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1. 发明申请

WO2007008937A3 ADIPONECTIN VARIANTS 审中-公开
公开(公告)号：WO2007008937A3
公开(公告)日：2007-05-18
申请号：PCT/US2006026971
申请日：2006-07-11
申请人： XENCOR INC , ZALEVSKY JONATHAN , NGUYEN DUC-HANH THI , MOORE GREGORY L , EZHEVSKY SERGEI A , DESJARLAIS JOHN R , CHIRINO ARTHUR J , CASH DARIAN , BERNETT MATTHEW J
发明人： ZALEVSKY JONATHAN , NGUYEN DUC-HANH THI , MOORE GREGORY L , EZHEVSKY SERGEI A , DESJARLAIS JOHN R , CHIRINO ARTHUR J , CASH DARIAN , BERNETT MATTHEW J
IPC分类号： C07K14/47 , A61P3/04 , A61P3/10 , A61P9/12 , C07K14/575
CPC分类号： C07K14/5759
摘要： An adiponectin variant comprising one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of said variant is improved by at least 3-fold relative to residues 110-244 of SEQ ID NO:1 (human adiponectin). Said adiponectin variant may not comprise residues 1-100 relative to SEQ ID NO:1.
摘要翻译：包含相对于相应的亲本脂连蛋白的一个或多个氨基酸修饰的脂联素变体，其中所述变体的溶解度相对于SEQ ID NO：1的残基110-244（人脂联素）提高至少3倍。所述脂联素变体可以不包含相对于SEQ ID NO：1的残基1-100。

2. 发明申请

WO2007008937A8 ADIPONECTIN VARIANTS 审中-公开
公开(公告)号：WO2007008937A8
公开(公告)日：2007-04-12
申请号：PCT/US2006026971
申请日：2006-07-11
申请人： XENCOR INC , ZALEVSKY JONATHAN , NGUYEN DUC-HANH THI , MOORE GREGORY L , EZHEVSKY SERGEI A , DESJARLAIS JOHN R , CHIRINO ARTHUR J , CASH DARIAN , BERNETT MATTHEW J
发明人： ZALEVSKY JONATHAN , NGUYEN DUC-HANH THI , MOORE GREGORY L , EZHEVSKY SERGEI A , DESJARLAIS JOHN R , CHIRINO ARTHUR J , CASH DARIAN , BERNETT MATTHEW J
IPC分类号： C07K14/47 , A61P3/04 , A61P3/10 , A61P9/12 , C07K14/575
CPC分类号： C07K14/5759
摘要： An adiponectin variant comprising one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of said variant is improved by at least 3-fold relative to residues 110-244 of SEQ ID NO:1 (human adiponectin). Said adiponectin variant may not comprise residues 1-100 relative to SEQ ID NO:1.
摘要翻译：包含相对于相应亲本脂联素的一个或多个氨基酸修饰的脂连蛋白变体，其中所述变体的溶解度相对于SEQ ID NO：1的残基110-244（人脂联素）提高至少3倍。所述脂连蛋白变体可以不包含相对于SEQ ID NO：1的残基1-100。

