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1. 发明申请

WO2009052152A3 TIGECYCLINE AND METHODS OF PREPARING INTERMEDIATES 审中-公开
公开(公告)号：WO2009052152A3
公开(公告)日：2009-04-23
申请号：PCT/US2008/079950
申请日：2008-10-15
申请人： WYETH , BERNATCHEZ, Michel , CHEW, Warren , DAIGNEAULT, Sylvain , PALUS, Ernest , MIRMEHRABI, Mahmoud , BOUCHARD, Luc
发明人： BERNATCHEZ, Michel , CHEW, Warren , DAIGNEAULT, Sylvain , PALUS, Ernest , MIRMEHRABI, Mahmoud , BOUCHARD, Luc
IPC分类号： C07C231/02 , C07C237/26
摘要： Methods of preparing and purifying 9-nitrominocycline and 9-aminominocycline and salts thereof used in the process of making tigecycline, are disclosed. In one embodiment, the invention is directed to a method of preparing the compound of formula 1 or a pharmaceutically acceptable salt thereof, comprising: (a) reacting nitric acid with the compound of formula 2, or a salt thereof, to produce a reaction mixture comprising an intermediate; and (b) further reacting the intermediate to form the compound of formula 1, wherein the intermediate is isolated from the reaction mixture, the method further comprising sparging with an inert gas prior to step (a).

2. 发明申请

WO2008052088A1 CHROMANE DERIVATIVES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO 审中-公开
标题翻译： CHROMANE衍生物，其合成及其中间体
公开(公告)号：WO2008052088A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/082452
申请日：2007-10-24
申请人： WYETH , SHAW, Chia-cheng , CHEW, Warren , GUILLEMETTE, Virginie , WEN, Xianghui , WANG, Youchu , TADYSON, Sam , DAIGNEAULT, Sylvain , BOUCHARD, Luc
发明人： SHAW, Chia-cheng , CHEW, Warren , GUILLEMETTE, Virginie , WEN, Xianghui , WANG, Youchu , TADYSON, Sam , DAIGNEAULT, Sylvain , BOUCHARD, Luc
IPC分类号： C07D311/66 , C07D311/58 , A61K31/453 , A61P25/18
CPC分类号： C07D311/58 , C07D311/66
摘要： Methods of preparing compounds of formula I or pharmaceutically acceptable salts thereof are provided: (CH2)n R3 0T^r N. Ar R2 R4 I wherein each of R1, R2, R3, R4, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译：提供了制备式I化合物或其药学上可接受的盐的方法：（CH 2）n R 3 O T r R n Ar R 2 R 4其中R 1，R 2，R 3，R 4，x，m，n和Ar各自为在本文的类和亚类中定义和描述，其是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。

3. 发明申请

WO2006050609A1 NEW HEXAFLUOROALCOHOL-BASED MONOMERS AND PROCESSES OF PREPARATION THEREOF 审中-公开
标题翻译：新型十六烷基醇单体及其制备方法
公开(公告)号：WO2006050609A1
公开(公告)日：2006-05-18
申请号：PCT/CA2005/001728
申请日：2005-11-14
申请人： ST-JEAN PHOTOCHIMIE INC. , INTERNATIONAL BUSINESS MACHINES CORPORATION (IBM) , MOTALLEBI, Shahrokh , DÉSILETS, Denis , MARCOTTE, Ian , BOUCHARD, Luc , FEGHALI, Khalil , VARANASI, Pushkara Rao , KHOJASTEH, Mahmoud
发明人： MOTALLEBI, Shahrokh , DÉSILETS, Denis , MARCOTTE, Ian , BOUCHARD, Luc , FEGHALI, Khalil , VARANASI, Pushkara Rao , KHOJASTEH, Mahmoud
IPC分类号： C07C69/74 , G03F7/20 , H01L21/308
CPC分类号： G03F7/0046 , C07C69/757 , C07C2602/42 , G03F7/0397
摘要： The present invention relates to compounds of formula (I): wherein R 1 is H, or a C 1 -C 10 linear, branched or cyclic alkyl group which is unsubstituted or substituted with fluorine; R 2 is an alicyclic group having 5 to 20 carbon atoms which is unsubstituted or substituted with fluorine; and R 3 represents a C 1 -C 10 linear or branched alkylène which is unsubstituted or substituted with fluorine. Processes for preparing such compounds are also disclosed. The compounds of the present invention can be used as monomers in the fields of photolithography and semiconductor fabrication.
摘要翻译：本发明涉及式（I）的化合物：其中R 1是H或C 1 -C 10直链，支链或未取代或被氟取代的环状烷基; R 2是未被取代或被氟取代的碳原子数5〜20的脂环族基团; R 3表示未被取代或被氟取代的C 1 -C 10直链或支链烷基。还公开了制备这些化合物的方法。本发明的化合物可以用作光刻和半导体制造领域中的单体。

4. 发明申请

WO2003089066A1 METHOD FOR PREVENTING ASBESTOS FROM FREEING AIRBORNE PARTICLES 审中-公开
标题翻译：防止苯甲酸钠从空气中排出的方法
公开(公告)号：WO2003089066A1
公开(公告)日：2003-10-30
申请号：PCT/CA2003/000555
申请日：2003-04-15
申请人： BOUCHARD, Luc , VOISINE, Lisette
发明人： BOUCHARD, Luc , VOISINE, Lisette
IPC分类号： A62D3/00
CPC分类号： A62D3/40 , A62D2101/41 , B09B3/00 , B09B3/0066 , B09B3/0083 , C04B14/405 , C04B2111/00017 , C04B20/04
摘要： The method for preventing asbestos from freeing airborne particles comprises sequentially heating and the asbestos in the following surrounding temperatures values and maintaining the asbestos in these surrounding temperature values until the asbestos changes to the following corresponding colors: a) between 125°F (52°C) and 175°F (79°C) until the asbestos changes to a uniform pale russet-red color; b) between 225°F (107°C) and 275°F (135°C) until the asbestos changes to a uniform dark russet-red color; c) between 325°F (163°C) and 375°F (191°C) until the asbestos changes to a uniform dark orange color; d) between 425°F (218°C) and 475°F (246°C) until the asbestos changes to a uniform red color; e) between 525°F (274°C) and 575°F (302°C) until the asbestos changes to a uniform grey color; and f) between 625°F (329°C) and 675°F (357°C) until the asbestos changes to a uniform opaque white color. Once all the asbestos has reached an opaque white color, the surrounding temperature is decreased to an ambient temperature.
摘要翻译：用于防止石棉释放空气中的颗粒的方法包括在以下周围温度值中依次加热石棉并将石棉保持在这些周围温度值中，直到石棉变成以下相应的颜色：a）125°F ）和175°F（79℃），直到石棉变成均匀的淡红色 - 红色; b）在225°F（107°C）和275°F（135°C）之间，直到石棉变成均匀的暗的红玫瑰红色; c）在325°F（163°C）和375°F（191°C）之间，直到石棉变成均匀的深橙色; d）在425°F（218°C）和475°F（246°C）之间，直到石棉变成均匀的红色; e）在525°F（274°C）和575°F（302°C）之间，直到石棉变成均匀的灰色; 和f）在625°F（329℃）和675°F（357℃）之间，直到石棉变成均匀的不透明白色。一旦所有的石棉达到不透明的白色，周围的温度降低到环境温度。

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