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1. 发明申请

WO2009106991A3 PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS IN THE TREATMENT OF SKIN DISORDERS 审中-公开
公开(公告)号：WO2009106991A3
公开(公告)日：2009-09-03
申请号：PCT/IB2009/005350
申请日：2009-02-19
申请人： XENON PHARMACEUTICALS INC. , NOVARTIS AG. , BILLICH, Andreas , WINTHER, Michael, D. , GOLDBERG, Yigal, Paul , WINZENBURG, Gesine , RAPP, Karin , FRITZE, Andreas
发明人： BILLICH, Andreas , WINTHER, Michael, D. , GOLDBERG, Yigal, Paul , WINZENBURG, Gesine , RAPP, Karin , FRITZE, Andreas
IPC分类号： A61K31/501 , A61P17/00 , A61P17/08 , A61P17/10 , A61K9/00 , A61K47/08 , A61K47/10 , A61K47/32
摘要： Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human, including administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 and R 9a are defined herein, and compositions including a compound of formula (I).

2. 发明申请

WO2007071356A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2007071356A2
公开(公告)日：2007-06-28
申请号：PCT/EP2006/012179
申请日：2006-12-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MUHRER, Gerhard , WINZENBURG, Gesine
发明人： MUHRER, Gerhard , WINZENBURG, Gesine
IPC分类号： C08F6/28 , C08F6/10
CPC分类号： C08F6/003 , C08F6/005 , C08L33/00
摘要： A process for purifying a polymer containing residual volatile monomers by drying the polymer powder under vacuum at a pressure and at a temperature which allows the vaporization of the residual monomers and optionally de-aggregating by sieving.
摘要翻译：通过在压力和温度下在真空下干燥聚合物粉末来纯化含有残留挥发性单体的聚合物的方法，所述压力和温度允许残余单体蒸发并任选地通过筛分去聚集。

3. 发明申请

WO2008040763A1 PHARMACEUTICAL COMPOSITIONS COMPRISING BISPHOSPHONATES 审中-公开
标题翻译：包含二磷酸的药物组合物
公开(公告)号：WO2008040763A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060508
申请日：2007-10-03
申请人： NOVARTIS AG , PETERSEN, Holger , SIGG, Juergen , LOEFFLER, Rolf , WINZENBURG, Gesine
发明人： PETERSEN, Holger , SIGG, Juergen , LOEFFLER, Rolf , WINZENBURG, Gesine
IPC分类号： A61K9/16 , A61K9/00 , A61K31/663 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/1647
摘要： The present invention relates to depot formulations comprising a poorly water soluble salt of a bisphosphonate forming together with one or more biocompatible polymers. The depot formulation may be in the form of microparticles or implants. The depot formulations are useful for the treatment and prevention of proliferative diseases including cancer.
摘要翻译：本发明涉及包含与一种或多种生物相容性聚合物一起形成的二膦酸盐的难溶于水的盐的贮库制剂。贮库制剂可以是微粒或植入物的形式。贮库制剂可用于治疗和预防包括癌症在内的增殖性疾病。

4. 发明申请

WO2018134062A1 DIP TUBE 审中-公开
公开(公告)号：WO2018134062A1
公开(公告)日：2018-07-26
申请号：PCT/EP2018/050258
申请日：2018-01-05
申请人： NOVARTIS AG
发明人： TIMBAL, Olivier , WINZENBURG, Gesine
IPC分类号： A61J1/20
摘要： A dip tube (10) for extracting a fluid (102) from a bottle (104) comprises an adapter (12) configured to be at least partially inserted into a neck (106) of the bottle (104) and being provided with a connecting port (38) which is configured to be connected to a suction device (118), an elongated hollow withdrawal tube (14) which has a cross-sectional area that is smaller than a cross-sectional area of the adapter (12) and which is configured to protrude from the adapter (12) into a fluid receiving space (108) of the bottle (104), when the adapter (12) is inserted in the bottle neck (106), and which is arranged in fluid communication with the connecting port (38) of the adapter (12), and a sealing disc (52) extending from an outer circumferential surface (54) of the withdrawal tube (14) and being configured to abut against an inner surface (128) of the bottle (104) so as to seal the fluid receiving space (108) of the bottle (104).

5. 发明申请

WO2017134597A1 GALENIC FORMULATIONS OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的GALENIC配方
公开(公告)号：WO2017134597A1
公开(公告)日：2017-08-10
申请号：PCT/IB2017/050569
申请日：2017-02-02
申请人： NOVARTIS AG
发明人： WINZENBURG, Gesine , TRUEBY, Bernd , CHEN, Fabian , AYALASOMAYAJULA, Surya Prakash , BUSH, Christopher , BERKHIN, Masha
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61K31/216 , A61K31/41
CPC分类号： A61K9/4808 , A61K9/2054 , A61K9/2846 , A61K31/225 , A61K31/41 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, and sodium ions, appropriate for use in pediatrics or other patients where low and individual dosing is required or who encounter problems with swallowing e.g. as a result of a disease or because of age, to the manufacture of said solid dosage form and to invention embodiments relating to therapy using said dosage form.
摘要翻译：本发明涉及包含1:1摩尔比的沙丙胺醇和缬沙坦的固体单位口服剂型，优选以所谓的血管紧张素受体脑啡肽酶抑制剂（ARNI）LCZ696的形式存在，其中是沙丙胺醇，缬沙坦和钠离子的复杂盐水合物，适用于需要低剂量和个人剂量或遇到吞咽问题的儿科或其他患者。由于疾病或由于年龄的原因，制造所述固体剂型以及涉及使用所述剂型治疗的发明实施方案。

6. 发明申请

WO2017134600A1 NEW USE OF A COMBINATION OF SACUBITRIL AND VALSARTAN 审中-公开
标题翻译： SACUBITRIL和VALSARTAN联用的新用法
公开(公告)号：WO2017134600A1
公开(公告)日：2017-08-10
申请号：PCT/IB2017/050573
申请日：2017-02-02
申请人： NOVARTIS AG
发明人： CHEN, Fabian , AYALASOMAYAJULA, Surya Prakash , BUSH, Christopher , BERKHIN, Masha , WINZENBURG, Gesine , TRUEBY, Bernd
IPC分类号： A61K9/48 , A61K31/216 , A61K31/41
CPC分类号： A61K9/4808 , A61K9/2054 , A61K9/2846 , A61K31/225 , A61K31/41 , A61K45/06 , A61K2300/00
摘要： : The present invention relates to methods and pharmaceutical compositions for treating heart failure in a pediatric human patient comprising administration to said patient of a therapeutically effective amount or a prophylactically effective amount of a combination of a therapeutic agent blocking the angiotensin receptor and a therapeutic agent inhibiting the NEP enzyme, in particular of a combination of sacubitril and valsartan in a pharmaceutically acceptable form and in a 1:1 molar ratio.
摘要翻译：本发明涉及用于治疗儿科人类患者的心力衰竭的方法和药物组合物，所述方法和药物组合物包含向所述患者施用治疗有效量或预防有效量的治疗剂阻断血管紧张素受体和抑制NEP酶的治疗剂，特别是药学上可接受的形式和1：1摩尔比的sacubitril和缬沙坦的组合。

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