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1. 发明申请

WO2008057254A2 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的三聚体化合物
公开(公告)号：WO2008057254A2
公开(公告)日：2008-05-15
申请号：PCT/US2007022651
申请日：2007-10-26
申请人： WYETH CORP , LI WEI , LI JIANCHANG , WU YUCHUAN , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFAYDEN IAIN , HOTCHANDANI RAJEEV , WU JUNJUN
发明人： LI WEI , LI JIANCHANG , WU YUCHUAN , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFAYDEN IAIN , HOTCHANDANI RAJEEV , WU JUNJUN
IPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , A61K31/4155 , A61K31/4192 , A61K31/443 , A61K31/496 , A61K31/5377 , C07D333/76 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04
CPC分类号： C07D307/91 , C07D333/76 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The present invention relates to compositions of the formula (I): and pharmaceutically acceptable salts, hydrates, or esters thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating pathologic conditions or disorders mediated wholly or in part by matrix metalloproteinases, such as asthma and chronic obstructive pulmonary disease, comprising administering a therapeutically effective amount of a compound of formula (I) to a mammal (e.g., a human) in need thereof.
摘要翻译：本发明涉及式（I）的组合物及其药学上可接受的盐，水合物或酯，其中R 1，R 2，R 3， R 4，R 5，R 5，X和Y如本文所定义。本教导还提供了制备式I化合物的方法，以及治疗由基质金属蛋白酶如哮喘和慢性阻塞性肺疾病全部或部分介导的病理状况或病症的方法，包括给予治疗有效量的式（I）给予有需要的哺乳动物（例如，人）。

2. 发明申请

WO2008137816A3 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的三聚体化合物
公开(公告)号：WO2008137816A3
公开(公告)日：2009-05-14
申请号：PCT/US2008062593
申请日：2008-05-05
申请人： WYETH CORP , LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
发明人： LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
IPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , A61P19/00 , A61P35/00 , C07D333/76 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D307/91 , C07D333/76 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，R 4，X和Y如本文所定义。本教导还提供制备式I化合物的方法和抑制基质金属蛋白酶特别是MMP-12的方法，所述方法可能涉及哺乳动物（包括人）中发现的病理学障碍。

3. 发明申请

WO2008137816A8 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的三聚体化合物
公开(公告)号：WO2008137816A8
公开(公告)日：2010-01-28
申请号：PCT/US2008062593
申请日：2008-05-05
申请人： WYETH CORP , LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
发明人： LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
IPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , A61P19/00 , A61P35/00 , C07D333/76 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D307/91 , C07D333/76 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，R 4，X和Y如本文所定义。本教导还提供制备式I化合物的方法和抑制基质金属蛋白酶特别是MMP-12的方法，所述方法可能涉及哺乳动物（包括人）中发现的病理学障碍。

4. 发明申请

WO2007092435A3 11-BETA HSD1 INHIBITORS 审中-公开
标题翻译： 11-BETA HSD1抑制剂
公开(公告)号：WO2007092435A3
公开(公告)日：2007-12-27
申请号：PCT/US2007003134
申请日：2007-02-07
申请人： WYETH CORP , XIANG JASON SHAOYUN , SAIAH EDDINE , TAM STEVE Y , MCKEW JOHN C , CHEN LIHREN , IPEK MANUS , LEE KATHERINE , LI HUAN-QUI , LI JIANCHANG , LI WEI , MANSOUR TAREK SUHAYL , SURI VIPIN , VARGAS RICHARD , WU YUCHUAN , WAN ZHAO-KUI , LEE JINBO , BINNUN EVA , WILSON DOUGLAS P
发明人： XIANG JASON SHAOYUN , SAIAH EDDINE , TAM STEVE Y , MCKEW JOHN C , CHEN LIHREN , IPEK MANUS , LEE KATHERINE , LI HUAN-QUI , LI JIANCHANG , LI WEI , MANSOUR TAREK SUHAYL , SURI VIPIN , VARGAS RICHARD , WU YUCHUAN , WAN ZHAO-KUI , LEE JINBO , BINNUN EVA , WILSON DOUGLAS P
IPC分类号： C07D211/96 , A61K31/44 , A61K31/495 , C07D295/22 , C07D401/04
CPC分类号： C07D211/96 , C07D295/26 , C07D401/04 , C07D403/02 , C07D409/02 , C07D413/02
摘要： This invention relates to inhibiting 11ßHSD1.
摘要翻译：本发明涉及抑制11βHSD1。

