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1. 发明申请

WO1995024420A1 A POLYMORPH OF ASPARTAME AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译： ASPARTAME的聚合物及其制备方法
公开(公告)号：WO1995024420A1
公开(公告)日：1995-09-14
申请号：PCT/GB1995000496
申请日：1995-03-08
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , GARTI, Nissim , MILHOFER, Helga
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C07K05/06
CPC分类号： C07K5/0613 , A23L27/32
摘要： The invention provides a polymorph of aspartame, designated APM II, and characterized by: a) X-ray diffraction powder patterns (d-values), as set forth in Table I herein; b) an infrared diffraction pattern, as represented by curves 3 in Figures (1a) and (1b) appended hereto; and c) differential scanning calorimetric patterns, as represented by thermograph b in Figure (2) appended hereto.
摘要翻译：本发明提供了称为APM II的阿斯巴甜的多晶型物，其特征在于：a）如本文表I所示的X射线衍射粉末图案（d值） b）红外衍射图，如附图（1a）和（1b）中的曲线3所示; 和c）差示扫描量热图，如附图（2）中的温度计b所示。

2. 发明申请

WO1995033807A1 WATER-IN-OIL MICROEMULSION 审中-公开
标题翻译：水中微乳液
公开(公告)号：WO1995033807A1
公开(公告)日：1995-12-14
申请号：PCT/GB1995001251
申请日：1995-05-31
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , GARTI, Nissim , EZRAHI, Shmaryahu , ASERIN, Abraham
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C10M173/00
CPC分类号： C10M173/00 , C10M125/26 , C10M129/06 , C10M129/14 , C10M129/16 , C10M135/08 , C10M137/10 , C10M145/36 , C10M2201/02 , C10M2201/087 , C10M2201/10 , C10M2201/102 , C10M2201/105 , C10M2207/021 , C10M2207/022 , C10M2207/024 , C10M2207/04 , C10M2207/046 , C10M2209/104 , C10M2209/108 , C10M2219/04 , C10M2219/042 , C10M2223/045 , C10N2210/02 , C10N2240/08 , C10N2250/02
摘要： The invention provides a water-in-oil microemulsion having high fire resistance, consisting of mineral oil; at least 50 wt.% water; and at least one polyethoxylated nonionic alcohol surfactant, the alcohol having 12-18 carbon atoms and having attached thereto between 2 and 25 ethoxy groups.
摘要翻译：本发明提供一种具有高耐火性的油包水微乳液，由矿物油组成; 至少50重量％的水; 和至少一种聚乙氧基化的非离子醇表面活性剂，所述醇具有12-18个碳原子，并且其上连接有2至25个乙氧基。

3. 发明申请

WO1995030341A1 COMESTIBLE PRODUCTS CONTAINING SAPONINS 审中-公开
标题翻译：含有柚子的不可思议的产品
公开(公告)号：WO1995030341A1
公开(公告)日：1995-11-16
申请号：PCT/GB1995000921
申请日：1995-04-24
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , GARTI, Nissim , MADAR, Zecharia , STERNHEIM, Boaz
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： A23L01/035
CPC分类号： C07J71/0005 , A23L29/10
摘要： The invention provides a comestible product comprising a fenugreek saponin as an emulsifying agent therein, said fenugreek saponin comprising a mixture of glucosidic steroids having formula (Ia or Ib) wherein R1, R2 and R3 are H, CH3, H; CH3, H, H; H, CH3, OH; or CH3, H, H respectively; and R4 is hydrogen or a unit of 2-5 interconnected sugar moieties, the moieties comprising mannose, glucose, rhamanose, xylose and galactose, and having different and improved properties when compared to products produced with soybean saponins.
摘要翻译：本发明提供一种含有葫芦巴皂苷作为乳化剂的可食用产品，所述葫芦巴皂苷包含具有式（Ia或Ib）的糖苷类固醇的混合物，其中R 1，R 2和R 3为H，CH 3，H; CH3，H，H; H，CH 3，OH; 或CH3，H，H; 并且R4是氢或2-5个互连的糖部分的单元，所述部分包含甘露糖，葡萄糖，鼠李糖，木糖和半乳糖，并且与用大豆皂苷生产的产品相比具有不同的和改进的性质。

