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1. 发明申请

WO2005123664A3 PROCESSES FOR THE PREPARATION OF 2-CYANO-3-NAPHTHALENE-1-YL-ACRYLIC ACID ALKYL OR BENZYL ESTERS 审中-公开
标题翻译：制备2-氰基-3-萘磺酸-1-乙酰丙酸或苯甲酸酯的方法
公开(公告)号：WO2005123664A3
公开(公告)日：2006-07-13
申请号：PCT/US2005020182
申请日：2005-06-09
申请人： WYETH CORP , LIU WEIGUO , CONSIDINE JOHN L , DING ZHIXIAN , POTOSKI JOHN
发明人： LIU WEIGUO , CONSIDINE JOHN L , DING ZHIXIAN , POTOSKI JOHN
IPC分类号： C07C253/30 , C07C255/41
CPC分类号： C07C253/30 , C07C255/41
摘要： The present invention provides processes for the preparation of compounds of Formula III that are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases.
摘要翻译：本发明提供了可用于制备用于治疗炎性疾病的药物的式III化合物的方法。

2. 发明申请

WO2007059421A3 POLYMORPHS OF 5-CYCLOPROPYL-2-(4-FLUOROPHENYL)-6-[(2-HYDROXYETHYL)(METHYLSULFONYL) AMINO]-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE AND METHODS OF MAKING THE SAME 审中-公开
标题翻译： 5-环丙基-2-（4-氟苯基）-6 - [（2-羟基乙基）（甲基磺酰基）氨基] -N-甲基-1-苯并呋喃-3-甲酰胺的多晶型物及其制备方法
公开(公告)号：WO2007059421A3
公开(公告)日：2007-07-26
申请号：PCT/US2006060750
申请日：2006-11-09
申请人： WYETH CORP , VIROPHARMA INC , LIU WEIGUO , WANG QIUXIA , TONG WEI , RAVEENDRANATH PANOLIL , IERA SILVIO
发明人： LIU WEIGUO , WANG QIUXIA , TONG WEI , RAVEENDRANATH PANOLIL , IERA SILVIO
IPC分类号： C07D307/84 , A61K31/34 , A61P31/12
CPC分类号： C07D307/84
摘要： Substantially pure polymorphic forms of 5-cyclopro?yl-2-(4- fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-l- benzofuran-3-carboxamide are produced by recrystallization in an organic solvent.
摘要翻译： 5-环丙基-2-（4-氟苯基）-6 - [（2-羟乙基）（甲基磺酰基）氨基] -N-甲基-1-苯并呋喃-3-甲酰胺的基本上纯的多晶型形式是通过重结晶有机溶剂。

3. 发明申请

WO2007146072A2 PROCESS FOR SYNTHESIZING PIPERAZINE-PIPERIDINE COMPOUNDS 审中-公开
标题翻译：合成哌嗪 - 哌啶化合物的方法
公开(公告)号：WO2007146072A2
公开(公告)日：2007-12-21
申请号：PCT/US2007013433
申请日：2007-06-07
申请人： WYETH CORP , LIU WEIGUO , DRAGAN VLADIMIR , STRONG HENRY LEE , WU YANZHONG , WEN ZHIXIN , LIANG JESSICA KANGPING , DURUTLIC HARIS , SUTHERLAND KAREN WIGGINS , PILCHER ANTHONY SCOTT
发明人： LIU WEIGUO , DRAGAN VLADIMIR , STRONG HENRY LEE , WU YANZHONG , WEN ZHIXIN , LIANG JESSICA KANGPING , DURUTLIC HARIS , SUTHERLAND KAREN WIGGINS , PILCHER ANTHONY SCOTT
IPC分类号： C07D215/40 , C07D401/14 , C07D405/14
CPC分类号： C07D401/14 , C07D215/40
摘要： The present invention relates to processes for synthesizing piperazine-piperidine compounds, and compounds useful as 5-HT 1A binding agents, particularly as 5-HT 1A receptor antagonists and agonists. The processes also allow for safer and environmentally tolerant production of these useful compounds.
摘要翻译：本发明涉及用于合成哌嗪 - 哌啶化合物的方法和用作5-HT 1A结合剂的化合物，特别是作为5-HT 1A受体拮抗剂和激动剂。这些方法还允许这些有用化合物的更安全和环境耐受的生产。

