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1. 发明申请

WO2013023856A1 USE OF A POLYSACCHARIDE POLYMER FROM THE SEEDS OF THE TAMARIND SEED IN PROTECTING AGAINST TOBACCO-ASSOCIATED DAMAGES 审中-公开
标题翻译：使用来自保护反对烟草相关损害的TAMARIND种子的多糖聚合物
公开(公告)号：WO2013023856A1
公开(公告)日：2013-02-21
申请号：PCT/EP2012/063975
申请日：2012-07-17
申请人： ZAMBON S.P.A. , SARDINA, Marco , ALETTI, Adonella , MELLONI, Elsa
发明人： SARDINA, Marco , ALETTI, Adonella , MELLONI, Elsa
IPC分类号： A61K31/715 , A61K36/48 , A61K9/00 , A61P11/00
CPC分类号： A61K31/715 , A61K9/0078 , A61K9/08 , A61K36/48
摘要： Use of a polysaccharide polymer obtained from the seeds of the tamarind tree for use in protecting the epithelial cells of the respiratory tract by damages induced by tobacco smoke.
摘要翻译：使用从罗望子树种子获得的多糖聚合物用于通过烟草烟雾引起的损伤来保护呼吸道上皮细胞。

2. 发明申请

WO2012007113A1 POLYSACCHARIDE POLYMER FROM THE SEEDS OF THE TAMARIND TREE FOR USE IN TREATING DRY COUGH 审中-公开
标题翻译：来自TAMARIND树种子的多糖聚合物用于处理干酪
公开(公告)号：WO2012007113A1
公开(公告)日：2012-01-19
申请号：PCT/EP2011/003284
申请日：2011-07-01
申请人： ZAMBON SPA , MELLONI, Elsa , SARDINA, Marco
发明人： MELLONI, Elsa , SARDINA, Marco
IPC分类号： A61K36/48 , A61P11/14
CPC分类号： A61K36/48 , A61K9/0078
摘要： Use of a polysaccharide polymer obtained from the seeds of the tamarind tree for treating dry cough; said polysaccharide being locally administered to the mucous membranes of the high respiratory airways of a subject suffering from dry cough as an aerosolized liquid preparation, for example by suitable commercially available inhalation devices.
摘要翻译：使用从罗望子树种子得到的多糖聚合物治疗干咳; 所述多糖局部施用于作为雾化液体制剂的患有干咳的受试者的高呼吸气道的粘膜，例如通过适合的市售吸入装置。

3. 发明申请

WO2014167028A1 A PHARMACEUTICAL COMPOSITION CONTAINING BUDESONIDE AND FORMOTEROL. 审中-公开
标题翻译：含有BUDESONIDE和FORMOTEROL的药物组合物。
公开(公告)号：WO2014167028A1
公开(公告)日：2014-10-16
申请号：PCT/EP2014/057209
申请日：2014-04-09
申请人： ZAMBON S.P.A.
发明人： CAPONETTI, Giovanni , MAGGI, Loretta , SARDINA, Marco , CASTEGINI, Franco , FAIELLA, Gianluigi , REBOLINI, Daniela
IPC分类号： A61K9/16 , A61K31/167 , A61K31/58
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K31/167 , A61K31/58 , A61K2300/00
摘要： The present invention relates to drug formulations in dry powder form for administration by inhalation and indicated for the treatment of obstructive airway syndromes such as asthma and chronic obstructive pulmonary disease (COPD). In particular, the invention relates to an inhalable pharmaceutical composition comprising a first powder consisting of budesonide, or one of its pharmaceutically allowable salts, in a quantity greater than 5% w/w of said first powder, leucine in a quantity in the range of 5 to 70% w/w of said first powder, and lactose in a quantity in the range of 20 to 90% w/w of said first powder; a second powder consisting of formoterol, or one of its pharmaceutically allowable salts, in a quantity greater than 1% w/w of said second powder, leucine in a quantity in the range of 5 to 70% w/w of said second powder, and lactose in a quantity in the range of 20 to 90% w/w of said second powder; and a third powder consisting of leucine in a quantity in the range of 5 to 70% w/w of said third powder, and lactose in a quantity in the range of 20 to 90% w/w of said third powder. Said composition has a fine particle fraction (FPF) greater than 60% and a delivered fraction (DF) greater than 90%.
摘要翻译：本发明涉及用于通过吸入施用并指示用于治疗阻塞性气道综合征如哮喘和慢性阻塞性肺病（COPD）的干粉形式的药物制剂。特别地，本发明涉及一种可吸入药物组合物，其包含由布地奈德或其药学上允许的盐之一组成的第一种粉末，其量大于所述第一种粉末的5％w / w，亮氨酸的量范围为 5〜70％w / w的所述第一粉末，所述第一粉末的乳糖的量在20〜90％w / w的范围内; 由福莫特罗或其药学上允许的盐之一组成的第二粉末，其量大于所述第二粉末的1％w / w，亮氨酸的量为所述第二种粉末的5-70％w / w，和所述第二粉末的20至90％w / w范围内的量的乳糖; 和由所述第三粉末的5-70％（w / w）范围内的亮氨酸组成的第三粉末和所述第三粉末的量为20-90％w / w的量的乳糖。所述组合物具有大于60％的细颗粒级分（FPF）和大于90％的传递级分（DF）。

