专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006020935A3 STABILIZING FORMULATIONS 审中-公开
公开(公告)号：WO2006020935A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/028861
申请日：2005-08-12
申请人： WYETH , LI, Li , KANTOR, Angela , MACMILLAN, Shannon, B
发明人： LI, Li , KANTOR, Angela , MACMILLAN, Shannon, B
IPC分类号： A61K39/395 , C07K16/00
摘要： Formulations are described that are suitable for storage of proteins, such as antibodies, over a relatively broad range of protein concentrations, pH, and buffer types. Also described are methods of storing a protein and methods of identifying a suitable formulation for storage of a specific protein. In general, a formulation contains low to no surfactant, no to relatively low salt concentrations, and requires a relatively low buffer concentration.

2. 发明申请

WO2010148321A1 SLOW DISSOLUTION METHOD FOR RECONSTITUTION OF LYOPHILIZED MATERIAL 审中-公开
标题翻译：慢解析方法，用于重新分析LYOPHILIZED材料
公开(公告)号：WO2010148321A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/039205
申请日：2010-06-18
申请人： WYETH LLC , TCHESSALOV, Serguei , KANTOR, Angela , LI, Li , LUKSHA, Nicholas , WARNE, Nicholas
发明人： TCHESSALOV, Serguei , KANTOR, Angela , LI, Li , LUKSHA, Nicholas , WARNE, Nicholas
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , A61K9/0019 , A61K9/19 , A61K39/39591 , C07K2317/24 , C07K2317/52 , C07K2317/56
摘要： The present invention relates to robust, reproducible and convenient methods for reconstituting lyophilized substance. Among other things, the present invention provides methods for reconstituting lyophilized substances without involving substantial mixing, shaking or other types of agitation. In some embodiments, the present invention provides a method of reconstituting a lyophilized substance by including the steps of providing a container containing a lyophilized substance, introducing a diluent into the container so that the diluent and the lyophilized substance come into contact with each other while maintaining the container substantially still until the lyophilized substance is substantially dissolved.
摘要翻译：本发明涉及用于重构冻干物质的鲁棒，可重现和方便的方法。除其他之外，本发明提供了重组冻干物质而不涉及大量混合，摇动或其它类型的搅动的方法。在一些实施方案中，本发明提供了一种重组冻干物质的方法，包括以下步骤：提供含有冻干物质的容器，将稀释剂引入容器中，使得稀释剂和冻干物质彼此接触，同时保持容器基本上仍然直到冻干物质基本上溶解。

3. 发明申请

WO2007146268A2 METHODS FOR REDUCING OR PREVENTING LIQUID-LIQUID PHASE SEPARATION IN HIGH CONCENTRATION PROTEIN SALUTIONS 审中-公开
标题翻译：降低或预防高浓度蛋白质中液相液相分离的方法
公开(公告)号：WO2007146268A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013747
申请日：2007-06-12
申请人： WYETH , LI, Li , KANTOR, Angela , WARNE, Nicholas, W.
发明人： LI, Li , KANTOR, Angela , WARNE, Nicholas, W.
IPC分类号： G01N33/50
CPC分类号： C07K1/36
摘要： Methods of formulating proteins at high concentrations in protein solutions, wherein the protein solutions lack or have reduced liquid-liquid phase separation are described. Such protein solutions are substantially clear and substantially homogenous. Additionally, methods of concentrating and purifying proteins using liquid-liquid phase separation are provided.
摘要翻译：在蛋白质溶液中配制高浓度蛋白质的方法，其中蛋白质溶液缺乏或液 - 液相分离减少。这种蛋白质溶液基本上是清楚的并且基本上均匀。另外，提供了使用液 - 液相分离来浓缩和纯化蛋白质的方法。