4. 发明申请

WO2005040176A2 METHODS FOR THE PREPARATION OF {2-[(8,9)-DIOXO-2,6-DIAZA-BICYCLO[5.2.0]-NON-1(7)-EN-2-YL]ETHYL} PHOSPHONIC ACID AND ESTERS THEREOF 审中-公开
标题翻译：制备{2 - [（8,9）二氧代-2,6-二氮杂双环[5.2.0] -NON-1（7）-EN-2-YL]乙基}磷酸及其酯的方法
公开(公告)号：WO2005040176A2
公开(公告)日：2005-05-06
申请号：PCT/US2004034831
申请日：2004-10-20
申请人： WYETH CORP , WILK BOGDAN K , VID GALINA , LIU WEIGUO , SHI XINXU
发明人： WILK BOGDAN K , VID GALINA , LIU WEIGUO , SHI XINXU
IPC分类号： A61K31/675 , C07F9/645 , C07F9/02
CPC分类号： C07F9/645
摘要： The present invention provides methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid, and esters thereof.
摘要翻译：本发明提供了制备{2 - [（8,9） - 二氧代-2,6-二氮杂 - 双环[5.2.0] - 壬-1（7） - 烯-2-基]乙基}膦酸酸及其酯。

5. 发明申请

WO2006022954A3 BENZOUREAS HAVING ANTI-DIABETIC ACTIVITY 审中-公开
标题翻译：具有抗糖尿病活性的BENZOUREAS
公开(公告)号：WO2006022954A3
公开(公告)日：2006-10-12
申请号：PCT/US2005018721
申请日：2005-05-26
申请人： MERCK & CO INC , LIU WEIGUO , WOOD HAROLD B , LAU-PHUA FIONA WAI-YU
发明人： LIU WEIGUO , WOOD HAROLD B , LAU-PHUA FIONA WAI-YU
IPC分类号： A61K31/42 , C07D413/04
CPC分类号： C07D413/14
摘要： Benzourea compounds of Formula I having aryl-(CH 2 ) x -oxazolidinedione or aryl-(CH 2 ) x -thiazolidinedione substituents on one of the N atoms of the benzourea ring, wherein x is 0 or 1, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia and other symptoms such as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity, that are often associated with type 2 diabetes.
摘要翻译：式I的苯并脲化合物，其具有芳基 - （CH 2）2 - 恶唑烷二酮或芳基 - （CH 2 CH 2）x

6. 发明申请

WO2010053586A2 SYSTEMS, METHODS AND SUBSTRATES OF MONOCRYSTALLINE GERMANIUM CRYSTAL GROWTH 审中-公开
标题翻译：单晶锗晶体生长的系统，方法和基材
公开(公告)号：WO2010053586A2
公开(公告)日：2010-05-14
申请号：PCT/US2009006052
申请日：2009-11-09
申请人： AXT INC , LIU WEIGUO
发明人： LIU WEIGUO
IPC分类号： C30B29/08 , C30B15/20
CPC分类号： C30B29/08 , C30B11/04
摘要： Systems, methods, and substrates directed to growth of monocrystalline germanium (Ge) crystals are disclosed. In one exemplary implementation, there is provided a method for growing a monocrystalline germanium (Ge) crystal. Moreover, the method may include loading first raw Ge material into a crucible, loading second raw Ge material into a container for supplementing the Ge melt material, sealing the crucible and the container in an ampoule, placing the ampoule with the crucible into a crystal growth furnace, as well as melting the first and second raw Ge material and controlling the crystallizing temperature gradient of the melt to reproducibly provide monocrystalline germanium ingots with improved/desired characteristics.
摘要翻译：公开了涉及单晶锗（Ge）晶体生长的系统，方法和衬底。在一个示例性实施方案中，提供了用于生长单晶锗（Ge）晶体的方法。此外，该方法可以包括将第一原料Ge材料加载到坩埚中，将第二原料Ge材料加载到用于补充Ge熔体材料的容器中，将坩埚和容器密封在安瓿中，将安瓿与坩埚放置成晶体生长炉子，以及熔化第一和第二原始锗材料并控制熔体的结晶温度梯度以可重复地提供具有改进/期望特性的单晶锗锭。