5. 发明申请

WO2012134968A3 PROPORTIONAL CONTROL USING STATE SPACE BASED SCHEDULING 审中-公开
标题翻译：使用基于状态空间的调度的比例控制
公开(公告)号：WO2012134968A3
公开(公告)日：2012-12-27
申请号：PCT/US2012030222
申请日：2012-03-23
申请人： CATERPILLAR INC , LI WEI , QIAN ANG , KINGDON RYAN , KRAUSE STEVEN , THOMSON NORVAL
发明人： LI WEI , QIAN ANG , KINGDON RYAN , KRAUSE STEVEN , THOMSON NORVAL
IPC分类号： E02F9/20 , E02F3/76
CPC分类号： E02F3/651
摘要： A method for proportional state space based scheduling of gain within a machine includes generating a speed error value and when the speed error value is substantially nonzero producing an implement position difference value representing the amount by which an implement position differs from a position that would provide a desired machine speed. The method then converts the implement position difference value to a desired implement position command and differences the desired implement position command and a position signal indicative of the current implement position to produce an implement difference value. The implement difference value is used to generate one or more implement actuator signals.
摘要翻译：一种用于基于比例状态空间的机器内增益调度的方法包括产生速度误差值，以及当速度误差值基本上非零时，产生实现位置差值，该值表示实施位置与提供所需机器速度。该方法然后将实施位置差值转换为期望的实施位置命令，并且将期望的实施位置命令和表示当前实施位置的位置信号差异以产生实现差异值。工具差异值用于产生一个或多个实施执行器信号。

6. 发明申请

WO2009087546A3 UNEQUAL ERROR PROTECTION FOR WIRELESS APPLICATIONS WITH CROSS LAYER DESIGN 审中-公开
标题翻译：具有交叉层设计的无线应用的不等错误保护
公开(公告)号：WO2009087546A3
公开(公告)日：2009-10-15
申请号：PCT/IB2008055674
申请日：2008-12-15
申请人： FRANCE TELECOM , LI WEI , BENKO JOHN
发明人： LI WEI , BENKO JOHN
IPC分类号： H04L1/00
CPC分类号： H04L1/0009 , H04L1/0014 , H04L1/0015 , H04L1/007 , H04L2001/0098
摘要： Providing current transmission conditions from a data-link layer (or below) to an application layer, determining coding schemes, with différent coding schemes applied for encoding the data as determined by a threshold of transmission conditions, and transmitting the encoded data. The threshold of transmission conditions may correspond to the existing signal to noise ratio (SNR) in a transmission médium. One of the coding schemes may be a cross layer unequal error protection (UEP) coding scheme. The cross layer UEP may include adding error coding to both of the header and data packet portions of the data if the transmission conditions (eg. like the SNR) are below the threshold of transmission conditions.
摘要翻译：从数据链路层（或以下）向应用层提供当前的传输条件，确定编码方案，其中应用不同的编码方案来对由传输条件的阈值确定的数据进行编码，并且传输编码的数据。传输条件的阈值可以对应于传输信道中现有的信噪比（SNR）。其中一种编码方案可以是跨层不等错误保护（UEP）编码方案。如果传输条件（例如，像SNR）低于传输条件的阈值，则跨层UEP可以包括向数据的报头部分和数据包部分二者添加错误编码。

7. 发明申请

WO2009033033A3 COMPOSITIONS OF KINASE INHIBITORS AND THEIR USE FOR TREATMENT OF CANCER AND OTHER DISEASES RELATED TO KINASES 审中-公开
标题翻译：激酶抑制剂的组合物及其与治疗癌症及其他相关疾病的用途
公开(公告)号：WO2009033033A3
公开(公告)日：2009-04-30
申请号：PCT/US2008075418
申请日：2008-09-05
申请人： BOSTON BIOMEDICAL INC , LI CHIANG JIA , LIU JI-FENG , LI YOUZHI , LI WEI , ROGOFF HARRY
发明人： LI CHIANG JIA , LIU JI-FENG , LI YOUZHI , LI WEI , ROGOFF HARRY
IPC分类号： C07D417/02 , C07D209/34
CPC分类号： C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K45/06 , C07D417/04
摘要： The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.
摘要翻译：本发明涉及新型噻唑取代的二氢吲哚-2-酮作为CSCPK和相关激酶的抑制剂; 涉及通过使用激酶抑制剂抑制癌症干细胞的方法; 含有这些化合物的药物组合物; 以及使用这些化合物治疗哺乳动物中蛋白激酶相关病症的方法; 以及制备这些化合物及其中间体的方法。

8. 发明申请

WO2008081252A9 DELAYED BRANCH DECISION IN QUADRATURE DECOMPOSITION WITH M-SEARCHTNG 审中-公开
标题翻译：用M-SEARCHTNG进行正交分解的延迟分配决策
公开(公告)号：WO2008081252A9
公开(公告)日：2009-04-30
申请号：PCT/IB2007003961
申请日：2007-12-17
申请人： NOKIA CORP , NOKIA INC , LI WEI , WANG HAIFENG , LILLEBERG JORMA O , CHEN MING , CHENG SHIXIN
发明人： LI WEI , WANG HAIFENG , LILLEBERG JORMA O , CHEN MING , CHENG SHIXIN
IPC分类号： H04L25/03
CPC分类号： H04L25/03216 , H04L2025/03426
摘要： A QRD-M decomposition includes a first and a sequential second stage, at least. In the first stage, M branches are selected from among more than M branches entering the first stage as survive branches from which multiple decompositions are calculated. In the second stage, more than M branches are selected from among those branches entering the second stage as survive branches from which multiple decompositions are calculated. The symbol of the received signal is decided from a branch that is a survive branch of both the first and second stages. The second stage may be within a window that may include additional stages at which the pruning decision down to M survive branches is delayed. One or more windows may be used in a single QRD-M decomposition. In an embodiment, all branches entering the second stage are survive branches. It is shown that the marginal increased computational load increases accuracy.
摘要翻译： QRD-M分解至少包括第一和第二阶段。在第一阶段，从分支进入第一阶段的M个分支中选出M个分支作为计算多个分解的生存分支。在第二阶段，从进入第二阶段的那些分支中选出超过M个分支作为计算多重分解的生存分支。接收信号的符号由作为第一和第二级的存活分支的分支决定。第二阶段可能在一个窗口内，可能包括另外一个阶段，在此阶段，由M延续出来的剪枝决定被延迟。单个QRD-M分解中可以使用一个或多个窗口。在一个实施例中，进入第二阶段的所有分支都是能够分支的。显示边际增加的计算负载提高了精度。