4. 发明申请

WO2010148337A1 LYOPHILIZED FORMULATIONS FOR SMALL MODULAR IMMUNOPHARMACEUTICALS 审中-公开
标题翻译：用于小型模块化免疫球蛋白的LYOPHILIZED制剂
公开(公告)号：WO2010148337A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/039227
申请日：2010-06-18
申请人： WYETH LLC , TCHESSALOV, Serguei , KANTOR, Angela , LI, Li , LUKSHA, Nicholas , WARNE, Nicholas
发明人： TCHESSALOV, Serguei , KANTOR, Angela , LI, Li , LUKSHA, Nicholas , WARNE, Nicholas
IPC分类号： A61K9/19
CPC分类号： A61K39/39591 , A61K9/0014 , A61K9/19 , A61K47/183 , A61K47/26 , C07K16/2887 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2319/00
摘要： The present invention provides, among other things, stable formulations for small modular immunopharmaceutical (SMIP TM ) proteins. In some embodiments, the present invention provides a formulation containing a lyophilized mixture of a small modular immunopharmaceutical protein, wherein less than 7% of the lyophilized small modular immunopharmaceutical protein exists in aggregated form. Formulations according to the invention may contain buffering agents, stabilizers, bulking agents, surfactants and/or other excipients. The present invention also provides formulations for lyophilization, reconstitution and methods of use thereof.
摘要翻译：本发明尤其提供了用于小型模块化免疫药物（SMIPTM）蛋白质的稳定制剂。在一些实施方案中，本发明提供含有小模块化免疫药物蛋白质的冻干混合物的制剂，其中小于7％的冻干小模块化免疫药物蛋白以聚集形式存在。根据本发明的制剂可以含有缓冲剂，稳定剂，填充剂，表面活性剂和/或其它赋形剂。本发明还提供了用于冻干，重构和其使用方法的制剂。

5. 发明申请

WO2007136693A2 PREDICTION OF RELATIVE POLYPEPTIDE SOLUBILITY BY POLYETHYLENE GLYCOL PRECIPITATION 审中-公开
标题翻译：通过聚乙二醇降解预测相对多肽溶解度
公开(公告)号：WO2007136693A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/011818
申请日：2007-05-17
申请人： WYETH , LI, Li , KANTOR, Angela , WARNE, Nicholas, W.
发明人： LI, Li , KANTOR, Angela , WARNE, Nicholas, W.
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N33/6803
摘要： A method is described for predicting the relative solubility of a polypeptide using polyethylene glycol (PEG) based volume exclusion precipitation. Different polypeptides can be tested for their solubilities relative to each other or relative to a reference. A single polypeptide can be tested for its relative solubility under different experimental conditions. The solubility determinations can be made by comparison based on graphs plotting the log solubility of the polypeptide against a range of PEG concentrations. Additionally, a method is provided for the high throughput visual or automated screening of multiple polypeptides for relative solubility differences, in a method that can omit the step of measuring the actual solubility or actual amount of precipitation of each sample at each PEG concentration.
摘要翻译：描述了一种用于使用基于聚乙二醇（PEG）的体积排阻沉淀来预测多肽的相对溶解度的方法。可以测试不同的多肽相对于彼此或相对于参考物的溶解度。可以在不同的实验条件下测试单个多肽的相对溶解度。可以基于绘制多肽对一定范围的PEG浓度的对数溶解度的图表进行比较来进行溶解度测定。此外，提供了一种方法，可以省略在每个PEG浓度下测量每个样品的实际溶解度或实际沉淀量的步骤，用于多个多肽的高通量视觉或自动筛选相对溶解度差异。

6. 发明申请

WO2007109221A2 METHODS FOR REDUCING PROTEIN AGGREGATION 审中-公开
标题翻译：降低蛋白质聚集的方法
公开(公告)号：WO2007109221A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006787
申请日：2007-03-19
申请人： WYETH , WARNE, Nicholas, William , KANTOR, Angela , CROWLEY, Thomas, Joseph , SOLEY, Erin, Christine , LI, Li , LUKSHA, Nicholas, Gary , NEIDHARDT, Edie, Anna
发明人： WARNE, Nicholas, William , KANTOR, Angela , CROWLEY, Thomas, Joseph , SOLEY, Erin, Christine , LI, Li , LUKSHA, Nicholas, Gary , NEIDHARDT, Edie, Anna
IPC分类号： A61K39/395
CPC分类号： A61K39/39591 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K47/183 , A61K47/26 , C07K2319/30
摘要： Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations.
摘要翻译：提供了减少制剂中蛋白质或蛋白质聚集的方法，以及具有降低的聚集性质的蛋白质制剂。本文描述的方法和制剂维持蛋白质的生物活性并增加蛋白质制剂的保质期。

7. 发明申请

WO2006083689A2 ANTI A BETA ANTIBODY FORMULATION 审中-公开
标题翻译：抗体抗体制剂
公开(公告)号：WO2006083689A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002837
申请日：2006-01-27
申请人： NEURALAB LIMITED , WYETH , LUISI, Donna , WARNE, Nicholas, W. , KANTOR, Angela
发明人： LUISI, Donna , WARNE, Nicholas, W. , KANTOR, Angela
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K31/198 , A61K31/4172 , A61K39/39591 , A61K47/02 , A61K47/183 , C07K16/18 , C07K2317/24
摘要： The present invention provides formulations for maintaining the stability of Aβ binding polypeptides, for example, Aβ antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.
摘要翻译：本发明提供了用于维持Aβ结合多肽（例如Aβ抗体）的稳定性的制剂。示例性制剂包括张力剂如甘露醇和缓冲剂或氨基酸如组氨酸。其它示例性制剂包括足够量的抗氧化剂以抑制副产物形成，例如形成高分子量多肽聚集体，低分子量多肽降解片段及其混合物。本发明的制剂任选地包含张力剂，例如甘露醇，缓冲剂或氨基酸，例如组氨酸。该制剂适用于几种不同的给药途径。