7. 发明申请

WO2008109237A4 MACROPHAGE CELL-LINES FOR PROPAGATION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS 审中-公开
标题翻译：用于繁殖猪繁殖与呼吸综合征病毒的巨噬细胞系
公开(公告)号：WO2008109237A4
公开(公告)日：2009-02-26
申请号：PCT/US2008053887
申请日：2008-02-13
申请人： UNIV WASHINGTON , SRIKUMARAN SUBRAMANIAM , LIU WEIGUO , SHANTHALINGAM SUDARVILI
发明人： SRIKUMARAN SUBRAMANIAM , LIU WEIGUO , SHANTHALINGAM SUDARVILI
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： A61K39/12 , A01K2217/00 , A61K2039/525 , C07K14/70596 , C12N5/0645 , C12N2510/00 , C12N2510/02 , C12N2770/10034
摘要： Particular aspects provide novel recombinant cells and cell lines (e.g., macrophage cell lines) that are permissive for propagation of porcine reproductive and respiratory syndrome virus (PRRSV) propagation in vitro or in vivo. In certain aspects, novel nucleic acid sequences encoding porcine sialoadhesin were transfected into existing macrophage cell-lines from other species, rendering them permissive to PRRSV infection, and suitable for propagation of PRRSV. Particular aspects provide exemplary recombinant cloned cell lines that support the replication of PRRSV, with an obtainable PRRSV titre of between 2x105/ml and 2x106/ml. Additional aspects provide novel nucleic acid sequences and polymorphisms thereof that encode for porcine sialoadhesin. Further aspects provide PRRSV propagation and preparation methods using the novel recombinant cell lines, and methods for PRRSV antigen and vaccine production using same. Yet further aspect provide transgenic, chimerical or engrafted animals having cell comprising nucleic acid sequences encoding porcine sialoadhesin.
摘要翻译：具体方面提供了新的重组细胞和细胞系（例如，巨噬细胞细胞系），其允许体外或体内繁殖猪繁殖与呼吸综合征病毒（PRRSV）繁殖。在某些方面，编码猪唾液酸粘附素的新核酸序列被转染到来自其他物种的现有巨噬细胞系中，使它们容许PRRSV感染，并适合繁殖PRRSV。具体方面提供了支持PRRSV复制的示例性重组克隆细胞系，其可获得的PRRSV效价在2x105 / ml和2x106 / ml之间。另外的方面提供编码猪唾液酸粘附素的新型核酸序列及其多态性。其它方面提供了使用新型重组细胞系的PRRSV繁殖和制备方法，以及使用PRRSV抗原和疫苗生产的方法。又一方面提供具有包含编码猪唾液酸粘附素的核酸序列的细胞的转基因，嵌合或移植动物。

