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1. 发明申请

WO2010010547A2 DETECTOR FOR PEROXIDE-BASED EXPLOSIVES 审中-公开
标题翻译：基于过氧化物的爆炸物探测器
公开(公告)号：WO2010010547A2
公开(公告)日：2010-01-28
申请号：PCT/IL2009/000477
申请日：2009-05-12
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , NAAMAN, Ron , CAPUA, Eyal , CAO, Roberto
发明人： NAAMAN, Ron , CAPUA, Eyal , CAO, Roberto
IPC分类号： G01N33/22 , G01N27/12
CPC分类号： G01N27/126 , G01N33/0057 , Y10T436/142222 , Y10T436/143333 , Y10T436/16 , Y10T436/179228 , Y10T436/18 , Y10T436/20 , Y10T436/202499 , Y10T436/203332 , Y10T436/204165 , Y10T436/204998 , Y10T436/205831 , Y10T436/206664 , Y10T436/207497
摘要： The present invention provides a device for the detection of a peroxide-based explosive, in particular, triacetone triperoxide (TATP), which is based on a molecular controlled semiconductor resistor (MOCSER) and composed of at least one insulating or semi-insulating layer, at least one conducting semiconductor layer, two conducting pads and a layer of multifunctional organic molecules capable of adsorbing molecules of said peroxide-based explosive. The invention further provides an array of semiconductor devices for the selective detection of a peroxide-based explosive, as well as a method for the selective detection of vapors of a peroxide-based explosive in a gaseous mixture using said array.
摘要翻译：本发明提供一种用于检测基于过氧化物的炸药，特别是基于分子控制半导体电阻器（MOCSER）并由至少一个绝缘或半绝缘层构成的三丙酮三过氧化物（TATP）的装置，至少一个导电半导体层，两个导电焊盘和能吸附所述基于过氧化物的炸药的分子的多官能有机分子层。本发明还提供了一种用于选择性检测基于过氧化物的炸药的半导体器件阵列，以及使用所述阵列选择性地检测气体混合物中基于过氧化物的炸药的蒸气的方法。

2. 发明申请

WO2012168932A1 PROTEIN DETECTOR BASED ON MOLECULAR CONTROLLED SEMICONDUCTOR RESISTOR 审中-公开
标题翻译：基于分子控制半导体电阻的蛋白质检测器
公开(公告)号：WO2012168932A1
公开(公告)日：2012-12-13
申请号：PCT/IL2012/000215
申请日：2012-05-31
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , NAAMAN, Ron , CAPUA, Eyal , BAVLI, Danny , TKACHEV, Maria
发明人： NAAMAN, Ron , CAPUA, Eyal , BAVLI, Danny , TKACHEV, Maria
IPC分类号： G01N27/414 , G01N27/12
CPC分类号： G01N27/4145
摘要： The invention provides a semiconductor device for the detection of an active site-containing protein or a ligand thereof in a solution, said device comprising at least one insulating or semi-insulating layer; at least one conducting semiconductor layer; two conducting pads on top of the upper layer making electrical contact with said at least one conducting semiconductor layer, such that electrical current can flow between them at a finite distance from the surface of the device; a protective molecular layer fabricated on top of said upper layer and protecting said layer from corrosion; and said ligand or active site- containing protein linked to said protective molecular layer. Exposure of said ligand or active site-containing protein to a solution containing said active site-containing protein or ligand, respectively, causes a current change through the device when a constant electric potential is applied between the two conducting pads. The semiconductor device can be seen as a molecularly controlled semiconductor resistor (MOCSER) protein sensor based on doped and undoped GaAs stack structure. The GaAs is protected against etching in aqueous environments by the protective molecular layer.
摘要翻译：本发明提供一种用于在溶液中检测含活性位点的蛋白质或其配体的半导体器件，所述器件包括至少一个绝缘或半绝缘层; 至少一个导电半导体层; 在上层的顶部上的两个导电焊盘与所述至少一个导电半导体层电接触，使得电流可以在它们之间在与器件表面有限距离的位置之间流动; 在所述上层顶部制造的保护分子层，并保护所述层免受腐蚀; 和与所述保护性分子层连接的所述配体或含活性位点的蛋白质。当在两个导电垫之间施加恒定的电位时，所述配体或含活性位点的蛋白质分别暴露于含有所述含活性位点的蛋白质或配体的溶液中，导致通过该装置的电流变化。半导体器件可以看作是基于掺杂和未掺杂的GaAs堆叠结构的分子控制半导体电阻（MOCSER）蛋白质传感器。在保护分子层的水溶液环境中保护GaAs不被腐蚀。