3. 发明申请

WO2006074432A3 ADIPONECTIN VARIANTS 审中-公开
公开(公告)号：WO2006074432A3
公开(公告)日：2006-12-21
申请号：PCT/US2006000627
申请日：2006-01-09
申请人： XENCOR INC , CHIRINO ARTHUR J , CASH DARIAN , NGUYEN DUC-HAHN THI , MOORE GREGORY L , DESJARLAIS JOHN R , ZALEVSKY JONATHAN , EZHEVSKY SERGEI A
发明人： CHIRINO ARTHUR J , CASH DARIAN , NGUYEN DUC-HAHN THI , MOORE GREGORY L , DESJARLAIS JOHN R , ZALEVSKY JONATHAN , EZHEVSKY SERGEI A
IPC分类号： C07K14/47 , A61P3/04 , A61P3/10 , A61P9/12 , C07K14/575
CPC分类号： C07K14/52 , A61K38/00 , C07K14/5759
摘要： Adiponectin variants comprising one or more amino acid modifications to corresponding wild-type adiponectins at positions having predetermined hydrophobicity, predetermined polarity, predetermined electrostatic potential, Met, aromatic amino acid, Cys corresponding to position 152 of SEQ ID NO:1, amino acid affecting isoelectric point of the wild-type or variant adiponectin, amino acid affecting beta sheet formation, helix capping, or dipole interactions, or a combination thereof, wherein the adiponectin variants exhibit improved stability, solubility or soluble expression, expression yield, the ability to induce phosphorylation of AMPK, or a combination thereof, as compared to the corresponding wild-type adiponectins.
摘要翻译：在具有预定疏水性，预定极性，预定静电势，Met，芳族氨基酸，对应于SEQ ID NO：1的152位的Cys，影响等电点的氨基酸的位置处包含对相应野生型脂连蛋白的一个或多个氨基酸修饰的脂联素变体野生型或变体脂联素的位点，影响β片形成的氨基酸，螺旋帽或偶极相互作用，或其组合，其中所述脂联素变体表现出改善的稳定性，溶解性或可溶性表达，表达产量，诱导磷酸化的能力的AMPK或其组合，与相应的野生型脂连蛋白相比。

4. 发明申请

WO2006074432A9 ADIPONECTIN VARIANTS 审中-公开
公开(公告)号：WO2006074432A9
公开(公告)日：2006-09-28
申请号：PCT/US2006000627
申请日：2006-01-09
申请人： XENCOR INC , CHIRINO ARTHUR J , CASH DARIAN , NGUYEN DUC-HAHN THI , MOORE GREGORY L , DESJARLAIS JOHN R , ZALEVSKY JONATHAN , EZHEVSKY SERGEI A
发明人： CHIRINO ARTHUR J , CASH DARIAN , NGUYEN DUC-HAHN THI , MOORE GREGORY L , DESJARLAIS JOHN R , ZALEVSKY JONATHAN , EZHEVSKY SERGEI A
CPC分类号： C07K14/52 , A61K38/00 , C07K14/5759
摘要： Adiponectin variants comprising one or more amino acid modifications to corresponding wild-type adiponectins at positions having predetermined hydrophobicity, predetermined polarity, predetermined electrostatic potential, Met, aromatic amino acid, Cys corresponding to position 152 of SEQ ID NO:1, amino acid affecting isoelectric point of the wild-type or variant adiponectin, amino acid affecting beta sheet formation, helix capping, or dipole interactions, or a combination thereof, wherein the adiponectin variants exhibit improved stability, solubility or soluble expression, expression yield, the ability to induce phosphorylation of AMPK, or a combination thereof, as compared to the corresponding wild-type adiponectins.
摘要翻译：在具有预定疏水性，预定极性，预定静电位，Met，芳香族氨基酸，对应于SEQ ID NO：1的位置152的Cys，影响等电点的氨基酸的位置，包含与相应的野生型脂连蛋白的一个或多个氨基酸修饰的脂连蛋白变体野生型或变体脂联素的点，影响β片形成的氨基酸，螺旋封端或偶极相互作用或其组合，其中脂联素变体表现出改善的稳定性，溶解性或可溶性表达，表达产量，诱导磷酸化的能力的AMPK或其组合，与相应的野生型脂连蛋白相比。

