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1. 发明申请

WO2017162669A1 VAGINAL PREPARATIONS FOR MAINTAINING AND/OR RESTORING HEALTHY FEMALE MICROBIOTA 审中-公开
标题翻译：阴道准备维持和/或恢复健康女性微波
公开(公告)号：WO2017162669A1
公开(公告)日：2017-09-28
申请号：PCT/EP2017/056691
申请日：2017-03-21
申请人： YUN NV , UNIVERSITEIT ANTWERPEN
发明人： LEBEER, Sarah , CLAES, Ingmar , OERLEMANS, Eline , VAN DEN BROEK, Marianne
IPC分类号： C12R1/25 , A61K35/747 , C12N1/20 , C12R1/225
摘要： The present invention is directed to the direct application of beneficial or probiotic bacteria to the vaginal niche for maintenance of a healthy vaginal microbiota and to help restore an unbalanced vaginal microbiota. The application is based on the use of selected Lactobacillus strains as anti-pathogenic agents, in particular L. pentosus and/or L. plantarum, against common vaginal pathogens, whereby produced acids such as lactic acid are important antimicrobial factors.
摘要翻译：本发明涉及将有益或益生菌直接施用于阴道生态位以维持健康的阴道微生物群并帮助恢复不平衡的阴道微生物群。本申请基于使用选定的乳酸杆菌菌株作为抗致病剂，特别是戊糖乳杆菌和/或植物乳杆菌来对抗普通的阴道病原体，由此产生的酸例如乳酸是重要的抗微生物因子。

2. 发明申请

WO2018083212A1 MICROBIOME-SAFE COSMETIC CLEANING COMPOSITIONS 审中-公开
标题翻译：微生物安全化妆品清洁组合物
公开(公告)号：WO2018083212A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/078131
申请日：2017-11-03
申请人： YUN NV , UNIVERSITEIT ANTWERPEN
发明人： HENKENS, Tim , KIEKENS, Filip , LEBEER, Sarah , CLAES, Ingmar
IPC分类号： A61K8/36 , A61K8/37 , A61Q19/10
摘要： The present invention relates to microbiome-safe cosmetic cleaning compositions (i.e. soaps) and uses thereof in preserving the natural microflora of the human or animal skin/vagina. These cleaning compositions may also be beneficially used in combination with topical probiotic therapies, which may be compromised when using classical soaps. In particular, the present invention provides cosmetic cleaning compositions comprising at least one organic acid, as preservative; and at least one glycerol ester as surfactant. For these compositions it was found that they have the typical characteristics of a soap without the negative effects on the natural microflora of the skin/vagina.
摘要翻译：本发明涉及微生物组安全的化妆清洁组合物（即肥皂）及其在保存人类或动物皮肤/阴道的天然微生物群落中的用途。这些清洁组合物也可有利地与局部益生菌疗法组合使用，当使用经典的肥皂时可能会损害局部益生菌疗法。特别地，本发明提供了包含至少一种有机酸作为防腐剂的化妆清洁组合物; 和至少一种甘油酯作为表面活性剂。对于这些组合物，发现它们具有肥皂的典型特征，而对皮肤/阴道的天然微生物区系没有负面影响。

3. 发明申请

WO2023017141A2 SPRAYABLE FORMULATION COMPRISING VIABLE AND/OR STABLE BACTERIA 审中-公开
公开(公告)号：WO2023017141A2
公开(公告)日：2023-02-16
申请号：PCT/EP2022/072628
申请日：2022-08-12
申请人： YUN NV , UNIVERSITEIT ANTWERPEN
发明人： HENKENS, Tim , CLAES, Ingmar , SIMONS, Alix , GAMGAMI, Imane , LEBEER, Sarah , DE BOECK, Ilke , SPACOVA, Irina
IPC分类号： A61K8/25 , A61K8/92 , A61K8/99 , A61K35/747 , A61Q19/00 , A61K9/00 , A61K47/02 , A61K47/44 , A61P31/14 , A61K2035/115 , A61K2800/41 , A61K2800/84 , A61K35/00 , A61K9/0014 , A61K9/0043 , A61K9/006 , A61K9/10 , A61L2/00 , A61P1/00
摘要： The present invention relates to a sprayable formulation comprising live and/or stable bacteria and methods for making such sprayable formulation; in particular in the form of a liquid spray. The invention further relates to the use of this sprayable formulation in human or veterinarian medicine and the use of this sprayable formulation for the prevention and/or treatment of respiratory diseases. The invention further provides methods for the prevention and/or treatment of respiratory diseases.

