAYER, Jason , ZHANG, Xiaohu
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0263 , G06Q30/0273 , G06Q30/0276
摘要： Methods, systems and apparatus, including computer program products, provide adjustments to advertisement impression estimates based on sampled data. According to one method, an estimated number of advertisement impressions is made based on the sampled data and the estimate is discounted to achieve a level of certainty that the resulting discounted estimate is less than the actual number of advertisement impressions. The amount of the discount can be determined based on a sampling error model of the sampling data.
摘要翻译：包括计算机程序产品在内的方法，系统和装置根据采样数据对广告印象估计进行调整。根据一种方法，基于采样的数据进行估计的广告印象数量，并且估计值被折扣以达到所得到的折扣估计值小于实际广告印象数量的可靠性水平。可以根据采样数据的采样误差模型确定折扣量。

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