5. 发明申请

WO2005113598A2 TNF SUPER FAMILY MEMBERS WITH ALTERED IMMUNOGENICITY 审中-公开
标题翻译：具有改变的免疫原性的TNF超家族成员
公开(公告)号：WO2005113598A2
公开(公告)日：2005-12-01
申请号：PCT/US2005018130
申请日：2005-05-23
申请人： XENCOR INC , MARSHALL SHANNON ALICIA , MOORE GREGORY L , CHIRINO ARTHUR J , DESJARLAIS JOHN R
发明人： MARSHALL SHANNON ALICIA , MOORE GREGORY L , CHIRINO ARTHUR J , DESJARLAIS JOHN R
IPC分类号： C07K14/705 , C07K14/715
CPC分类号： C07K14/70575
摘要： The present invention relates to non-naturally occurring variant Tumor Necrosis Factor Super Family member proteins with reduced immunogenicity. More specifically, the present invention relates to variant BAFF, RANKL, TRAIL, CD40L and APRIL proteins with reduced immunogenicity.
摘要翻译：本发明涉及具有降低的免疫原性的非天然存在的变体肿瘤坏死因子超家族成员蛋白。更具体地，本发明涉及具有降低的免疫原性的变体BAFF，RANKL，TRAIL，CD40L和APRIL蛋白。

6. 发明申请

WO2004099249A3 OPTIMIZED FC VARIANTS AND METHODS FOR THEIR GENERATION 审中-公开
标题翻译：优化FC变量及其生成方法
公开(公告)号：WO2004099249A3
公开(公告)日：2006-01-26
申请号：PCT/US2004009298
申请日：2004-03-26
申请人： XENCOR INC , LAZAR GREGORY ALAN , CHIRINO ARTHUR J , DANG WEI , DESJARLAIS JOHN RUDOLPH , DOBERSTEIN STEPHEN KOHL , HAYES ROBERT J , KARKI SHER BAHADUR , VAFA OMID
发明人： LAZAR GREGORY ALAN , CHIRINO ARTHUR J , DANG WEI , DESJARLAIS JOHN RUDOLPH , DOBERSTEIN STEPHEN KOHL , HAYES ROBERT J , KARKI SHER BAHADUR , VAFA OMID
IPC分类号： C07K16/00 , C07K16/28 , C07K16/32 , C07K16/24 , C07K16/30
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译：本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。

7. 发明申请

WO2006042333A3 PREDICTION AND ASSESSMENT OF IMMUNOGENICITY 审中-公开
标题翻译：预测和评估免疫原性
公开(公告)号：WO2006042333A3
公开(公告)日：2006-08-17
申请号：PCT/US2005037123
申请日：2005-10-12
申请人： XENCOR INC , BARBOSA MARIA D F S , CHIRINO ARTHUR J
发明人： BARBOSA MARIA D F S , CHIRINO ARTHUR J
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/56977 , G01N33/6803 , G01N2333/70539
摘要： A system and method to predict and assess immunogenicity, especially prior to on-set of immunogenic conditions. Also disclosed are methods to identify relevant peptides associated with the formation of antibodies in patients treated with a given protein therapeutic. In various aspects, the present application is directed to methods of determining the immunological compatibility of a subject with a therapeutic agent such as a proteinaceous therapeutic agent, methods of determining vaccine efficacy by determining the immunological compatibility of a subject with a therapeutic agent, and selecting a therapeutic agent for a subject in need of treatment. Methods of designing a therapeutic agent with reduced immunogenicity for a subject and methods for designing vaccines with enhanced immunogenicity for a subject are also contemplated.
摘要翻译：预测和评估免疫原性的系统和方法，尤其是在免疫原性条件开始之前。还公开了鉴定与用给定蛋白质治疗剂治疗的患者中抗体形成相关的相关肽的方法。在各个方面，本申请涉及确定受试者与治疗剂例如蛋白质治疗剂的免疫相容性的方法，通过确定受试者与治疗剂的免疫相容性来确定疫苗功效的方法，以及选择用于需要治疗的受试者的治疗剂。还设想了为受试者设计具有降低的免疫原性的治疗剂的方法和设计用于受试者的具有增强的免疫原性的疫苗的方法。

