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1. 发明申请

WO2011035159A1 ARYL SULPHONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译： ARYL SULPHONE DERIVATIVES作为钙通道阻塞剂
公开(公告)号：WO2011035159A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049339
申请日：2010-09-17
申请人： ZALICUS PHARMACEUTICALS LTD. , PAJOUHESH, Hassan , GALEMMO, Robert , HOLLAND, Richard , ZHOU, Yuanxi , ZHU, Yongbao , SIMONSON, Eric , CHAHAL, Navjot , GRIMWOOD, Mike
发明人： PAJOUHESH, Hassan , GALEMMO, Robert , HOLLAND, Richard , ZHOU, Yuanxi , ZHU, Yongbao , SIMONSON, Eric , CHAHAL, Navjot , GRIMWOOD, Mike
IPC分类号： C07C317/14
CPC分类号： C07C317/44 , A61K31/095 , C07C317/14 , C07C317/22 , C07C317/28 , C07C317/30 , C07C317/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity, are disclosed. Specifically, a series of compounds containing aryl sulphone derivatives, as exemplified by Formula (I).
摘要翻译：公开了有效改善由不希望的钙通道活性，特别是不需要的N型和/或T型钙通道活性表征的病症的方法和化合物。具体而言，是一系列含有芳基砜衍生物的化合物，如式（I）所例举。

2. 发明申请

WO2011032291A1 SELECTIVE CALCIUM CHANNEL MODULATORS 审中-公开
标题翻译：选择性钙通道调制器
公开(公告)号：WO2011032291A1
公开(公告)日：2011-03-24
申请号：PCT/CA2010/001471
申请日：2010-09-17
申请人： ZALICUS PHARMACEUTICALS LTD . , PAJOUHESH , Hassan , ZHU, Yongbao , ZHOU, Yuanxi , GRIMWOOD, Mike , SIMONSON, Eric
发明人： PAJOUHESH , Hassan , ZHU, Yongbao , ZHOU, Yuanxi , GRIMWOOD, Mike , SIMONSON, Eric
IPC分类号： C07D211/34 , A61K31/397 , A61K31/40 , A61K31/4465 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61P25/00 , C07D205/04 , C07D207/08 , C07D211/48 , C07D401/12 , C07D413/06
CPC分类号： C07D401/12 , C07D205/04 , C07D207/08 , C07D207/09 , C07D211/22 , C07D211/34 , C07D211/48 , C07D211/58 , C07D401/06 , C07D413/06
摘要： Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T- type calcium channel activity are disclosed using a series of compounds containing N-acylated cyclic amines linked to an aπl ring as shown in formula (I).
摘要翻译：使用一系列含有与apl环连接的N-酰化的环胺的化合物（如式（I）所示），公开了有效改善由不需要的钙通道活性，特别是不需要的T型钙通道活性表征的病症的方法和化合物。

3. 发明申请

WO2004076291A2 ROLLER CAM BUCKLE 审中-公开
标题翻译：滚轮卡车
公开(公告)号：WO2004076291A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/003163
申请日：2004-02-03
申请人： SIMONSON, Eric , SIMONSON, Roger
发明人： SIMONSON, Eric , SIMONSON, Roger
IPC分类号： B65D
CPC分类号： B60P7/083 , Y10T24/2175 , Y10T24/40 , Y10T24/4016
摘要： A method and apparatus for reducing friction in a cam buckle for tightening a strap. The cam buckle includes a frame, a brake member, a roller member, a biasing element and a webbed strap. The brake member includes a serrated surface and is rotatably coupled to the frame and pivotal about a first axis. The roller member is rotatably coupled to the frame about a second axis, wherein the first axis and the second axis are substantially parallel to each other. The biasing element is operable to bias the serrated surface of the brake member toward the roller member. The webbed strap is formed from a polymeric material and is operable to be biased between the serrated surface and the roller member so that the brake member biases the webbed strap against the roller member. With this arrangement, when the webbed strap is placed in tension, such tension is maintained by preventing movement of the webbed strap in one direction and allowing movement in a second direction to increase the tension. The roller member is operable to rotate with movement of the webbed strap in the second direction to increase the tension in the webbed strap.
摘要翻译：一种用于减小用于紧固带的凸轮扣中的摩擦的方法和装置。凸轮扣包括框架，制动构件，滚动构件，偏压元件和带状带。制动构件包括锯齿状表面并且可旋转地联接到框架并围绕第一轴线枢转。辊构件围绕第二轴线可旋转地联接到框架，其中第一轴线和第二轴线基本上彼此平行。偏置元件可操作以将制动构件的锯齿状表面朝向辊构件偏压。网状带由聚合物材料形成，并且可操作地偏置在锯齿状表面和辊构件之间，使得制动构件将带状带偏压在辊构件上。通过这种布置，当将带状带放置在紧张状态时，通过防止带状带在一个方向上的移动并允许沿第二方向移动以增加张力来保持这种张力。辊构件可操作以随着带状带在第二方向的移动而旋转，以增加带状带中的张力。

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