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1. 发明申请

WO03101461A8 NORETHINDRONE SUSTAINED RELEASE FORMULATIONS AND METHODS ASSOCIATED THEREWITH 审中-公开
标题翻译： NORETHINDRONE持续释放制剂及其相关方法
公开(公告)号：WO03101461A8
公开(公告)日：2005-02-03
申请号：PCT/US0316933
申请日：2003-05-30
申请人： WATSON PHARMACEUTICALS INC , ANIGBOGU ANGELA , QUAN DANYI , RUIZ ANNA
发明人： ANIGBOGU ANGELA , QUAN DANYI , RUIZ ANNA
IPC分类号： A61K47/10 , A61F13/00 , A61K9/70 , A61K31/56 , A61K31/565 , A61K31/567 , A61K47/22 , A61K47/32 , A61P5/30 , A61P15/18 , C07J1/00
CPC分类号： A61K9/7061 , A61K31/56 , A61K31/565 , A61K31/567
摘要： Sustained delivery formulations of norethindrone are disclosed and described. In one aspect, the formulation may be a transdermal formulation that includes both norethindrone and norethindrone acetate. In another aspect, the formulation may further include a penetration enhancer. Coadministration of norethindrone and norethindrone acetate has been found to provide a number of advantages, such as achievement of peak norethindrone serum levels substantially within 24 hours after initiation of administration.
摘要翻译：公开并描述了炔诺酮的持续递送制剂。在一个方面，该制剂可以是包含炔诺酮和醋酸炔诺酮的透皮制剂。在另一方面，制剂可以进一步包含渗透促进剂。已发现炔诺酮和醋酸炔诺酮的共同给药提供了许多优点，例如在开始给药后大体上在24小时内实现高达炔诺酮血清水平。

2. 发明申请

WO2005060540A3 NORETHINDRONE SUSTAINED RELEASE TRANSDERMAL FORMULATION 审中-公开
标题翻译： NORTHHINDRONE可持续发布超声波配方
公开(公告)号：WO2005060540A3
公开(公告)日：2006-01-05
申请号：PCT/US2004040073
申请日：2004-11-30
申请人： WATSON PHARMACEUTICALS INC , QUAN DANYI , RUIZ ANA , ANIGBOGU ANGELA
发明人： QUAN DANYI , RUIZ ANA , ANIGBOGU ANGELA
IPC分类号： A61F13/00 , A61K9/70 , A61K31/56 , A61K31/565 , A61K31/567 , A61F13/02 , A61L15/16
CPC分类号： A61K9/7061 , A61K31/56 , A61K31/565 , A61K31/567
摘要： Sustained delivery formulations of norethindrone are disclosed and described. In one aspect, the formulation may be a transdermal formulation that includes both norethindrone and norethindrone acetate. In another aspect, the formulation may further include a penetration enhancer. Coadministration of norethindrone and norethindrone acetate has been found to provide a number of advantages, such as achievement of peak norethindrone serum levels substantially within 24 hours after initiation of administration.
摘要翻译：公开和描述炔诺酮的持续递送制剂。一方面，制剂可以是包括炔诺酮和醋酸炔诺酮二者的透皮制剂。在另一方面，制剂还可包含渗透增强剂。已经发现炔诺酮和醋酸炔诺酮的共同施用提供了许多优点，例如在开始给药后24小时内达到顶点炔诺酮血清水平。