4. 发明申请

WO1995021199A1 GALACTOMANNAN PRODUCTS AND COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：糖醇产品及其组合物
公开(公告)号：WO1995021199A1
公开(公告)日：1995-08-10
申请号：PCT/GB1995000239
申请日：1995-02-07
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , GARTI, Nissim , ASERIN, Abraham , MADAR, Zecharia , STERNHEIM, Boaz
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C08B37/14
CPC分类号： C08B37/0087 , A23L29/238 , A61K8/737 , A61K8/97 , A61K31/715 , A61Q19/00
摘要： The invention provides an isolated galactomannan having at least 50 repeating units of mannose and galactose in a ratio of between 0.5-1.0 and 1.8-1.0, and having a protein content of less than 20 wt. %, a saponin content of less than 5 wt. %, and a lipid content of less than 1 wt. %, which can be used as an active ingredient in nutraceutical and cosmetic products.
摘要翻译：本发明提供一种分离的半乳甘露聚糖，其具有至少50个重复单元的甘露糖和半乳糖，其比例为0.5-1.0至1.8-1.0，蛋白质含量小于20wt。％，皂苷含量小于5wt。％，脂质含量小于1wt。％，可用作营养保健品和化妆品中的活性成分。

5. 发明申请

WO1995004473A1 REMOVAL OF CHOLESTEROL FROM EDIBLES 审中-公开
标题翻译：从食物中去除胆固醇
公开(公告)号：WO1995004473A1
公开(公告)日：1995-02-16
申请号：PCT/US1994008814
申请日：1994-08-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HEINE, Holliday, C. , GARTI, Nissim
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , HEINE, Holliday, C.
IPC分类号： A23L01/015
CPC分类号： A23C7/043 , A23C15/145 , A23L5/273 , A23L15/00 , A23L29/238 , A23V2002/00 , A23V2200/3262 , A23V2300/02 , A23V2300/14
摘要： A process for the removal of a predetermined percentage of cholesterol from edibles which contain such cholesterol by hydrocolloid extractants according to the inventions, preferably galactomannoses, is disclosed. Also disclosed is the in vivo use of such extractants to provide control of cholesterol levels.
摘要翻译：公开了一种通过根据本发明的水解胶体提取物从包含这种胆固醇的食品中除去预定百分比的胆固醇的方法，优选为半乳糖甘露糖。还公开了这种提取剂的体内使用以提供对胆固醇水平的控制。

6. 发明申请

WO1998002411A1 A PROCESS FOR THE SEPARATION OF AMINO ACIDS AND THEIR SALTS FROM AN AQUEOUS SOLUTION 审中-公开
标题翻译：一种用于分离氨基酸及其水溶液的方法
公开(公告)号：WO1998002411A1
公开(公告)日：1998-01-22
申请号：PCT/GB1997001874
申请日：1997-07-11
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir , COHEN-SYDOV, Nadjda
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C07C227/40
CPC分类号： C07C227/40
摘要： The invention provides a process for the separation of amino acids and their salts from impurities contained in an aqueous feed solution containing the same, wherein the solution has a pH value of pH > pl, in the case of acidic amino acids, has a pH value of pH
摘要翻译：本发明提供了一种从含有该氨基酸及其盐的含水原料溶液中的杂质中分离氨基酸及其盐的方法，其中，在酸性氨基酸的情况下，该溶液的pH值> P1的pH值为pH，具有pH值在碱性氨基酸的情况下为pH