4. 发明申请

WO2016055546A1 PHARMACEUTICAL COMPOSITION CONTAINING BUDESONIDE AND FORMOTEROL. 审中-公开
标题翻译：含有BUDESONIDE和FORMOTEROL的药物组合物。
公开(公告)号：WO2016055546A1
公开(公告)日：2016-04-14
申请号：PCT/EP2015/073190
申请日：2015-10-07
申请人： ZAMBON S.P.A.
发明人： MAGGI, Loretta , CAPONETTI, Giovanni , SARDINA, Marco , CASTEGINI, Franco
IPC分类号： A61K9/00 , A61K9/16 , A61K31/167 , A61K31/58
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K31/167 , A61K31/58 , A61K2300/00
摘要： The present invention relates to inhalation formulations of drugs in the form of dry powder for inhalation administration, suitable for the treatment of obstructive diseases of the airways, such as asthma and chronic obstructive pulmonary disease (COPD). In particular, the invention relates to a pharmaceutical composition for inhalation comprising a first powder comprising budesonide or a pharmaceutically acceptable salt thereof, in an amount greater than 5% by weight of said first powder, leucine in an amount from 5 to 70% by weight of said first powder, lactose in an amount from 20 to 90% by weight of said first powder; a second powder comprising formoterol or a pharmaceutically acceptable salt thereof, in an amount greater than 1% by weight of said second powder, leucine in an amount from 5 to 70% by weight of said second powder, lactose in an amount from 20 to 90% by weight of said second powder and a third powder comprising a mixture of a first lactose which has an X50 from 3 to 75 µm, with a second lactose which has an X50 from 1.5 to 10 µm, the content of said first and second lactose in said mixture being respectively from 85% to 96% and from 4% to 15%. Said composition has a fine particle fraction (FPF) greater than 60% and a delivered fraction (DF) greater than 80%.
摘要翻译：本发明涉及用于吸入给药的干粉形式的药物的吸入制剂，其适用于治疗气道阻塞性疾病，例如哮喘和慢性阻塞性肺病（COPD）。特别地，本发明涉及用于吸入的药物组合物，其包含第一粉末，其包含布地奈德或其药学上可接受的盐，其量大于所述第一粉末的5重量％，亮氨酸的量为5-70重量％的所述第一粉末，所述第一粉末的量为20至90重量％的乳糖; 包含福莫特罗或其药学上可接受的盐的第二粉末，其量大于所述第二粉末的1重量％，亮氨酸的量为所述第二粉末的5至70重量％，量为20至90的乳糖所述第二粉末的重量％和第三粉末，其包含具有3至75μm的X50的第一乳糖和具有1.5至10μm的X50的第二乳糖的混合物，所述第一和第二乳糖的含量在所述混合物中分别为85％至96％和4％至15％。所述组合物具有大于60％的细颗粒级分（FPF）和大于80％的传递级分（DF）。

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