3. 发明申请

WO0191724A3 TRANSDERMAL DELIVERY OF LASOFOXIFENE 审中-公开
标题翻译： LASOFOXIFENE的透皮递送
公开(公告)号：WO0191724A3
公开(公告)日：2002-05-30
申请号：PCT/US0117567
申请日：2001-05-31
申请人： WATSON PHARMACEUTICALS INC , FIKSTAD DAVID , QUAN DANYI
发明人： FIKSTAD DAVID , QUAN DANYI
IPC分类号： A61K9/00 , A61K9/70 , A61K31/40 , A61K31/445 , A61K31/46 , A61K47/10 , A61K47/14 , A61P5/30
CPC分类号： A61K9/7061 , A61K9/7084 , A61K31/40
摘要： The present invention to provide methods, pharmaceutical formulations, and devices for the transdermal delivery of 5-substituted-6-cyclic-5,6,7,8,-tetrahydronaphthalene2-o1 compounds ("lasofoxifene" or "CP-336,156") and pharmaceutically acceptable salts thereof. The invention also provides transdermal compositions of CP-336,156 or its salts dissolved or dispersed in a suitable carrier vehicle, optionally containing permeation enhancers and other excipients. The carrier vehicle may be a pressure sensitive adhesive, polymeric reservoir, or a fluid of controlled viscosity. The carrier vehicle may be contained in a device for purposes of holding the composition against the skin surface. Such devices may be in the form of matrix patches (drug in adhesive) or reservoir patches (drug in a liquid or polymeric reservoir with peripheral, in-line, or over-layed pressure sensitive adhesive). Further provided by this invention are methods for treating pathologies associated with the binding of lasofoxifene with the human estrogen receptor-alpha. For example, the invention formulations and devices are useful to treat or prevent bone loss, obesity, breast cancer, endometriosis, cardiovascular disease and prostatic disease.
摘要翻译：本发明提供5-取代-6-环-5,6,7,8-四氢萘-2-基化合物（“拉索昔芬”或“CP-336,156”）的透皮递送的方法，药物制剂和装置，以及其药学上可接受的盐。本发明还提供CP-336,156或其盐溶解或分散在合适的载体载体中的透皮组合物，任选地含有渗透促进剂和其它赋形剂。载体载体可以是压敏粘合剂，聚合物储存器或具有可控粘度的流体。载体载体可以容纳在用于将组合物保持在皮肤表面上的装置中。这样的装置可以是基质贴片（粘合剂中的药物）或储存器贴片（液体中的药物或具有外围，在线或过度叠加的压敏粘合剂的聚合物储存器）的形式。本发明进一步提供的是用于治疗与拉索非昔芬与人雌激素受体-α的结合相关的病理学的方法。例如，本发明的制剂和装置可用于治疗或预防骨丢失，肥胖，乳腺癌，子宫内膜异位症，心血管疾病和前列腺疾病。

4. 发明申请

WO2007075433A3 BEVERAGE SYSTEMS 审中-公开
标题翻译：饮料系统
公开(公告)号：WO2007075433A3
公开(公告)日：2007-12-13
申请号：PCT/US2006047941
申请日：2006-12-14
申请人： XEL HERBACEUTICALS INC , QUAN DANYI , XIONG WADE W
发明人： QUAN DANYI , XIONG WADE W
IPC分类号： A23K1/175
CPC分类号： A23L2/52
摘要： A beverage and supplement system includes a beverage container (12) having: i) a liquid contained therein; and ii) a dispensive opening (14). A removable envelope (18) is in communication with the dispensive opening of the container, and has a first side (20) sealed to a second side (22) with the supplement (24) being contained therebetween. The second side of the envelope is rupturable upon application of force to the first side in an amount sufficient to rupture the second side without rupturing the first side, in order to dispense the supplement from the envelope without contacting the supplement with an external object.
摘要翻译：饮料和补充系统包括饮料容器（12），其具有：i）容纳在其中的液体; 和ii）昂贵的开口（14）。可拆卸的外壳（18）与容器的昂贵的开口连通，并且具有密封到第二侧（22）的第一侧（20），其间包含有补充物（24）。信封的第二面在向第一面施加足够的力以使第二面破裂而不破坏第一面的情况下是可破裂的，以便从信封中分配补充物而不会使补充物与外部物体接触。

5. 发明申请

WO2006012238A3 GREEN TEA FORMULATIONS AND METHODS OF PREPARATION 审中-公开
标题翻译：绿茶配方和制备方法
公开(公告)号：WO2006012238A3
公开(公告)日：2006-07-13
申请号：PCT/US2005022328
申请日：2005-06-24
申请人： XEL HERBACEUTICALS INC , QUAN DANYI , XIONG WADE W
发明人： QUAN DANYI , XIONG WADE W
IPC分类号： A23F3/00 , A23F3/16 , A23F3/18
CPC分类号： A23F3/18 , A23F3/163
摘要： Green tea formulations and methods for the preparation thereof are disclosed and described. Generally speaking, the method of preparation includes the mixing of fresh tea leaves in an amount of cold water, followed by pulverization of the leaves to release their intracellular material from the cells of the green tea leaves into the water and form an aqueous extract component. The remaining cellular material forms a leaf residue component which is removed from the mixture. Once the leaf residue is removed, the aqueous extract component is collected and may be dried or further processed to produce a final tea extract that has good natural color, robust natural flavor, and pleasant organoleptic properties, which also is high in polyphenol content, and may be used for various purposes such as the creation of a green tea beverage.
摘要翻译：公开并描述了绿茶制剂及其制备方法。一般而言，制备方法包括将新鲜茶叶在一定量的冷水中混合，然后粉碎叶片以将它们的细胞内物质从绿茶叶的细胞释放到水中并形成水性提取物组分。剩余的细胞材料形成从混合物中除去的叶渣组分。一旦叶渣被除去，收集含水提取物组分并且可以干燥或进一步加工以产生具有良好的天然色泽，坚固的天然风味和令人愉快的感官特性（其也具有高的多酚含量）的最终茶提取物，以及可用于各种目的，例如创建绿茶饮料。