7. 发明申请

WO1997013761A1 A PROCESS FOR THE RECOVERY OF ASCORBIC ACID 审中-公开
标题翻译：抗坏血酸的恢复方法
公开(公告)号：WO1997013761A1
公开(公告)日：1997-04-17
申请号：PCT/GB1996002041
申请日：1996-08-21
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir , VITNER, Asher , REUVENY, Tal
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： The invention provides a process for the recovery of ascorbic acid from an aqueous feed solution containing the acid at a concentration of less then 0.7 mol/kg, including adsorbing a major portion of the ascorbic acid with a solid phase adsorbent resin selected from resins carrying a pyridine function and resins of similar or weaker basicity, separating the ascorbic acid-containing resin from residual aqueous solution, and subjecting the ascorbic acid-containing resin to a desorbing operation with a neutral solvent at a temperature of at least 20 DEG C higher than the termperature at which the adsorbtion is carried out, whereby there is obtained a solution of ascorbic acid in solvent in which the concentration of ascorbic acid is at least equal to its concentration in the aqueous feed solution.
摘要翻译：本发明提供了从含有浓度小于0.7mol / kg的酸的含水进料溶液中回收抗坏血酸的方法，包括用固相吸附树脂吸附大部分抗坏血酸，所述固相吸附树脂选自携带吡啶功能和碱性相似或较弱的树脂，将残留水溶液分离出含有抗坏血酸的树脂，并使用含有抗坏血酸的树脂在比中性溶剂至少高20℃以上的温度下进行解吸操作进行吸附的温度，从而得到抗坏血酸在溶剂中的溶液，其中抗坏血酸的浓度至少等于其在进料水溶液中的浓度。

8. 发明申请

WO1996011281A1 PROCESS FOR THE PREPARATION OF LONG-CHAIN ALKYL GLYCOSIDES 审中-公开
标题翻译：制备长链氨基糖苷的方法
公开(公告)号：WO1996011281A1
公开(公告)日：1996-04-18
申请号：PCT/GB1995002373
申请日：1995-10-06
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir , KOTLYAR, Sofia , APFELBAUM, Francoise , MAGDASSI, Shlomo , BRAUN, Sergei
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C12P19/44
CPC分类号： C12P19/44
摘要： The invention provides a process for the preparation of long-chain alkyl glycosides, comprising reacting a glucose-containing reactant and a C8-C18 fatty alcohol in the presence of a glucosidase and a reaction promoter effective to promote the formation of the alkyl glycoside when the promoter is present in an amount of less than about 50 wt.% of the total reaction mixture.
摘要翻译：本发明提供了制备长链烷基糖苷的方法，包括在葡萄糖苷酶和反应促进剂存在下使含葡萄糖的反应物与C8-C18脂肪醇反应，所述反应促进剂有效促进烷基糖苷的形成促进剂的存在量小于总反应混合物的约50重量％。

9. 发明申请

WO1995025081A1 A PROCESS AND EXTRACTANT COMPOSITION FOR EXTRACTING ACIDS 审中-公开
标题翻译：用于提取酸的方法和提取物组合物
公开(公告)号：WO1995025081A1
公开(公告)日：1995-09-21
申请号：PCT/GB1995000535
申请日：1995-03-13
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C07C51/48
CPC分类号： C07C51/48
摘要： The invention provides a process for the recovery of a water-soluble carboxylic or mineral acid having a pKa higher than 2 from an aqueous feed solution containing the acid or a salt thereof, comprising extracting the acid with a water-immiscible extractant composition, the composition comprising: (a) at least one secondary or tertiary alkyl amine, in which the aggregate number of carbon atoms is at least 20, as a primary extractant; and (b) a sterically hindered, polar, organic compound having at least 5 carbon atoms, a basicity weaker than that of the primary extractant, and temperature-sensitive, extraction-modifying properties; separating the acid containing the extractant and subjecting it to a stripping operation at a temperature of at least 20 DEG C higher than the temperature at which the extraction is carried out, wherein the sterically hindered, polar, organic compound both modifies the extracting power of the primary extractant composition and facilitates the temperature-sensitive stripping operation. The invention also provides an extractant composition for use in such a process.
摘要翻译：本发明提供一种从含有酸或其盐的含水进料溶液中回收具有高于2的pKa的水溶性羧酸或无机酸的方法，包括用水不混溶的萃取剂组合物萃取酸，该组合物包括：（a）至少一种其中总碳原子数为20以上的仲或叔烷基胺作为主要提取剂; 和（b）具有至少5个碳原子的空间位阻极性有机化合物，其碱性弱于初级萃取剂，碱度低于温度敏感性，萃取 - 改性性质; 分离含有萃取剂的酸，并在比进行萃取的温度高至少20℃的温度下进行汽提操作，其中空间位阻极性有机化合物改变了萃取剂的萃取力初级萃取剂组合物，并有助于温度敏感的汽提操作。本发明还提供了用于这种方法的萃取剂组合物。