4. 发明申请

WO2018078067A1 AEROSOL SPRAY CONTAINING VIABLE BACTERIAL SPECIES 审中-公开
标题翻译：气溶胶喷雾含有细菌种类
公开(公告)号：WO2018078067A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077547
申请日：2017-10-27
申请人： YUN NV , UNIVERSITEIT ANTWERPEN
发明人： HENKENS, Tim , KIEKENS, Filip , LEBEER, Sarah , CLAES, Ingmar
IPC分类号： A61Q19/00 , A61K8/99
摘要： The present invention is directed to an aerosol spray containing one or more bacterial species and at least one siloxane suitable for applying said one or more bacterial species to a surface or into the environment.
摘要翻译：本发明涉及含有一种或多种细菌物种和至少一种适用于将所述一种或多种细菌物种施用于表面或环境中的至少一种硅氧烷的气溶胶喷雾剂。

5. 发明申请

WO2018002248A1 PRESERVATION OF MICROORGANISMS 审中-公开
标题翻译：微生物的保存
公开(公告)号：WO2018002248A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/066176
申请日：2017-06-29
申请人： YUN NV , UNIVERSITEIT ANTWERPEN
发明人： KIEKENS, Filip , HENKENS, Tim , LEBEER, Sarah , CLAES, Ingmar
IPC分类号： C12N1/04 , C12N1/20 , A61K9/00 , A61K47/12 , A61K35/74
摘要： The present invention relates to the field of preservation of microorganisms, and in particular provides a 2-compartment system comprising a first compartment comprising microcapsules with microorganisms in a non-aqueous composition in the core of said microcapsules, and a second aqueous organic acid-containing compartment. It further provides methods for preserving microorganisms, on the basis of such systems, as well as uses of such systems for preserving microorganisms.
摘要翻译：本发明涉及微生物保存领域，并且具体提供了一种2-隔室系统，其包含第一隔室和第二隔室，所述第一隔室包含具有处于所述微胶囊核心中的非水性组合物中的微生物的微胶囊，和第二含水有机酸的隔室。它进一步提供了在这种系统的基础上保存微生物的方法，以及这种系统用于保存微生物的方法。

6. 发明申请

WO2017220525A1 DERMATOLOGICAL PREPARATIONS FOR MAINTAINING AND/OR RESTORING HEALTHY SKIN MICROBIOTA 审中-公开
标题翻译：用于维护和/或恢复健康皮肤微生物的皮肤病制剂
公开(公告)号：WO2017220525A1
公开(公告)日：2017-12-28
申请号：PCT/EP2017/065006
申请日：2017-06-20
申请人： YUN NV , UNIVERSITEIT ANTWERPEN
发明人： LEBEER, Sarah , CLAES, Ingmar , OERLEMANS, Eline , VAN DEN BROEK, Marianne
IPC分类号： A61Q19/00 , C12R1/25 , A61K35/747 , C12R1/225 , A61P17/00 , A61K8/99
摘要： The present invention is directed to the direct application of beneficial or probiotic bacteria to the skin for maintenance of a healthy skin microbiota and to help restore an unbalanced skin microbiota. The application is based on the use of selected Lactobacillus strains as anti-5 pathogenic agents, in particular L. plantarum, L. pentosus and/or L. rhamnosus, against common skin pathogens, whereby produced acids such as lactic acid are important antimicrobial factors.
摘要翻译：本发明涉及将有益或益生菌直接施用于皮肤以维持健康的皮肤微生物群并帮助恢复不平衡的皮肤微生物群。本申请基于使用选定的乳酸杆菌菌株作为抗-5致病剂，特别是植物乳杆菌，戊糖乳杆菌和/或鼠李糖乳杆菌，针对普通皮肤病原体，由此产生的酸例如乳酸是重要的抗微生物因子

7. 发明申请

WO2020128022A1 NOVEL DOLOSIGRANULUM PIGRUM STRAINS AND USES THEROF 审中-公开
公开(公告)号：WO2020128022A1
公开(公告)日：2020-06-25
申请号：PCT/EP2019/086763
申请日：2019-12-20
申请人： UNIVERSITEIT ANTWERPEN
发明人： LEBEER, Sarah , JÖRISSEN, Jennifer , DE BOECK, Ilke
IPC分类号： A61K35/66 , A61K35/74 , A61P11/06 , A61P31/04
摘要： The present invention relates to novel isolated bacterial strains of the Dolosigranulum pigrum species and variants thereof having at least 99% sequence identity in its 16S rRNA gene to said novel strains. The present invention further relates to the use of these bacterial strains, and compositions comprising said strains for use as a probiotic, such as for improving or restoring the flora/microbiota of the respiratory tract and skin. The present invention further relates to the use of these bacterial strains as an antibacterial agent; for use in human or veterinary medicine; for use in the treatment of human or veterinary diseases; or for use in personal hygiene industry, food industry, cleaning industry, pharma industry, or biocontrol applications.