6. 发明申请

WO2006023063A2 PRODUCT CONTAINER WITH REMOVABLY ATTACHED MAGNET 审中-公开
标题翻译：带有可拆卸连接磁铁的产品容器
公开(公告)号：WO2006023063A2
公开(公告)日：2006-03-02
申请号：PCT/US2005022662
申请日：2005-06-28
申请人： XEL HERBACEUTICALS INC , XIONG WADE W , QUAN DANYI
发明人： XIONG WADE W , QUAN DANYI
IPC分类号： B65D73/00
CPC分类号： B65D75/366 , B65D2203/02 , B65D2313/04 , B65D2575/366 , B65D2575/367 , Y10S206/818
摘要： A product container (10) configured to be magnetically affixed to a support surface (13) to contain and dispense a product (20) in a location adjacent to the support surface includes an enclosure (12) configured to contain the product and to provide for dispensing of the product therefrom. An access opening (14) is formed in at least one side of the enclosure, the access opening being configured to provide access to the product to allow an individual to withdraw the product from the enclosure. A magnet (16) is re-usably attached to the enclosure and is configured to magnetically affix the enclosure to the support surface. The magnet has indicia (18) disposed thereon to convey information relating to the product.
摘要翻译：被配置成磁性地固定到支撑表面（13）上以将产品（20）容纳和分配在与支撑表面相邻的位置中的产品容器（10）包括外壳（12），其被配置为容纳产品并且用于从中分配产品。进入开口（14）形成在外壳的至少一侧中，进入开口被配置为提供对产品的进入以允许个人从外壳中取出产品。磁体（16）可重复使用地附接到外壳并被构造成将外壳磁性地固定到支撑表面。该磁体上设有标记（18）以传达与产品有关的信息。

7. 发明申请

WO9940955A3 PRESSURE SENSITIVE ADHESIVE MATRIX PATCH FOR THE TREATMENT OF ONYCHOMYCOSIS 审中-公开
标题翻译：压力敏感胶粘剂治疗骨质疏松症
公开(公告)号：WO9940955A3
公开(公告)日：2004-01-08
申请号：PCT/US9900677
申请日：1999-01-12
申请人： WATSON PHARMACEUTICALS INC
发明人： VENKATESHWARAN SRINIVASAN , QUAN DANYI
IPC分类号： A61F13/06 , A61F13/10 , A61K8/49 , A61K9/70 , A61K31/10 , A61K31/137 , A61K31/4164 , A61K31/4174 , A61K31/4196 , A61K31/496 , A61Q3/00 , C09J7/02 , C09J11/06 , C09J133/00 , C09J175/04 , C09J183/04 , C09J201/00 , A61K31/27
CPC分类号： A61K9/7061 , A61F13/105 , A61K8/4946 , A61Q3/00
摘要： A device (10) for treating antifungal infections of toenails, fingernails (11) is made up of an occlusive backing layer, a pressure sensitive adhesive matrix layer in which is uniformly dispersed an effective amount of an antifungal agent, and optionally a chemical enhancer. The matrix layer has a first surface adhering to the backing layer, a second surface adapted to be in diffusional contact with the infected nail and surrounding skin area. The device (10) is configured, when applied, to cover, to adhere to the nail, and surrounding skin areas for an extended period of time without causing irritation to the skin or inhibiting normal physical activity while providing a continuous delivery of antifungal agent to the infected area.
摘要翻译：用于治疗脚趾甲的抗真菌感染的装置（10）由指骨背衬层，压敏粘合剂基质层组成，其中均匀地分散有效量的抗真菌剂和任选的化学增强剂。基质层具有粘附到背衬层的第一表面，适于与被感染的指甲和周围皮肤区域扩散接触的第二表面。所述装置（10）在被施加时被构造成覆盖，粘附到指甲上并且周围的皮肤区域延长的时间段，而不会对皮肤产生刺激或抑制正常的身体活动，同时提供抗真菌剂的连续递送感染区域。

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