10. 发明申请

WO1998026062A2 SYNTHETIC ANTISENSE OLIGODEOXYNUCLEOTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：合成抗体寡糖氧化酶和含有它们的药物组合物
公开(公告)号：WO1998026062A2
公开(公告)日：1998-06-18
申请号：PCT/US1997023598
申请日：1997-12-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , SOREQ, Hermona , SEIDMAN, Shlomo , ECKSTEIN, Fritz , FRIEDMAN, Alon , KAUFER, Daniela
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： C12N15/00
CPC分类号： C12Y301/01007 , A01K2217/05 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2310/3521
摘要： A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-ODN) capable of selectively modulating human acetylcholinesterase (AChE) production and a pharmaceutical or medical composition comprising at least one AD-ODN as an active ingredient. In an embodiment the AS-ODN can be selected from 5'ACGCTTTCTTGAGGC 3' (SEQ ID NO.1), 5'GGCACCCTGGGCAGC 3' (SEQ ID NO.2); 5'CCACGTCCTCCTGCACCGTC 3' (SEQ ID NO.6); 5'ATGAACTCGATCTCGTAGCC 3' (SEQ ID NO.7); 5'GCCAGAGGAGGAGGAGAAGG 3' (SEQ ID NO.4); 5'TAGCGTCTACCACCCCTGAC 3' (SEQ ID NO.5), 5'TCTGTGTTATAGCCCAGCCC 3' (SEQ ID NO.17); and 5'GGCCTGTAACAGTTTATTT 3' (SEQ ID NO.18). A nuclease resistant antisense targeted against the splice junction in the AChEmRNA post splice message is disclosed. In an embodiment, a nuclease resistant AS-ODN targeted against the E4-E6 junction in the E1-E4-E6 splice variant AChEmRNA is disclosed as being highly specific for the muscle and central nervous system splice variant of AChE. The synthetic nuclease resistant AS-ODNs are capable of selectively modulating human AChE production in the central nervous system or capable of selectively reducing human AChE deposition in the neuromuscular junction. The present invention also provides a method to restore balanced cholinergic signaling in the brain and spinal cord or reduce AChE in the neuromuscular junction in patients in need of such treatment comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of the synthetic nuclease resistant AS-ODN capable of selectively modulating human AChE production.
摘要翻译：能够选择性调节人乙酰胆碱酯酶（AChE）生产的合成核酸酶抗性反义寡脱氧核苷酸（AS-ODN）和包含至少一种AD-ODN作为活性成分的药物或医药组合物。在一个实施方案中，AS-ODN可以选自5'ACGCTTTCTTGAGGC 3'（SEQ ID NO.1），5'GGCACCCTGGGCAGC 3'（SEQ ID NO.2）; 5'CCACGTCCTCCTGCACCGTC 3'（SEQ ID NO.6）; 5'ATGAACTCGATCTCGTAGCC 3'（SEQ ID NO.7）; 5'GCCAGAGGAGGAGGAGAAGG 3'（SEQ ID NO.4）; 5'TAGCGTCTACCACCCCTGAC 3'（SEQ ID NO.5），5'TCTGTGTTATAGCCCAGCCC 3'（SEQ ID NO.17）; 和5'GGCCTGTAACAGTTTATTT 3'（SEQ ID NO.18）。公开了针对针对AChEmRNA后剪接消息中的剪接连接的核酸酶抗性反义。在一个实施方案中，公开了针对E1-E4-E6剪接变体AChEmRNA中的E4-E6连接的核酸酶抗性AS-ODN作为AChE的肌肉和中枢神经系统剪接变体的高度特异性。合成的核酸酶抗性AS-ODNs能够选择性调节中枢神经系统中的人AChE产生或能够选择性地降低神经肌肉接头中的人类AChE沉积。本发明还提供一种在需要这种治疗的患者中恢复脑和脊髓中的平衡胆碱能信号传导或减少神经肌肉接头中的AChE的方法，包括向需要这种治疗的患者施用治疗有效量的至少一种的能够选择性调节人AChE生产的合成核酸酶抗性AS-ODN。

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