8. 发明申请

WO2007001457A3 ANTIBODIES OPERABLY LINKED TO SELECTED CHEMOATTRACTANTS 审中-公开
标题翻译：抗体可操作地连接到选择的化学试剂
公开(公告)号：WO2007001457A3
公开(公告)日：2007-09-13
申请号：PCT/US2005041221
申请日：2005-11-14
申请人： XENCOR INC , ABEL KENTON , CHIRINO ARTHUR J , VAFA OMID
发明人： ABEL KENTON , CHIRINO ARTHUR J , VAFA OMID
IPC分类号： A61K47/48
CPC分类号： C07K16/30 , A61K47/65 , A61K47/6813 , A61K47/6851 , C07K16/00 , C07K2317/55 , C07K2319/00 , C07K2319/30
摘要： An antibody or fragment thereof operably linked to a one or more chemoattractants selected from the group consisting of: C5a or fragments thereof; C3a or fragments thereof; C4a or fragments thereof; and, formyl-Met-Leu-Phe (fMLP).
摘要翻译：与选自下列的一种或多种化学引诱剂可操作地连接的抗体或其片段：C5a或其片段; C3a或其片段; C4a或其片段; 和甲酰基-Met-Leu-Phe（fMLP）。

9. 发明申请

WO2004014938A3 THROMBOPOIESIS-STIMULATING PROTEINS HAVING REDUCED IMMUNOGENICITY 审中-公开
标题翻译：具有降低免疫原性的血栓形成刺激蛋白
公开(公告)号：WO2004014938A3
公开(公告)日：2007-04-05
申请号：PCT/US0324913
申请日：2003-08-11
申请人： XENCOR INC , CHIRINO ARTHUR J , YAZAL JAMAL EL , MARSHALL SHANNON ALICIA , MCDONNELL PETER , VIELMETTER JOST
发明人： CHIRINO ARTHUR J , YAZAL JAMAL EL , MARSHALL SHANNON ALICIA , MCDONNELL PETER , VIELMETTER JOST
IPC分类号： A61K38/00 , C07K20060101 , C07K14/52 , C07K14/575
CPC分类号： C07K14/524 , A61K38/00 , C07K2319/30 , C07K2319/40
摘要： The present invention relates to variant thrombopoietin proteins that possess thrombopoiesis-stimulating activity and have reduced immunogenicity. In particular, variants of thrombopoietin with reduced ability to bind one or more class II MHC molecules are described.
摘要翻译：本发明涉及具有血小板生成刺激活性且具有降低的免疫原性的变体血小板生成蛋白。特别地，描述了具有降低的结合一种或多种II类MHC分子的能力降低的血小板生成素的变体。

10. 发明申请

WO2004063963A3 NOVEL PROTEINS WITH ALTERED IMMUNOGENICITY 审中-公开
标题翻译：具有改良免疫原性的新蛋白
公开(公告)号：WO2004063963A3
公开(公告)日：2005-11-10
申请号：PCT/US2004000491
申请日：2004-01-08
申请人： XENCOR INC , CHIRINO ARTHUR J , DAHIYAT BASSIL I , DESJARLAIS JOHN RUDOLPH , MARSHALL SHANNON ALICIA
发明人： CHIRINO ARTHUR J , DAHIYAT BASSIL I , DESJARLAIS JOHN RUDOLPH , MARSHALL SHANNON ALICIA
IPC分类号： A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C12N15/11 , G06F17/50 , G06F19/16 , G06F19/00
CPC分类号： G06F19/16
摘要： The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties.
摘要翻译：本发明提供了将用于调节蛋白免疫原性的计算方法与用于鉴定具有期望的结构和功能性质的序列的计算方法组合的方法。更具体地，本发明的方法可用于鉴定通过影响抗原摄取，MHC结合，T细胞结合或抗体结合而增加或降低蛋白质免疫原性的修饰，同时保留或增强功能性质。

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