8. 发明申请

WO2022195075A1 NOVEL LACTIC ACID BACTERIAL SPECIES AND ITS USES 审中-公开
公开(公告)号：WO2022195075A1
公开(公告)日：2022-09-22
申请号：PCT/EP2022/057147
申请日：2022-03-18
申请人： UNIVERSITEIT ANTWERPEN
发明人： LEGEIN, Marie , LEBEER, Sarah
IPC分类号： C12N1/20 , A01N63/20 , C12R1/225
摘要： The present invention relates to the identification of a novel isolated lactic acid bacterial species. More specifically, a novel Latilactobacillus species, Latilactobacillus fragifolii sp. nov., with the type strain AMBP162T is proposed. The present invention further relates to the use of a formulation comprising the novel lactic acid bacterial species in the agricultural field and human and/or veterinary medicine.

9. 发明申请

WO2015140299A1 ORONASOPHARYNGEAL PROBIOTICS 审中-公开
公开(公告)号：WO2015140299A1
公开(公告)日：2015-09-24
申请号：PCT/EP2015/055930
申请日：2015-03-20
申请人： UNIVERSITEIT ANTWERPEN
发明人： BROECKX, Géraldine , CLAES, Ingmar , KIEKENS, Filip , LEBEER, Sarah , VAN DEN BROEK, Marianne
IPC分类号： A61K9/00 , A61K35/74 , A61K31/7016 , A61P11/00
CPC分类号： A61K35/747 , A61K2300/00
摘要： The present invention is directed to a novel probiotic oronasopharyngeal formulation of spray-dried bacteria comprising saccharides as protectants, for administration in the oronasopharyngeal cavity. Resuscitation of the formulation of the present invention gives rise to rapid deployable and viable microorganisms with preserved antimicrobial activity, and was found particularly useful for nasopharyngeal administration to treat respiratory conditions in humans and animals. In a further aspect, the present invention is directed to the probiotic microorganisms used in the aforementioned formulation. As evident from the examples hereinafter, spray-dried compositions comprising Lactobacillus strains, in particular comprising Lactobacillus rhamnosus proved optimal in the oronasopharyngeal applications of the present invention. The application also provides the use of Lactobacillus strains as anti-pathogenic and antibiofilm agents, in particular against the common nasopharyngeal pathogens (whereby produced acids such as lactic acid are important antimicrobial factors). Also disclosed are the processes associated with the manufacture of the spray-dried probiotic formulations of the present invention, as well as the use thereof in treating or preventing of infections of the oronasopharyngeal cavity.
摘要翻译：本发明涉及一种包含糖作为保护剂的喷雾干燥细菌的新型益生唾液酸鼻咽制剂，用于在口腔内施用。复制本发明的制剂产生具有保留的抗微生物活性的快速可展开和可行的微生物，并且被发现特别适用于鼻咽给药以治疗人和动物的呼吸状况。在另一方面，本发明涉及上述制剂中使用的益生菌微生物。从下文的实施例可以看出，包含乳酸杆菌菌株，特别是包含鼠李糖乳杆菌的喷雾干燥组合物在本发明的鼻咽部应用中证明是最佳的。该应用还提供了使用乳杆菌属菌株作为抗病原和抗菌膜剂，特别是针对常见的鼻咽病原体（由此产生的酸如乳酸是重要的抗菌因子）。还公开了与本发明的喷雾干燥的益生菌制剂的制造相关的方法，以及其在治疗或预防肛门口腔感染中的用途。

10. 发明申请

WO2022112609A1 LIMOSILACTOBACILLUS REUTERI STRAIN WITH HIGH RIBOFLAVIN PRODUCTION AND USES THEREOF 审中-公开
公开(公告)号：WO2022112609A1
公开(公告)日：2022-06-02
申请号：PCT/EP2021/083615
申请日：2021-11-30
申请人： UNIVERSITEIT ANTWERPEN
发明人： LEBEER, Sarah , AHANNACH, Sarah , SPACOVA, Irina , WITTOUCK, Stijn
IPC分类号： C12N1/20 , C12P25/00
摘要： The present invention to the identification of a novel isolated bacterial strain, the Limosilactobacillus reuteri strain which is characterized by a naturally occurring overproduction of riboflavin (vitamin B2) compared to other known strains of lactobacilli. Said strain of the Limosilactobacillus species is deposited under accession number LMG P-32020. In a further aspect, also the uses of said L. reuteri strain are disclosed herein. In particular, the use of said strain in food and feed industry, human and veterinary health, large-scale vitamin production, cosmetics and consumer care products is disclosed.

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