8. 发明申请

WO2006081587A2 STABILIZED LIQUID POLYPEPTIDE FORMULATIONS 审中-公开
标题翻译：稳定液体多肽配方
公开(公告)号：WO2006081587A2
公开(公告)日：2006-08-03
申请号：PCT/US2006/004741
申请日：2006-01-27
申请人： WYETH , LUISI, Donna , WARNE, Nicholas, W. , KANTOR, Angela
发明人： LUISI, Donna , WARNE, Nicholas, W. , KANTOR, Angela
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/08 , A61K31/198 , A61K31/4172 , A61K39/39591 , A61K47/02 , A61K47/183 , A61K47/22 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/56
摘要： The present invention provides formulations for maintaining the stability of polypeptides, in particular, therapeutic antigen-binding polypeptides such as antibodies and the like, for example, anti-Aβ antibodies. The formulations generally include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine, and thus, the formulations are suitable for several different routes of administration.
摘要翻译：本发明提供用于维持多肽的稳定性，特别是治疗性抗原结合多肽如抗体等抗体，例如抗Aβ抗体的制剂。制剂通常包括足够量的抗氧化剂以抑制副产物形成，例如形成高分子量多肽聚集体，低分子量多肽降解片段及其混合物。本发明的制剂任选地包含张度剂，例如甘露糖醇，以及缓冲剂或氨基酸，例如组氨酸，因此，该制剂适合于几种不同的给药途径。

9. 发明申请

WO2008101179A2 USE OF SUCROSE TO SUPPRESS MANNITOL-INDUCED PROTEIN AGGREGATION 审中-公开
标题翻译：使用西红柿抑制曼尼托醇诱导的蛋白质聚集
公开(公告)号：WO2008101179A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/054115
申请日：2008-02-15
申请人： WYETH , SEK, David, C. , WARNE, Nicholas, W. , HO, Kin , LUISI, Donna, L. , KANTOR, Angela
发明人： SEK, David, C. , WARNE, Nicholas, W. , HO, Kin , LUISI, Donna, L. , KANTOR, Angela
IPC分类号： A61K9/10 , A61K47/26 , A61K38/00 , A61K39/395
CPC分类号： A61K9/10 , A61K39/39591 , A61K47/26
摘要： The present invention provides a method for suppressing rnannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.
摘要翻译：本发明提供了通过向含有蛋白质的液体制剂提供蔗糖来抑制丹宁醇诱导的蛋白质聚集的方法。本发明还提供了用于储存和制备含有蛋白质和甘露糖醇和蔗糖的组合的液体制剂的方法，使得蔗糖的存在抑制甘露醇诱导的蛋白质聚集。

10. 发明申请

WO2010062896A1 STABLE ANTIBODY COMPOSITIONS AND METHODS FOR STABILIZING SAME 审中-公开
标题翻译：稳定的抗体组合物和用于稳定其的方法
公开(公告)号：WO2010062896A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/065714
申请日：2009-11-24
申请人： ABBOTT LABORATORIES , CORREIA, Ivan R. , RADZIEJEWSKI, Czeslaw H. , FRAUNHOFER, Wolfgang , WARNE, Nicholas W. , KANTOR, Angela
发明人： CORREIA, Ivan R. , RADZIEJEWSKI, Czeslaw H. , FRAUNHOFER, Wolfgang , WARNE, Nicholas W. , KANTOR, Angela
IPC分类号： G01N33/50
CPC分类号： C07K16/244 , A61K9/0019 , A61K39/3955 , A61K39/39591 , A61K47/183 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K16/065 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/94
摘要： The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation.
摘要翻译：本发明提供了用于抑制包含λ轻链的免疫球蛋白分级分离的组合物和方法，基于以下观察结果：在组氨酸存在下，铁导致包含λ轻链的重组完全人IgG分子由于在铰链区域。本发明还提供了包含结合IL-12 / IL-23的p40亚基的抗体或其抗原结合部分的水性药物制剂和包含组氨酸的缓冲体系，其中所述制剂具有增强的稳定性，包括增强的抗性碎片。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式