9. 发明申请

WO2008081252A2 DELAYED BRANCH DECISION IN QUADRATURE DECOMPOSITION WITH M-SEARCHTNG 审中-公开
标题翻译：用M-SEARCHTNG进行正交分解的延迟分配决策
公开(公告)号：WO2008081252A2
公开(公告)日：2008-07-10
申请号：PCT/IB2007003961
申请日：2007-12-17
申请人： NOKIA CORP , NOKIA INC , LI WEI , WANG HAIFENG , LILLEBERG JORMA O , CHEN MING , CHENG SHIXIN
发明人： LI WEI , WANG HAIFENG , LILLEBERG JORMA O , CHEN MING , CHENG SHIXIN
IPC分类号： H04L25/03
CPC分类号： H04L25/03216 , H04L2025/03426
摘要： A QRD-M decomposition includes a first and a sequential second stage, at least. In the first stage, M branches are selected from among more than M branches entering the first stage as survive branches from which multiple decompositions are calculated. In the second stage, more than M branches are selected from among those branches entering the second stage as survive branches from which multiple decompositions are calculated. The symbol of the received signal is decided from a branch that is a survive branch of both the first and second stages. The second stage may be within a window that may include additional stages at which the pruning decision down to M survive branches is delayed. One or more windows may be used in a single QRD-M decomposition. In an embodiment, all branches entering the second stage are survive branches. It is shown that the marginal increased computational load increases accuracy.
摘要翻译： QRD-M分解至少包括第一和第二阶段。在第一阶段，从分支进入第一阶段的M个分支中选出M个分支作为计算多个分解的生存分支。在第二阶段，从进入第二阶段的那些分支中选出超过M个分支作为计算多重分解的生存分支。接收信号的符号由作为第一和第二级的存活分支的分支决定。第二阶段可能在一个窗口内，可能包括另外一个阶段，在此阶段，由M延续出来的剪枝决定被延迟。单个QRD-M分解中可以使用一个或多个窗口。在一个实施例中，进入第二阶段的所有分支都是能够分支的。显示边际增加的计算负载提高了精度。

10. 发明申请

WO2007050429A3 ARRAY INTERCONNECT FOR IMPROVED DIRECTIVITY 审中-公开
标题翻译：改善方向的阵列互连
公开(公告)号：WO2007050429A3
公开(公告)日：2008-03-27
申请号：PCT/US2006040900
申请日：2006-10-19
申请人： SONOSITE INC , HIPPE RICK , LI WEI , COLEMAN ALLAN
发明人： HIPPE RICK , LI WEI , COLEMAN ALLAN
IPC分类号： B06B1/06
CPC分类号： B06B1/0622
摘要： Systems and methods which improve the directivity of a transducer array by reducing electrical cross-talk between conductors connected to individual transducer array elements through the use of a plurality of interconnect circuits are shown. A plurality of signal transmission path circuits, such as circuit boards, flexible printed circuits, etc., are used to provide electrical power to and receive signals from transducer elements of a transducer array. Embodiments couple transducer elements to conductive traces of the signal transmission path circuits in a manner such that adjacent transducer elements are not connected to conductive traces on the same signal transmission path circuit. In some embodiments, a plurality of signal transmission path circuits are offset such that two identical signal transmission path circuits can be used to provide connectivity to array transducer elements using more widely spaced conductive traces, thus reducing electrical cross-talk effects.
摘要翻译：示出了通过减少通过使用多个互连电路连接到各个换能器阵列元件的导体之间的电串扰来改善换能器阵列的方向性的系统和方法。诸如电路板，柔性印刷电路等的多个信号传输路径电路被用于向换能器阵列的换能器元件提供电力并从其接收信号。实施例将传感器元件耦合到信号传输路径电路的导电迹线，使得相邻的换能器元件不连接到同一信号传输路径电路上的导电迹线。在一些实施例中，多个信号传输路径电路被偏移，使得可以使用两个相同的信号传输路径电路来提供使用更广泛间隔的导电迹线的阵列换能器元件的连接性，从而减少电串扰效应。

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