3. 发明申请

WO2017221250A1 SYSTEM AND METHOD FOR USE IN ANALYSIS OF CHIRAL MOLECULES 审中-公开
标题翻译：用于分析手性分子的系统和方法
公开(公告)号：WO2017221250A1
公开(公告)日：2017-12-28
申请号：PCT/IL2017/050692
申请日：2017-06-21
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： NAAMAN, Ron , KANTOR-URIEL, Nirit , CAPUA, Eyal , KUMAR, Anup , WALDECK, David
IPC分类号： G01R33/12
CPC分类号： G01R33/1284
摘要： A system and method are described, for use in determining parameters of chiral molecules. The system comprising: an electrode comprising an adsorption surface, and at least first and second pairs of electrical contacts defining respectively first and second axes of electrical path being substantially perpendicular to between them, wherein said adsorption surface is configured for adsorption of a plurality of molecules to be tested; a field generating unit configured to selectively apply electric field onto said adsorption surface of said electrode; and a control unit comprising at least a power source utility and a voltage detection utility and configured to generate and transmit electrical current through said electrode via said first pair of electrical contact. The control unit further operates the field generating unit to apply selected electric field onto said electrode, and determine data about resulting Hall voltage between said second pair of electrical contacts. The data about resulting Hall voltage being indicative of chirality of said plurality of molecules.
摘要翻译：描述了用于确定手性分子参数的系统和方法。该系统包括：包括吸附表面的电极，以及至少第一和第二对电触点，分别限定基本上垂直于它们之间的第一和第二电通路轴线，其中所述吸附表面被配置用于吸附多个分子待测; 场生成单元，被配置为选择性地将电场施加到所述电极的所述吸附表面上; 以及控制单元，其至少包括电源设施和电压检测设施，并且被配置为通过所述第一对电触点产生并传输电流通过所述电极。控制单元还操作场生成单元以将选择的电场施加到所述电极上，并且确定关于所述第二对电触点之间的所得霍尔电压的数据。关于所得霍尔电压的数据指示所述多个分子的手性。

4. 发明申请

WO2019043693A1 SYSTEM AND METHOD FOR SEPARATION OF CHIRAL COMPOUNDS USING MAGNETIC INTERACTIONS 审中-公开
公开(公告)号：WO2019043693A1
公开(公告)日：2019-03-07
申请号：PCT/IL2018/050942
申请日：2018-08-26
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
发明人： NAAMAN, Ron , CAPUA, Eyal , LAHAV, Meir , TASSINARI, Francesco , PALTIEL, Yossef , YOCHELIS, Shira
IPC分类号： G01N30/00 , B01D7/02 , B01D9/00
摘要： Systems and methods are disclosed for use in the separation of chiral compounds, and enantiomers in particular. The system comprises a cavity (110) for containing a fluid mixture that comprises one or more types of chiral molecules, which may also include enantiomers, and at least one ferromagnetic or paramagnetic substrate (120) providing at least one interface (130) with said fluid mixture. The substrate (120) is magnetized providing a magnetic field Bz perpendicular to said ferromagnetic or paramagnetic interface (130), thereby providing a variation in the interaction energy of chiral molecules of different handedness, aka. enantiomers, with said substrate (120).

5. 发明申请

WO2014111945A1 GAAS-BASED DETECTOR HIGHLY STABLE IN AQUEOUS SOLUTIONS 审中-公开
标题翻译：基于GAAS的检测器在水溶液中稳定
公开(公告)号：WO2014111945A1
公开(公告)日：2014-07-24
申请号：PCT/IL2014/050071
申请日：2014-01-21
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD
发明人： NAAMAN, Ron , TKACHEV, Maria , TATIKONDA, Anand Kumar , CAPUA, Eyal
IPC分类号： G01N27/12 , G01N27/414
CPC分类号： G01N27/4145 , G01N27/4148 , G01N33/54373 , H01L21/02118 , H01L21/02282 , H01L21/30612 , H01L29/20
摘要： The present invention provides semiconductor devices, particularly devices based on the Molecular Controlled Semiconductor Resistor (MOCSER), which are highly stable in aqueous solutions. The semiconductor devices of the invention may be used for the detection of various target molecules, e.g., proteins, peptides, carbohydrates and small molecules, in different solutions such as physiological solution, bodily fluids and bodily fluid-based solutions.
摘要翻译：本发明提供半导体器件，特别是基于分子控制半导体电阻器（MOCSER）的器件，其在水溶液中是高度稳定的。本发明的半导体器件可用于在诸如生理溶液，体液和基于体液的溶液之类的不同溶液中检测各种靶分子，例如蛋白质，肽，碳水化合物和小分子。

6. 发明申请

WO2020084613A1 A SYSTEM AND METHOD FOR PROMOTING CHEMICAL REACTIONS 审中-公开
公开(公告)号：WO2020084613A1
公开(公告)日：2020-04-30
申请号：PCT/IL2019/051143
申请日：2019-10-23
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
发明人： NAAMAN, Ron , FONTANESI, Claudio , TASSINARI, Francesco , MISHRA, Suryakant , CAPUA, Eyal , PALTIEL, Yossef , YOCHELIS, Shira , METZGER, Tzuriel
IPC分类号： B01J19/08 , B01J19/22
摘要： A system and method for use in synthesis and promoting interactions of chiral molecules. The system comprising: a container configured for containing fluid mixture comprising one or more reactant molecules, and at least one surface comprising ferromagnetic or paramagnetic material, located to be in at least partial contact with reactants in said container. The ferromagnetic of paramagnetic material is magnetized with magnetization direction perpendicular to said at least one surface, thereby providing chiral selective synthesis from said one or more reactant molecules. The technique enables selective interactions of enantiomers of selected handedness of chiral molecules or formation of selected enantiomers from achiral molecule reactants.

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