8. 发明申请

WO2007136573A3 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
标题翻译：抗生素双胶体化合物
公开(公告)号：WO2007136573A3
公开(公告)日：2008-03-27
申请号：PCT/US2007011372
申请日：2007-05-11
申请人： MERCK & CO INC , GE MIN , HE JIAFANG , LAU FIONA WAI YU , LIANG GUI-BAI , LIN SONGNIAN , LIU WEIGUO , WALSH SHAWN P , YANG LIHU
发明人： GE MIN , HE JIAFANG , LAU FIONA WAI YU , LIANG GUI-BAI , LIN SONGNIAN , LIU WEIGUO , WALSH SHAWN P , YANG LIHU
IPC分类号： C07D213/64 , A61K31/343 , A61K31/351 , A61K31/381 , A61K31/427 , A61K31/4412 , A61P1/18 , C07C62/34 , C07D307/93 , C07D333/78 , C07D405/04 , C07D407/12 , C07D413/12 , C07D417/12
CPC分类号： C07D213/643 , C07C62/34 , C07C62/38 , C07C229/50 , C07C2603/08 , C07D307/93 , C07D311/94 , C07D333/78 , C07D405/04 , C07D407/12 , C07D413/12 , C07D417/12
摘要： Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：与环双环稠合的环状羧酸或羧酸衍生物（如酰胺）的三环化合物（包括其药学上可接受的盐和前体药物）是G-蛋白偶联受体40（GPR40）的激动剂，可用作治疗性化合物，特别是在 2型糖尿病的治疗，以及经常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症。

9. 发明申请

WO2007136572A3 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
标题翻译：抗糖尿病双环化合物
公开(公告)号：WO2007136572A3
公开(公告)日：2008-01-10
申请号：PCT/US2007011369
申请日：2007-05-11
申请人： MERCK & CO INC , GE MIN , HE JIAFANG , LAU FIONA WAI YU , LIANG GUI-BAI , LIN SONGNIAN , LIU WEIGUO , WALSH SHAWN P , YANG LIHU
发明人： GE MIN , HE JIAFANG , LAU FIONA WAI YU , LIANG GUI-BAI , LIN SONGNIAN , LIU WEIGUO , WALSH SHAWN P , YANG LIHU
IPC分类号： C07D213/64 , A61K31/343 , A61K31/351 , A61K31/381 , A61K31/427 , A61K31/4412 , A61P1/18 , C07C62/34 , C07D307/93 , C07D333/78 , C07D405/04 , C07D407/12 , C07D413/12 , C07D417/12
CPC分类号： C07D213/643 , C07C62/34 , C07C62/38 , C07C229/50 , C07C2603/08 , C07D307/93 , C07D311/94 , C07D333/78 , C07D405/04 , C07D407/12 , C07D413/12 , C07D417/12
摘要： Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：含有与双环稠合的环丙基羧酸或羧酸衍生物（例如酰胺）的三环化合物，包括其药学上可接受的盐和前药，是G-蛋白偶联受体40（GPR40）的激动剂，并且可用作治疗化合物，特别是 2型糖尿病的治疗以及通常与该疾病相关的病症，包括肥胖和脂质紊乱，例如混合性或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症。

10. 发明申请

WO2014160592A3 FACTOR XIa INHIBITORS 审中-公开
标题翻译：因子XIA抑制剂
公开(公告)号：WO2014160592A3
公开(公告)日：2014-12-24
申请号：PCT/US2014031388
申请日：2014-03-21
申请人： MERCK SHARP & DOHME , OGAWA ANTHONY , EDMONDSON SCOTT , ERION MARK , NEELAMKAVIL SANTOSH , GUO ZHUYAN , MAL RUDRAJIT , HE JIAFANG , LIU WEIGUO , VANDE BUNTE ELLEN K
发明人： OGAWA ANTHONY , EDMONDSON SCOTT , ERION MARK , NEELAMKAVIL SANTOSH , GUO ZHUYAN , MAL RUDRAJIT , HE JIAFANG , LIU WEIGUO , VANDE BUNTE ELLEN K
IPC分类号： A61K31/435
CPC分类号： C07D213/64 , A61K31/551 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/044 , C07D491/052 , C07F9/65583
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The invention includes compounds for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier.
摘要翻译：本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。本发明包括用于抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成以及抑制哺乳动物栓塞形成的化合物，其包含本发明化合物在药学上可接受的载体中。

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